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Items: 1 to 50 of 99

1.

CYP3A4 induction in the liver and intestine of PXR/CYP3A-humanized mice: approaches by mass spectrometry imaging and portal blood analysis.

Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y.

Mol Pharmacol. 2019 Aug 27. pii: mol.119.117333. doi: 10.1124/mol.119.117333. [Epub ahead of print]

2.

Characterization of oral microbiota in marmosets: Feasibility of using the marmoset as a human oral disease model.

Takehara S, Zeredo JL, Kumei Y, Kagiyama K, Fukasawa K, Oshiro A, Ueno M, Kojimahara N, Minakuchi S, Kawaguchi Y.

PLoS One. 2019 Feb 7;14(2):e0207560. doi: 10.1371/journal.pone.0207560. eCollection 2019.

3.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.

4.

Evolution and diversification of the plant gibberellin receptor GID1.

Yoshida H, Tanimoto E, Hirai T, Miyanoiri Y, Mitani R, Kawamura M, Takeda M, Takehara S, Hirano K, Kainosho M, Akagi T, Matsuoka M, Ueguchi-Tanaka M.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7844-E7853. doi: 10.1073/pnas.1806040115. Epub 2018 Aug 1.

5.

Evaluation of 4╬▓-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Nitta SI, Hashimoto M, Kazuki Y, Takehara S, Suzuki H, Oshimura M, Akita H, Chiba K, Kobayashi K.

AAPS J. 2018 Apr 9;20(3):61. doi: 10.1208/s12248-018-0186-9.

PMID:
29858698
6.

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.

Drug Metab Dispos. 2018 Nov;46(11):1756-1766. doi: 10.1124/dmd.118.081216. Epub 2018 May 18.

PMID:
29777024
7.

Novel artificial stool material for external quality assurance (EQA) on a fecal immunochemical test for hemoglobin (FIT): The confirmed utility of stable hemoglobin and an internal standard material.

Yasui R, Yamada M, Takehara S, Sakurabayashi I, Watanabe K.

Clin Chim Acta. 2018 Aug;483:76-81. doi: 10.1016/j.cca.2018.04.021. Epub 2018 Apr 16.

PMID:
29673583
8.

Prevalence and risk factors of halitosis in Japanese school children.

Ueno M, Ohnuki M, Zaitsu T, Takehara S, Furukawa S, Kawaguchi Y.

Pediatr Int. 2018 Jun;60(6):588-592. doi: 10.1111/ped.13561. Epub 2018 May 9.

PMID:
29573072
9.

Gastrocnemius Myalgia as a Rare Initial Manifestation of Crohn's Disease.

Osada A, Yamada H, Takehara S, Tozuka Y, Fukushima T, Oka H, Okazaki H, Nagaoka S.

Intern Med. 2018 Jul 15;57(14):2001-2006. doi: 10.2169/internalmedicine.0327-17. Epub 2018 Feb 28.

10.

A 'NanoSuit' successfully protects petals of cherry blossoms in high vacuum: examination of living plants in an FE-SEM.

Takehara S, Takaku Y, Suzuki H, Ohta I, Shimomura M, Hariyama T.

Sci Rep. 2018 Jan 26;8(1):1685. doi: 10.1038/s41598-018-19968-w.

11.

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.

Abe S, Kobayashi K, Oji A, Sakuma T, Kazuki K, Takehara S, Nakamura K, Okada A, Tsukazaki Y, Senda N, Honma K, Yamamoto T, Ikawa M, Chiba K, Oshimura M, Kazuki Y.

Sci Rep. 2017 Nov 9;7(1):15189. doi: 10.1038/s41598-017-15033-0.

12.

"Pure" Suprasellar Schwannoma Presented with Communicating Hydrocephalus: A Case Report.

Oishi T, Takehara S, Yamamura Y, Tomida M, Ito S, Kuriki K, Namba H.

NMC Case Rep J. 2017 Jun 12;4(3):83-87. doi: 10.2176/nmccrj.cr.2016-0267. eCollection 2017 Jul.

13.

OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation.

Huang P, Yoshida H, Yano K, Kinoshita S, Kawai K, Koketsu E, Hattori M, Takehara S, Huang J, Hirano K, Ordonio RL, Matsuoka M, Ueguchi-Tanaka M.

J Integr Plant Biol. 2018 Feb;60(2):130-143. doi: 10.1111/jipb.12557. Epub 2017 Aug 1.

PMID:
28574161
14.

Relationships between occupational and behavioral parameters and oral health status.

Zaitsu T, Kanazawa T, Shizuma Y, Oshiro A, Takehara S, Ueno M, Kawaguchi Y.

Ind Health. 2017 Aug 8;55(4):381-390. doi: 10.2486/indhealth.2017-0011. Epub 2017 May 2.

15.

[Hemodialysis Increases the Incidence of Post-Traumatic Seizure in Hemodialysis Patients with Traumatic Intracranial Hemorrhage].

Oishi T, Takehara S, Yamamura Y, Tomida M, Ikegaya N, Seki G, Ohta N.

No Shinkei Geka. 2017 Apr;45(4):303-309. doi: 10.11477/mf.1436203500. Japanese.

PMID:
28415054
16.

A modified 'NanoSuit®' preserves wet samples in high vacuum: direct observations on cells and tissues in field-emission scanning electron microscopy.

Takaku Y, Suzuki H, Kawasaki H, Ohta I, Ishii D, Hirakawa S, Tsutsui T, Matsumoto H, Takehara S, Nakane C, Sakaida K, Suzuki C, Muranaka Y, Kikuchi H, Konno H, Shimomura M, Hariyama T.

R Soc Open Sci. 2017 Mar 1;4(3):160887. doi: 10.1098/rsos.160887. eCollection 2017 Mar.

17.

Characteristics of undergraduate dental students in Japan: English competency and willingness to study abroad.

Takehara S, Wright F, Kawaguchi Y, Ishida Y, Morio I, Tagami J.

Int Dent J. 2016 Oct;66(5):311-7. doi: 10.1111/idj.12244. Epub 2016 Jun 10.

PMID:
27283476
18.

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.

Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, Chiba K.

J Steroid Biochem Mol Biol. 2016 Oct;163:121-8. doi: 10.1016/j.jsbmb.2016.04.018. Epub 2016 Apr 29.

PMID:
27137100
19.

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.

Kazuki Y, Akita M, Kobayashi K, Osaki M, Satoh D, Ohta R, Abe S, Takehara S, Kazuki K, Yamazaki H, Kamataki T, Oshimura M.

Sci Rep. 2016 Feb 23;6:21419. doi: 10.1038/srep21419.

20.

Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.

Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M.

BMC Biotechnol. 2015 Jun 19;15:58. doi: 10.1186/s12896-015-0142-z.

21.

Antheridiogen determines sex in ferns via a spatiotemporally split gibberellin synthesis pathway.

Tanaka J, Yano K, Aya K, Hirano K, Takehara S, Koketsu E, Ordonio RL, Park SH, Nakajima M, Ueguchi-Tanaka M, Matsuoka M.

Science. 2014 Oct 24;346(6208):469-73. doi: 10.1126/science.1259923.

22.

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.

Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimizu R, Nakauchi H, Yamamoto T, Oshimura M.

Sci Rep. 2014 Aug 27;4:6136. doi: 10.1038/srep06136.

23.

Saliva viscosity as a potential risk factor for oral malodor.

Ueno M, Takeuchi S, Takehara S, Kawaguchi Y.

Acta Odontol Scand. 2014 Nov;72(8):1005-9. doi: 10.3109/00016357.2014.938115. Epub 2014 Aug 13.

PMID:
25115949
24.

A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region.

Takehara S, Schulz TC, Abe S, Takiguchi M, Kazuki K, Kishigami S, Wakayama T, Tomizuka K, Oshimura M, Kazuki Y.

Transgenic Res. 2014 Jun;23(3):441-53. doi: 10.1007/s11248-014-9781-4. Epub 2014 Feb 2.

PMID:
24488595
25.

Expression and purification of a GRAS domain of SLR1, the rice DELLA protein.

Sato T, Miyanoiri Y, Takeda M, Naoe Y, Mitani R, Hirano K, Takehara S, Kainosho M, Matsuoka M, Ueguchi-Tanaka M, Kato H.

Protein Expr Purif. 2014 Mar;95:248-58. doi: 10.1016/j.pep.2014.01.006. Epub 2014 Jan 23.

PMID:
24463428
26.

Highly stable maintenance of a mouse artificial chromosome in human cells and mice.

Kazuki K, Takehara S, Uno N, Imaoka N, Abe S, Takiguchi M, Hiramatsu K, Oshimura M, Kazuki Y.

Biochem Biophys Res Commun. 2013 Dec 6;442(1-2):44-50. doi: 10.1016/j.bbrc.2013.10.171. Epub 2013 Nov 9.

PMID:
24216103
27.

Degradation of MUC7 and MUC5B in human saliva.

Takehara S, Yanagishita M, Podyma-Inoue KA, Kawaguchi Y.

PLoS One. 2013 Jul 18;8(7):e69059. doi: 10.1371/journal.pone.0069059. Print 2013.

28.

Development of a highly sensitive bioluminescent enzyme immunoassay for hepatitis B virus surface antigen capable of detecting divergent mutants.

Minekawa T, Takehara S, Takahashi M, Okamoto H.

Clin Vaccine Immunol. 2013 Aug;20(8):1255-65. doi: 10.1128/CVI.00186-13. Epub 2013 Jun 12.

29.

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.

Hashimoto M, Kobayashi K, Watanabe M, Kazuki Y, Takehara S, Inaba A, Nitta S, Senda N, Oshimura M, Chiba K.

J Lipid Res. 2013 Aug;54(8):2060-8. doi: 10.1194/jlr.M033464. Epub 2013 May 24.

30.

A novel and stable mouse artificial chromosome vector.

Takiguchi M, Kazuki Y, Hiramatsu K, Abe S, Iida Y, Takehara S, Nishida T, Ohbayashi T, Wakayama T, Oshimura M.

ACS Synth Biol. 2014 Dec 19;3(12):903-14. doi: 10.1021/sb3000723. Epub 2012 Oct 17.

PMID:
23654256
31.

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y, Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M, Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K, Tomizuka K, Oshimura M.

Hum Mol Genet. 2013 Feb 1;22(3):578-92. doi: 10.1093/hmg/dds468. Epub 2012 Nov 2.

PMID:
23125282
32.

The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5╬▒.

Miyamoto T, Nakayama EE, Yokoyama M, Ibe S, Takehara S, Kono K, Yokomaku Y, Pizzato M, Luban J, Sugiura W, Sato H, Shioda T.

PLoS One. 2012;7(10):e47757. doi: 10.1371/journal.pone.0047757. Epub 2012 Oct 19.

33.

The relationship between turbidity of mouth-rinsed water and oral health status.

Takeuchi S, Ueno M, Takehara S, Pham TA, Hakuta C, Morishima S, Shinada K, Kawaguchi Y.

Acta Odontol Scand. 2013 Jan;71(1):183-8. doi: 10.3109/00016357.2011.654258. Epub 2012 Feb 20.

PMID:
22339260
34.

Clinical trial of oral malodor treatment in patients with periodontal diseases.

Pham TA, Ueno M, Zaitsu T, Takehara S, Shinada K, Lam PH, Kawaguchi Y.

J Periodontal Res. 2011 Dec;46(6):722-9. doi: 10.1111/j.1600-0765.2011.01395.x. Epub 2011 Jul 18.

PMID:
21762407
35.

Refined human artificial chromosome vectors for gene therapy and animal transgenesis.

Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N, Oshimura M.

Gene Ther. 2011 Apr;18(4):384-93. doi: 10.1038/gt.2010.147. Epub 2010 Nov 18.

36.

Enhanced MR angiography for depiction of spinal dural arteriovenous fistula in the craniocervical junction.

Yamashita T, Takehara S, Miyazaki K, Kitahama Y, Namba H.

J Neuroradiol. 2011 Jul;38(3):196-8. doi: 10.1016/j.neurad.2010.08.003. Epub 2010 Oct 18. No abstract available.

PMID:
20961618
37.

Refolding and polymerization pathways of neuroserpin.

Takehara S, Zhang J, Yang X, Takahashi N, Mikami B, Onda M.

J Mol Biol. 2010 Nov 12;403(5):751-62. doi: 10.1016/j.jmb.2010.07.047. Epub 2010 Aug 4.

PMID:
20691191
38.

Relationship between oral malodor and glycosylated salivary proteins.

Takehara S, Yanagishita M, Podyma-Inoue KA, Ueno M, Shinada K, Kawaguchi Y.

J Med Dent Sci. 2010 Mar;57(1):25-33.

PMID:
20437763
39.

Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial.

Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Zaitsu T, Ohnuki M, Wright FA, Kawaguchi Y.

Trials. 2010 Feb 12;11:14. doi: 10.1186/1745-6215-11-14.

40.

Complete genetic correction of ips cells from Duchenne muscular dystrophy.

Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, Hoshiya H, Hiramatsu K, Yoshino T, Kazuki K, Ishihara C, Takehara S, Higaki K, Nakagawa M, Takahashi K, Yamanaka S, Oshimura M.

Mol Ther. 2010 Feb;18(2):386-93. doi: 10.1038/mt.2009.274. Epub 2009 Dec 8.

41.

ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.

Obara Y, Yamauchi A, Takehara S, Nemoto W, Takahashi M, Stork PJ, Nakahata N.

J Biol Chem. 2009 Aug 28;284(35):23564-73. doi: 10.1074/jbc.M109.027821. Epub 2009 Jul 6.

42.

The 2.1-A crystal structure of native neuroserpin reveals unique structural elements that contribute to conformational instability.

Takehara S, Onda M, Zhang J, Nishiyama M, Yang X, Mikami B, Lomas DA.

J Mol Biol. 2009 Apr 24;388(1):11-20. doi: 10.1016/j.jmb.2009.03.007. Epub 2009 Mar 10.

PMID:
19285087
43.

Factors affecting the motivation for dental check-ups and anxiety in the elderly in Tokyo.

Takehara S, Shimoyama K.

Gerodontology. 2009 Jun;26(2):105-11. doi: 10.1111/j.1741-2358.2008.00241.x. Epub 2009 Feb 26.

PMID:
19260990
44.

A randomized double blind crossover placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor.

Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Kawaguchi Y.

Trials. 2008 Dec 9;9:71. doi: 10.1186/1745-6215-9-71.

45.

Cleaved serpin refolds into the relaxed state via a stressed conformer.

Onda M, Nakatani K, Takehara S, Nishiyama M, Takahashi N, Hirose M.

J Biol Chem. 2008 Jun 20;283(25):17568-78. doi: 10.1074/jbc.M709262200. Epub 2008 Apr 7.

46.

Clinical oral malodor measurement with a portable sulfide monitor.

Ueno M, Shinada K, Yanagisawa T, Mori C, Yokoyama S, Furukawa S, Takehara S, Kawaguchi Y.

Oral Dis. 2008 Apr;14(3):264-9. doi: 10.1111/j.1601-0825.2007.01374.x.

PMID:
18336374
47.

Primary structure and function of a cytotoxic outer-membrane protein (ComP) of Plesiomonas shigelloides.

Tsugawa H, Ogawa A, Takehara S, Kimura M, Okawa Y.

FEMS Microbiol Lett. 2008 Apr;281(1):10-6. doi: 10.1111/j.1574-6968.2007.01041.x.

48.

Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos.

Nagano T, Takehara S, Takahashi M, Aizawa S, Yamamoto A.

Development. 2006 Dec;133(23):4643-54. Epub 2006 Oct 25.

49.
50.

Magnetoencephalographic study of cortical activity evoked by electrogustatory stimuli.

Yamamoto C, Takehara S, Morikawa K, Nakagawa S, Yamaguchi M, Iwaki S, Tonoike M, Yamamoto T.

Chem Senses. 2003 Mar;28(3):245-51.

PMID:
12714447

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