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A program of exercise, brain training, and lecture to prevent cognitive decline.

Kouzuki M, Kato T, Wada-Isoe K, Takeda S, Tamura A, Takanashi Y, Azumi S, Kojima Y, Maruyama C, Hayashi M, Itou M, Urakami K.

Ann Clin Transl Neurol. 2020 Feb 18. doi: 10.1002/acn3.50993. [Epub ahead of print]


Retrospective study of the recurrence risk of preterm birth in Japan.

Seyama R, Makino S, Nojiri S, Takeda J, Suzuki T, Maruyama Y, Takeda S, Itakura A.

J Matern Fetal Neonatal Med. 2020 Feb 18:1-5. doi: 10.1080/14767058.2020.1727435. [Epub ahead of print]


Novel Method of Cervicoplasty Using Autologous Peritoneum for Cervicovaginal Atresia.

Fujino K, Ikemoto Y, Kitade M, Takeda S.

Surg J (N Y). 2020 Feb 11;6(1):e28-e32. doi: 10.1055/s-0040-1701213. eCollection 2020 Jan.


Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance.

Chung WY, Correa E, Yoshimura K, Chang MC, Dennison A, Takeda S, Chang YT.

Am J Transl Res. 2020 Jan 15;12(1):171-179. eCollection 2020.


Publisher Correction: Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride.

Takizawa H, Hara Y, Mizobe Y, Ohno T, Suzuki S, Inoue K, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Hoshino M, Komaki H, Takeda S, Aoki Y.

Sci Rep. 2020 Feb 7;10(1):2462. doi: 10.1038/s41598-020-59351-2.


Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer.

Ishii H, Saitoh M, Sakamoto K, Sakamoto K, Saigusa D, Kasai H, Ashizawa K, Miyazawa K, Takeda S, Masuyama K, Yoshimura K.

Br J Cancer. 2020 Feb 5. doi: 10.1038/s41416-020-0732-y. [Epub ahead of print]


Changes over an 8-year period in Streptococcus pyogenes emm types in pharyngeal isolates from non-invasive infection patients at a pediatric facility.

Okabe T, Norose Y, Hida M, Takeda S, Takase M, Suzuki Y, Ohkuni H.

J Nippon Med Sch. 2020 Jan 31. doi: 10.1272/jnms.JNMS.2020_87-502. [Epub ahead of print]


microRNA-191 regulates endometrial cancer cell growth via TET1-mediated epigenetic modulation of APC.

Yang C, Ota-Kurogi N, Ikeda K, Okumura T, Horie-Inoue K, Takeda S, Inoue S.

J Biochem. 2020 Jan 31. pii: mvaa014. doi: 10.1093/jb/mvaa014. [Epub ahead of print]


The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks.

Hu Q, Klages-Mundt N, Wang R, Lynn E, Kuma Saha L, Zhang H, Srivastava M, Shen X, Tian Y, Kim H, Ye Y, Paull T, Takeda S, Chen J, Li L.

Cell Rep. 2020 Jan 28;30(4):1235-1245.e4. doi: 10.1016/j.celrep.2019.12.067.


Expectations and anxieties of Duchenne muscular dystrophy patients and their families during the first-in-human clinical trial of NS-065/NCNP-01.

Shimizu R, Ohata M, Tachimori H, Kimura E, Harada Y, Takeshita E, Tamaura A, Takeda S, Komaki H.

Brain Dev. 2020 Jan 25. pii: S0387-7604(20)30019-X. doi: 10.1016/j.braindev.2020.01.001. [Epub ahead of print]


A rare case of right-sided infective endocarditis caused by group B Streptococcus complicated with septic knee arthritis and subcutaneous abscess in the lower extremity.

Takeda S, Tanaka Y, Takeichi Y, Hirata H, Tabuchi A.

Acute Med Surg. 2019 Sep 17;7(1):e456. doi: 10.1002/ams2.456. eCollection 2020 Jan-Dec.


Clinical practice with steroid therapy for Duchenne muscular dystrophy: An expert survey in Asia and Oceania.

Takeuchi F, Nakamura H, Yonemoto N, Komaki H, Rosales RL, Kornberg AJ, Bretag AH, Dejthevaporn C, Goh KJ, Jong YJ, Kim DS, Khadilkar SV, Shen D, Wong KT, Chai J, Chan SH, Khan S, Ohnmar O, Nishino I, Takeda S, Nonaka I.

Brain Dev. 2020 Jan 21. pii: S0387-7604(19)30713-2. doi: 10.1016/j.braindev.2019.12.005. [Epub ahead of print]


Estrogen Induces Mammary Ductal Dysplasia via the Upregulation of Myc Expression in a DNA-Repair-Deficient Condition.

Itou J, Takahashi R, Sasanuma H, Tsuda M, Morimoto S, Matsumoto Y, Ishii T, Sato F, Takeda S, Toi M.

iScience. 2020 Feb 21;23(2):100821. doi: 10.1016/j.isci.2020.100821. Epub 2020 Jan 9.


Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells.

Alauddin M, Okumura T, Rajaxavier J, Khozooei S, Pöschel S, Takeda S, Singh Y, Brucker SY, Wallwiener D, Koch A, Salker MS.

Mol Nutr Food Res. 2020 Jan 24:e1900390. doi: 10.1002/mnfr.201900390. [Epub ahead of print]


Early phase 2 trial of TAS-205 in patients with Duchenne muscular dystrophy.

Komaki H, Maegaki Y, Matsumura T, Shiraishi K, Awano H, Nakamura A, Kinoshita S, Ogata K, Ishigaki K, Saitoh S, Funato M, Kuru S, Nakayama T, Iwata Y, Yajima H, Takeda S.

Ann Clin Transl Neurol. 2020 Jan 20. doi: 10.1002/acn3.50978. [Epub ahead of print]


Influence of Percutaneous Occlusion of Atrial Septal Defect on Left Atrial Function Evaluated Using 2D Speckle Tracking Echocardiography.

Suzuki K, Kato T, Koyama S, Shinohara T, Inukai S, Sato J, Yamamoto H, Omori D, Yoshida S, Takeda S, Nishikawa H, Ohashi N, Sakurai H, Saitoh S.

Int Heart J. 2020 Jan 31;61(1):83-88. doi: 10.1536/ihj.19-173. Epub 2020 Jan 17.


A rare case of the recurrent surgery for cribriform-morular variant of papillary thyroid carcinoma.

Enomoto K, Tamagawa S, Kumashiro N, Warigaya K, Takeda S, Gunduz M, Murata SI, Hotomi M.

Int J Surg Case Rep. 2020;66:385-389. doi: 10.1016/j.ijscr.2019.11.060. Epub 2019 Dec 6.


Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle.

Tsoumpra MK, Sawatsubashi S, Imamura M, Fukumoto S, Takeda S, Matsumoto T, Aoki Y.

J Mol Endocrinol. 2020 Apr;64(3):195-208. doi: 10.1530/JME-19-0229.


Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells: A randomised, double-blind placebo-controlled feasibility trial.

Tewary S, Lucas ES, Fujihara R, Kimani PK, Polanco A, Brighton PJ, Muter J, Fishwick KJ, Da Costa MJMD, Ewington LJ, Lacey L, Takeda S, Brosens JJ, Quenby S.

EBioMedicine. 2020 Jan;51:102597. doi: 10.1016/j.ebiom.2019.102597. Epub 2020 Jan 9.


Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response.

Tanaka A, Kanmura S, Morinaga Y, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Takeshita M, Takeda S, Ido A.

Mol Med Rep. 2020 Mar;21(3):1181-1191. doi: 10.3892/mmr.2020.10925. Epub 2020 Jan 9.


Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions.

Takeda S.

Front Neurosci. 2019 Dec 13;13:1274. doi: 10.3389/fnins.2019.01274. eCollection 2019. Review.


Advantages of the external fixator for stabilizing pedicled abdominal or groin flap.

Takeda S, Mitsuya S, Yamamoto M, Mitsuya M, Hirata H.

J Plast Reconstr Aesthet Surg. 2019 Dec 16. pii: S1748-6815(19)30569-8. doi: 10.1016/j.bjps.2019.11.058. [Epub ahead of print] No abstract available.


Novel properties of myoferlin in glucose metabolism via pathways involving modulation of adipose functions.

Nozato Y, Takami Y, Yamamoto K, Nagasawa M, Nozato S, Imaizumi Y, Takeshita H, Wang C, Ito Y, Takeda S, Takeya Y, Sugimoto K, Nakagami H, Hanayama R, Rakugi H.

FASEB J. 2020 Feb;34(2):2792-2811. doi: 10.1096/fj.201901539RR. Epub 2020 Jan 7.


Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.

Shinohara M, Tashiro Y, Shinohara M, Hirokawa J, Suzuki K, Onishi-Takeya M, Mukouzono M, Takeda S, Saito T, Fukumori A, Saido TC, Morishita R, Sato N.

FASEB J. 2020 Feb;34(2):2425-2435. doi: 10.1096/fj.201901028RR. Epub 2019 Dec 16.


Distribution of Flavan-3-ol Species in Ripe Strawberry Fruit Revealed by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging.

Enomoto H, Takahashi S, Takeda S, Hatta H.

Molecules. 2019 Dec 26;25(1). pii: E103. doi: 10.3390/molecules25010103.


Correlation Between Subjective Happiness and Pleasant Activities at Workplace in Nursing Staff for Older Individuals in Japan.

Takeda S, Nakayama S, Uddin MS, Hiramoto A, Inoue M.

Community Ment Health J. 2019 Dec 28. doi: 10.1007/s10597-019-00539-w. [Epub ahead of print]


Novel inter-domain Ca2+-binding site in the gelsolin superfamily protein fragmin.

Takeda S, Fujiwara I, Sugimoto Y, Oda T, Narita A, Maéda Y.

J Muscle Res Cell Motil. 2019 Dec 20. doi: 10.1007/s10974-019-09571-5. [Epub ahead of print]


Assessment of extravasation on ruptured uterine artery pseudoaneurysm using contrast-enhanced ultrasonography during uterine balloon tamponade.

Takeda J, Makino S, Hirai C, Shimanuki Y, Inagaki T, Itakura A, Takeda S.

J Int Med Res. 2019 Dec 20:300060519893166. doi: 10.1177/0300060519893166. [Epub ahead of print] No abstract available.


Brachial-ankle pulse wave velocity in healthy Japanese adolescents: reference values for the assessment of arterial stiffness and cardiovascular risk profiles.

Sougawa Y, Miyai N, Utsumi M, Miyashita K, Takeda S, Arita M.

Hypertens Res. 2019 Dec 18. doi: 10.1038/s41440-019-0370-z. [Epub ahead of print]


The Effectiveness of Training Programs on the Fidelity of Neuropsychological Tests.

Takeda S, Banno Y, Sugimoto T, Fujii F, Kimura A, Sakurai T.

Yonago Acta Med. 2019 Oct 25;62(4):278-284. doi: 10.33160/yam.2019.11.003. eCollection 2019 Dec.


Evaluation of an automated point-of-care test system for measuring thrombin-antithrombin complex in dogs.

Kato D, Takahashi M, Yonezawa T, Ohmi A, Takeda S, Nakagawa T, Hosoda S, Kanemoto H, Fukushima K, Ohno K, Matsuki N, Tsujimoto H.

J Vet Emerg Crit Care (San Antonio). 2020 Jan;30(1):102-106. doi: 10.1111/vec.12913. Epub 2019 Dec 17.


Chronic Chagastic cardiomyopathy associated with membranoproliferative glomerulonephritis: Report of an autopsy case.

Shintaku M, Takeda S, Miura S, Yutani C, Tsutsumi Y.

Pathol Int. 2020 Jan;70(1):47-52. doi: 10.1111/pin.12883. Epub 2019 Dec 16.


The phosphatidylethanolamine biosynthesis pathway provides a new target for cancer chemotherapy.

Guan Y, Chen X, Wu M, Zhu W, Arslan A, Takeda S, Nguyen MH, Majeti R, Thomas D, Zheng M, Peltz G.

J Hepatol. 2019 Nov 22. pii: S0168-8278(19)30676-2. doi: 10.1016/j.jhep.2019.11.007. [Epub ahead of print]


Identification of novel mutations of ovarian cancer-related genes from RNA-sequencing data for Japanese epithelial ovarian cancer patients.

Nagasawa S, Ikeda K, Horie-Inoue K, Sato S, Takeda S, Hasegawa K, Inoue S.

Endocr J. 2019 Nov 19. doi: 10.1507/endocrj.EJ19-0283. [Epub ahead of print]


Oxytocin induced labor causes region and sex-specific transient oligodendrocyte cell death in neonatal mouse brain.

Hirayama T, Hiraoka Y, Kitamura E, Miyazaki S, Horie K, Fukuda T, Hidema S, Koike M, Itakura A, Takeda S, Nishimori K.

J Obstet Gynaecol Res. 2020 Jan;46(1):66-78. doi: 10.1111/jog.14149. Epub 2019 Nov 19.


Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents.

Póti Á, Gyergyák H, Németh E, Rusz O, Tóth S, Kovácsházi C, Chen D, Szikriszt B, Spisák S, Takeda S, Szakács G, Szallasi Z, Richardson AL, Szüts D.

Genome Biol. 2019 Nov 14;20(1):240. doi: 10.1186/s13059-019-1867-0.


Roles of vascular risk factors in the pathogenesis of dementia.

Takeda S, Rakugi H, Morishita R.

Hypertens Res. 2020 Mar;43(3):162-167. doi: 10.1038/s41440-019-0357-9. Epub 2019 Nov 14. Review.


Segmental aplasia of a uterine horn in two RccHan:WIST rats.

Shimotsuma Y, Takeda S, Ogata K, Miyata K.

J Toxicol Pathol. 2019 Oct;32(4):293-296. doi: 10.1293/tox.2019-0015. Epub 2019 Jun 22.



Takai S, Shimada A, Sawaguchi T, Takeda S, Kimura H.

Radiat Prot Dosimetry. 2019 Nov 11. pii: ncz250. doi: 10.1093/rpd/ncz250. [Epub ahead of print]


Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy.

Mori-Yoshimura M, Mizuno Y, Yoshida S, Ishihara N, Minami N, Morimoto E, Maruo K, Nonaka I, Komaki H, Nishino I, Sekiguchi M, Sato N, Takeda S, Takahashi Y.

Neuromuscul Disord. 2019 Dec;29(12):930-939. doi: 10.1016/j.nmd.2019.09.006. Epub 2019 Sep 18.


Metalloestrogenic effects of cadmium are absent in long-term estrogen-deprived MCF-7 cells: Evidence for the involvement of constitutively activated estrogen receptor α and very low expression of G protein-coupled estrogen receptor 1.

Hirao-Suzuki M, Takeda S, Kodama Y, Takiguchi M, Toda A, Ohara M.

Toxicol Lett. 2020 Feb 1;319:22-30. doi: 10.1016/j.toxlet.2019.10.018. Epub 2019 Nov 3.


(S)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist.

Morishita K, Miike T, Takeda S, Fukui M, Ito Y, Kitao T, Ozawa SI, Hirono S, Shirahase H.

Chem Pharm Bull (Tokyo). 2019;67(11):1211-1224. doi: 10.1248/cpb.c19-00541.


Dynamic Changes in Ultrastructure of the Primary Cilium in Migrating Neuroblasts in the Postnatal Brain.

Matsumoto M, Sawada M, García-González D, Herranz-Pérez V, Ogino T, Bang Nguyen H, Quynh Thai T, Narita K, Kumamoto N, Ugawa S, Saito Y, Takeda S, Kaneko N, Khodosevich K, Monyer H, García-Verdugo JM, Ohno N, Sawamoto K.

J Neurosci. 2019 Dec 11;39(50):9967-9988. doi: 10.1523/JNEUROSCI.1503-19.2019. Epub 2019 Nov 4.


Fabrication of tissue-engineered cell sheets by automated cell culture equipment.

Nishimura A, Nakajima R, Takagi R, Zhou G, Suzuki D, Kiyama M, Nozaki T, Owaki T, Takahara T, Nagai S, Nakamura T, Sugaya M, Terada K, Igarashi Y, Hanzawa H, Okano T, Shimizu T, Yamato M, Takeda S.

J Tissue Eng Regen Med. 2019 Dec;13(12):2246-2255. doi: 10.1002/term.2968. Epub 2019 Nov 14.


Elliptic neutron-focusing supermirror for illuminating small samples in neutron reflectometry.

Hosobata T, Yamada NL, Hino M, Yoshinaga H, Nemoto F, Hori K, Kawai T, Yamagata Y, Takeda M, Takeda S.

Opt Express. 2019 Sep 16;27(19):26807-26820. doi: 10.1364/OE.27.026807.


Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.

Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S.

Genes (Basel). 2019 Oct 30;10(11). pii: E868. doi: 10.3390/genes10110868. Review.


Comparative transcriptome analysis of galls from four different host plants suggests the molecular mechanism of gall development.

Takeda S, Yoza M, Amano T, Ohshima I, Hirano T, Sato MH, Sakamoto T, Kimura S.

PLoS One. 2019 Oct 24;14(10):e0223686. doi: 10.1371/journal.pone.0223686. eCollection 2019.


Correction: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer.

Kuwahara T, Hazama S, Suzuki N, Yoshida S, Tomochika S, Nakagami Y, Matsui H, Shindo Y, Kanekiyo S, Tokumitsu Y, Iida M, Tsunedomi R, Takeda S, Yoshino S, Okayama N, Suehiro Y, Yamasaki T, Fujita T, Kawakami Y, Ueno T, Nagano H.

Br J Cancer. 2019 Nov;121(11):983-984. doi: 10.1038/s41416-019-0605-4.


Generation of time-domain-multiplexed two-dimensional cluster state.

Asavanant W, Shiozawa Y, Yokoyama S, Charoensombutamon B, Emura H, Alexander RN, Takeda S, Yoshikawa JI, Menicucci NC, Yonezawa H, Furusawa A.

Science. 2019 Oct 18;366(6463):373-376. doi: 10.1126/science.aay2645.


A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders.

Takeda T, Takeda S, Kakigi A.

Auris Nasus Larynx. 2020 Feb;47(1):25-41. doi: 10.1016/j.anl.2019.09.005. Epub 2019 Oct 15. Review.


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