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Illuminating Clues of Cancer Buried in Prostate MR Image: Deep Learning and Expert Approaches.

Akatsuka J, Yamamoto Y, Sekine T, Numata Y, Morikawa H, Tsutsumi K, Yanagi M, Endo Y, Takeda H, Hayashi T, Ueki M, Tamiya G, Maeda I, Fukumoto M, Shimizu A, Tsuzuki T, Kimura G, Kondo Y.

Biomolecules. 2019 Oct 30;9(11). pii: E673. doi: 10.3390/biom9110673.


Electrostatically Driven Guest Binding in Self-Assembled Molecular Network of Hexagonal Pyridine Macrocycle at the Liquid/Solid Interface: Symmetry Breaking Induced by Coadsorbed Solvent Molecules.

Iritani K, Takeda H, Kather M, Yokoi M, Moeglen M, Ikeda M, Otsubo Y, Ozawa Y, Tahara K, Hirose K, De Feyter S, Tobe Y.

Langmuir. 2019 Nov 13. doi: 10.1021/acs.langmuir.9b02748. [Epub ahead of print]


[Combination of Immunotherapy and Hyperthermia].

Kubota Y, Takeda T, Takeda T, Noda T, Hattori N, Nakamura K, Yasuda T, Hasegawa T, Yokoyama Y, Yamamoto H, Takeda H.

Gan To Kagaku Ryoho. 2019 Oct;46(10):1605-1607. Japanese.


Intermittent hypoxia, energy expenditure, and visceral adipocyte recovery.

Umeda A, Miyagawa K, Mochida A, Takeda H, Takeda K, Okada Y, Gozal D.

Respir Physiol Neurobiol. 2019 Oct 16;273:103332. doi: 10.1016/j.resp.2019.103332. [Epub ahead of print]


A Nearly Complete Genome of Ciona intestinalis Type A (C. robusta) Reveals the Contribution of Inversion to Chromosomal Evolution in the Genus Ciona.

Satou Y, Nakamura R, Yu D, Yoshida R, Hamada M, Fujie M, Hisata K, Takeda H, Satoh N.

Genome Biol Evol. 2019 Nov 1;11(11):3144-3157. doi: 10.1093/gbe/evz228.


Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.

Nagakura Y, Miwa M, Yoshida M, Miura R, Tanei S, Tsuji M, Takeda H.

Eur J Pharmacol. 2019 Dec 1;864:172716. doi: 10.1016/j.ejphar.2019.172716. Epub 2019 Oct 4.


Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site.

Takeda H, Ohe R, Fukui T, Suzuki S, Nakamura S, Watanabe K, Yoshioka T.

Case Rep Oncol. 2019 Aug 16;12(2):666-670. doi: 10.1159/000502416. eCollection 2019 May-Aug.


Usefulness of pre- and post-stent optical frequency domain imaging findings in the prediction of periprocedural cardiac troponin elevation in patients with coronary artery disease.

Otsuka K, Shimada K, Ishikawa H, Nakamura H, Katayama H, Takeda H, Fujimoto K, Kasayuki N, Yoshiyama M.

Heart Vessels. 2019 Sep 27. doi: 10.1007/s00380-019-01512-z. [Epub ahead of print]


A case of invasive pulmonary aspergillosis diagnosed by transbronchial lung biopsy during treatment for diabetic ketoacidosis in a type 1 diabetic patient.

Watanabe N, Saito K, Kiritani A, Fujimoto S, Yamanaka Y, Fujisaki I, Hosoda C, Miyagawa H, Seki Y, Kinoshita A, Takeda H, Endo Y, Kuwano K.

J Infect Chemother. 2019 Sep 18. pii: S1341-321X(19)30251-X. doi: 10.1016/j.jiac.2019.08.011. [Epub ahead of print]


Exploring the hepatitis C virus genome using single molecule real-time sequencing.

Takeda H, Yamashita T, Ueda Y, Sekine A.

World J Gastroenterol. 2019 Aug 28;25(32):4661-4672. doi: 10.3748/wjg.v25.i32.4661. Review.


Efficacy and Safety of Alogliptin in Elderly Patients With Type 2 Diabetes Mellitus.

Takeda H, Sasai N, Ito S, Obana M, Takuma T, Takai M, Kaneshige H, Machimura H, Kanamori A, Matsuba I.

J Clin Med Res. 2019 Sep;11(9):651-663. doi: 10.14740/jocmr3953. Epub 2019 Sep 1.


Comparison of the clinical effect of dutasteride therapy for benign prostatic hyperplasia when initiated at different time points: A multicentre, observational, retrospective chart review study.

Shima Y, Kawano Y, Kobayashi A, Yamanishi T, Takeda H, Palacios-Moreno JM, Yamada M, Masumori N.

Int J Clin Pract. 2019 Sep 11:e13418. doi: 10.1111/ijcp.13418. [Epub ahead of print]


Quantitative Evaluation of Reactivity and Toxicity of Acyl Glucuronides by [35S]Cysteine Trapping.

Harada H, Toyoda Y, Abe Y, Endo T, Takeda H.

Chem Res Toxicol. 2019 Oct 21;32(10):1955-1964. doi: 10.1021/acs.chemrestox.9b00111. Epub 2019 Sep 20.


An energy landscape approach to understanding variety and robustness in tissue morphogenesis.

Takeda H, Kameo Y, Inoue Y, Adachi T.

Biomech Model Mechanobiol. 2019 Sep 7. doi: 10.1007/s10237-019-01222-5. [Epub ahead of print]


Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers.

Eso Y, Shimizu T, Takeda H, Takai A, Marusawa H.

J Gastroenterol. 2019 Sep 7. doi: 10.1007/s00535-019-01620-7. [Epub ahead of print] Review.


Determination of the pathogenicity of known COL4A5 intronic variants by in vitro splicing assay.

Horinouchi T, Nozu K, Yamamura T, Minamikawa S, Nagano C, Sakakibara N, Nakanishi K, Shima Y, Morisada N, Ishiko S, Aoto Y, Nagase H, Takeda H, Rossanti R, Kaito H, Matsuo M, Iijima K.

Sci Rep. 2019 Sep 3;9(1):12696. doi: 10.1038/s41598-019-48990-9.


Phagocytic elimination of synapses by microglia during sleep.

Choudhury ME, Miyanishi K, Takeda H, Islam A, Matsuoka N, Kubo M, Matsumoto S, Kunieda T, Nomoto M, Yano H, Tanaka J.

Glia. 2020 Jan;68(1):44-59. doi: 10.1002/glia.23698. Epub 2019 Aug 19.


Comprehensive analysis of syndromic hearing loss patients in Japan.

Ideura M, Nishio SY, Moteki H, Takumi Y, Miyagawa M, Sato T, Kobayashi Y, Ohyama K, Oda K, Matsui T, Ito T, Suzumura H, Nagai K, Izumi S, Nishiyama N, Komori M, Kumakawa K, Takeda H, Kishimoto Y, Iwasaki S, Furutate S, Ishikawa K, Fujioka M, Nakanishi H, Nakayama J, Horie R, Ohta Y, Naito Y, Kakudo M, Sakaguchi H, Kataoka Y, Sugahara K, Hato N, Nakagawa T, Tsuchihashi N, Kanda Y, Kihara C, Tono T, Miyanohara I, Ganaha A, Usami SI.

Sci Rep. 2019 Aug 19;9(1):11976. doi: 10.1038/s41598-019-47141-4.


Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction.

Chigira T, Nagatoishi S, Takeda H, Yoshimaru T, Katagiri T, Tsumoto K.

Biochem Biophys Res Commun. 2019 Oct 8;518(1):183-189. doi: 10.1016/j.bbrc.2019.08.028. Epub 2019 Aug 14.


On the Right to Science: Recommendations of Selection Criteria for IMIA Scientific Meetings.

Lehmann CU, Borycki E, Cho KH, Espinosa A, Geissbuhler A, Huesing E, Hurlen P, Kimura M, Tchuitcheu GK, Kushniruk A, Lovis C, Luna D, Moen A, Park HA, Seroussi B, Silva ML, Takeda H, Weber P, Westbrook J, Koch S.

Yearb Med Inform. 2019 Aug;28(1):11-13. doi: 10.1055/s-0039-1677924. Epub 2019 Aug 16.


CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.

Takeda H, Kataoka S, Nakayama M, Ali MAE, Oshima H, Yamamoto D, Park JW, Takegami Y, An T, Jenkins NA, Copeland NG, Oshima M.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15635-15644. doi: 10.1073/pnas.1904714116. Epub 2019 Jul 12.


Proton Shell Evolution below ^{132}Sn: First Measurement of Low-Lying β-Emitting Isomers in ^{123,125}Ag.

Chen ZQ, Li ZH, Hua H, Watanabe H, Yuan CX, Zhang SQ, Lorusso G, Nishimura S, Baba H, Browne F, Benzoni G, Chae KY, Crespi FCL, Doornenbal P, Fukuda N, Gey G, Gernhäuser R, Inabe N, Isobe T, Jiang DX, Jungclaus A, Jung HS, Jin Y, Kameda D, Kim GD, Kim YK, Kojouharov I, Kondev FG, Kubo T, Kurz N, Kwon YK, Li XQ, Lou JL, Lane GJ, Li CG, Luo DW, Montaner-Pizá A, Moschner K, Niu CY, Naqvi F, Niikura M, Nishibata H, Odahara A, Orlandi R, Patel Z, Podolyák Z, Sumikama T, Söderström PA, Sakurai H, Schaffner H, Simpson GS, Steiger K, Suzuki H, Taprogge J, Takeda H, Vajta Z, Wang HK, Wu J, Wendt A, Wang CG, Wu HY, Wang X, Wu CG, Xu C, Xu ZY, Yagi A, Ye YL, Yoshinaga K.

Phys Rev Lett. 2019 May 31;122(21):212502. doi: 10.1103/PhysRevLett.122.212502.


Improved Value for the Gamow-Teller Strength of the ^{100}Sn Beta Decay.

Lubos D, Park J, Faestermann T, Gernhäuser R, Krücken R, Lewitowicz M, Nishimura S, Sakurai H, Ahn DS, Baba H, Blank B, Blazhev A, Boutachkov P, Browne F, Čeliković I, de France G, Doornenbal P, Fang Y, Fukuda N, Giovinazzo J, Goel N, Górska M, Ilieva S, Inabe N, Isobe T, Jungclaus A, Kameda D, Kim YK, Kojouharov I, Kubo T, Kurz N, Kwon YK, Lorusso G, Moschner K, Murai D, Nishizuka I, Patel Z, Rajabali MM, Rice S, Schaffner H, Shimizu Y, Sinclair L, Söderström PA, Steiger K, Sumikama T, Suzuki H, Takeda H, Wang Z, Warr N, Watanabe H, Wu J, Xu Z.

Phys Rev Lett. 2019 Jun 7;122(22):222502. doi: 10.1103/PhysRevLett.122.222502.


Correction: Four-in-One Antibodies Have Superior Cancer Inhibitory Activity against EGFR, HER2, HER3, and VEGF through Disruption of HER/MET Crosstalk.

Hu S, Fu W, Xu W, Yang Y, Cruz M, Berezov SD, Jorissen D, Takeda H, Zhu W.

Cancer Res. 2019 Jul 1;79(13):3525. doi: 10.1158/0008-5472.CAN-19-1515. No abstract available.


Development of Visible-Light Driven Cu(I) Complex Photosensitizers for Photocatalytic CO2 Reduction.

Takeda H, Monma Y, Sugiyama H, Uekusa H, Ishitani O.

Front Chem. 2019 Jun 6;7:418. doi: 10.3389/fchem.2019.00418. eCollection 2019.


Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector.

Takeda H, Takahashi M, Hara T, Izumi Y, Bamba T.

J Lipid Res. 2019 Aug;60(8):1465-1474. doi: 10.1194/jlr.D094516. Epub 2019 Jun 14.


Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility.

Yanagihara K, Matsumoto T, Aoki N, Sato J, Wakamura T, Kiyota H, Tateda K, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Akiba Y, Masunaga S, Takeuchi K, Takeda H, Miki M, Kumagai T, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Ishigaki S, Kobayasi N, Takasaki J, Mezaki K, Iwata S, Katouno Y, Inose R, Niki Y, Kawana A, Fujikura Y, Kudo M, Hirano T, Yamamoto M, Miyazawa N, Tsukada H, Aso S, Yamamoto Y, Iinuma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Kawabata A, Sugaki Y, Seki M, Hamaguchi S, Toyokawa M, Kakeya H, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Hayasi M, Mikasa K, Kasahara K, Koizumi A, Korohasi N, Matumoto T, Yosimura Y, Katanami Y, Takesue Y, Wada Y, Sugimoto K, Yamamoto T, Kuwabara M, Doi M, Simizu S, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Yatera K, Fujita M, Kadota J, Hiramatsu K, Aoki Y, Magarifuchi H, Oho M, Morinaga Y, Suga M, Muranaka H, Fujita J, Higa F, Tateyama M.

J Infect Chemother. 2019 Sep;25(9):657-668. doi: 10.1016/j.jiac.2019.05.006. Epub 2019 Jun 10.


Effectiveness of pharmaceutical support by pharmacists in urinary care teams.

Umemura T, Wakita E, Asano M, Mizuno T, Kozaki K, Ikeda Y, Takeda H.

J Pharm Health Care Sci. 2019 Jun 3;5:11. doi: 10.1186/s40780-019-0141-7. eCollection 2019.


[A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®) Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treated with Chemoradiotherapy].

Mizumachi T, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C, Kumagai S, Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y, Onimaru R, Shirato H, Fukuda S.

Gan To Kagaku Ryoho. 2019 Apr;46(4):685-689. Japanese.


OTOF mutation analysis with massively parallel DNA sequencing in 2,265 Japanese sensorineural hearing loss patients.

Iwasa YI, Nishio SY, Sugaya A, Kataoka Y, Kanda Y, Taniguchi M, Nagai K, Naito Y, Ikezono T, Horie R, Sakurai Y, Matsuoka R, Takeda H, Abe S, Kihara C, Ishino T, Morita SY, Iwasaki S, Takahashi M, Ito T, Arai Y, Usami SI.

PLoS One. 2019 May 16;14(5):e0215932. doi: 10.1371/journal.pone.0215932. eCollection 2019.


Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.

Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.

Neoplasia. 2019 Jun;21(6):545-556. doi: 10.1016/j.neo.2019.03.007. Epub 2019 Apr 28.


Metastasis of advanced gastric cancer to the extraocular muscle: a case report.

Goto S, Takeda H, Sasahara Y, Takanashi I, Yamashita H.

J Med Case Rep. 2019 Apr 26;13(1):107. doi: 10.1186/s13256-019-2031-x.


Efficacy and Safety of Adding Sitagliptin in Type 2 Diabetes Patients on Insulin: Age-Stratified Comparison at One Year in the ASSIST-K Study.

Takai M, Ishikawa M, Maeda H, Kanamori A, Kubota A, Amemiya H, Iizuka T, Iemitsu K, Iwasaki T, Uehara G, Umezawa S, Obana M, Kaneshige H, Kaneshiro M, Kawata T, Sasai N, Saito T, Takuma T, Takeda H, Tanaka K, Nakajima S, Hoshino K, Honda S, Machimura H, Matoba K, Minagawa F, Minami N, Miyairi Y, Mokubo A, Motomiya T, Waseda M, Miyakawa M, Terauchi Y, Tanaka Y, Matsuba I.

J Clin Med Res. 2019 May;11(5):311-320. doi: 10.14740/jocmr3677. Epub 2019 Apr 14.


Characteristics of awareness and behavior of medical staff for prevention of falling accidents among inpatients.

Kinoshita M, Takeda H, Yamada C, Kumagai T, Kakamu T, Hidaka T, Masuishi Y, Endo S, Hashimoto S, Fukushima T.

Fukushima J Med Sci. 2019;65(1):13-23. doi: 10.5387/fms.2018-22.


Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite.

Abe K, Shimada A, Tayama S, Nishikawa H, Kaneko T, Tsuda S, Karaiwa A, Matsui T, Ishitani T, Takeda H.

Cell Rep. 2019 Apr 16;27(3):928-939.e4. doi: 10.1016/j.celrep.2019.03.068.


Targeted in vivo epigenome editing of H3K27me3.

Fukushima HS, Takeda H, Nakamura R.

Epigenetics Chromatin. 2019 Mar 13;12(1):17. doi: 10.1186/s13072-019-0263-z.


Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.

Shiomi M, Takeda H, Irino Y, Kimura N, Yamada S, Kuniyoshi N, Kikumori A, Koike Y, Koike T, Yoshida M, Izumi Y, Shinohara M, Bamba T, Ishida T.

Atherosclerosis. 2019 May;284:18-23. doi: 10.1016/j.atherosclerosis.2019.02.020. Epub 2019 Feb 28.


Estimation of the economic value of herd-life length based on simulated changes in survival rate.

Sasaki O, Takeda H, Nishiura A.

Anim Sci J. 2019 Mar;90(3):323-332. doi: 10.1111/asj.13158. Epub 2018 Dec 25.


Changes in the Pneumococcal Vaccine Serotypes in Adult Noninvasive Pneumonia after the Introduction of Pneumococcal Conjugate Vaccination for Children.

Takeda H, Sato C, Bin C, Nishidzuka M, Watanabe M, Yamamoto T, Suzuki H, Oishi K, Tsuchida F.

J Glob Infect Dis. 2019 Jan-Mar;11(1):30-35. doi: 10.4103/jgid.jgid_167_17.


Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan.

Shimbashi R, Chang B, Tanabe Y, Takeda H, Watanabe H, Kubota T, Kasahara K, Oshima K, Nishi J, Maruyama T, Kuronuma K, Fujita J, Ikuse T, Kinjo Y, Suzuki M, Kerdsin A, Shimada T, Fukusumi M, Tanaka-Taya K, Matsui T, Sunagawa T, Ohnishi M, Oishi K; Adult IPD Study Group.

PLoS One. 2019 Feb 21;14(2):e0212418. doi: 10.1371/journal.pone.0212418. eCollection 2019.


Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers.

Mitsuhashi H, Homma S, Beermann ML, Ishimaru S, Takeda H, Yu BK, Liu K, Duraiswamy S, Boyce FM, Miller JB.

Sci Rep. 2019 Feb 19;9(1):2274. doi: 10.1038/s41598-018-36684-7.


Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

Kim SK, Takeda H, Takai A, Matsumoto T, Kakiuchi N, Yokoyama A, Yoshida K, Kaido T, Uemoto S, Minamiguchi S, Haga H, Shiraishi Y, Miyano S, Seno H, Ogawa S, Marusawa H.

J Gastroenterol. 2019 Jul;54(7):628-640. doi: 10.1007/s00535-019-01555-z. Epub 2019 Feb 12.


Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro.

Kobayshi K, Abe Y, Kawai A, Furihata T, Harada H, Endo T, Takeda H.

Xenobiotica. 2019 Dec;49(12):1434-1446. doi: 10.1080/00498254.2019.1580796. Epub 2019 Mar 5.


Demonstration of on-chip quantum dot microcavity lasers in a molecularly engineered annular groove.

Chen C, Yuan J, Wan L, Chandrahalim H, Chen Z, Nishimura N, Takeda H, Yoshioka H, Liu W, Oki Y, Fan X, Li Z.

Opt Lett. 2019 Feb 1;44(3):495-498. doi: 10.1364/OL.44.000495.


The new era of precision medicine in hepatocellular carcinoma: the urgent need for promising biomarkers.

Takeda H, Nishikawa H, Osaki Y.

Hepatobiliary Surg Nutr. 2018 Dec;7(6):490-491. doi: 10.21037/hbsn.2018.08.06. No abstract available.


Chaperone-mediated secretion switching from early to middle substrates in the type III secretion system encoded by Salmonella pathogenicity island 2.

Takaya A, Takeda H, Tashiro S, Kawashima H, Yamamoto T.

J Biol Chem. 2019 Mar 8;294(10):3783-3793. doi: 10.1074/jbc.RA118.005072. Epub 2019 Jan 16.


Utility of ultrasound-guided liver tumor biopsy for next-generation sequencing-based clinical sequencing.

Eso Y, Kou T, Nagai H, Kim YH, Kanai M, Matsumoto S, Mishima M, Arasawa S, Iguchi E, Nakamura F, Takeda H, Takai A, Takahashi K, Ueda Y, Muto M, Seno H.

Hepatol Res. 2019 May;49(5):579-589. doi: 10.1111/hepr.13312. Epub 2019 Feb 7.


First Observation of ^{20}B and ^{21}B.

Leblond S, Marqués FM, Gibelin J, Orr NA, Kondo Y, Nakamura T, Bonnard J, Michel N, Achouri NL, Aumann T, Baba H, Delaunay F, Deshayes Q, Doornenbal P, Fukuda N, Hwang JW, Inabe N, Isobe T, Kameda D, Kanno D, Kim S, Kobayashi N, Kobayashi T, Kubo T, Lee J, Minakata R, Motobayashi T, Murai D, Murakami T, Muto K, Nakashima T, Nakatsuka N, Navin A, Nishi S, Ogoshi S, Otsu H, Sato H, Satou Y, Shimizu Y, Suzuki H, Takahashi K, Takeda H, Takeuchi S, Tanaka R, Togano Y, Tuff AG, Vandebrouck M, Yoneda K.

Phys Rev Lett. 2018 Dec 28;121(26):262502. doi: 10.1103/PhysRevLett.121.262502.


Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.

Inuzuka T, Ueda Y, Arasawa S, Takeda H, Matsumoto T, Osaki Y, Uemoto S, Seno H, Marusawa H.

Sci Rep. 2018 Dec 24;8(1):18070. doi: 10.1038/s41598-018-36093-w.


The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.

Tanaka H, Watanabe A, Konishi M, Nakai Y, Yoshioka H, Ohkawara T, Takeda H, Harashima H, Akita H.

Heliyon. 2018 Dec 3;4(12):e00959. doi: 10.1016/j.heliyon.2018.e00959. eCollection 2018 Dec.

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