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CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure.

Tsunekuni K, Konno M, Haraguchi N, Koseki J, Asai A, Matsuoka K, Kobunai T, Takechi T, Doki Y, Mori M, Ishii H.

Sci Rep. 2019 Oct 16;9(1):14861. doi: 10.1038/s41598-019-50968-6.


Estrogen Down-regulator Fulvestrant Potentiates Antitumor Activity of Fluoropyrimidine in Estrogen-responsive MCF-7 Human Breast Cancer Cells.

Nukatsuka M, Saito H, Noguchi S, Takechi T.

In Vivo. 2019 Sep-Oct;33(5):1439-1445. doi: 10.21873/invivo.11622.


ChIP-seq Analysis to Explore DNA Replication Profile in Trifluridine-treated Human Colorectal Cancer Cells In Vitro.

Kobunai T, Matsuoka K, Takechi T.

Anticancer Res. 2019 Jul;39(7):3565-3570. doi: 10.21873/anticanres.13502.


Effective Sequential Combined Chemotherapy with Trifluridine/Tipiracil and Regorafenib in Human Colorectal Cancer Cells.

Matsuoka K, Nakagawa F, Tanaka N, Okabe H, Matsuo K, Takechi T.

Int J Mol Sci. 2018 Sep 25;19(10). pii: E2915. doi: 10.3390/ijms19102915.


Multicenter, Open-Label, Randomized Controlled Trial of Warfarin and Edoxaban Tosilate Hydrate for the Treatment of Deep Vein Thrombosis in Persons with Severe Motor Intellectual Disabilities.

Ohmori H, Nakamura M, Kada A, Saito AM, Sanayama Y, Shinagawa T, Fujita H, Wakisaka A, Maruhashi K, Okumura A, Takizawa N, Murata H, Inoue M, Kaneko H, Taniguchi H, Kawasaki M, Sano N, Akaboshi S, Tanuma N, Sone S, Kumode M, Takechi T, Koretsune Y, Sumimoto R, Miyanomae T.

Kurume Med J. 2018 Dec 21;65(1):11-16. doi: 10.2739/kurumemedj.MS651003. Epub 2018 Aug 30.


Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma.

Takechi T, Kumokawa T, Kato R, Higuchi T, Kaneko T, Ieiri I.

J Clin Pharmacol. 2018 Oct;58(10):1361-1370. doi: 10.1002/jcph.1149. Epub 2018 May 10.


Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression.

Matsuoka K, Nakagawa F, Kobunai T, Takechi T.

Oncotarget. 2018 Feb 5;9(17):13438-13450. doi: 10.18632/oncotarget.24412. eCollection 2018 Mar 2.


Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene.

Takechi T, Hirota T, Sakai T, Maeda N, Kobayashi D, Ieiri I.

Drug Metab Dispos. 2018 May;46(5):628-635. doi: 10.1124/dmd.117.079061. Epub 2018 Feb 2.


5-Chloro-2,4-dihydroxypyridine, CDHP, prevents lung metastasis of basal-like breast cancer cells by reducing nascent adhesion formation.

Itou J, Tsukihara H, Nukatsuka M, Toi M, Takechi T.

Cancer Med. 2018 Feb;7(2):463-470. doi: 10.1002/cam4.1265. Epub 2018 Jan 22.


Combined efficacy and mechanism of trifluridine and SN-38 in a 5-FU-resistant human colorectal cancer cell lines.

Matsuoka K, Takechi T.

Am J Cancer Res. 2017 Dec 1;7(12):2577-2586. eCollection 2017.


Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro.

Matsuoka K, Kobunai T, Nukatsuka M, Takechi T.

Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):249-255. doi: 10.1016/j.bbrc.2017.10.044. Epub 2017 Oct 9.


MicroRNA profiles involved in trifluridine resistance.

Tsunekuni K, Konno M, Asai A, Koseki J, Kobunai T, Takechi T, Doki Y, Mori M, Ishii H.

Oncotarget. 2017 May 23;8(32):53017-53027. doi: 10.18632/oncotarget.18078. eCollection 2017 Aug 8.


Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer.

Suzuki N, Nakagawa F, Takechi T.

Oncol Lett. 2017 Jul;14(1):639-646. doi: 10.3892/ol.2017.6258. Epub 2017 May 26.


Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.

Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, Nishizuka SS.

Sci Rep. 2017 May 23;7(1):2262. doi: 10.1038/s41598-017-02548-9.


Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines.

Tsukihara H, Tsunekuni K, Takechi T.

PLoS One. 2016 Sep 29;11(9):e0163961. doi: 10.1371/journal.pone.0163961. eCollection 2016.


[A case of X-linked myotubular myopathy with chylothorax].

Oishi T, Sato T, Matsushita K, Takechi T, Murakami N, Fujieda M.

No To Hattatsu. 2016 Jan;48(1):34-6. Japanese.


Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.

Shimamoto Y, Nukatsuka M, Takechi T, Fukushima M.

Int J Mol Med. 2016 Feb;37(2):319-28. doi: 10.3892/ijmm.2015.2427. Epub 2015 Dec 10.


Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression.

Kikuchi O, Ohashi S, Nakai Y, Nakagawa S, Matsuoka K, Kobunai T, Takechi T, Amanuma Y, Yoshioka M, Ida T, Yamamoto Y, Okuno Y, Miyamoto S, Nakagawa H, Matsubara K, Chiba T, Muto M.

Am J Cancer Res. 2015 Jul 15;5(8):2431-40. eCollection 2015.


Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.

Tsukihara H, Nakagawa F, Sakamoto K, Ishida K, Tanaka N, Okabe H, Uchida J, Matsuo K, Takechi T.

Oncol Rep. 2015 May;33(5):2135-42. doi: 10.3892/or.2015.3876. Epub 2015 Mar 23.


Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase.

Nakamura A, Nakajima G, Okuyama R, Kuramochi H, Kondoh Y, Kanemura T, Takechi T, Yamamoto M, Hayashi K.

Gastric Cancer. 2014 Jan;17(1):188-95. doi: 10.1007/s10120-013-0249-7. Epub 2013 Mar 15.


Combination therapy using oral S-1 and targeted agents against human tumor xenografts in nude mice.

Nukatsuka M, Saito H, Nakagawa F, Tsujimoto H, Sakamoto K, Tsukioka S, Uchida J, Kiniwa M, Kobunai T, Takechi T.

Exp Ther Med. 2012 May;3(5):755-762. Epub 2012 Feb 13.


Efficacy of combination chemotherapy using oral fluoropyrimidine S-1 with oxaliplatin (SOX) against colorectal cancer in vivo.

Nukatsuka M, Saito H, Sakamoto K, Nakagawa F, Uchida J, Kobunai T, Shiraishi K, Takechi T.

Anticancer Res. 2012 Jul;32(7):2807-12.


Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels.

Jin M, Kawakami K, Fukui Y, Tsukioka S, Oda M, Watanabe G, Takechi T, Oka T, Minamoto T.

Cancer Sci. 2009 Dec;100(12):2325-30. doi: 10.1111/j.1349-7006.2009.01321.x. Epub 2009 Aug 25.


A case of recurrent paroxysmal cold hemoglobinuria with the different temperature thresholds of Donath-Landsteiner antibodies.

Ogose T, Wakata Y, Kaneko M, Shinahara K, Takechi T, Kotani H.

J Pediatr Hematol Oncol. 2007 Oct;29(10):716-9.


Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs.

Ooyama A, Okayama Y, Takechi T, Sugimoto Y, Oka T, Fukushima M.

Cancer Sci. 2007 Apr;98(4):577-83.


Changes to the dihydropyrimidine dehydrogenase gene copy number influence the susceptibility of cancers to 5-FU-based drugs: Data mining of the NCI-DTP data sets and validation with human tumour xenografts.

Kobunai T, Ooyama A, Sasaki S, Wierzba K, Takechi T, Fukushima M, Watanabe T, Nagawa H.

Eur J Cancer. 2007 Mar;43(4):791-8. Epub 2007 Jan 24.


Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs.

Ooyama A, Takechi T, Toda E, Nagase H, Okayama Y, Kitazato K, Sugimoto Y, Oka T, Fukushima M.

Cancer Sci. 2006 Jun;97(6):510-22. Erratum in: Cancer Sci. 2006 Aug;97(8):799.


Idiopathic thrombocytopenic purpura associated with Helicobacter pylori infection.

Takechi T, Unemoto J, Ishihara M, Hosokawa T, Zushi N, Shiraishi T, Ogura H, Wakiguchi H.

Pediatr Int. 2006 Feb;48(1):76-8. No abstract available.


[An case report of a therapeutic vancomycin monitoring in an infant with shunt-related purulent meningitis].

Takechi T, Inai N, Inoue K, Kotani H, Shiraishi T, Ogura H, Shinno K.

No To Hattatsu. 2005 Nov;37(6):522-4. Japanese. No abstract available.


[Complications of tracheostomy in patients with severe motor and intellectual disabilities and their management].

Kotani H, Hino H, Takechi T, Shiraishi T, Ogura H.

No To Hattatsu. 2005 Nov;37(6):473-8. Japanese.


Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.

Takechi T, Okabe H, Ikeda K, Fujioka A, Nakagawa F, Ohshimo H, Kitazato K, Fukushima M.

Oncol Rep. 2005 Jul;14(1):33-9.


Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity.

Fujiwara H, Terashima M, Irinoda T, Takagane A, Abe K, Nakaya T, Yonezawa H, Oyama K, Takahashi M, Saito K, Takechi T, Fukushima M, Shirasaka T.

Eur J Cancer. 2003 Nov;39(16):2387-94.


Gene expression in colorectal cancer and in vitro chemosensitivity to 5-fluorouracil: a study of 88 surgical specimens.

Yoshinare K, Kubota T, Watanabe M, Wada N, Nishibori H, Hasegawa H, Kitajima M, Takechi T, Fukushima M.

Cancer Sci. 2003 Jul;94(7):633-8.


[A critical pneumonia by multidrug-resistant Enterococcus faecium in a chronic hemodialysis patient. A case report].

Morii K, Takechi T, Shimizu Y.

Kansenshogaku Zasshi. 2002 Dec;76(12):1035-9. Japanese.


Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR.

Fujiwara H, Terashima M, Irinoda T, Takagane A, Abe K, Kashiwaba M, Oyama K, Takahashi M, Maesawa C, Saito K, Takechi T, Fukushima M.

Jpn J Cancer Res. 2002 Dec;93(12):1342-50.


Induction of thymidine phosphorylase by interferon and taxanes occurs only in human cancer cells with low thymidine phosphorylase activity.

Fukushima M, Okabe H, Takechi T, Ichikawa W, Hirayama R.

Cancer Lett. 2002 Dec 10;187(1-2):103-10.


Infiltrations of Epstein-Barr virus-carrying cells in granular lymphocyte-proliferative disorders corresponding to chronic active Epstein-Barr virus infection.

Takechi T, Maeda A, Hisakawa H, Wakiguchi H, Takeuchi T, Sonobe H, Ohtsuki Y.

Pediatr Hematol Oncol. 2002 Oct-Nov;19(7):459-65.


Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.

Terashima M, Irinoda T, Fujiwara H, Nakaya T, Takagane A, Abe K, Yonezawa H, Oyama K, Inaba T, Saito K, Takechi T, Fukushima M.

Anticancer Res. 2002 Mar-Apr;22(2A):761-8.


Screening of differentially expressed genes in 5-fluorouracil-resistant human gastrointestinal tumor cells.

Takechi T, Koizumi K, Tsujimoto H, Fukushima M.

Jpn J Cancer Res. 2001 Jun;92(6):696-703.


Intractable Q fever treated with recombinant gamma interferon.

Morisawa Y, Wakiguchi H, Takechi T, Kurashige T, Nagaoka H.

Pediatr Infect Dis J. 2001 May;20(5):546-7.


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