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Items: 37

1.

Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives.

Kusakabe Y, Mizutani S, Kamo S, Yoshimoto T, Tomoshige S, Kawasaki T, Takasawa R, Tsubaki K, Kuramochi K.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1390-1394. doi: 10.1016/j.bmcl.2019.03.034. Epub 2019 Mar 26.

PMID:
30935798
2.

Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.

Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S.

Biochem Biophys Res Commun. 2019 Apr 9;511(3):665-670. doi: 10.1016/j.bbrc.2019.01.136. Epub 2019 Feb 27.

PMID:
30826057
3.

Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.

Tamori S, Nozaki Y, Motomura H, Nakane H, Katayama R, Onaga C, Kikuchi E, Shimada N, Suzuki Y, Noike M, Hara Y, Sato K, Sato T, Yamamoto K, Hanawa T, Imai M, Abe R, Yoshimori A, Takasawa R, Tanuma SI, Akimoto K.

Oncotarget. 2018 Nov 23;9(92):36515-36529. doi: 10.18632/oncotarget.26369. eCollection 2018 Nov 23.

4.

Venous thromboembolism in two adolescents with Down syndrome.

Kurokami T, Takasawa R, Takeda S, Kurobe M, Takasawa K, Nishioka M, Shimohira M.

Turk J Pediatr. 2018;60(4):429-432.

PMID:
30859769
5.

Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.

Shimada N, Takasawa R, Tanuma SI.

Arch Biochem Biophys. 2018 Jan 15;638:1-7. doi: 10.1016/j.abb.2017.12.008. Epub 2017 Dec 8.

PMID:
29225125
6.

Risk of coronary artery lesions in young infants with Kawasaki disease: need for a new diagnostic method.

Satoh K, Wakejima Y, Gau M, Kiguchi T, Matsuda N, Takasawa R, Takasawa K, Nishioka M, Shimohira M.

Int J Rheum Dis. 2018 Mar;21(3):746-754. doi: 10.1111/1756-185X.13223. Epub 2017 Nov 3.

PMID:
29105337
7.

Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer.

Nozaki Y, Tamori S, Inada M, Katayama R, Nakane H, Minamishima O, Onodera Y, Abe M, Shiina S, Tamura K, Kodama D, Sato K, Hara Y, Abe R, Takasawa R, Yoshimori A, Shinomiya N, Tanuma SI, Akimoto K.

Genes Cancer. 2017 Jul;8(7-8):628-639. doi: 10.18632/genesandcancer.148.

8.

Piceatannol, a natural trans-stilbene compound, inhibits human glyoxalase I.

Takasawa R, Akahane H, Tanaka H, Shimada N, Yamamoto T, Uchida-Maruki H, Sai M, Yoshimori A, Tanuma SI.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1169-1174. doi: 10.1016/j.bmcl.2017.01.070. Epub 2017 Jan 25.

PMID:
28169168
9.

An infant case of severe hypereosinophilia and systemic symptoms with multiple drug hypersensitivity and reactivation of cytomegalovirus and BK virus.

Kobayashi A, Takasawa R, Takasawa K, Nishioka M, Kaneko M, Ono H, Maekawa T, Morio T, Shimohira M.

Allergol Int. 2017 Jul;66(3):479-481. doi: 10.1016/j.alit.2016.10.002. Epub 2016 Nov 12. No abstract available.

10.

TLSC702, a Novel Inhibitor of Human Glyoxalase I, Induces Apoptosis in Tumor Cells.

Takasawa R, Shimada N, Uchiro H, Takahashi S, Yoshimori A, Tanuma S.

Biol Pharm Bull. 2016;39(5):869-73. doi: 10.1248/bpb.b15-00710.

11.

Structure-based design of dipeptide derivatives for the human neutral endopeptidase.

Misawa K, Suzuki Y, Takahashi S, Yoshimori A, Takasawa R, Shibuya Y, Tanuma S.

Bioorg Med Chem. 2011 Oct 15;19(20):5935-47. doi: 10.1016/j.bmc.2011.08.064. Epub 2011 Sep 1.

PMID:
21937235
12.

Discovery of a new type inhibitor of human glyoxalase I by myricetin-based 4-point pharmacophore.

Takasawa R, Tao A, Saeki K, Shionozaki N, Tanaka R, Uchiro H, Takahashi S, Yoshimori A, Tanuma S.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42. doi: 10.1016/j.bmcl.2011.05.046. Epub 2011 May 23.

PMID:
21669529
13.

Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis.

Saeki K, Nose Y, Hirao N, Takasawa R, Tanuma S.

Biol Pharm Bull. 2011;34(2):290-4.

14.

Glycogen synthase kinase-3β2 has lower phosphorylation activity to tau than glycogen synthase kinase-3β1.

Saeki K, Machida M, Kinoshita Y, Takasawa R, Tanuma S.

Biol Pharm Bull. 2011;34(1):146-9.

15.

DR396, an apoptotic DNase γ inhibitor, attenuates high mobility group box 1 release from apoptotic cells.

Yamada Y, Fujii T, Ishijima R, Tachibana H, Yokoue N, Takasawa R, Tanuma S.

Bioorg Med Chem. 2011 Jan 1;19(1):168-71. doi: 10.1016/j.bmc.2010.11.037. Epub 2010 Nov 23.

PMID:
21167721
16.

The release of high mobility group box 1 in apoptosis is triggered by nucleosomal DNA fragmentation.

Yamada Y, Fujii T, Ishijima R, Tachibana H, Yokoue N, Takasawa R, Tanuma S.

Arch Biochem Biophys. 2011 Feb 15;506(2):188-93. doi: 10.1016/j.abb.2010.11.011. Epub 2010 Nov 17.

PMID:
21093407
17.

Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.

Takahashi S, Kamiya T, Saeki K, Nezu T, Takeuchi S, Takasawa R, Sunaga S, Yoshimori A, Ebizuka S, Abe T, Tanuma S.

Bioorg Med Chem. 2010 Nov 15;18(22):8112-8. doi: 10.1016/j.bmc.2010.08.056. Epub 2010 Oct 12.

PMID:
20947360
18.

Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.

Takasawa R, Saeki K, Tao A, Yoshimori A, Uchiro H, Fujiwara M, Tanuma S.

Bioorg Med Chem. 2010 Oct 1;18(19):7029-33. doi: 10.1016/j.bmc.2010.08.012. Epub 2010 Aug 9.

PMID:
20801663
19.

Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3.

Sakai J, Yoshimori A, Nose Y, Mizoroki A, Okita N, Takasawa R, Tanuma S.

Bioorg Med Chem. 2008 May 1;16(9):4854-9. doi: 10.1016/j.bmc.2008.03.046. Epub 2008 Mar 21.

PMID:
18387304
20.

Design and synthesis of a caged Zn2+ probe, 8-benzenesulfonyloxy-5-N,N-dimethylaminosulfonylquinolin-2-ylmethyl-pendant 1,4,7,10-tetraazacyclododecane, and its hydrolytic uncaging upon complexation with Zn2+.

Aoki S, Sakurama K, Ohshima R, Matsuo N, Yamada Y, Takasawa R, Tanuma S, Takeda K, Kimura E.

Inorg Chem. 2008 Apr 7;47(7):2747-54. doi: 10.1021/ic702002m. Epub 2008 Mar 6.

PMID:
18321042
21.

Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis.

Hayakawa A, Kawamoto Y, Nakajima H, Sakai J, Takasawa R, Nakashima I, Magae J, Tanuma S.

Apoptosis. 2008 Apr;13(4):523-30. doi: 10.1007/s10495-008-0184-y.

PMID:
18297401
22.

Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects.

Takasawa R, Takahashi S, Saeki K, Sunaga S, Yoshimori A, Tanuma S.

Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. doi: 10.1016/j.bmc.2008.01.031. Epub 2008 Jan 24.

PMID:
18258440
23.

Development of HER2-antagonistic peptides as novel anti-breast cancer drugs by in silico methods.

Nakajima H, Mizuta N, Sakaguchi K, Fujiwara I, Yoshimori A, Takahashi S, Takasawa R, Tanuma S.

Breast Cancer. 2008;15(1):65-72. doi: 10.1007/s12282-007-0018-8.

PMID:
18224397
24.

Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO.

Yoshimori A, Sakai J, Sunaga S, Kobayashi T, Takahashi S, Okita N, Takasawa R, Tanuma S.

BMC Pharmacol. 2007 Jun 27;7:8.

25.

The involvement of ATP produced via (ADP-Ribose)n in the maintenance of DNA replication apparatus during DNA repair.

Maruta H, Okita N, Takasawa R, Uchiumi F, Hatano T, Tanuma S.

Biol Pharm Bull. 2007 Mar;30(3):447-50.

26.

A new fluorescent probe for zinc(II): an 8-hydroxy-5-N,N-dimethylaminosulfonylquinoline-pendant 1,4,7,10-tetraazacyclododecane.

Aoki S, Sakurama K, Matsuo N, Yamada Y, Takasawa R, Tanuma S, Shiro M, Takeda K, Kimura E.

Chemistry. 2006 Dec 4;12(35):9066-80.

PMID:
16953498
27.

Differential apoptotic pathways in human keratinocyte HaCaT cells exposed to UVB and UVC.

Takasawa R, Nakamura H, Mori T, Tanuma S.

Apoptosis. 2005 Oct;10(5):1121-30.

PMID:
16151645
28.

Identification of a novel gene family, paralogs of inhibitor of apoptosis proteins present in plants, fungi, and animals.

Higashi K, Takasawa R, Yoshimori A, Goh T, Tanuma S, Kuchitsu K.

Apoptosis. 2005 May;10(3):471-80.

PMID:
15909109
29.

Structure-based design of an agonistic peptide targeting Fas.

Yoshimori A, Takasawa R, Hayakawa A, Mizuno M, Yoshida J, Tanuma S.

Apoptosis. 2005 Mar;10(2):323-9.

PMID:
15843893
30.
31.
32.

Use of an adjustable soft segment as an effective molecular design for crystal engineering of hydrogen-bonded tape motifs.

Takasawa R, Yoshikawa I, Araki K.

Org Biomol Chem. 2004 Apr 21;2(8):1125-32. Epub 2004 Mar 18.

PMID:
15064787
33.

Monitoring apoptosis with fluorescent Zn2+-indicators.

Kimura E, Takasawa R, Tanuma S, Aoki S.

Sci STKE. 2004 Mar 2;2004(223):PL7.

PMID:
15010549
34.
35.
36.

DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats.

Yao H, Takasawa R, Fukuda K, Shiokawa D, Sadanaga-Akiyoshi F, Ibayashi S, Tanuma S, Uchimura H.

Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):112-8.

PMID:
11457498
37.

Characterization of two DNase gamma-specific monoclonal antibodies and the in situ detection of DNase gamma in the nuclei of apoptotic rat thymocytes.

Shiokawa D, Tanaka M, Kimura T, Hashizume K, Takasawa R, Ohyama H, Fujita K, Yamada T, Tanuma S.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):343-9.

PMID:
10964668

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