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Items: 1 to 50 of 63

1.

Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation.

Kishino Y, Hasegawa T, Kato A, Nishiya Y, Rozhnal V, Watanabe K, Takasaki W, Yamoto T, Mori K.

Mutat Res Genet Toxicol Environ Mutagen. 2019 Feb;838:37-45. doi: 10.1016/j.mrgentox.2018.11.016. Epub 2018 Dec 5.

PMID:
30678826
2.

A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.

Tamai S, Iguchi T, Niino N, Mikamoto K, Sakurai K, Sayama A, Shimoda H, Takasaki W, Mori K.

J Toxicol Sci. 2017;42(1):73-84. doi: 10.2131/jts.42.73.

3.

Promising approach for the preclinical assessment of cardiac risks using left ventricular pressure-volume loop analyses in anesthetized monkeys.

Ishizaka T, Yoshimatsu Y, Maeda Y, Takasaki W, Chiba K, Mori K.

J Pharmacol Toxicol Methods. 2017 Mar - Apr;84:1-10. doi: 10.1016/j.vascn.2016.10.004. Epub 2016 Oct 15.

PMID:
27756610
4.

MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia.

Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, Mori K.

J Appl Toxicol. 2016 Dec;36(12):1614-1621. doi: 10.1002/jat.3326. Epub 2016 Apr 12.

5.

Localization of connexin 32 in spontaneous liver lesions of mice.

Igarashi I, Makino T, Kai K, Teranishi M, Takasaki W, Satoh H, Furuhama K.

J Vet Med Sci. 2016 Jan;78(1):113-6. doi: 10.1292/jvms.14-0437. Epub 2015 Aug 11.

6.

Hepatic glutathione contributes to attenuation of thioacetamide-induced hepatic necrosis due to suppression of oxidative stress in diet-induced obese mice.

Shirai M, Matsuoka M, Makino T, Kai K, Teranishi M, Takasaki W.

J Toxicol Sci. 2015 Aug;40(4):509-21. doi: 10.2131/jts.40.509.

7.

MicroRNA profiling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model.

Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, Mori K.

J Toxicol Sci. 2015 Jun;40(3):375-82. doi: 10.2131/jts.40.375.

8.

Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy.

Itoh S, Nagata M, Hattori C, Takasaki W.

J Toxicol Sci. 2015 Feb;40(1):109-14. doi: 10.2131/jts.40.109.

9.

Subcutaneous soft tissue sarcoma with rhabdoid features in a dog.

Sayama A, Okado K, Imaoka M, Yokouchi Y, Jindo T, Takasaki W.

J Toxicol Pathol. 2014 Jul;27(2):131-8. doi: 10.1293/tox.2013-0044. Epub 2014 Feb 5.

10.

Metabolomic analysis of arginine metabolism in acute hepatic injury in rats.

Saitoh W, Yamauchi S, Watanabe K, Takasaki W, Mori K.

J Toxicol Sci. 2014 Feb;39(1):41-50.

11.

Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin.

Kawai R, Aida T, Hattori H, Furukawa T, Mori K, Takasaki W, Takahashi N, Kawada T.

J Toxicol Sci. 2013;38(4):571-9.

13.

Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin.

Kai K, Yamaguchi T, Yoshimatsu Y, Kinoshita J, Teranishi M, Takasaki W.

J Toxicol Sci. 2013;38(2):269-77.

14.

Effect of body-weight loading onto the articular cartilage on the occurrence of quinolone-induced chondrotoxicity in juvenile rats.

Goto K, Imaoka M, Goto M, Kikuchi I, Suzuki T, Jindo T, Takasaki W.

Toxicol Lett. 2013 Feb 4;216(2-3):124-9. doi: 10.1016/j.toxlet.2012.11.017. Epub 2012 Nov 29.

PMID:
23201441
15.

Background lesions during a 24-month observation period in connexin 32-deficient mice.

Igarashi I, Makino T, Suzuki Y, Kai K, Teranishi M, Takasaki W, Furuhama K.

J Vet Med Sci. 2013 Feb;75(2):207-10. Epub 2012 Sep 21.

16.

Gender differences in the liver micronucleus test in rats with partial hepatectomy.

Itoh S, Hattori C, Nagata M, Takasaki W.

Toxicol Lett. 2012 Nov 15;214(3):296-300. doi: 10.1016/j.toxlet.2012.09.003. Epub 2012 Sep 12.

PMID:
22982763
17.

Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information.

Arakawa S, Fujimoto K, Kato A, Endo S, Fukahori A, Shinagawa A, Fischer T, Mueller J, Takasaki W.

Drug Metab Dispos. 2012 Mar;40(3):497-503. doi: 10.1124/dmd.111.042911. Epub 2011 Dec 14.

PMID:
22170331
18.

Methemoglobinemia induced by 1,2-dichloro-4-nitrobenzene in mice with a disrupted glutathione S-transferase Mu 1 gene.

Arakawa S, Maejima T, Kiyosawa N, Yamaguchi T, Shibaya Y, Aida Y, Kawai R, Fujimoto K, Manabe S, Takasaki W.

Drug Metab Dispos. 2010 Sep;38(9):1545-52. doi: 10.1124/dmd.110.033597. Epub 2010 Jun 18.

PMID:
20562208
19.

Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys.

Kimotsuki T, Tanaka K, Sugiura T, Koyama K, Nakamura T, Kamimura Y, Takasaki W, Manabe S.

J Toxicol Pathol. 2010 Mar;23(1):11-7. doi: 10.1293/tox.23.11. Epub 2010 Apr 5.

20.

Highly frequent anti-idiotype antibody in cynomolgus monkeys developed against mouse-derived regions of anti-Fas antibody humanized by complementarity determining region grafting.

Saito-Yabe M, Yoshigae Y, Takasaki W, Kurihara A, Ikeda T, Okazaki O.

Br J Pharmacol. 2009 Sep;158(2):548-57. doi: 10.1111/j.1476-5381.2009.00326.x. Epub 2009 Jul 23.

21.

Age-related differences of QT interval and autonomic nervous system activity in female cynomolgus monkeys.

Ishizaka T, Yoshimatsu Y, Ozawa M, Kimotsuki T, Takasaki W, Manabe S, Yasuda M.

J Pharmacol Toxicol Methods. 2009 Nov-Dec;60(3):288-95. doi: 10.1016/j.vascn.2009.06.003. Epub 2009 Jul 6.

PMID:
19586616
22.

Evaluation of drug-induced QT prolongation in a halothane-anesthetized monkey model: effects of sotalol.

Ishizaka T, Yoshimatsu Y, Ozawa M, Kimotsuki T, Takasaki W, Manabe S, Yasuda M.

J Pharmacol Toxicol Methods. 2009 Mar-Apr;59(2):86-93.

PMID:
19367688
23.

Decrease in protein binding and its effect on toxicokinetics (TK)/toxicodynamics (TD) of diclofenac and propranolol in pregnant rats.

Miida H, Noritake Y, Shimoda H, Honda K, Matsuoka T, Sakurai K, Shirai M, Manabe S, Takasaki W, Ueno K.

J Toxicol Sci. 2008 Dec;33(5):525-36.

24.

Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats.

Hashimoto K, Takasaki W, Yamoto T, Manabe S, Sato I, Tsuda S.

J Toxicol Sci. 2008 Oct;33(4):421-9.

25.

Toxicokintic and toxicodynamic analysis of clofibrate based on free drug concentrations in nagase analbuminemia rats (NAR).

Miida H, Arakawa S, Shibaya Y, Honda K, Kiyosawa N, Watanabe K, Manabe S, Takasaki W, Ueno K.

J Toxicol Sci. 2008 Aug;33(3):349-61.

26.

Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene.

Fujimoto K, Arakawa S, Watanabe T, Yasumo H, Ando Y, Takasaki W, Manabe S, Yamoto T, Oda S.

Drug Metab Dispos. 2007 Dec;35(12):2196-202. Epub 2007 Sep 7.

PMID:
17827337
27.

DNA damage measured by comet assay and 8-OH-dG formation related to blood chemical analyses in aged rats.

Hashimoto K, Takasaki W, Sato I, Tsuda S.

J Toxicol Sci. 2007 Aug;32(3):249-59.

28.

Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene.

Fujimoto K, Arakawa S, Shibaya Y, Miida H, Ando Y, Yasumo H, Hara A, Uchiyama M, Iwabuchi H, Takasaki W, Manabe S, Yamoto T.

Drug Metab Dispos. 2006 Sep;34(9):1495-501. Epub 2006 Jun 7.

PMID:
16760226
29.
30.

Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.

Itoh K, Yamamura M, Takasaki W, Sasaki T, Masubuchi A, Tanaka Y.

Biopharm Drug Dispos. 2006 Apr;27(3):133-9.

PMID:
16400710
31.

Expression of the theta class GST isozyme, YdfYdf, in low GST dogs.

Watanabe T, Ohashi Y, Kosaka T, Arakawa S, Shibaya Y, Yamoto T, Manabe S, Takasaki W.

Arch Toxicol. 2006 May;80(5):250-7. Epub 2005 Oct 20.

PMID:
16237518
32.

Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes.

Takasaki W, Yamamura M, Nozaki A, Nitanai T, Sasahara K, Itoh K, Tanaka Y.

Chirality. 2005 Mar;17(3):135-41.

PMID:
15704197
33.

A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S,R)-sulfoximine.

Watanabe T, Sagisaka H, Arakawa S, Shibaya Y, Watanabe M, Igarashi I, Tanaka K, Totsuka S, Takasaki W, Manabe S.

J Toxicol Sci. 2003 Dec;28(5):455-69.

34.

Low glutathione S-transferase dogs.

Watanabe T, Sugiura T, Manabe S, Takasaki W, Ohashi Y.

Arch Toxicol. 2004 Apr;78(4):218-25. Epub 2003 Dec 18.

PMID:
14685647
35.

Modifying TNFalpha for therapeutic use: a perspective on the TNF receptor system.

Hasegawa A, Takasaki W, Greene MI, Murali R.

Mini Rev Med Chem. 2001 May;1(1):5-16. Review.

PMID:
12369987
36.

Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in rat liver microsomes.

Ishigami M, Takasaki W, Ikeda T, Komai T, Ito K, Sugiyama Y.

Drug Metab Dispos. 2002 Aug;30(8):904-10.

PMID:
12124308
37.

Inhibition of in vitro metabolism of simvastatin by itraconazole in humans and prediction of in vivo drug-drug interactions.

Ishigam M, Uchiyama M, Kondo T, Iwabuchi H, Inoue S, Takasaki W, Ikeda T, Komai T, Ito K, Sugiyama Y.

Pharm Res. 2001 May;18(5):622-31.

PMID:
11465417
38.

Drug interaction between simvastatin and itraconazole in male and female rats.

Ishigami M, Kawabata K, Takasaki W, Ikeda T, Komai T, Ito K, Sugiyama Y.

Drug Metab Dispos. 2001 Jul;29(7):1068-72.

PMID:
11408375
39.

Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans.

Yoshigae Y, Konno K, Takasaki W, Ikeda T.

J Toxicol Sci. 2000 Dec;25(5):433-41.

PMID:
11201174
40.

A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.

Ishigami M, Honda T, Takasaki W, Ikeda T, Komai T, Ito K, Sugiyama Y.

Drug Metab Dispos. 2001 Mar;29(3):282-8.

PMID:
11181496
41.

Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.

Yamashita M, Kushihara M, Hirasawa N, Takasaki W, Takahagi H, Takayanagi M, Ohuchi K.

Br J Pharmacol. 2000 Jan;129(2):367-73.

42.

Stereoselective pharmacokinetics of RS-8359, a selective and reversible inhibitor of A-type monoamine oxidase, in rats, mice, dogs, and monkeys.

Takasaki W, Yamamura M, Shigehara E, Suzuki Y, Tonohiro T, Hara T, Tanaka Y.

Biol Pharm Bull. 1999 May;22(5):498-503.

PMID:
10375171
43.

Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNF alpha binding to its receptor.

Takasaki W, Kajino Y, Kajino K, Murali R, Greene MI.

Nat Biotechnol. 1997 Nov;15(12):1266-70.

PMID:
9359109
44.

Enzyme-linked immunosorbent assay of pravastatin, a HMG-CoA reductase inhibitor, in human plasma.

Muramatsu S, Takasaki W, Uchiyama M, Komokata Y, Tanaka Y, Takahagi H.

J Immunoassay. 1996 Feb;17(1):13-27.

PMID:
8926304
45.

Stereospecific taurine conjugation of the trans-OH metabolite (active metabolite) of CS-670, a new 2-arylpropionic acid nonsteroidal anti-inflammatory drug, in dogs.

Asami M, Takasaki W, Iwabuchi H, Haruyama H, Wachi K, Terada A, Tanaka Y.

Biol Pharm Bull. 1995 Nov;18(11):1584-9.

PMID:
8593485
46.

Quantitative determination of diol metabolites of CS-670, a new antiinflammatory agent, by capillary column gas chromatography-mass spectrometry.

Asami M, Yamamura M, Takasaki W, Tanaka Y.

J Chromatogr B Biomed Appl. 1995 Mar 10;665(1):107-16.

PMID:
7795780
48.

Superiority of plasma 11-dehydro-TXB2 to TXB2 as an index of in vivo TX formation in rabbits after dosing of CS-518, a TX synthase inhibitor.

Takasaki W, Nakagawa A, Asai F, Ushiyama S, Sugidachi A, Matsuda K, Oshima T, Tanaka Y.

Thromb Res. 1993 Jul 1;71(1):69-76.

PMID:
8367836
49.
50.

Changes in plasma and urinary 11-dehydrothromboxane B2 in healthy subjects produced by oral CS-518, a novel thromboxane synthase inhibitor.

Uematsu T, Takasaki W, Kosuge K, Wada K, Matsuno H, Tanaka Y, Yamamura N, Nakashima M.

Eur J Clin Pharmacol. 1993;45(3):283-6.

PMID:
8276056

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