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Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace.

Roberts AD, Finnigan W, Wolde-Michael E, Kelly P, Blaker JJ, Hay S, Breitling R, Takano E, Scrutton NS.

MRS Commun. 2019 May 15;9(2):486-504. doi: 10.1557/mrc.2019.35. Epub 2019 Apr 24.


Continuous repetitive data acquisition with 123I-FP-CIT SPECT: Effects of rotation speed and rotation time.

Matsutomo N, Takano E, Yamamoto T, Sato E.

J Nucl Med Technol. 2019 Jun 10. pii: jnmt.119.228783. doi: 10.2967/jnmt.119.228783. [Epub ahead of print]


Retraction: The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

Mansour M, Haupt S, Chan AL, Godde N, Rizzitelli A, Loi S, Caramia F, Deb S, Takano EA, Bishton M, Johnstone C, Monahan B, Levav-Cohen Y, Jiang YH, Yap AS, Fox S, Bernard O, Anderson R, Haupt Y.

Cancer Res. 2019 Jun 1;79(11):3008. doi: 10.1158/0008-5472.CAN-19-1133. No abstract available.


Site-specific post-imprinting modification of molecularly imprinted polymer nanocavities with a modifiable functional monomer for prostate cancer biomarker recognition.

Matsumoto H, Sunayama H, Kitayama Y, Takano E, Takeuchi T.

Sci Technol Adv Mater. 2019 Apr 1;20(1):305-312. doi: 10.1080/14686996.2019.1583495. eCollection 2019.


SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli.

Jervis AJ, Carbonell P, Taylor S, Sung R, Dunstan MS, Robinson CJ, Breitling R, Takano E, Scrutton NS.

ACS Synth Biol. 2019 Mar 18. doi: 10.1021/acssynbio.8b00399. [Epub ahead of print]


Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters.

Del Carratore F, Zych K, Cummings M, Takano E, Medema MH, Breitling R.

Commun Biol. 2019 Feb 28;2:83. doi: 10.1038/s42003-019-0333-6. eCollection 2019.


Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli.

Jervis AJ, Carbonell P, Vinaixa M, Dunstan MS, Hollywood KA, Robinson CJ, Rattray NJW, Yan C, Swainston N, Currin A, Sung R, Toogood H, Taylor S, Faulon JL, Breitling R, Takano E, Scrutton NS.

ACS Synth Biol. 2019 Jan 18;8(1):127-136. doi: 10.1021/acssynbio.8b00398. Epub 2019 Jan 7.


A Pretreatment-Free, Polymer-Based Platform Prepared by Molecular Imprinting and Post-Imprinting Modifications for Sensing Intact Exosomes.

Mori K, Hirase M, Morishige T, Takano E, Sunayama H, Kitayama Y, Inubushi S, Sasaki R, Yashiro M, Takeuchi T.

Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1612-1615. doi: 10.1002/anie.201811142. Epub 2019 Jan 3.


Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase.

Sabatini M, Comba S, Altabe S, Recio-Balsells AI, Labadie GR, Takano E, Gramajo H, Arabolaza A.

FEBS J. 2018 Dec;285(23):4494-4511. doi: 10.1111/febs.14675. Epub 2018 Oct 25.


An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.

Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS.

Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018.


A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes.

Hernandez-Ortega A, Vinaixa M, Zebec Z, Takano E, Scrutton NS.

Sci Rep. 2018 Sep 26;8(1):14396. doi: 10.1038/s41598-018-32816-1.


Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction.

Robinson CJ, Dunstan MS, Swainston N, Titchmarsh J, Takano E, Scrutton NS, Jervis AJ.

Methods Enzymol. 2018;608:369-392. doi: 10.1016/bs.mie.2018.04.011.


Trial of activity with a human-shaped robot for care recipients.

Takano E, Osawa A, Ueda I, Itoh N, Teranishi T, Kondo I.

Geriatr Gerontol Int. 2018 Aug;18(8):1298-1299. doi: 10.1111/ggi.13442. No abstract available.


Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism.

Amara A, Takano E, Breitling R.

BMC Genomics. 2018 Jul 4;19(1):519. doi: 10.1186/s12864-018-4905-5.


Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, Scrutton NS.

ACS Catal. 2018 Mar 2;8(3):2012-2020. doi: 10.1021/acscatal.7b04115. Epub 2018 Jan 24.


Synthetic Biology: Reports from CSHA 2016 and More.

You L, Takano E.

Biotechnol J. 2018 May;13(5):e1800160. doi: 10.1002/biot.201800160. No abstract available.


Metabolomics tools for the synthetic biology of natural products.

Hollywood KA, Schmidt K, Takano E, Breitling R.

Curr Opin Biotechnol. 2018 Dec;54:114-120. doi: 10.1016/j.copbio.2018.02.015. Epub 2018 Mar 19. Review.


Orthogonal Regulatory Circuits for Escherichia coli Based on the γ-Butyrolactone System of Streptomyces coelicolor.

Biarnes-Carrera M, Lee CK, Nihira T, Breitling R, Takano E.

ACS Synth Biol. 2018 Apr 20;7(4):1043-1055. doi: 10.1021/acssynbio.7b00425. Epub 2018 Mar 19.


Selenzyme: enzyme selection tool for pathway design.

Carbonell P, Wong J, Swainston N, Takano E, Turner NJ, Scrutton NS, Kell DB, Breitling R, Faulon JL.

Bioinformatics. 2018 Jun 15;34(12):2153-2154. doi: 10.1093/bioinformatics/bty065.


Output ordering and prioritisation system (OOPS): ranking biosynthetic gene clusters to enhance bioactive metabolite discovery.

Peña A, Del Carratore F, Cummings M, Takano E, Breitling R.

J Ind Microbiol Biotechnol. 2018 Jul;45(7):615-619. doi: 10.1007/s10295-017-1993-1. Epub 2017 Dec 18.


LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.

Pang JB, Molania R, Chand A, Knower K, Takano EA, Byrne DJ, Mikeska T, Millar EKA, Lee CS, O'Toole SA, Clyne C, Gorringe KL, Dobrovic A, Fox SB.

Oncotarget. 2017 Jul 28;8(48):83626-83636. doi: 10.18632/oncotarget.18886. eCollection 2017 Oct 13.


A transatlantic perspective on 20 emerging issues in biological engineering.

Wintle BC, Boehm CR, Rhodes C, Molloy JC, Millett P, Adam L, Breitling R, Carlson R, Casagrande R, Dando M, Doubleday R, Drexler E, Edwards B, Ellis T, Evans NG, Hammond R, Haseloff J, Kahl L, Kuiken T, Lichman BR, Matthewman CA, Napier JA, ÓhÉigeartaigh SS, Patron NJ, Perello E, Shapira P, Tait J, Takano E, Sutherland WJ.

Elife. 2017 Nov 14;6. pii: e30247. doi: 10.7554/eLife.30247.


Detection and Quantification of Butyrolactones from Streptomyces.

Biarnes-Carrera M, Breitling R, Takano E.

Methods Mol Biol. 2018;1673:117-128. doi: 10.1007/978-1-4939-7309-5_10.


Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.

Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stacker SA.

Sci Signal. 2017 Oct 3;10(499). pii: eaal2987. doi: 10.1126/scisignal.aal2987.


Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.

Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS.

ACS Catal. 2017 Sep 1;7(9):6268-6282. doi: 10.1021/acscatal.7b01924. Epub 2017 Aug 9.


BRCA2 carriers with male breast cancer show elevated tumour methylation.

Deb S, Gorringe KL, Pang JB, Byrne DJ, Takano EA, Investigators K, Dobrovic A, Fox SB.

BMC Cancer. 2017 Sep 11;17(1):641. doi: 10.1186/s12885-017-3632-7.


Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain.

Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K.

Mol Autism. 2017 Jun 28;8:33. doi: 10.1186/s13229-017-0149-5. eCollection 2017.


Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice.

Yamaguchi H, Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K.

Behav Brain Res. 2017 Aug 30;333:67-73. doi: 10.1016/j.bbr.2017.06.035. Epub 2017 Jun 24.


E6AP promotes prostate cancer by reducing p27 expression.

Raghu D, Paul PJ, Gulati T, Deb S, Khoo C, Russo A, Gallo E, Blandino G, Chan AL, Takano E, Sandhu SK, Fox SB, Williams S, Haupt S, Gamell C, Haupt Y.

Oncotarget. 2017 Jun 27;8(26):42939-42948. doi: 10.18632/oncotarget.17224.


antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification.

Blin K, Wolf T, Chevrette MG, Lu X, Schwalen CJ, Kautsar SA, Suarez Duran HG, de Los Santos ELC, Kim HU, Nave M, Dickschat JS, Mitchell DA, Shelest E, Breitling R, Takano E, Lee SY, Weber T, Medema MH.

Nucleic Acids Res. 2017 Jul 3;45(W1):W36-W41. doi: 10.1093/nar/gkx319.


Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.

Pang JB, Savas P, Fellowes AP, Mir Arnau G, Kader T, Vedururu R, Hewitt C, Takano EA, Byrne DJ, Choong DY, Millar EK, Lee CS, O'Toole SA, Lakhani SR, Cummings MC, Mann GB, Campbell IG, Dobrovic A, Loi S, Gorringe KL, Fox SB.

Mod Pathol. 2017 Jul;30(7):952-963. doi: 10.1038/modpathol.2017.21. Epub 2017 Mar 24.


GATA3 expression in triple-negative breast cancers.

Byrne DJ, Deb S, Takano EA, Fox SB.

Histopathology. 2017 Jul;71(1):63-71. doi: 10.1111/his.13187. Epub 2017 Apr 19.


MDM4 is a rational target for treating breast cancers with mutant p53.

Miranda PJ, Buckley D, Raghu D, Pang JB, Takano EA, Vijayakumaran R, Teunisse AF, Posner A, Procter T, Herold MJ, Gamell C, Marine JC, Fox SB, Jochemsen A, Haupt S, Haupt Y.

J Pathol. 2017 Apr;241(5):661-670. doi: 10.1002/path.4877. Epub 2017 Mar 1.


Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.

Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y.

Sci Signal. 2017 Jan 10;10(461). pii: eaaf8223. doi: 10.1126/scisignal.aaf8223.


A Programmable Signaling Molecular Recognition Nanocavity Prepared by Molecular Imprinting and Post-Imprinting Modifications.

Horikawa R, Sunayama H, Kitayama Y, Takano E, Takeuchi T.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13023-13027. doi: 10.1002/anie.201605992.


Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

Paul PJ, Raghu D, Chan AL, Gulati T, Lambeth L, Takano E, Herold MJ, Hagekyriakou J, Vessella RL, Fedele C, Shackleton M, Williams ED, Fox S, Williams S, Haupt S, Gamell C, Haupt Y.

Oncogene. 2016 Dec 1;35(48):6235-6245. doi: 10.1038/onc.2016.159. Epub 2016 Sep 19.


SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production.

Ra LF, P C, A C, M D, D F, Aj J, Njw R, Cj R, N S, M V, A W, C Y, P B, R B, Gg C, Jl F, C G, R G, Db K, J M, Ns S, P S, E T, Nj T.

Synth Syst Biotechnol. 2016 Aug 25;1(4):271-275. doi: 10.1016/j.synbio.2016.07.001. eCollection 2016 Dec.


Differences in the effect of exercise interventions between prefrail older adults and older adults without frailty: A pilot study.

Takano E, Teranishi T, Watanabe T, Ohno K, Kitaji S, Sawa S, Kanada Y, Toba K, Kondo I.

Geriatr Gerontol Int. 2017 Sep;17(9):1265-1269. doi: 10.1111/ggi.12853. Epub 2016 Aug 21.


Synthetic Biology of Natural Products.

Breitling R, Takano E.

Cold Spring Harb Perspect Biol. 2016 Oct 3;8(10). pii: a023994. doi: 10.1101/cshperspect.a023994. Review.


Natural Product Biosynthesis in Escherichia coli: Mentha Monoterpenoids.

Toogood HS, Tait S, Jervis A, Ní Cheallaigh A, Humphreys L, Takano E, Gardiner JM, Scrutton NS.

Methods Enzymol. 2016;575:247-70. doi: 10.1016/bs.mie.2016.02.020. Epub 2016 Mar 24.


A 'Plug and Play' Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli.

Leferink NGH, Jervis AJ, Zebec Z, Toogood HS, Hay S, Takano E, Scrutton NS.

ChemistrySelect. 2016 Jun 21;1(9):1893-1896. doi: 10.1002/slct.201600563.


Towards synthesis of monoterpenes and derivatives using synthetic biology.

Zebec Z, Wilkes J, Jervis AJ, Scrutton NS, Takano E, Breitling R.

Curr Opin Chem Biol. 2016 Oct;34:37-43. doi: 10.1016/j.cbpa.2016.06.002. Epub 2016 Jun 14. Review.


SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJ, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, Goble C, Goodacre R, Kell DB, Feuvre RL, Micklefield J, Scrutton NS, Shapira P, Takano E, Turner NJ.

Biochem Soc Trans. 2016 Jun 15;44(3):675-7. doi: 10.1042/BST20160009.


The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

Mansour M, Haupt S, Chan AL, Godde N, Rizzitelli A, Loi S, Caramia F, Deb S, Takano EA, Bishton M, Johnstone C, Monahan B, Levav-Cohen Y, Jiang YH, Yap AS, Fox S, Bernard O, Anderson R, Haupt Y.

Cancer Res. 2016 Jul 15;76(14):4236-48. doi: 10.1158/0008-5472.CAN-15-1553. Epub 2016 May 26. Retraction in: Cancer Res. 2019 Jun 1;79(11):3008.


Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle.

Carbonell P, Currin A, Jervis AJ, Rattray NJ, Swainston N, Yan C, Takano E, Breitling R.

Nat Prod Rep. 2016 Aug 27;33(8):925-32. doi: 10.1039/c6np00018e. Epub 2016 May 17. Review.


Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism.

Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K.

Autism Res. 2016 Sep;9(9):926-39. doi: 10.1002/aur.1596. Epub 2015 Dec 30.


Molecularly Imprinted Polymer Arrays as Synthetic Protein Chips Prepared by Transcription-type Molecular Imprinting by Use of Protein-Immobilized Dots as Stamps.

Kuwata T, Uchida A, Takano E, Kitayama Y, Takeuchi T.

Anal Chem. 2015 Dec 1;87(23):11784-91. doi: 10.1021/acs.analchem.5b03134. Epub 2015 Nov 16.


Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour.

Huang KT, Mikeska T, Li J, Takano EA, Millar EK, Graham PH, Boyle SE, Campbell IG, Speed TP, Dobrovic A, Fox SB.

BMC Cancer. 2015 Oct 9;15:669. doi: 10.1186/s12885-015-1676-0.


Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.


Targeting Mdmx to treat breast cancers with wild-type p53.

Haupt S, Buckley D, Pang JM, Panimaya J, Paul PJ, Gamell C, Takano EA, Lee YY, Hiddingh S, Rogers TM, Teunisse AF, Herold MJ, Marine JC, Fox SB, Jochemsen A, Haupt Y.

Cell Death Dis. 2015 Jul 16;6:e1821. doi: 10.1038/cddis.2015.173.

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