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Items: 1 to 50 of 103

1.

Tolerability and pharmacokinetics of intravitreal sirolimus.

Mudumba S, Bezwada P, Takanaga H, Hosoi K, Tsuboi T, Ueda K, Kawazu K, Ali Y, Naor J.

J Ocul Pharmacol Ther. 2012 Oct;28(5):507-14. Epub 2012 Jun 4.

PMID:
22662868
2.

Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells.

Hou BH, Takanaga H, Grossmann G, Chen LQ, Qu XQ, Jones AM, Lalonde S, Schweissgut O, Wiechert W, Frommer WB.

Nat Protoc. 2011 Oct 27;6(11):1818-33. doi: 10.1038/nprot.2011.392.

PMID:
22036884
3.

Optical sensors for measuring dynamic changes of cytosolic metabolite levels in yeast.

Bermejo C, Haerizadeh F, Takanaga H, Chermak D, Frommer WB.

Nat Protoc. 2011 Oct 27;6(11):1806-17. doi: 10.1038/nprot.2011.391.

PMID:
22036883
4.

A new monoclonal antibody, 4F2, specific for the oligodendroglial cell lineage, recognizes ATP-dependent RNA helicase Ddx54: possible association with myelin basic protein.

Ueki T, Tsuruo Y, Yamamoto Y, Yoshimura K, Takanaga H, Seiwa C, Motojima K, Asou H, Yamamoto M.

J Neurosci Res. 2012 Jan;90(1):48-59. doi: 10.1002/jnr.22736. Epub 2011 Sep 19.

PMID:
21932369
5.

Essential role of the Hedgehog signaling pathway in human glioma-initiating cells.

Takezaki T, Hide T, Takanaga H, Nakamura H, Kuratsu J, Kondo T.

Cancer Sci. 2011 Jul;102(7):1306-12. doi: 10.1111/j.1349-7006.2011.01943.x. Epub 2011 May 3.

6.

Sugar transporters for intercellular exchange and nutrition of pathogens.

Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ, Guo WJ, Kim JG, Underwood W, Chaudhuri B, Chermak D, Antony G, White FF, Somerville SC, Mudgett MB, Frommer WB.

Nature. 2010 Nov 25;468(7323):527-32. doi: 10.1038/nature09606.

7.

Dynamic analysis of cytosolic glucose and ATP levels in yeast using optical sensors.

Bermejo C, Haerizadeh F, Takanaga H, Chermak D, Frommer WB.

Biochem J. 2010 Dec 1;432(2):399-406. doi: 10.1042/BJ20100946.

8.

Facilitative plasma membrane transporters function during ER transit.

Takanaga H, Frommer WB.

FASEB J. 2010 Aug;24(8):2849-58. doi: 10.1096/fj.09-146472. Epub 2010 Mar 30.

9.

Osmotic induction of calcium accumulation in human embryonic kidney cells detected with a high sensitivity FRET calcium sensor.

Hou BH, Takanaga H, Griesbeck O, Frommer WB.

Cell Calcium. 2009 Aug;46(2):130-5. doi: 10.1016/j.ceca.2009.06.003. Epub 2009 Jul 22.

10.

Quantitative imaging for discovery and assembly of the metabo-regulome.

Okumoto S, Takanaga H, Frommer WB.

New Phytol. 2008;180(2):271-95. doi: 10.1111/j.1469-8137.2008.02611.x. Review.

11.

Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells.

Takanaga H, Tsuchida-Straeten N, Nishide K, Watanabe A, Aburatani H, Kondo T.

Stem Cells. 2009 Jan;27(1):165-74. doi: 10.1634/stemcells.2008-0580.

12.

Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport.

Suzuki Y, Kovacs CS, Takanaga H, Peng JB, Landowski CP, Hediger MA.

J Bone Miner Res. 2008 Aug;23(8):1249-56. doi: 10.1359/jbmr.080314.

13.

GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor.

Takanaga H, Chaudhuri B, Frommer WB.

Biochim Biophys Acta. 2008 Apr;1778(4):1091-9. doi: 10.1016/j.bbamem.2007.11.015. Epub 2007 Dec 14.

14.

Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.

Kaper T, Looger LL, Takanaga H, Platten M, Steinman L, Frommer WB.

PLoS Biol. 2007 Oct;5(10):e257.

15.

Fluxomics: mass spectrometry versus quantitative imaging.

Wiechert W, Schweissgut O, Takanaga H, Frommer WB.

Curr Opin Plant Biol. 2007 Jun;10(3):323-30. Epub 2007 May 3. Review.

16.

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene.

Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA.

J Bone Miner Res. 2007 Feb;22(2):274-85.

17.

Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1).

Mackenzie B, Takanaga H, Hubert N, Rolfs A, Hediger MA.

Biochem J. 2007 Apr 1;403(1):59-69.

19.

Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain.

Takanaga H, Mackenzie B, Peng JB, Hediger MA.

Biochem Biophys Res Commun. 2005 Nov 25;337(3):892-900. Epub 2005 Sep 30.

PMID:
16226721
20.

Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.

Okabe M, Unno M, Harigae H, Kaku M, Okitsu Y, Sasaki T, Mizoi T, Shiiba K, Takanaga H, Terasaki T, Matsuno S, Sasaki I, Ito S, Abe T.

Biochem Biophys Res Commun. 2005 Aug 5;333(3):754-62.

PMID:
15963465
21.
22.

Functional characterization of adenosine transport across the BBB in mice.

Murakami H, Ohkura A, Takanaga H, Matsuo H, Koyabu N, Naito M, Tsuruo T, Ohtani H, Sawada Y.

Int J Pharm. 2005 Feb 16;290(1-2):37-44. Epub 2005 Jan 4.

PMID:
15664128
23.

Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino.

Takanaga H, Mackenzie B, Suzuki Y, Hediger MA.

J Biol Chem. 2005 Mar 11;280(10):8974-84. Epub 2005 Jan 4.

24.

Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line.

Koyabu N, Takanaga H, Matsuo H, Naito M, Tsuruo T, Ohtani H, Sawada Y.

Drug Metab Pharmacokinet. 2004 Aug;19(4):270-9.

25.

mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells.

Ohtsuki S, Watanabe Y, Hori S, Suzuki H, Bhongsatiern J, Fujiyoshi M, Kamoi M, Kamiya N, Takanaga H, Terasaki T.

Biol Pharm Bull. 2004 Sep;27(9):1437-40.

26.

Retinal selectivity of gene expression in rat retinal versus brain capillary endothelial cell lines by differential display analysis.

Tomi M, Abukawa H, Nagai Y, Hata T, Takanaga H, Ohtsuki S, Terasaki T, Hosoya K.

Mol Vis. 2004 Aug 9;10:537-43.

27.

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs.

Mori S, Ohtsuki S, Takanaga H, Kikkawa T, Kang YS, Terasaki T.

J Neurochem. 2004 Aug;90(4):931-41.

28.

Beta-naphthoflavone disturbs astrocytic differentiation of C6 glioma cells by inhibiting autocrine interleukin-6.

Takanaga H, Yoshitake T, Yatabe E, Hara S, Kunimoto M.

J Neurochem. 2004 Aug;90(3):750-7.

29.

Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.

Ohtsuki S, Takizawa T, Takanaga H, Hori S, Hosoya K, Terasaki T.

J Neurochem. 2004 Aug;90(3):743-9.

30.

CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.

Kahr H, Schindl R, Fritsch R, Heinze B, Hofbauer M, Hack ME, Mörtelmaier MA, Groschner K, Peng JB, Takanaga H, Hediger MA, Romanin C.

J Physiol. 2004 May 15;557(Pt 1):121-32. Epub 2004 Mar 12.

31.

Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.

Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T.

J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4.

PMID:
14762099
32.

cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6.

Takanaga H, Yoshitake T, Hara S, Yamasaki C, Kunimoto M.

J Biol Chem. 2004 Apr 9;279(15):15441-7. Epub 2004 Jan 29.

33.

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction.

Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA.

Pflugers Arch. 2004 Feb;447(5):465-8. Epub 2003 Nov 18. Review.

PMID:
14624363
34.

The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier.

Tetsuka K, Takanaga H, Ohtsuki S, Hosoya K, Terasaki T.

J Neurochem. 2003 Nov;87(4):891-901.

35.

New approaches to in vitro models of blood-brain barrier drug transport.

Terasaki T, Ohtsuki S, Hori S, Takanaga H, Nakashima E, Hosoya K.

Drug Discov Today. 2003 Oct 15;8(20):944-54. Review.

PMID:
14554158
36.

Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2).

Kondo T, Hosoya K, Hori S, Tomi M, Ohtsuki S, Takanaga H, Nakashima E, Iizasa H, Asashima T, Ueda M, Obinata M, Terasaki T.

Cell Struct Funct. 2003 Jun;28(3):145-53.

37.

Selective disappearance of an axonal protein, 440-kDa ankyrinB, associated with neuronal degeneration induced by methylmercury.

Sakaue M, Takanaga H, Adachi T, Hara S, Kunimoto M.

J Neurosci Res. 2003 Sep 15;73(6):831-9.

PMID:
12949909
38.

Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice.

Song Y, Peng X, Porta A, Takanaga H, Peng JB, Hediger MA, Fleet JC, Christakos S.

Endocrinology. 2003 Sep;144(9):3885-94.

PMID:
12933662
39.

Sodium-dependent ascorbic acid transporter family SLC23.

Takanaga H, Mackenzie B, Hediger MA.

Pflugers Arch. 2004 Feb;447(5):677-82. Epub 2003 Jul 4. Review.

PMID:
12845532
40.

Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.

Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T.

J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40.

PMID:
12679720
41.
42.

Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies.

Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR.

Lab Invest. 2002 Dec;82(12):1755-64.

PMID:
12480925
43.

The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain.

Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T.

J Cereb Blood Flow Metab. 2002 Nov;22(11):1327-35.

PMID:
12439290
44.

Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity.

Kang YS, Ohtsuki S, Takanaga H, Tomi M, Hosoya K, Terasaki T.

J Neurochem. 2002 Dec;83(5):1188-95.

45.
46.

Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells.

Wakayama K, Ohtsuki S, Takanaga H, Hosoya K, Terasaki T.

Neurosci Res. 2002 Oct;44(2):173-80.

PMID:
12354632
47.

Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.

Yamamoto C, Murakami H, Koyabu N, Takanaga H, Matsuo H, Uchiumi T, Kuwano M, Naito M, Tsuruo T, Ohtani H, Sawada Y.

J Pharm Pharmacol. 2002 Aug;54(8):1055-63.

PMID:
12195819
48.

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Tian R, Koyabu N, Takanaga H, Matsuo H, Ohtani H, Sawada Y.

Pharm Res. 2002 Jun;19(6):802-9.

PMID:
12134950
49.

Influence of cell density and thyroid hormone on glial cell development in primary cultures of embryonic rat cerebral hemisphere.

Adachi T, Takanaga H, Sakurai Y, Ishido M, Kunimoto M, Asou H.

J Neurosci Res. 2002 Jul 1;69(1):61-71.

PMID:
12111816
50.

Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.

Hosoya K, Tomi M, Ohtsuki S, Takanaga H, Saeki S, Kanai Y, Endou H, Naito M, Tsuruo T, Terasaki T.

J Pharmacol Exp Ther. 2002 Jul;302(1):225-31.

PMID:
12065721

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