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A multimodal molecular imaging study evaluates pharmacological alteration of the tumor microenvironment to improve radiation response.

Takakusagi Y, Naz S, Takakusagi K, Ishima M, Murata H, Ohta K, Miura M, Sugawara F, Sakaguchi K, Kishimoto S, Munasinghe JP, Mitchell JB, Krishna MC.

Cancer Res. 2018 Oct 9. pii: canres.1654.2018. doi: 10.1158/0008-5472.CAN-18-1654. [Epub ahead of print]


SUVmax-based Parameters of FDG-PET/CT Reliably Predict Pathologic Complete Response After Preoperative Hyperthermo-chemoradiotherapy in Rectal Cancer.

Murata H, Okamoto M, Takahashi T, Motegi M, Ogoshi K, Shoji H, Onishi M, Takakusagi Y, Okonogi N, Kawamura H, Okazaki A, Asao T, Kuwano H, Nakano T.

Anticancer Res. 2018 Oct;38(10):5909-5916. doi: 10.21873/anticanres.12935.


Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.

Nuryadi E, Sasaki Y, Hagiwara Y, Permata TBM, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda SE, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, Nakano T.

Oncotarget. 2018 Aug 24;9(66):32642-32652. doi: 10.18632/oncotarget.25982. eCollection 2018 Aug 24.


Using the QCM Biosensor-Based T7 Phage Display Combined with Bioinformatics Analysis for Target Identification of Bioactive Small Molecule.

Takakusagi Y, Takakusagi K, Sugawara F, Sakaguchi K.

Methods Mol Biol. 2018;1795:159-172. doi: 10.1007/978-1-4939-7874-8_14.


Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.

Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC.

Cancer Res. 2018 Jul 15;78(14):3783-3792. doi: 10.1158/0008-5472.CAN-18-0491. Epub 2018 May 23.


Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging.

Nitta N, Takakusagi Y, Kokuryo D, Shibata S, Tomita A, Higashi T, Aoki I, Harada M.

Nanomedicine. 2018 Apr 4;14(4):1315-1324. doi: 10.1016/j.nano.2018.03.006. [Epub ahead of print]


Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.

Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE.

Clin Cancer Res. 2018 Jul 1;24(13):3137-3148. doi: 10.1158/1078-0432.CCR-17-1957. Epub 2018 Mar 29.


Rational Design of [13 C,D14 ]Tert-butylbenzene as a Scaffold Structure for Designing Long-lived Hyperpolarized 13 C Probes.

Imakura Y, Nonaka H, Takakusagi Y, Ichikawa K, Maptue NR, Funk AM, Khemtong C, Sando S.

Chem Asian J. 2018 Feb 2;13(3):280-283. doi: 10.1002/asia.201701652. Epub 2018 Jan 16.


Predictive factors of acute skin reactions to carbon ion radiotherapy for the treatment of malignant bone and soft tissue tumors.

Takakusagi Y, Saitoh JI, Kiyohara H, Oike T, Noda SE, Ohno T, Nakano T.

Radiat Oncol. 2017 Nov 22;12(1):185. doi: 10.1186/s13014-017-0927-4.


The Impact of the Grid Size on TomoTherapy for Prostate Cancer.

Kawashima M, Kawamura H, Onishi M, Takakusagi Y, Okonogi N, Okazaki A, Sekihara T, Ando Y, Nakano T.

J Med Phys. 2017 Jul-Sep;42(3):144-150. doi: 10.4103/jmp.JMP_123_16.


Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies.

Takakusagi Y, Kishimoto S, Naz S, Matsumoto S, Saito K, Hart CP, Mitchell JB, Krishna MC.

Antioxid Redox Signal. 2018 Jan 10;28(2):131-140. doi: 10.1089/ars.2017.7106. Epub 2017 Sep 8.


Maximum standardized uptake value on FDG-PET predicts survival in stage I non-small cell lung cancer following carbon ion radiotherapy.

Shirai K, Abe T, Saitoh JI, Mizukami T, Irie D, Takakusagi Y, Shiba S, Okano N, Ebara T, Ohno T, Nakano T.

Oncol Lett. 2017 Jun;13(6):4420-4426. doi: 10.3892/ol.2017.5952. Epub 2017 Mar 29.


An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T-cell immunotherapy and radiotherapy.

Sato H, Suzuki Y, Yoshimoto Y, Noda SE, Murata K, Takakusagi Y, Okazaki A, Sekihara T, Nakano T.

Clin Case Rep. 2017 Feb 15;5(4):380-384. doi: 10.1002/ccr3.758. eCollection 2017 Apr.


A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure.

Nishihara T, Kameyama Y, Nonaka H, Takakusagi Y, Hyodo F, Ichikawa K, Sando S.

Chem Asian J. 2017 May 4;12(9):949-953. doi: 10.1002/asia.201700098. Epub 2017 Apr 13.


Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State.

Nonaka H, Hirano M, Imakura Y, Takakusagi Y, Ichikawa K, Sando S.

Sci Rep. 2017 Jan 9;7:40104. doi: 10.1038/srep40104.


Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses.

Shoji H, Motegi M, Takakusagi Y, Asao T, Kuwano H, Takahashi T, Ogoshi K.

Oncol Rep. 2017 Feb;37(2):695-704. doi: 10.3892/or.2016.5300. Epub 2016 Dec 7.


Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer.

Shirai K, Saitoh JI, Musha A, Abe T, Kobayashi D, Takakusagi Y, Takaysu Y, Shino M, Toyoda M, Takahashi K, Chikamatsu K, Ohno T, Nakano T.

Anticancer Res. 2016 Dec;36(12):6571-6578.


Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution.

Takakusagi Y, Inoue K, Naganuma T, Hyodo F, Ichikawa K.

J Magn Reson. 2016 Sep;270:157-160. doi: 10.1016/j.jmr.2016.07.015. Epub 2016 Jul 27.


Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe.

Nishihara T, Yoshihara HA, Nonaka H, Takakusagi Y, Hyodo F, Ichikawa K, Can E, Bastiaansen JA, Takado Y, Comment A, Sando S.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10626-9. doi: 10.1002/anie.201603731. Epub 2016 Aug 2.


Solitary cardiac metastasis of uterine cervical cancer with antemortem diagnosis: A case report and literature review.

Tsuchida K, Oike T, Ohtsuka T, Ide M, Takakusagi Y, Noda SE, Tamaki T, Kubo N, Hirota Y, Ohno T, Nakano T.

Oncol Lett. 2016 May;11(5):3337-3341. Epub 2016 Apr 6.


Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity.

Hata R, Nonaka H, Takakusagi Y, Ichikawa K, Sando S.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1765-8. doi: 10.1002/anie.201509457. Epub 2015 Dec 21.


Clinical outcomes of helical tomotherapy for super-elderly patients with localized and locally advanced prostate cancer: comparison with patients under 80 years of age.

Okonogi N, Katoh H, Kawamura H, Tamaki T, Kaminuma T, Murata K, Ohkubo Y, Takakusagi Y, Onishi M, Sekihara T, Okazaki A, Nakano T.

J Radiat Res. 2015 Nov;56(6):889-96. doi: 10.1093/jrr/rrv040. Epub 2015 Aug 27.


Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.

Ikeda K, Kamisuki S, Uetake S, Mizusawa A, Ota N, Sasaki T, Tsukuda S, Kusayanagi T, Takakusagi Y, Morohashi K, Yamori T, Dan S, Shiina I, Sugawara F.

Bioorg Med Chem. 2015 Sep 15;23(18):6118-24. doi: 10.1016/j.bmc.2015.08.001. Epub 2015 Aug 5.


Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions.

Hata R, Nonaka H, Takakusagi Y, Ichikawa K, Sando S.

Chem Commun (Camb). 2015 Aug 7;51(61):12290-2. doi: 10.1039/c5cc04597e.


13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.

Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris HD, Lizak MJ, Munasinghe JP, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Clin Cancer Res. 2015 Nov 15;21(22):5073-81. doi: 10.1158/1078-0432.CCR-14-1717. Epub 2015 Feb 11.


Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302.

Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ.

Cancer Metab. 2015 Jan 29;3(1):2. doi: 10.1186/s40170-014-0026-z. eCollection 2015.


Multimodal biopanning of T7 phage-displayed peptides reveals angiomotin as a potential receptor of the anti-angiogenic macrolide Roxithromycin.

Takakusagi K, Takakusagi Y, Suzuki T, Toizaki A, Suzuki A, Kawakatsu Y, Watanabe M, Saito Y, Fukuda R, Nakazaki A, Kobayashi S, Sakaguchi K, Sugawara F.

Eur J Med Chem. 2015 Jan 27;90:809-21. doi: 10.1016/j.ejmech.2014.12.015. Epub 2014 Dec 12.


Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC.

PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014.


In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization.

Matsumoto S, Saito K, Takakusagi Y, Matsuo M, Munasinghe JP, Morris HD, Lizak MJ, Merkle H, Yasukawa K, Devasahayam N, Suburamanian S, Mitchell JB, Krishna MC.

Antioxid Redox Signal. 2014 Sep 10;21(8):1145-55. doi: 10.1089/ars.2013.5725. Epub 2014 Apr 7.


Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein.

Kuroiwa Y, Takakusagi Y, Kusayanagi T, Kuramochi K, Imai T, Hirayama T, Ito I, Yoshida M, Sakaguchi K, Sugawara F.

PLoS One. 2013 May 3;8(5):e63073. doi: 10.1371/journal.pone.0063073. Print 2013.


Mapping a disordered portion of the Brz2001-binding site on a plant monooxygenase, DWARF4, using a quartz-crystal microbalance biosensor-based T7 phage display.

Takakusagi Y, Manita D, Kusayanagi T, Izaguirre-Carbonell J, Takakusagi K, Kuramochi K, Iwabata K, Kanai Y, Sakaguchi K, Sugawara F.

Assay Drug Dev Technol. 2013 Apr;11(3):206-15. doi: 10.1089/adt.2012.478. Epub 2013 Mar 20.


Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.

Tsukuda S, Kusayanagi T, Umeda E, Watanabe C, Tosaki YT, Kamisuki S, Takeuchi T, Takakusagi Y, Shiina I, Sugawara F.

Bioorg Med Chem. 2013 Jan 1;21(1):311-20. doi: 10.1016/j.bmc.2012.10.037. Epub 2012 Oct 29.


The antitumor agent doxorubicin binds to Fanconi anemia group F protein.

Kusayanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F.

Bioorg Med Chem. 2012 Nov 1;20(21):6248-55. doi: 10.1016/j.bmc.2012.09.015. Epub 2012 Sep 16.


Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.

Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2012 Jul 1;20(13):3985-90. doi: 10.1016/j.bmc.2012.05.016. Epub 2012 May 15.


Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction.

Manita D, Toba Y, Takakusagi Y, Matsumoto Y, Kusayanagi T, Takakusagi K, Tsukuda S, Takada K, Kanai Y, Kamisuki S, Sakaguchi K, Sugawara F.

Bioorg Med Chem. 2011 Dec 15;19(24):7690-7. doi: 10.1016/j.bmc.2011.09.059. Epub 2011 Oct 5.


Characterization of marine X-family DNA polymerases and comparative analysis of base excision repair proteins.

Kodera H, Takeuchi R, Uchiyama Y, Takakusagi Y, Iwabata K, Miwa H, Hanzawa N, Sugawara F, Sakaguchi K.

Biochem Biophys Res Commun. 2011 Nov 11;415(1):193-9. doi: 10.1016/j.bbrc.2011.10.058. Epub 2011 Oct 18.


Screening of a library of T7 phage-displayed peptides identifies alphaC helix in 14-3-3 protein as a CBP501-binding site.

Matsumoto Y, Shindo Y, Takakusagi Y, Takakusagi K, Tsukuda S, Kusayanagi T, Sato H, Kawabe T, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2011 Dec 1;19(23):7049-56. doi: 10.1016/j.bmc.2011.10.004. Epub 2011 Oct 7.


Foam fractionation of protein: correlation of protein adsorption onto bubbles with a pH-induced conformational transition.

Nakabayashi T, Takakusagi Y, Iwabata K, Sakaguchi K.

Anal Biochem. 2011 Dec 15;419(2):173-9. doi: 10.1016/j.ab.2011.08.019. Epub 2011 Aug 18.


Heterogeneous nucleation of protein crystals on fluorinated layered silicate.

Ino K, Udagawa I, Iwabata K, Takakusagi Y, Kubota M, Kurosaka K, Arai K, Seki Y, Nogawa M, Tsunoda T, Mizukami F, Taguchi H, Sakaguchi K.

PLoS One. 2011;6(7):e22582. doi: 10.1371/journal.pone.0022582. Epub 2011 Jul 27.


A screening of a library of T7 phage-displayed peptide identifies E2F-4 as an etoposide-binding protein.

Takami M, Takakusagi Y, Kuramochi K, Tsukuda S, Aoki S, Morohashi K, Ohta K, Kobayashi S, Sakaguchi K, Sugawara F.

Molecules. 2011 May 24;16(5):4278-94. doi: 10.3390/molecules16054278.


Use of phage display technology for the determination of the targets for small-molecule therapeutics.

Takakusagi Y, Takakusagi K, Sugawara F, Sakaguchi K.

Expert Opin Drug Discov. 2010 Apr;5(4):361-89. doi: 10.1517/17460441003653155.


A sulfoglycolipid beta-sulfoquinovosyldiacylglycerol (betaSQDG) binds to Met1-Arg95 region of murine DNA polymerase lambda (Mmpol lambda) and inhibits its nuclear transit.

Takakusagi K, Takakusagi Y, Ohta K, Aoki S, Sugawara F, Sakaguchi K.

Protein Eng Des Sel. 2010 Feb;23(2):51-60. doi: 10.1093/protein/gzp064. Epub 2009 Nov 20.


DNA polymerase mu interacts with a meiosis-specific RecA homolog Lim15 during meiosis in Coprinus cinereus.

Yanai T, Sakamoto A, Iwabata K, Koshiyama A, Sugawara H, Nara T, Takakusagi Y, Sakaguchi K.

Biochem Biophys Res Commun. 2009 Dec 4;390(1):32-7. doi: 10.1016/j.bbrc.2009.09.052. Epub 2009 Sep 18.


[Validation of small-molecule/protein interactions by the T7 phage display strategy using a quartz-crystal microbalance device].

Takakusagi Y, Takakusagi K, Sugawara F, Sakaguchi K.

Tanpakushitsu Kakusan Koso. 2009 Jul;54(9):1203-9. Japanese. No abstract available.


Identification of small molecule binding molecules by affinity purification using a specific ligand immobilized on PEGA resin.

Kuramochi K, Miyano Y, Enomoto Y, Takeuchi R, Ishi K, Takakusagi Y, Saitoh T, Fukudome K, Manita D, Takeda Y, Kobayashi S, Sakaguchi K, Sugawara F.

Bioconjug Chem. 2008 Dec;19(12):2417-26. doi: 10.1021/bc8002716.


Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device.

Nishiyama K, Takakusagi Y, Kusayanagi T, Matsumoto Y, Habu S, Kuramochi K, Sugawara F, Sakaguchi K, Takahashi H, Natsugari H, Kobayashi S.

Bioorg Med Chem. 2009 Jan 1;17(1):195-202. doi: 10.1016/j.bmc.2008.11.004. Epub 2008 Nov 8.


Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool.

Takakusagi Y, Kuramochi K, Takagi M, Kusayanagi T, Manita D, Ozawa H, Iwakiri K, Takakusagi K, Miyano Y, Nakazaki A, Kobayashi S, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2008 Nov 15;16(22):9837-46. doi: 10.1016/j.bmc.2008.09.061. Epub 2008 Sep 30.


Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device.

Takakusagi Y, Kuroiwa Y, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2008 Aug 1;16(15):7410-4. doi: 10.1016/j.bmc.2008.06.007. Epub 2008 Jun 12.


Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.

Mizushina Y, Takeuchi T, Takakusagi Y, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.

Int J Mol Med. 2008 Mar;21(3):281-90.


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