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Items: 1 to 50 of 257

1.

Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice.

Corty RW, Kumar V, Tarantino LM, Takahashi JS, Valdar W.

G3 (Bethesda). 2018 Dec 10;8(12):3783-3790. doi: 10.1534/g3.118.200194.

2.

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1.

Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES.

Cell Rep. 2018 Oct 2;25(1):1-9.e5. doi: 10.1016/j.celrep.2018.09.015.

3.

An evolutionary hotspot defines functional differences between CRYPTOCHROMES.

Rosensweig C, Reynolds KA, Gao P, Laothamatas I, Shan Y, Ranganathan R, Takahashi JS, Green CB.

Nat Commun. 2018 Mar 19;9(1):1138. doi: 10.1038/s41467-018-03503-6.

4.

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.

Ye Y, Xiang Y, Ozguc FM, Kim Y, Liu CJ, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo AY, Zhou B, Wang L, Chen Z, Takahashi JS, Mills GB, Yoo SH, Han L.

Cell Syst. 2018 Mar 28;6(3):314-328.e2. doi: 10.1016/j.cels.2018.01.013. Epub 2018 Mar 7.

PMID:
29525205
5.

Sleeping sickness is a circadian disorder.

Rijo-Ferreira F, Carvalho T, Afonso C, Sanches-Vaz M, Costa RM, Figueiredo LM, Takahashi JS.

Nat Commun. 2018 Jan 4;9(1):62. doi: 10.1038/s41467-017-02484-2.

6.

Novel transcriptional networks regulated by CLOCK in human neurons.

Fontenot MR, Berto S, Liu Y, Werthmann G, Douglas C, Usui N, Gleason K, Tamminga CA, Takahashi JS, Konopka G.

Genes Dev. 2017 Nov 1;31(21):2121-2135. doi: 10.1101/gad.305813.117. Epub 2017 Dec 1.

7.

Guidelines for Genome-Scale Analysis of Biological Rhythms.

Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB.

J Biol Rhythms. 2017 Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3.

8.

Circadian rhythms in parasites.

Rijo-Ferreira F, Takahashi JS, Figueiredo LM.

PLoS Pathog. 2017 Oct 12;13(10):e1006590. doi: 10.1371/journal.ppat.1006590. eCollection 2017 Oct. Review. No abstract available.

9.

Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.

Yoo SH, Kojima S, Shimomura K, Koike N, Buhr ED, Furukawa T, Ko CH, Gloston G, Ayoub C, Nohara K, Reyes BA, Tsuchiya Y, Yoo OJ, Yagita K, Lee C, Chen Z, Yamazaki S, Green CB, Takahashi JS.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8855-E8864. doi: 10.1073/pnas.1706611114. Epub 2017 Oct 2.

10.

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, Zhan X, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B.

J Exp Med. 2017 Nov 6;214(11):3263-3277. doi: 10.1084/jem.20161630. Epub 2017 Oct 2.

11.

Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems.

Chen Z, Yoo SH, Takahashi JS.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:231-252. doi: 10.1146/annurev-pharmtox-010617-052645. Epub 2017 Oct 2.

PMID:
28968186
12.

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.

Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW.

Neuron. 2017 Sep 27;96(1):130-144.e6. doi: 10.1016/j.neuron.2017.09.015.

13.

Molecular Architecture of the Circadian Clock in Mammals.

Takahashi JS.

In: Sassone-Corsi P, Christen Y, editors. A Time for Metabolism and Hormones [Internet]. Cham (CH): Springer; 2016.
2016 Apr 5.

14.

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage.

Wang H, van Spyk E, Liu Q, Geyfman M, Salmans ML, Kumar V, Ihler A, Li N, Takahashi JS, Andersen B.

Cell Rep. 2017 Aug 1;20(5):1061-1072. doi: 10.1016/j.celrep.2017.07.022.

15.

Bmal1 function in skeletal muscle regulates sleep.

Ehlen JC, Brager AJ, Baggs J, Pinckney L, Gray CL, DeBruyne JP, Esser KA, Takahashi JS, Paul KN.

Elife. 2017 Jul 20;6. pii: e26557. doi: 10.7554/eLife.26557.

16.

Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System.

Acosta-Rodríguez VA, de Groot MHM, Rijo-Ferreira F, Green CB, Takahashi JS.

Cell Metab. 2017 Jul 5;26(1):267-277.e2. doi: 10.1016/j.cmet.2017.06.007.

17.

Trypanosoma brucei metabolism is under circadian control.

Rijo-Ferreira F, Pinto-Neves D, Barbosa-Morais NL, Takahashi JS, Figueiredo LM.

Nat Microbiol. 2017 Mar 13;2:17032. doi: 10.1038/nmicrobiol.2017.32.

18.

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.

Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM, Takahashi JS, Partch CL.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1560-1565. doi: 10.1073/pnas.1615310114. Epub 2017 Jan 31.

19.

Enriching the Circadian Proteome.

Takahashi JS.

Cell Metab. 2017 Jan 10;25(1):1-2. doi: 10.1016/j.cmet.2016.12.014.

20.

Transcriptional architecture of the mammalian circadian clock.

Takahashi JS.

Nat Rev Genet. 2017 Mar;18(3):164-179. doi: 10.1038/nrg.2016.150. Epub 2016 Dec 19. Review.

21.

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.

Lee WH, Higuchi H, Ikeda S, Macke EL, Takimoto T, Pattnaik BR, Liu C, Chu LF, Siepka SM, Krentz KJ, Rubinstein CD, Kalejta RF, Thomson JA, Mullins RF, Takahashi JS, Pinto LH, Ikeda A.

Elife. 2016 Nov 15;5. pii: e19264. doi: 10.7554/eLife.19264.

22.

Forward-genetics analysis of sleep in randomly mutagenized mice.

Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M.

Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142. Epub 2016 Nov 2.

23.

An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls.

Verkooijen S, van Bergen AH, Knapen SE, Vreeker A, Abramovic L, Pagani L, Jung Y, Riemersma-van der Lek R, Schoevers RA, Takahashi JS, Kahn RS, Boks MPM, Ophoff RA.

J Affect Disord. 2017 Jan 15;208:248-254. doi: 10.1016/j.jad.2016.08.076. Epub 2016 Oct 11.

24.

Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms.

Qu Z, Zhang H, Huang M, Shi G, Liu Z, Xie P, Li H, Wang W, Xu G, Zhang Y, Yang L, Huang G, Takahashi JS, Zhang WJ, Xu Y.

Elife. 2016 Sep 22;5. pii: e17171. doi: 10.7554/eLife.17171.

25.

Circadian Oscillations of NADH Redox State Using a Heterologous Metabolic Sensor in Mammalian Cells.

Huang G, Zhang Y, Shan Y, Yang S, Chelliah Y, Wang H, Takahashi JS.

J Biol Chem. 2016 Nov 11;291(46):23906-23914. Epub 2016 Sep 19.

26.

Identification of mutations through dominant screening for obesity using C57BL/6 substrains.

Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M.

Sci Rep. 2016 Sep 2;6:32453. doi: 10.1038/srep32453.

27.

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.

He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z.

Cell Metab. 2016 Apr 12;23(4):610-21. doi: 10.1016/j.cmet.2016.03.007.

28.

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder.

Pagani L, St Clair PA, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Makhinson J, Lopez MC, Montoya G, Montoya CP, Aldana I, Navarro L, Freimer DG, Safaie B, Keung LW, Greenspan K, Chou K, Escobar JI, Ospina-Duque J, Kremeyer B, Ruiz-Linares A, Cantor RM, Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Bearden CE, Takahashi JS, Freimer NB.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E754-61. doi: 10.1073/pnas.1513525113. Epub 2015 Dec 28.

29.

Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale.

Wang GZ, Hickey SL, Shi L, Huang HC, Nakashe P, Koike N, Tu BP, Takahashi JS, Konopka G.

Cell Rep. 2015 Dec 1;13(9):1868-80. doi: 10.1016/j.celrep.2015.10.043. Epub 2015 Nov 19.

30.

A tunable artificial circadian clock in clock-defective mice.

D'Alessandro M, Beesley S, Kim JK, Chen R, Abich E, Cheng W, Yi P, Takahashi JS, Lee C.

Nat Commun. 2015 Nov 30;6:8587. doi: 10.1038/ncomms9587.

31.

Molecular components of the circadian clock in mammals.

Takahashi JS.

Diabetes Obes Metab. 2015 Sep;17 Suppl 1:6-11. doi: 10.1111/dom.12514. Review.

32.

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.

Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M.

Neuron. 2015 Mar 4;85(5):1086-102. doi: 10.1016/j.neuron.2015.02.006.

33.

ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals.

Takahashi JS, Kumar V, Nakashe P, Koike N, Huang HC, Green CB, Kim TK.

Methods Enzymol. 2015;551:285-321. doi: 10.1016/bs.mie.2014.10.059. Epub 2014 Dec 26.

35.

The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity.

Plikus MV, Van Spyk EN, Pham K, Geyfman M, Kumar V, Takahashi JS, Andersen B.

J Biol Rhythms. 2015 Jun;30(3):163-82. doi: 10.1177/0748730414563537. Epub 2015 Jan 13. Review.

36.

In vivo single-cell detection of metabolic oscillations in stem cells.

Stringari C, Wang H, Geyfman M, Crosignani V, Kumar V, Takahashi JS, Andersen B, Gratton E.

Cell Rep. 2015 Jan 6;10(1):1-7. doi: 10.1016/j.celrep.2014.12.007. Epub 2014 Dec 24.

37.

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant.

Izumo M, Pejchal M, Schook AC, Lange RP, Walisser JA, Sato TR, Wang X, Bradfield CA, Takahashi JS.

Elife. 2014 Dec 19;3. doi: 10.7554/eLife.04617.

38.

Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase.

Johnson BP, Walisser JA, Liu Y, Shen AL, McDearmon EL, Moran SM, McIntosh BE, Vollrath AL, Schook AC, Takahashi JS, Bradfield CA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18757-62. doi: 10.1073/pnas.1421708111. Epub 2014 Dec 15.

39.

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells.

Umemura Y, Koike N, Matsumoto T, Yoo SH, Chen Z, Yasuhara N, Takahashi JS, Yagita K.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5039-48. doi: 10.1073/pnas.1419272111. Epub 2014 Nov 11.

40.

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.

Nangle SN, Rosensweig C, Koike N, Tei H, Takahashi JS, Green CB, Zheng N.

Elife. 2014 Aug 15;3:e03674. doi: 10.7554/eLife.03674.

41.

Phosphorylation of LSD1 by PKCα is crucial for circadian rhythmicity and phase resetting.

Nam HJ, Boo K, Kim D, Han DH, Choe HK, Kim CR, Sun W, Kim H, Kim K, Lee H, Metzger E, Schuele R, Yoo SH, Takahashi JS, Cho S, Son GH, Baek SH.

Mol Cell. 2014 Mar 6;53(5):791-805. doi: 10.1016/j.molcel.2014.01.028. Epub 2014 Feb 27.

42.

Central circadian control of female reproductive function.

Miller BH, Takahashi JS.

Front Endocrinol (Lausanne). 2014 Jan 22;4:195. doi: 10.3389/fendo.2013.00195. eCollection 2013. Review.

43.

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.

Kumar V, Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS.

Science. 2013 Dec 20;342(6165):1508-12. doi: 10.1126/science.1245503.

44.

Epidermal stem cells ride the circadian wave.

Kumar V, Andersen B, Takahashi JS.

Genome Biol. 2013 Nov 29;14(11):140. doi: 10.1186/gb4142.

45.

TH17 cell differentiation is regulated by the circadian clock.

Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV.

Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884.

46.

Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.

Gao P, Yoo SH, Lee KJ, Rosensweig C, Takahashi JS, Chen BP, Green CB.

J Biol Chem. 2013 Dec 6;288(49):35277-86. doi: 10.1074/jbc.M113.509604. Epub 2013 Oct 24.

47.

FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA.

Nat Med. 2013 Sep;19(9):1147-52. doi: 10.1038/nm.3249. Epub 2013 Aug 11.

48.

Molecular architecture of the mammalian circadian clock.

Partch CL, Green CB, Takahashi JS.

Trends Cell Biol. 2014 Feb;24(2):90-9. doi: 10.1016/j.tcb.2013.07.002. Epub 2013 Aug 1. Review.

49.

Molecular components of the Mammalian circadian clock.

Buhr ED, Takahashi JS.

Handb Exp Pharmacol. 2013;(217):3-27. doi: 10.1007/978-3-642-25950-0_1. Review.

50.

Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.

Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS.

Elife. 2013 Apr 9;2:e00426. doi: 10.7554/eLife.00426.

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