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Items: 1 to 50 of 2584

1.

Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2.

Tanaka K, Tanaka T, Nakano T, Hozumi Y, Yanagida M, Araki Y, Iwazaki K, Takagi M, Goto K.

Cell Signal. 2019 Oct 15:109428. doi: 10.1016/j.cellsig.2019.109428. [Epub ahead of print]

PMID:
31626956
2.

Diagnostic feature of imaging for hernia through the foramen of Winslow.

Miyoshi Y, Hirano Y, Kondo Y, Note H, Takagi M, Takizawa S, Okamoto K, Tanaka H.

Acute Med Surg. 2019 Jun 12;6(4):423-424. doi: 10.1002/ams2.437. eCollection 2019 Oct. No abstract available.

3.

[Effects of Renal Function Evaluation with or without Serum Creatinine Adjustment on Cisplatin/Fluorouracil Therapy for Cervical Cancer].

Takagi M, Sagara A, Ishizawa A, Ito A, Miyazaki M, Senzaki K, Nagai T, Yamada K.

Yakugaku Zasshi. 2019;139(10):1327-1332. doi: 10.1248/yakushi.19-00114. Japanese.

4.

Breeding performance of Indonesian beef cattle as recipients for embryo transfer.

Lestari TD, Ismudiono I, Sardjito T, Yamato O, Takagi M, Yabuki A, Srianto P.

J Vet Med Sci. 2019 Oct 2. doi: 10.1292/jvms.19-0429. [Epub ahead of print]

5.

Analysis of intestinal immunity and flora in a collagen-induced mouse arthritis model: differences during arthritis progression.

Nemoto N, Takeda Y, Nara H, Araki A, Gazi Y, Takakubo Y, Naganuma Y, Takagi M, Asao H.

Int Immunol. 2019 Sep 28. pii: dxz058. doi: 10.1093/intimm/dxz058. [Epub ahead of print]

PMID:
31562738
6.

Barrett's adenocarcinoma with esophageal varices successfully treated by endoscopic submucosal dissection with direct varices coagulation.

Ueda C, Yosizaki T, Katayama N, Okamoto N, Hashimura H, Matsumoto M, Takagi M, Ikeoka S, Momose K, Eguchi T, Yamashita H, Okada A.

Clin J Gastroenterol. 2019 Sep 26. doi: 10.1007/s12328-019-01048-9. [Epub ahead of print]

PMID:
31559540
7.

Estimation of the radiation dose via indoor dust in the Ibaraki and Chiba prefectures, 150-200 km south from the Fukushima Daiichi Nuclear Power Plant.

Takagi M, Tanaka A, Nakayama SF.

Chemosphere. 2019 Dec;236:124778. doi: 10.1016/j.chemosphere.2019.124778. Epub 2019 Sep 5.

PMID:
31549670
8.

Technical note: improved positioning protocol for patient setup accuracy in conventional radiotherapy for lung cancer.

Chai H, Narita Y, Takagi M, Kudo M, Kimura T, Kattou K.

Radiol Phys Technol. 2019 Sep 23. doi: 10.1007/s12194-019-00537-3. [Epub ahead of print]

PMID:
31549292
9.

Cell-Based and Scaffold-Based Therapies for Joint Preservation in Early-Stage Osteonecrosis of the Femoral Head: A Review of Basic Research.

Maruyama M, Lin T, Pan CC, Moeinzadeh S, Takagi M, Yang YP, Goodman SB.

JBJS Rev. 2019 Sep;7(9):e5. doi: 10.2106/JBJS.RVW.18.00202. No abstract available.

PMID:
31503099
10.

In situ ruminal degradation and in vitro fermentation characteristics, and antioxidative activities of the lotus rhizome.

Asano S, Aoki K, Kaizuka Y, Kobayashi Y, Watanabe K, Kato C, Saito C, Nishimura S, Kato T, Takagi M, Kajikawa H.

Anim Sci J. 2019 Sep 4. doi: 10.1111/asj.13285. [Epub ahead of print]

PMID:
31486172
11.

Study of the polyribosyl-ribitol-phosphate precipitation mechanism by salts and organic solvents.

Simas RG, Takagi M, Miranda EA.

Int J Biol Macromol. 2019 Aug 13;140:102-108. doi: 10.1016/j.ijbiomac.2019.08.110. [Epub ahead of print]

PMID:
31419558
12.

T929I and K1774N mutation pair and M918L single mutation identified in the voltage-gated sodium channel gene of pyrethroid-resistant Thrips tabaci (Thysanoptera: Thripidae) in Japan.

Jouraku A, Kuwazaki S, Iida H, Ohta I, Kusano H, Takagi M, Yokoyama T, Kubota N, Shibao M, Shirotsuka K, Iwasaki A, Takezawa Y, Takeda M.

Pestic Biochem Physiol. 2019 Jul;158:77-87. doi: 10.1016/j.pestbp.2019.04.012. Epub 2019 Apr 25.

PMID:
31378364
13.

Does a computerized neuropsychological test predict prolonged recovery in concussed children presenting to the ED?

Takagi M, Hearps SJC, Babl FE, Anderson N, Bressan S, Clarke C, Davis GA, Doyle M, Dunne K, Lanyon C, Rausa V, Thompson E, Anderson V.

Child Neuropsychol. 2019 Jul 31:1-15. doi: 10.1080/09297049.2019.1639653. [Epub ahead of print]

PMID:
31364925
14.

Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders.

Liu Y, van den Wildenberg WPM, de Graaf Y, Ames SL, Baldacchino A, Bø R, Cadaveira F, Campanella S, Christiansen P, Claus ED, Colzato LS, Filbey FM, Foxe JJ, Garavan H, Hendershot CS, Hester R, Jester JM, Karoly HC, Kräplin A, Kreusch F, Landrø NI, Littel M, Loeber S, London ED, López-Caneda E, Lubman DI, Luijten M, Marczinski CA, Metrik J, Montgomery C, Papachristou H, Mi Park S, Paz AL, Petit G, Prisciandaro JJ, Quednow BB, Ray LA, Roberts CA, Roberts GMP, de Ruiter MB, Rupp CI, Steele VR, Sun D, Takagi M, Tapert SF, van Holst RJ, Verdejo-Garcia A, Vonmoos M, Wojnar M, Yao Y, Yücel M, Zack M, Zucker RA, Huizenga HM, Wiers RW.

Neurosci Biobehav Rev. 2019 Oct;105:288-304. doi: 10.1016/j.neubiorev.2019.07.006. Epub 2019 Jul 15. Review.

15.

Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.

Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K.

Cancer Med. 2019 Sep;8(11):5274-5288. doi: 10.1002/cam4.2356. Epub 2019 Jul 15.

16.

Neuroanatomical alterations in people with high and low cannabis dependence.

Lorenzetti V, Chye Y, Suo C, Walterfang M, Lubman DI, Takagi M, Whittle S, Verdejo-Garcia A, Cousijn J, Pantelis C, Seal M, Fornito A, Yücel M, Solowij N.

Aust N Z J Psychiatry. 2019 Jul 12:4867419859077. doi: 10.1177/0004867419859077. [Epub ahead of print]

PMID:
31298035
17.

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome.

Milman A, Andorin A, Postema PG, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Conte G, Juang JJM, Leshem E, Michowitz Y, Fogelman R, Hochstadt A, Mizusawa Y, Giustetto C, Arbelo E, Huang Z, Corrado D, Delise P, Allocca G, Takagi M, Wijeyeratne YD, Mazzanti A, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Jespersen CH, Tfelt-Hansen J, Veltmann C, Priori SG, Behr ER, Yan GX, Brugada J, Gaita F, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B.

Heart Rhythm. 2019 Oct;16(10):1468-1474. doi: 10.1016/j.hrthm.2019.07.003. Epub 2019 Jul 5.

PMID:
31284050
18.

Foveal abnormalities determined by optical coherence tomography angiography in children with history of retinopathy of prematurity.

Takagi M, Maruko I, Yamaguchi A, Kakehashi M, Hasegawa T, Iida T.

Eye (Lond). 2019 Jul 4. doi: 10.1038/s41433-019-0500-5. [Epub ahead of print]

PMID:
31273311
19.

Long-Term Evaluation of Low-Dose Betamethasone for Ataxia Telangiectasia.

Hasegawa S, Kumada S, Tanuma N, Tsuji-Hosokawa A, Kashimada A, Mizuno T, Moriyama K, Sugawara Y, Shirai I, Miyata Y, Nishida H, Mashimo H, Hasegawa T, Hosokawa T, Hisakawa H, Uematsu M, Fujine A, Miyata R, Sakuma H, Kashimada K, Imai K, Morio T, Hayashi M, Mizutani S, Takagi M.

Pediatr Neurol. 2019 May 13. pii: S0887-8994(18)31187-1. doi: 10.1016/j.pediatrneurol.2019.05.006. [Epub ahead of print]

PMID:
31272782
20.

Evaluation of the Immunomodulatory Activities of the Probiotic Strain Lactobacillus fermentum UCO-979C.

Garcia-Castillo V, Komatsu R, Clua P, Indo Y, Takagi M, Salva S, Islam MA, Alvarez S, Takahashi H, Garcia-Cancino A, Kitazawa H, Villena J.

Front Immunol. 2019 Jun 13;10:1376. doi: 10.3389/fimmu.2019.01376. eCollection 2019.

21.

Full-thickness skin reconstruction with basic fibroblast growth factor-impregnated collagen-gelatin sponge.

Matsumine H, Fujimaki H, Takagi M, Mori S, Iwata T, Shimizu M, Takeuchi M.

Regen Ther. 2019 Jun 19;11:81-87. doi: 10.1016/j.reth.2019.06.001. eCollection 2019 Dec.

22.

Noncoding RNA transcription at enhancers and genome folding in cancer.

Isoda T, Morio T, Takagi M.

Cancer Sci. 2019 Aug;110(8):2328-2336. doi: 10.1111/cas.14107. Epub 2019 Jul 10. Review.

23.

Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation.

Igata M, Islam MA, Tada A, Takagi M, Kober AKMH, Albarracin L, Aso H, Ikeda-Ohtsubo W, Miyazawa K, Yoda K, He F, Takahashi H, Villena J, Kitazawa H.

Front Immunol. 2019 May 29;10:1180. doi: 10.3389/fimmu.2019.01180. eCollection 2019.

24.

A prospective observational study to assess PD-L1 expression in small biopsy samples for non-small-cell lung cancer.

Tsunoda A, Morikawa K, Inoue T, Miyazawa T, Hoshikawa M, Takagi M, Mineshita M.

BMC Cancer. 2019 Jun 7;19(1):546. doi: 10.1186/s12885-019-5773-3.

25.

Identification of key modules and hub genes for small-cell lung carcinoma and large-cell neuroendocrine lung carcinoma by weighted gene co-expression network analysis of clinical tissue-proteomes.

Nakamura H, Fujii K, Gupta V, Hata H, Koizumu H, Hoshikawa M, Naruki S, Miyata Y, Takahashi I, Miyazawa T, Sakai H, Tsumoto K, Takagi M, Saji H, Nishimura T.

PLoS One. 2019 Jun 5;14(6):e0217105. doi: 10.1371/journal.pone.0217105. eCollection 2019.

26.

[Evaluation of Naturally Occurring Compounds Regulating Brown/Beige Adipocyte Differentiation].

Hirai T, Takagi M, Nakashima KI, Inoue M.

Yakugaku Zasshi. 2019;139(6):861-866. doi: 10.1248/yakushi.18-00173-3. Review. Japanese.

27.

An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids.

Takahashi N, Hoshi H, Higa A, Hiyama G, Tamura H, Ogawa M, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M.

Cells. 2019 May 20;8(5). pii: E481. doi: 10.3390/cells8050481.

28.

Protocol of mesenchymal stem cell inoculation to nonwoven fabric scaffold.

Fu B, Yamada K, Fujiwara M, Iwai R, Takagi M.

Cytotechnology. 2019 Jun;71(3):743-750. doi: 10.1007/s10616-019-00320-7. Epub 2019 May 23.

PMID:
31123912
29.

Effects of Capsaicin on Biomimetic Membranes.

Sharma N, Phan HTT, Yoda T, Shimokawa N, Vestergaard MC, Takagi M.

Biomimetics (Basel). 2019 Feb 13;4(1). pii: E17. doi: 10.3390/biomimetics4010017.

30.

Behavioral and Emotional Difficulties after Pediatric Concussion.

Gornall A, Takagi M, Clarke C, Babl FE, Davis GA, Dunne K, Anderson N, Hearps SJC, Demaneuf T, Rausa V, Anderson V.

J Neurotrauma. 2019 Aug 5. doi: 10.1089/neu.2018.6235. [Epub ahead of print]

PMID:
31072265
31.

Washing cytology of removed self-expandable metal stent for biliary stricture: A novel cytology technique.

Nakahara K, Morita R, Michikawa Y, Suetani K, Tsuji K, Sato J, Endo A, Ariizumi Y, Takagi M, Itoh F.

Diagn Cytopathol. 2019 Jul;47(7):743-745. doi: 10.1002/dc.24206. Epub 2019 May 6. No abstract available.

PMID:
31059182
32.

Adherence to the guidelines and the pathological diagnosis of high-risk gastrointestinal stromal tumors in the real world.

Nishida T, Sakai Y, Takagi M, Ozaka M, Kitagawa Y, Kurokawa Y, Masuzawa T, Naito Y, Kagimura T, Hirota S; members of the STAR ReGISTry Study Group.

Gastric Cancer. 2019 Apr 30. doi: 10.1007/s10120-019-00966-4. [Epub ahead of print]

PMID:
31041650
33.

The unstable pacing thresholds of the leadless transcatheter pacemaker affected by body positions in subacute phase after implant.

Yoh M, Takagi M, Takahashi H, Yoshio T, Shiojima I.

Eur Heart J Case Rep. 2018 Dec 27;3(1):yty160. doi: 10.1093/ehjcr/yty160. eCollection 2019 Mar.

34.

Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation.

Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Schaedelin S, Shakeshaft C, Takagi M, Tsivgoulis G, Bonetti B, Kallmünzer B, Arihiro S, Alberti A, Polymeris AA, Ambler G, Yoshimura S, Venti M, Bonati LH, Muir KW, Yamagami H, Thilemann S, Altavilla R, Peters N, Inoue M, Bobinger T, Agnelli G, Brown MM, Sato S, Acciarresi M, Jager HR, Bovi P, Schwab S, Lyrer P, Caso V, Toyoda K, Werring DJ, Engelter ST, De Marchis GM; CROMIS-2, RAF, RAF-DOAC, SAMURAI, NOACISP LONGTERM, Erlangen and Verona registry collaborators.

Ann Neurol. 2019 Jun;85(6):823-834. doi: 10.1002/ana.25489. Epub 2019 Apr 30.

35.

Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome.

Michowitz Y, Milman A, Andorin A, Sarquella-Brugada G, Gonzalez Corcia MC, Gourraud JB, Conte G, Sacher F, Juang JJM, Kim SH, Leshem E, Mabo P, Postema PG, Hochstadt A, Wijeyeratne YD, Denjoy I, Giustetto C, Mizusawa Y, Huang Z, Jespersen CH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Arbelo E, Mazzanti A, Allocca G, Brugada R, Casado-Arroyo R, Champagne J, Priori SG, Veltmann C, Delise P, Corrado D, Brugada J, Kusano KF, Hirao K, Calo L, Takagi M, Tfelt-Hansen J, Yan GX, Gaita F, Leenhardt A, Behr ER, Wilde AAM, Nam GB, Brugada P, Probst V, Belhassen B.

J Am Coll Cardiol. 2019 Apr 16;73(14):1756-1765. doi: 10.1016/j.jacc.2019.01.048.

PMID:
30975291
36.

Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome.

Hoshino A, Kanegane H, Nishi M, Tsuge I, Tokuda K, Kobayashi I, Imai K, Morio T, Takagi M.

Clin Immunol. 2019 Jun;203:9-13. doi: 10.1016/j.clim.2019.03.011. Epub 2019 Apr 2.

PMID:
30951839
37.

Case of herpes zoster complicated by diaphragmatic paralysis.

Waki Y, Nobeyama Y, Fukuchi O, Mukai T, Takagi M, Asahina A.

J Dermatol. 2019 Sep;46(9):e322-e324. doi: 10.1111/1346-8138.14878. Epub 2019 Apr 2. No abstract available.

PMID:
30938463
38.

Efficacy of a single measurement of plasma anti-Müllerian hormone concentration for ovum pick-up donor selection of Japanese Black heifers in herd breeding programs.

Fushimi Y, Monniaux D, Takagi M.

J Reprod Dev. 2019 Aug 9;65(4):369-374. doi: 10.1262/jrd.2019-003. Epub 2019 Mar 30.

39.

Infantile-onset spinocerebellar ataxia type 5 associated with a novel SPTBN2 mutation: A case report.

Mizuno T, Kashimada A, Nomura T, Moriyama K, Yokoyama H, Hasegawa S, Takagi M, Mizutani S.

Brain Dev. 2019 Aug;41(7):630-633. doi: 10.1016/j.braindev.2019.03.002. Epub 2019 Mar 18.

PMID:
30898343
40.

Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling.

Nomura R, Kashimada K, Suzuki H, Zhao L, Tsuji-Hosokawa A, Yagita H, Takagi M, Kanai Y, Bowles J, Koopman P, Kanai-Azuma M, Morio T.

J Cell Sci. 2019 Apr 15;132(8). pii: jcs223768. doi: 10.1242/jcs.223768.

41.

Decisional Conflict in Home Medical Care in a Family-Oriented Society: Family Members' Perspectives on Surrogate Decision Making from a Multicenter Cohort Study.

Tsuda S, Nakamura M, Miyachi J, Matsui Y, Takagi M, Ohashi H, Aoki S, Ono H, Ojima T.

J Palliat Med. 2019 Jul;22(7):814-822. doi: 10.1089/jpm.2018.0493. Epub 2019 Mar 8.

PMID:
30848687
42.

SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma.

Chosokabe M, Noguchi A, Hoshikawa M, Masuzawa M, Takagi M.

Anticancer Res. 2019 Mar;39(3):1143-1150. doi: 10.21873/anticanres.13223.

PMID:
30842143
43.

Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer, the short-term safety and surgical results: Japan Clinical Oncology Group Study (JCOG0501).

Terashima M, Iwasaki Y, Mizusawa J, Katayama H, Nakamura K, Katai H, Yoshikawa T, Ito Y, Kaji M, Kimura Y, Hirao M, Yamada M, Kurita A, Takagi M, Boku N, Sano T, Sasako M; Stomach Cancer Study Group, Japan Clinical Oncology Group.

Gastric Cancer. 2019 Sep;22(5):1044-1052. doi: 10.1007/s10120-019-00941-z. Epub 2019 Mar 2.

PMID:
30827001
44.

A study of second-line irinotecan plus cisplatin vs. irinotecan alone in platinum-naïve patients with early relapse of gastric cancer refractory to adjuvant S-1 monotherapy: exploratory subgroup analysis of the randomized phase III TRICS trial.

Nishikawa K, Murotani K, Fujitani K, Inagaki H, Akamaru Y, Tokunaga S, Takagi M, Tamura S, Sugimoto N, Shigematsu T, Yoshikawa T, Ishiguro T, Nakamura M, Hasegawa H, Morita S, Miyashita Y, Tsuburaya A, Sakamoto J, Tsujinaka T.

Cancer Chemother Pharmacol. 2019 May;83(5):867-874. doi: 10.1007/s00280-019-03802-9. Epub 2019 Feb 26.

PMID:
30806758
45.

Protocol for a prospective, longitudinal, cohort study of recovery pathways, acute biomarkers and cost for children with persistent postconcussion symptoms: the Take CARe Biomarkers study.

Takagi M, Babl FE, Anderson N, Bressan S, Clarke CJ, Crichton A, Dalziel K, Davis GA, Doyle M, Dunne K, Godfrey C, Hearps SJC, Ignjatovic V, Parkin G, Rausa V, Seal M, Thompson EJ, Truss K, Anderson V.

BMJ Open. 2019 Feb 24;9(2):e022098. doi: 10.1136/bmjopen-2018-022098.

46.

Epstein-Barr Virus-Associated γδ T-Cell Lymphoproliferative Disorder Associated With Hypomorphic IL2RG Mutation.

Tanita K, Hoshino A, Imadome KI, Kamiya T, Inoue K, Okano T, Yeh TW, Yanagimachi M, Shiraishi A, Ishimura M, Schober T, Rohlfs M, Takagi M, Imai K, Takada H, Ohga S, Klein C, Morio T, Kanegane H.

Front Pediatr. 2019 Feb 4;7:15. doi: 10.3389/fped.2019.00015. eCollection 2019.

47.

A Decision Tree-Based Survival Analysis of Patients with a History of Inappropriate Implantable Cardioverter-Defibrillator Therapy.

Yamamoto M, Okajima K, Shimane A, Ozawa T, Morishima I, Asai T, Takagi M, Kasai A, Fujii E, Kiyono K, Watanabe E, Ozaki Y.

Int Heart J. 2019 Mar 20;60(2):318-326. doi: 10.1536/ihj.18-288. Epub 2019 Feb 8.

48.

Understanding CO oxidation on the Pt(111) surface based on a reaction route network.

Sugiyama K, Sumiya Y, Takagi M, Saita K, Maeda S.

Phys Chem Chem Phys. 2019 Jul 3;21(26):14366-14375. doi: 10.1039/c8cp06856a.

PMID:
30723846
49.

Pembrolizumab-induced Ocular Myasthenia Gravis with Anti-titin Antibody and Necrotizing Myopathy.

Onda A, Miyagawa S, Takahashi N, Gochi M, Takagi M, Nishino I, Suzuki S, Oishi C, Yaguchi H.

Intern Med. 2019 Jun 1;58(11):1635-1638. doi: 10.2169/internalmedicine.1956-18. Epub 2019 Feb 1.

50.

Prior Anticoagulation and Short- or Long-Term Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients With Nonvalvular Atrial Fibrillation.

Tokunaga K, Koga M, Itabashi R, Yamagami H, Todo K, Yoshimura S, Kimura K, Sato S, Terasaki T, Inoue M, Shiokawa Y, Takagi M, Kamiyama K, Tanaka K, Takizawa S, Shiozawa M, Okuda S, Okada Y, Kameda T, Nagakane Y, Hasegawa Y, Shibuya S, Ito Y, Matsuoka H, Takamatsu K, Nishiyama K, Kario K, Yagita Y, Fujita K, Ando D, Kumamoto M, Arihiro S, Toyoda K; SAMURAI Study Investigators.

J Am Heart Assoc. 2019 Feb 5;8(3):e010593. doi: 10.1161/JAHA.118.010593.

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