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Items: 47


Effects of Psidium guajava leaf extract on secretion systems of Gram-negative enteropathogenic bacteria.

Nakasone N, Ogura Y, Higa N, Toma C, Koizumi Y, Takaesu G, Suzuki T, Yamashiro T.

Microbiol Immunol. 2018 May 23. doi: 10.1111/1348-0421.12604. [Epub ahead of print]


TAK1 regulates resident macrophages by protecting lysosomal integrity.

Sakamachi Y, Morioka S, Mihaly SR, Takaesu G, Foley JF, Fessler MB, Ninomiya-Tsuji J.

Cell Death Dis. 2017 Feb 9;8(2):e2598. doi: 10.1038/cddis.2017.23.


TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus.

Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei HT, Hanafusa H, Matsumoto K, Ninomiya-Tsuji J.

J Cell Sci. 2016 May 1;129(9):1855-65. doi: 10.1242/jcs.180505. Epub 2016 Mar 16.


Activated macrophage survival is coordinated by TAK1 binding proteins.

Mihaly SR, Morioka S, Ninomiya-Tsuji J, Takaesu G.

PLoS One. 2014 Apr 15;9(4):e94982. doi: 10.1371/journal.pone.0094982. eCollection 2014.


TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation.

Morioka S, Broglie P, Omori E, Ikeda Y, Takaesu G, Matsumoto K, Ninomiya-Tsuji J.

J Cell Biol. 2014 Feb 17;204(4):607-23. doi: 10.1083/jcb.201305070.


Structural insights into E2-E3 interaction for LC3 lipidation.

Metlagel Z, Otomo C, Ohashi K, Takaesu G, Otomo T.

Autophagy. 2014 Mar;10(3):522-3. doi: 10.4161/auto.27594. Epub 2014 Jan 9. Review.


Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.

Metlagel Z, Otomo C, Takaesu G, Otomo T.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18844-9. doi: 10.1073/pnas.1314755110. Epub 2013 Nov 4.


Lose the battle to win the war: bacterial strategies for evading host inflammasome activation.

Higa N, Toma C, Nohara T, Nakasone N, Takaesu G, Suzuki T.

Trends Microbiol. 2013 Jul;21(7):342-9. doi: 10.1016/j.tim.2013.04.005. Epub 2013 May 24. Review.


TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.

Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess PR, Dean GA, Yoshimura A, Matsumoto K, Suda T, Ninomiya-Tsuji J.

PLoS One. 2012;7(11):e51073. doi: 10.1371/journal.pone.0051073. Epub 2012 Nov 30.


Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.

Otomo C, Metlagel Z, Takaesu G, Otomo T.

Nat Struct Mol Biol. 2013 Jan;20(1):59-66. doi: 10.1038/nsmb.2431. Epub 2012 Dec 2.


TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.

Takaesu G, Kobayashi T, Yoshimura A.

J Biochem. 2012 Feb;151(2):157-66. doi: 10.1093/jb/mvr123. Epub 2011 Oct 5.


A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.

Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A.

J Immunol. 2009 May 15;182(10):5929-37. doi: 10.4049/jimmunol.0802672.


Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.

Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A.

Immunity. 2009 Mar 20;30(3):372-83. doi: 10.1016/j.immuni.2008.12.021. Epub 2009 Mar 12. Erratum in: Immunity. 2009 Jul 17;31(1):170.


An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.

Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G.

Biochem Biophys Res Commun. 2009 Apr 10;381(3):412-7. doi: 10.1016/j.bbrc.2009.02.052. Epub 2009 Feb 20.


Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis.

Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A.

Oncogene. 2009 Feb 26;28(8):1076-88. doi: 10.1038/onc.2008.464. Epub 2009 Jan 12.


TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.

Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T.

J Biol Chem. 2008 Dec 26;283(52):36211-20. doi: 10.1074/jbc.M806576200. Epub 2008 Nov 4. Erratum in: J Biol Chem. 2009 Dec 25;284(52):36720.


FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.

Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A.

J Biol Chem. 2008 Dec 5;283(49):33858-64. doi: 10.1074/jbc.M806923200. Epub 2008 Oct 10.


SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage.

Sitko JC, Yeh B, Kim M, Zhou H, Takaesu G, Yoshimura A, McBride WH, Jewett A, Jamieson CA, Cacalano NA.

Cell Signal. 2008 Dec;20(12):2221-30. doi: 10.1016/j.cellsig.2008.08.011. Epub 2008 Aug 23.


A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation.

Kang JS, Bae GU, Yi MJ, Yang YJ, Oh JE, Takaesu G, Zhou YT, Low BC, Krauss RS.

J Cell Biol. 2008 Aug 11;182(3):497-507. doi: 10.1083/jcb.200801119. Epub 2008 Aug 4.


Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells.

Shiraishi H, Yoshida H, Saeki K, Miura Y, Watanabe S, Ishizaki T, Hashimoto M, Takaesu G, Kobayashi T, Yoshimura A.

Int Immunol. 2008 Sep;20(9):1219-29. doi: 10.1093/intimm/dxn078. Epub 2008 Jul 17.


Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.

Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T.

J Biol Chem. 2008 Jun 20;283(25):17003-8. doi: 10.1074/jbc.M801286200. Epub 2008 Apr 23.


STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.

Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T.

J Biol Chem. 2008 May 30;283(22):14955-62. doi: 10.1074/jbc.M801123200. Epub 2008 Apr 9.


Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis.

Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A.

Hepatology. 2008 May;47(5):1644-54. doi: 10.1002/hep.22214.


Application of unstable Gfp variants to the kinetic study of Legionella pneumophila icm gene expression during infection.

Barysheva OV, Fujii J, Takaesu G, Yoshida SI.

Microbiology. 2008 Apr;154(Pt 4):1015-1025. doi: 10.1099/mic.0.2007/013144-0.


Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.

Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A.

J Immunol. 2008 Mar 15;180(6):3746-56.


Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.

Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A.

Genes Cells. 2008 Feb;13(2):199-208. doi: 10.1111/j.1365-2443.2007.01159.x.


HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein.

Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, Yoshimura A, Takaesu G.

Biochem Biophys Res Commun. 2008 Jan 4;365(1):189-94. Epub 2007 Nov 5.


Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes.

Mori H, Shichita T, Yu Q, Yoshida R, Hashimoto M, Okamoto F, Torisu T, Nakaya M, Kobayashi T, Takaesu G, Yoshimura A.

Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.


An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.

Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, Kobayashi T.

Int Immunol. 2007 May;19(5):609-19. Epub 2007 Mar 22.


Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.

Yoshiga D, Sato N, Torisu T, Mori H, Yoshida R, Nakamura S, Takaesu G, Kobayashi T, Yoshimura A.

Mol Endocrinol. 2007 May;21(5):1120-31. Epub 2007 Feb 20.


Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo.

Takaesu G, Kang JS, Bae GU, Yi MJ, Lee CM, Reddy EP, Krauss RS.

J Cell Biol. 2006 Nov 6;175(3):383-8. Epub 2006 Oct 30.


Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.

Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G.

J Biol Chem. 2006 Dec 1;281(48):36683-90. Epub 2006 Oct 6.


TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.

Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T.

Genes Cells. 2006 Aug;11(8):871-82.


Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A.

Gastroenterology. 2006 Jul;131(1):179-93.


A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. Epub 2006 Apr 19. Erratum in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121.


Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.

Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A.

J Exp Med. 2006 Apr 17;203(4):1021-31. Epub 2006 Apr 10.


Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.

Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A.

Oncogene. 2006 Apr 20;25(17):2520-30.


Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.

Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M, Yagita H, Nawata H, Yoshimura A.

Gastroenterology. 2006 Feb;130(2):373-88.


Mal-function of TLRs by SOCS.

Kobayashi T, Takaesu G, Yoshimura A.

Nat Immunol. 2006 Feb;7(2):123-4. No abstract available.


Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.

Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.

J Cell Sci. 2005 Jun 1;118(Pt 11):2355-62. Review.


Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.

Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K.

EMBO J. 2003 Dec 1;22(23):6277-88.


TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.

Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB.

J Mol Biol. 2003 Feb 7;326(1):105-15.


Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.

Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N.

Mol Cell Biol. 2002 Feb;22(4):992-1000.


A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.

Inoue H, Tateno M, Fujimura-Kamada K, Takaesu G, Adachi-Yamada T, Ninomiya-Tsuji J, Irie K, Nishida Y, Matsumoto K.

EMBO J. 2001 Oct 1;20(19):5421-30.


Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.

Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K.

Mol Cell Biol. 2001 Apr;21(7):2475-84.


TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K.

Mol Cell. 2000 Apr;5(4):649-58.

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