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Items: 15

1.

Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.

Ebiike H, Taka N, Matsushita M, Ohmori M, Takami K, Hyohdoh I, Kohchi M, Hayase T, Nishii H, Morikami K, Nakanishi Y, Akiyama N, Shindoh H, Ishii N, Isobe T, Matsuoka H.

J Med Chem. 2016 Dec 8;59(23):10586-10600. Epub 2016 Nov 29.

PMID:
27933954
2.

Prevalence and Factors Associated With Statin Use Among a Nationally Representative Sample of US Adults: National Health and Nutrition Examination Survey, 2011-2012.

Adedinsewo D, Taka N, Agasthi P, Sachdeva R, Rust G, Onwuanyi A.

Clin Cardiol. 2016 Sep;39(9):491-6. doi: 10.1002/clc.22577. Epub 2016 Aug 9.

3.

Virological failure after 1 year of first-line ART is not associated with HIV minority drug resistance in rural Cameroon .

Zoufaly A, Jochum J, Hammerl R, Nassimi N, Raymond Y, Burchard GD, Schmiedel S, Drexler JF, Campbell NK, Taka N, Awasom C, Metzner KJ, van Lunzen J, Feldt T.

J Antimicrob Chemother. 2015 Mar;70(3):922-5. doi: 10.1093/jac/dku470. Epub 2014 Nov 26.

4.

Determinants of HIV-1 drug resistance in treatment-naïve patients and its clinical implications in an antiretroviral treatment program in Cameroon.

Zoufaly A, Jochum J, Hammerl R, Nassimi N, Raymond Y, Burchard GD, Schmiedel S, Drexler JF, Kay CN, Taka N, Awasom C, Metzner K, Jan vL, Feldt T.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19615. doi: 10.7448/IAS.17.4.19615. eCollection 2014.

5.

The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor.

Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Sakata K, Sase H, Isobe T, Morikami K, Shindoh H, Mio T, Ebiike H, Taka N, Aoki Y, Ishii N.

Mol Cancer Ther. 2014 Nov;13(11):2547-58. doi: 10.1158/1535-7163.MCT-14-0248. Epub 2014 Aug 28.

6.

Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.

Ohtake Y, Sato T, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Yamaguchi M, Takami K, Yeu SY, Ahn KH, Matsuoka H, Morikawa K, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S.

J Med Chem. 2012 Sep 13;55(17):7828-40. doi: 10.1021/jm300884k. Epub 2012 Aug 28.

PMID:
22889351
7.

C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Ohtake Y, Sato T, Matsuoka H, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Higuchi T, Murakata M, Morikawa K, Shimma N, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S.

Bioorg Med Chem. 2012 Jul 1;20(13):4117-27. doi: 10.1016/j.bmc.2012.04.053. Epub 2012 May 4.

PMID:
22652255
8.

5a-Carba-β-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Ohtake Y, Sato T, Matsuoka H, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Higuchi T, Murakata M, Kobayashi T, Morikawa K, Shimma N, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S.

Bioorg Med Chem. 2011 Sep 15;19(18):5334-41. doi: 10.1016/j.bmc.2011.08.005. Epub 2011 Aug 8.

PMID:
21873071
9.

Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics.

Taka N, Matsuoka H, Sato T, Yoshino H, Imaoka I, Sato H, Kotake K, Kumagai Y, Kamei K, Ozaki K, Higashida A, Kuroki T.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3426-9. doi: 10.1016/j.bmcl.2009.05.059. Epub 2009 May 20.

PMID:
19481451
10.

Phosphocholine-containing glycosyl inositol-phosphoceramides from Trichoderma viride induce defense responses in cultured rice cells.

Uchiyama R, Aoki K, Sugimoto H, Taka N, Katayama T, Itonori S, Sugita M, Che FS, Kumagai H, Yamamoto K.

Biosci Biotechnol Biochem. 2009 Jan;73(1):74-8. Epub 2009 Jan 7.

11.

Selection of the germinal micronucleus in Paramecium caudatum: nuclear division and nuclear death.

Taka N, Kurokawa K, Araki T, Mikami K.

J Eukaryot Microbiol. 2006 May-Jun;53(3):177-84.

PMID:
16677339
12.

A novel platinum compound inhibits telomerase activity in vitro and reduces telomere length in a human hepatoma cell line.

Furuta M, Nozawa K, Takemura M, Izuta S, Murate T, Tsuchiya M, Yoshida K, Taka N, Nimura Y, Yoshida S.

Int J Cancer. 2003 May 10;104(6):709-15.

13.

6-Substituted 2,2-bis(fluoromethyl)-benzopyran-4-carboxamide K+ channel openers.

Taka N, Koga H, Sato H, Ishizawa T, Takahashi T, Imagawa J.

Bioorg Med Chem. 2000 Jun;8(6):1393-405.

PMID:
10896116
14.

Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers.

Takahashi T, Koga H, Sato H, Ishizawa T, Taka N, Imagawa J.

Bioorg Med Chem. 1998 Mar;6(3):323-37.

PMID:
9568286
15.

[Cytotoxic effects of diclofenac sodium].

Takahashi N, Miyakoshi M, Taka N, Kurihara T, Fujikawa K.

Nippon Ganka Gakkai Zasshi. 1993 Feb;97(2):145-9. Japanese.

PMID:
8475823

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