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Items: 1 to 50 of 185

1.

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A).

Yu K, Jiang T, Cui Y, Tajkhorshid E, Hartzell HC.

Proc Natl Acad Sci U S A. 2019 Sep 12. pii: 201904012. doi: 10.1073/pnas.1904012116. [Epub ahead of print]

PMID:
31515451
2.

A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.

Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA.

J Biol Chem. 2019 Sep 12. pii: jbc.RA119.008865. doi: 10.1074/jbc.RA119.008865. [Epub ahead of print]

3.

Correction to "Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213".

Denisov IG, Grinkova YV, Nandigrami P, Shekhar M, Tajkhorshid E, Sligar SG.

Biochemistry. 2019 Jun 18;58(24):2796. doi: 10.1021/acs.biochem.9b00438. Epub 2019 Jun 6. No abstract available.

PMID:
31181900
4.

Structural Insights into the Lipid A Transport Pathway in MsbA.

Padayatti PS, Lee SC, Stanfield RL, Wen PC, Tajkhorshid E, Wilson IA, Zhang Q.

Structure. 2019 Jul 2;27(7):1114-1123.e3. doi: 10.1016/j.str.2019.04.007. Epub 2019 May 23.

PMID:
31130486
5.

Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.

Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E.

Nature. 2019 May;569(7754):141-145. doi: 10.1038/s41586-019-1135-1. Epub 2019 Apr 24.

PMID:
31019304
6.

Pro-Nifuroxazide Self-Assembly Leads to Triggerable Nanomedicine for Anti-cancer Therapy.

Misra SK, Wu Z, Ostadhossein F, Ye M, Boateng K, Schulten K, Tajkhorshid E, Pan D.

ACS Appl Mater Interfaces. 2019 May 22;11(20):18074-18089. doi: 10.1021/acsami.9b01343. Epub 2019 May 13.

PMID:
31013055
7.

Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.

Muller MP, Jiang T, Sun C, Lihan M, Pant S, Mahinthichaichan P, Trifan A, Tajkhorshid E.

Chem Rev. 2019 May 8;119(9):6086-6161. doi: 10.1021/acs.chemrev.8b00608. Epub 2019 Apr 12.

PMID:
30978005
8.

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213.

Denisov IG, Grinkova YV, Nandigrami P, Shekhar M, Tajkhorshid E, Sligar SG.

Biochemistry. 2019 Mar 12;58(10):1411-1422. doi: 10.1021/acs.biochem.8b01268. Epub 2019 Feb 28. Erratum in: Biochemistry. 2019 Jun 18;58(24):2796.

PMID:
30785734
9.

Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing.

Henderson BJ, Grant S, Chu BW, Shahoei R, Huard SM, Saladi SSM, Tajkhorshid E, Dougherty DA, Lester HA.

eNeuro. 2019 Jan 4;5(6). pii: ENEURO.0465-18.2018. doi: 10.1523/ENEURO.0465-18.2018. eCollection 2018 Nov-Dec.

10.

Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming.

Starr ML, Sparks RP, Arango AS, Hurst LR, Zhao Z, Lihan M, Jenkins JL, Tajkhorshid E, Fratti RA.

J Biol Chem. 2019 Mar 1;294(9):3100-3116. doi: 10.1074/jbc.RA118.006552. Epub 2019 Jan 7.

PMID:
30617180
11.

Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor.

Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI.

Nat Commun. 2018 Nov 29;9(1):5055. doi: 10.1038/s41467-018-07477-3.

12.

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.

Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL.

Elife. 2018 Nov 29;7. pii: e37161. doi: 10.7554/eLife.37161.

13.

Calcium-Induced Lipid Nanocluster Structures: Sculpturing of the Plasma Membrane.

Hallock MJ, Greenwood AI, Wang Y, Morrissey JH, Tajkhorshid E, Rienstra CM, Pogorelov TV.

Biochemistry. 2018 Dec 18;57(50):6897-6905. doi: 10.1021/acs.biochem.8b01069. Epub 2018 Dec 4.

14.

Direct protein-lipid interactions shape the conformational landscape of secondary transporters.

Martens C, Shekhar M, Borysik AJ, Lau AM, Reading E, Tajkhorshid E, Booth PJ, Politis A.

Nat Commun. 2018 Oct 8;9(1):4151. doi: 10.1038/s41467-018-06704-1.

15.

Endocannabinoid Virodhamine Is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase.

Carnevale LN, Arango AS, Arnold WR, Tajkhorshid E, Das A.

Biochemistry. 2018 Nov 20;57(46):6489-6499. doi: 10.1021/acs.biochem.8b00691. Epub 2018 Nov 6.

16.

Probing key elements of teixobactin-lipid II interactions in membranes.

Wen PC, Vanegas JM, Rempe SB, Tajkhorshid E.

Chem Sci. 2018 Jul 20;9(34):6997-7008. doi: 10.1039/c8sc02616e. eCollection 2018 Sep 14.

17.

Selective Permeability of Carboxysome Shell Pores to Anionic Molecules.

Mahinthichaichan P, Morris DM, Wang Y, Jensen GJ, Tajkhorshid E.

J Phys Chem B. 2018 Oct 4;122(39):9110-9118. doi: 10.1021/acs.jpcb.8b06822. Epub 2018 Sep 21.

PMID:
30193460
18.

Constructing atomic structural models into cryo-EM densities using molecular dynamics - Pros and cons.

Wang Y, Shekhar M, Thifault D, Williams CJ, McGreevy R, Richardson J, Singharoy A, Tajkhorshid E.

J Struct Biol. 2018 Nov;204(2):319-328. doi: 10.1016/j.jsb.2018.08.003. Epub 2018 Aug 7.

PMID:
30092279
19.

Microscopic view of lipids and their diverse biological functions.

Wen PC, Mahinthichaichan P, Trebesch N, Jiang T, Zhao Z, Shinn E, Wang Y, Shekhar M, Kapoor K, Chan CK, Tajkhorshid E.

Curr Opin Struct Biol. 2018 Aug;51:177-186. doi: 10.1016/j.sbi.2018.07.003. Epub 2018 Jul 23. Review.

20.

Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin.

Chakravarti A, Selvadurai K, Shahoei R, Lee H, Fatma S, Tajkhorshid E, Huang RH.

J Biol Chem. 2018 Sep 7;293(36):14122-14133. doi: 10.1074/jbc.RA118.003998. Epub 2018 Jul 20.

21.

Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE.

Vermaas JV, Rempe SB, Tajkhorshid E.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7502-E7511. doi: 10.1073/pnas.1722399115. Epub 2018 Jul 19.

22.

Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins.

Kerr D, Tietjen GT, Gong Z, Tajkhorshid E, Adams EJ, Lee KYC.

Biochim Biophys Acta Biomembr. 2018 Oct;1860(10):2126-2133. doi: 10.1016/j.bbamem.2018.06.010. Epub 2018 Jun 18. Review.

PMID:
29920237
23.

Bacterial denitrifying nitric oxide reductases and aerobic respiratory terminal oxidases use similar delivery pathways for their molecular substrates.

Mahinthichaichan P, Gennis RB, Tajkhorshid E.

Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):712-724. doi: 10.1016/j.bbabio.2018.06.002. Epub 2018 Jun 5.

24.

A "cross-stitched" peptide with improved helicity and proteolytic stability.

Speltz TE, Mayne CG, Fanning SW, Siddiqui Z, Tajkhorshid E, Greene GL, Moore TW.

Org Biomol Chem. 2018 May 23;16(20):3702-3706. doi: 10.1039/c8ob00790j.

25.

Structure of the alternative complex III in a supercomplex with cytochrome oxidase.

Sun C, Benlekbir S, Venkatakrishnan P, Wang Y, Hong S, Hosler J, Tajkhorshid E, Rubinstein JL, Gennis RB.

Nature. 2018 May;557(7703):123-126. doi: 10.1038/s41586-018-0061-y. Epub 2018 Apr 25.

26.

Cytochrome aa3 Oxygen Reductase Utilizes the Tunnel Observed in the Crystal Structures To Deliver O2 for Catalysis.

Mahinthichaichan P, Gennis RB, Tajkhorshid E.

Biochemistry. 2018 Apr 10;57(14):2150-2161. doi: 10.1021/acs.biochem.7b01194. Epub 2018 Mar 29.

27.

Molecular insight into drug exporters within the cellular membrane.

Tajkhorshid E.

Pharmacol Res. 2018 Jul;133:328. doi: 10.1016/j.phrs.2018.03.008. Epub 2018 Mar 10. No abstract available.

PMID:
29535020
28.

PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations.

Scheurer M, Rodenkirch P, Siggel M, Bernardi RC, Schulten K, Tajkhorshid E, Rudack T.

Biophys J. 2018 Feb 6;114(3):577-583. doi: 10.1016/j.bpj.2017.12.003.

29.

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.

Denisov IG, Baylon JL, Grinkova YV, Tajkhorshid E, Sligar SG.

Biochemistry. 2018 Feb 6;57(5):805-816. doi: 10.1021/acs.biochem.7b01012. Epub 2017 Dec 14.

30.

Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 Is Modulated by Doxorubicin.

Arnold WR, Baylon JL, Tajkhorshid E, Das A.

Biochemistry. 2017 Dec 26;56(51):6700-6712. doi: 10.1021/acs.biochem.7b01025. Epub 2017 Dec 12.

31.

Salt bridges gate α-catenin activation at intercellular junctions.

Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D.

Mol Biol Cell. 2018 Jan 15;29(2):111-122. doi: 10.1091/mbc.E17-03-0168. Epub 2017 Nov 15.

32.

Chasing the open-state structure of pentameric ligand-gated ion channels.

Gonzalez-Gutierrez G, Wang Y, Cymes GD, Tajkhorshid E, Grosman C.

J Gen Physiol. 2017 Dec 4;149(12):1119-1138. doi: 10.1085/jgp.201711803. Epub 2017 Oct 31.

33.

Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1.

Tietjen GT, Baylon JL, Kerr D, Gong Z, Henderson JM, Heffern CTR, Meron M, Lin B, Schlossman ML, Adams EJ, Tajkhorshid E, Lee KYC.

Biophys J. 2017 Oct 3;113(7):1505-1519. doi: 10.1016/j.bpj.2017.08.003.

34.

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase.

Jiang T, Yu K, Hartzell HC, Tajkhorshid E.

Elife. 2017 Sep 16;6. pii: e28671. doi: 10.7554/eLife.28671.

35.

Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.

Chen S, Zhao Y, Wang Y, Shekhar M, Tajkhorshid E, Gouaux E.

Cell. 2017 Sep 7;170(6):1234-1246.e14. doi: 10.1016/j.cell.2017.07.045. Epub 2017 Aug 17.

36.

Lipid specificity of the membrane binding domain of coagulation factor X.

Muller MP, Wang Y, Morrissey JH, Tajkhorshid E.

J Thromb Haemost. 2017 Oct;15(10):2005-2016. doi: 10.1111/jth.13788. Epub 2017 Sep 1.

37.

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target.

Camara AKS, Zhou Y, Wen PC, Tajkhorshid E, Kwok WM.

Front Physiol. 2017 Jun 30;8:460. doi: 10.3389/fphys.2017.00460. eCollection 2017. Review.

38.

Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.

Padayatti PS, Leung JH, Mahinthichaichan P, Tajkhorshid E, Ishchenko A, Cherezov V, Soltis SM, Jackson JB, Stout CD, Gennis RB, Zhang Q.

Structure. 2017 Jul 5;25(7):1111-1119.e3. doi: 10.1016/j.str.2017.05.022. Epub 2017 Jun 22.

39.

Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters.

Yu X, Yang G, Yan C, Baylon JL, Jiang J, Fan H, Lu G, Hasegawa K, Okumura H, Wang T, Tajkhorshid E, Li S, Yan N.

Cell Res. 2017 Aug;27(8):1020-1033. doi: 10.1038/cr.2017.83. Epub 2017 Jun 16.

40.

Tribute to Klaus Schulten.

Tajkhorshid E, Chipot C.

J Phys Chem B. 2017 Apr 20;121(15):3203-3205. doi: 10.1021/acs.jpcb.7b02140. No abstract available.

PMID:
28423902
41.

A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.

Arcario MJ, Mayne CG, Tajkhorshid E.

J Biol Chem. 2017 Jun 9;292(23):9480-9492. doi: 10.1074/jbc.M117.780197. Epub 2017 Apr 18.

42.

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein.

Verhalen B, Dastvan R, Thangapandian S, Peskova Y, Koteiche HA, Nakamoto RK, Tajkhorshid E, Mchaourab HS.

Nature. 2017 Mar 30;543(7647):738-741. doi: 10.1038/nature21414. Epub 2017 Mar 13.

43.

Extension of the Highly Mobile Membrane Mimetic to Transmembrane Systems through Customized in Silico Solvents.

Vermaas JV, Pogorelov TV, Tajkhorshid E.

J Phys Chem B. 2017 Apr 20;121(15):3764-3776. doi: 10.1021/acs.jpcb.6b11378. Epub 2017 Mar 13.

44.

Mass spectrometry-based cross-linking study shows that the Psb28 protein binds to cytochrome b559 in Photosystem II.

Weisz DA, Liu H, Zhang H, Thangapandian S, Tajkhorshid E, Gross ML, Pakrasi HB.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2224-2229. doi: 10.1073/pnas.1620360114. Epub 2017 Feb 13.

45.

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome.

Zeng F, Chen Y, Remis J, Shekhar M, Phillips JC, Tajkhorshid E, Jin H.

Nature. 2017 Jan 26;541(7638):554-557. doi: 10.1038/nature21053. Epub 2017 Jan 11.

46.

Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail.

Vermaas JV, Tajkhorshid E.

Biochemistry. 2017 Jan 10;56(1):281-293. doi: 10.1021/acs.biochem.6b00468. Epub 2016 Dec 20.

47.

Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase.

Arnold WR, Baylon JL, Tajkhorshid E, Das A.

Biochemistry. 2016 Dec 20;55(50):6969-6980. Epub 2016 Dec 5.

48.

X-ray structures define human P2X(3) receptor gating cycle and antagonist action.

Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E.

Nature. 2016 Oct 6;538(7623):66-71. doi: 10.1038/nature19367. Epub 2016 Sep 14.

49.

Q-Band Electron-Nuclear Double Resonance Reveals Out-of-Plane Hydrogen Bonds Stabilize an Anionic Ubisemiquinone in Cytochrome bo3 from Escherichia coli.

Sun C, Taguchi AT, Vermaas JV, Beal NJ, O'Malley PJ, Tajkhorshid E, Gennis RB, Dikanov SA.

Biochemistry. 2016 Oct 11;55(40):5714-5725. Epub 2016 Sep 28.

50.

Binding Site Recognition and Docking Dynamics of a Single Electron Transport Protein: Cytochrome c2.

Singharoy A, Barragan AM, Thangapandian S, Tajkhorshid E, Schulten K.

J Am Chem Soc. 2016 Sep 21;138(37):12077-89. doi: 10.1021/jacs.6b01193. Epub 2016 Sep 7.

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