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Chemical modulation of siRNA lipophilicity for efficient delivery.

Tai W.

J Control Release. 2019 Jun 20. pii: S0168-3659(19)30343-8. doi: 10.1016/j.jconrel.2019.06.022. [Epub ahead of print] Review.


The efficacy of limited endoscopic sphincterotomy plus endoscopic papillary large balloon dilation for removal of large bile duct stones.

Kuo CM, Chiu YC, Liang CM, Wu CK, Lu LS, Tai WC, Kuo YH, Wu KL, Chuah SK, Kuo CH.

BMC Gastroenterol. 2019 Jun 18;19(1):93. doi: 10.1186/s12876-019-1017-x.


Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery.

Tai W.

Molecules. 2019 Jun 13;24(12). pii: E2211. doi: 10.3390/molecules24122211. Review.


Rational design of Zika virus subunit vaccine with enhanced efficacy.

Tai W, Chen J, Zhao G, Geng Q, He L, Chen Y, Zhou Y, Li F, Du L.

J Virol. 2019 Jun 12. pii: JVI.02187-18. doi: 10.1128/JVI.02187-18. [Epub ahead of print]


Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma.

Liu R, Qu Z, Lin Y, Lee CS, Tai WC, Chen S.

Front Pharmacol. 2019 May 24;10:594. doi: 10.3389/fphar.2019.00594. eCollection 2019.


A comparison between non-sedation and general endotracheal anesthesia for retrograde endoscopic common bile duct stone removal: A tertiary center experience.

Liang CM, Kuo CM, Lu LS, Wu CK, Tsai CE, Kuo MT, Chiu YC, Tai WC, Kuo YH, Kuo CH, Chuah SK, Changchien CS.

Biomed J. 2019 Apr;42(2):131-136. doi: 10.1016/ Epub 2019 May 7.


Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial.

Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK; Taiwan Acid-Related Disease Study Group.

Drug Des Devel Ther. 2019 Apr 26;13:1347-1356. doi: 10.2147/DDDT.S193559. eCollection 2019.


Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma.

Liu R, Dow Chan B, Mok DK, Lee CS, Tai WC, Chen S.

Molecules. 2019 May 17;24(10). pii: E1908. doi: 10.3390/molecules24101908.


Total Synthesis-Enabled Systematic Structure-Activity Relationship Study for Development of a Bioactive Alkyne-Tagged Derivative of Neolaxiflorin L.

Zhang M, Lee MM, Ye W, Wong WY, Chan BD, Chen S, Zhu L, Tai WC, Lee CS.

J Org Chem. 2019 Jun 7;84(11):7007-7016. doi: 10.1021/acs.joc.9b00748. Epub 2019 May 24.


Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow.

Xin Y, Chen X, Tang X, Li K, Yang M, Tai WC, Liu Y, Tan Y.

Biophys J. 2019 May 21;116(10):1803-1814. doi: 10.1016/j.bpj.2019.04.011. Epub 2019 Apr 19.


Dihydrochalcone-derived polyphenols from tea crab apple (Malus hupehensis) and their inhibitory effects on α-glucosidase in vitro.

Lv Q, Lin Y, Tan Z, Jiang B, Xu L, Ren H, Tai WC, Chan CO, Lee CS, Gu Z, Mok DKW, Chen S.

Food Funct. 2019 May 22;10(5):2881-2887. doi: 10.1039/c9fo00229d.


Protective effects of exopolysaccharide of a medicinal fungus on probiotic bacteria during cold storage and simulated gastrointestinal conditions.

Song AX, Mao YH, Siu KC, Tai WCS, Wu JY.

Int J Biol Macromol. 2019 Jul 15;133:957-963. doi: 10.1016/j.ijbiomac.2019.04.108. Epub 2019 Apr 24.


Publisher Correction: A ribonucleoprotein octamer for targeted siRNA delivery.

Tai W, Li J, Corey E, Gao X.

Nat Biomed Eng. 2018 Aug;2(8):622. doi: 10.1038/s41551-018-0272-4.


Castor Oil-Based Polyurethane Resin for Low-Density Composites with Bamboo Charcoal.

Chen YC, Tai W.

Polymers (Basel). 2018 Oct 5;10(10). pii: E1100. doi: 10.3390/polym10101100.


A ribonucleoprotein octamer for targeted siRNA delivery.

Tai W, Li J, Corey E, Gao X.

Nat Biomed Eng. 2018 May;2(5):326-337. doi: 10.1038/s41551-018-0214-1. Epub 2018 Apr 2. Erratum in: Nat Biomed Eng. 2018 Aug;2(8):622.


Bridging the Gap between Advancements in the Evolution of Diagnosis and Treatment towards Better Outcomes in Achalasia.

Chuah SK, Lim CS, Liang CM, Lu HI, Wu KL, Changchien CS, Tai WC.

Biomed Res Int. 2019 Feb 6;2019:8549187. doi: 10.1155/2019/8549187. eCollection 2019. Review.


A Critique of Resonance Frequency Analysis and a Novel Method for Quantifying Dental Implant Stability in Vitro.

Khouja N, Tai WC, Shen IY, Sorensen JA.

Int J Oral Maxillofac Implants. 2019 May/June;34(3):595–603. doi: 10.11607/jomi.7173. Epub 2019 Feb 26.


Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain.

He L, Tai W, Li J, Chen Y, Gao Y, Li J, Sun S, Zhou Y, Du L, Zhao G.

Viruses. 2019 Feb 19;11(2). pii: E166. doi: 10.3390/v11020166.


A 14 day esomeprazole- and amoxicillin-containing high-dose dual therapy regimen achieves a high eradication rate as first-line anti-Helicobacter pylori treatment in Taiwan: a prospective randomized trial.

Tai WC, Liang CM, Kuo CM, Huang PY, Wu CK, Yang SC, Kuo YH, Lin MT, Lee CH, Hsu CN, Wu KL, Hu TH, Chuah SK.

J Antimicrob Chemother. 2019 Jun 1;74(6):1718-1724. doi: 10.1093/jac/dkz046.


Exosomes in Inflammation and Inflammatory Disease.

Chan BD, Wong WY, Lee MM, Cho WC, Yee BK, Kwan YW, Tai WC.

Proteomics. 2019 Apr;19(8):e1800149. doi: 10.1002/pmic.201800149. Epub 2019 Mar 22. Review.


High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway.

Yao J, Zhang J, Tai W, Deng S, Li T, Wu W, Pu L, Fan D, Lei W, Zhang T, Dong Z.

Inflammation. 2019 Apr;42(2):471-484. doi: 10.1007/s10753-018-00956-1.


Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise.

Tai W, Voronin D, Chen J, Bao W, Kessler DA, Shaz B, Jiang S, Yazdanbakhsh K, Du L.

Front Microbiol. 2019 Jan 23;10:29. doi: 10.3389/fmicb.2019.00029. eCollection 2019.


In Vitro and in Vivo Antitumor Effects of Plant-Derived Miliusanes and Their Induction of Cellular Senescence.

Xu XY, Tsang SW, Guan YF, Liu KL, Pan WH, Lam CS, Lee KM, Xia YX, Xie WJ, Wong WY, Lee MML, Tai WCS, Zhang HJ.

J Med Chem. 2019 Feb 14;62(3):1541-1561. doi: 10.1021/acs.jmedchem.8b01742. Epub 2019 Jan 25.


Comment on "ALK is a therapeutic target for lethal sepsis".

Blasco RB, Patrucco E, Mota I, Tai WT, Chiarle R.

Sci Transl Med. 2018 Dec 12;10(471). pii: eaar4321. doi: 10.1126/scitranslmed.aar4321.


Treatment and Cost of Hepatocellular Carcinoma: A Population-Based Cohort Study in Taiwan.

Nguang SH, Wu CK, Liang CM, Tai WC, Yang SC, Ku MK, Yuan LT, Wang JW, Tseng KL, Hung TH, Hsu PI, Wu DC, Chuah SK, Hsu CN.

Int J Environ Res Public Health. 2018 Nov 26;15(12). pii: E2655. doi: 10.3390/ijerph15122655.


Genitourinary tuberculosis in Taiwan: A 15-year experience at a teaching hospital.

Huang TY, Hung CH, Hsu WH, Peng KT, Hung MS, Lai LJ, Chuang HJ, Tai WL, Ku YP, Wu TS.

J Microbiol Immunol Infect. 2019 Apr;52(2):312-319. doi: 10.1016/j.jmii.2018.10.007. Epub 2018 Nov 9.


Efficacy of a 14-day quadruple-therapy regimen for third-line Helicobacter pylori eradication.

Huang HT, Wang HM, Yang SC, Tai WC, Liang CM, Wu KL, Lee CH, Chuah SK.

Infect Drug Resist. 2018 Oct 30;11:2073-2080. doi: 10.2147/IDR.S185511. eCollection 2018.


Biomechanical Comparisons of One-Legged and Two-Legged Running Vertical Jumps.

Tai WH, Wang LI, Peng HT.

J Hum Kinet. 2018 Oct 15;64:71-76. doi: 10.1515/hukin-2017-0185. eCollection 2018 Sep.


A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population.

Su T, Ren Q, Lu Y, Tai W, Zhu Y, Li Z, Wen J, Hu L, Zhang L, Ma J.

J Cell Physiol. 2019 May;234(5):7012-7018. doi: 10.1002/jcp.27454. Epub 2018 Nov 13.


Clinicopathologic Characteristics and Survival of Patients with Gastroenteropancreatic Neuroendocrine Neoplasm in a Multi-Ethnic Asian Institution.

Tai WM, Tan SH, Tan DMY, Loke KSH, Ng DCE, Yan SX, Hwang JSG, Lim KH, Loh LM, Kek PC, Goh BKP, Lee SY, Chung AYF, Ong SYK.

Neuroendocrinology. 2019;108(4):265-277. doi: 10.1159/000495140. Epub 2018 Nov 6.


Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms.

Huang PY, Tsai KL, Liang CM, Tai WC, Rau KM, Wu KL, Huang CC, Chuah SK.

Kaohsiung J Med Sci. 2018 Nov;34(11):650-656. doi: 10.1016/j.kjms.2018.05.009. Epub 2018 Jun 20.


Platelet reactivity in diabetic patients with invasive Klebsiella pneumoniae liver abscess syndrome.

Lee CH, Chuah SK, Tai WC, Chen IL.

Infect Drug Resist. 2018 Oct 9;11:1669-1676. doi: 10.2147/IDR.S174913. eCollection 2018.


Heated humidified high-flow nasal oxygen prevents intraoperative body temperature decrease in non-intubated thoracoscopy.

Lai CJ, Yeh KC, Wang ML, Tai WH, Cheng YJ.

J Anesth. 2018 Dec;32(6):872-879. doi: 10.1007/s00540-018-2567-8. Epub 2018 Oct 15.


Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens.

Cui K, Tai W, Shan X, Hao J, Li G, Yu G.

Int J Biol Macromol. 2018 Dec;120(Pt B):1817-1822. doi: 10.1016/j.ijbiomac.2018.09.079. Epub 2018 Sep 14.


A ribonucleoprotein octamer for targeted siRNA delivery.

Tai W, Li J, Corey E, Gao X.

Nat Biomed Eng. 2018;2:326-337. Epub 2018 Jul 12.


Preclinical alveolar ridge preservation using small-sized particles of bone replacement graft in combination with a gelatin cryogel scaffold.

Chang PC, Chang HC, Lin TC, Tai WC.

J Periodontol. 2018 Oct;89(10):1221-1229. doi: 10.1002/JPER.17-0629. Epub 2018 Aug 29.


Effect of extracorporeal low-energy shock wave on diabetic gastroparesis in a rat model.

Wu KL, Chiu YC, Yao CC, Tsai CE, Hu ML, Kuo CM, Tai WC, Chuah SK, Hsiao CC.

J Gastroenterol Hepatol. 2019 Apr;34(4):720-727. doi: 10.1111/jgh.14368. Epub 2018 Jul 29.


A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV.

Zhao G, He L, Sun S, Qiu H, Tai W, Chen J, Li J, Chen Y, Guo Y, Wang Y, Shang J, Ji K, Fan R, Du E, Jiang S, Li F, Du L, Zhou Y.

J Virol. 2018 Aug 29;92(18). pii: e00837-18. doi: 10.1128/JVI.00837-18. Print 2018 Sep 15.


2018 Expert Consensus on the Management of Adverse Effects of Antiplatelet Therapy for Acute Coronary Syndrome in Taiwan.

Li YH, Fang CY, Hsieh IC, Huang WC, Lin TH, Sung SH, Chiu CZ, Wu CJ, Shyu KG, Chang PY, Fang CC, Lu TM, Chen CP, Tai WC, Sheu CC, Wei KC, Huang YH, Wu HM, Hwang JH.

Acta Cardiol Sin. 2018 May;34(3):201-210. doi: 10.6515/ACS.201805_34(3).20180302A. Review.


Multiple bacterial infections increase the risk of hepatic encephalopathy in patients with cirrhosis.

Yuan LT, Chuah SK, Yang SC, Liang CM, Wu CK, Tai WC, Hung TH, Nguang SH, Wang JW, Tseng KL, Ku MK, Hsu PI, Wu DC, Hsu CN.

PLoS One. 2018 May 10;13(5):e0197127. doi: 10.1371/journal.pone.0197127. eCollection 2018.


Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats.

Li YH, Tai WC, Khan I, Lu C, Lu Y, Wong WY, Chan WY, Wendy Hsiao WL, Lin G.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2018 Apr 3;36(2):65-83. doi: 10.1080/10590501.2018.1450186.


Rapamycin protects against paraquat-induced pulmonary epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.

Vongphouttha C, Zhu J, Deng S, Tai W, Wu W, Li Z, Lei W, Wang Y, Dong Z, Zhang T.

Exp Ther Med. 2018 Mar;15(3):3045-3051. doi: 10.3892/etm.2018.5795. Epub 2018 Jan 24.


Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds.

Zhu L, Ma W, Zhang M, Lee MM, Wong WY, Chan BD, Yang Q, Wong WT, Tai WC, Lee CS.

Nat Commun. 2018 Mar 29;9(1):1283. doi: 10.1038/s41467-018-03546-9.


Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen.

Nyon MP, Du L, Tseng CK, Seid CA, Pollet J, Naceanceno KS, Agrawal A, Algaissi A, Peng BH, Tai W, Jiang S, Bottazzi ME, Strych U, Hotez PJ.

Vaccine. 2018 Mar 27;36(14):1853-1862. doi: 10.1016/j.vaccine.2018.02.065. Epub 2018 Feb 26.


Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications.

Dai L, Jones CM, Chan WTK, Pham TA, Ling X, Gale EM, Rotile NJ, Tai WC, Anderson CJ, Caravan P, Law GL.

Nat Commun. 2018 Feb 27;9(1):857. doi: 10.1038/s41467-018-03315-8.


Detection of Shigella in Milk and Clinical Samples by Magnetic Immunocaptured-Loop-Mediated Isothermal Amplification Assay.

Zhang L, Wei Q, Han Q, Chen Q, Tai W, Zhang J, Song Y, Xia X.

Front Microbiol. 2018 Feb 6;9:94. doi: 10.3389/fmicb.2018.00094. eCollection 2018.


Noncovalent tagging of siRNA with steroids for transmembrane delivery.

Tai W, Gao X.

Biomaterials. 2018 Sep;178:720-727. doi: 10.1016/j.biomaterials.2018.02.007. Epub 2018 Feb 3.


Hot food and beverage consumption and the risk of esophageal squamous cell carcinoma: A case-control study in a northwest area in China.

Tai WP, Nie GJ, Chen MJ, Yaz TY, Guli A, Wuxur A, Huang QQ, Lin ZG, Wu J.

Medicine (Baltimore). 2017 Dec;96(50):e9325. doi: 10.1097/MD.0000000000009325.


First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan.

Liang CM, Chiu CH, Wang HM, Tai WC, Yao CC, Tsai CE, Kuo CM, Chiu YC, Wu KL, Lee CH, Tsai KL, Huang CF, Chuah SK.

Biomed Res Int. 2017;2017:3762194. doi: 10.1155/2017/3762194. Epub 2017 Dec 11.

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