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Items: 29


N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

Kruse K, Lee QS, Sun Y, Klomp J, Yang X, Huang F, Sun MY, Zhao S, Hong Z, Vogel SM, Shin JW, Leckband DE, Tai LM, Malik AB, Komarova YA.

J Cell Biol. 2019 Jan 7;218(1):299-316. doi: 10.1083/jcb.201802076. Epub 2018 Nov 21.


Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice.

Sugasini D, Thomas R, Yalagala PCR, Tai LM, Subbaiah PV.

Sci Rep. 2017 Sep 12;7(1):11263. doi: 10.1038/s41598-017-11766-0.


Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction.

Marottoli FM, Katsumata Y, Koster KP, Thomas R, Fardo DW, Tai LM.

ASN Neuro. 2017 Jul-Aug;9(4):1759091417719201. doi: 10.1177/1759091417719201.


In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption.

Thomas R, Diaz K, Koster KP, Tai LM.

J Vis Exp. 2017 Jun 20;(124). doi: 10.3791/55846.


Epidermal growth factor prevents APOE4-induced cognitive and cerebrovascular deficits in female mice.

Thomas R, Morris AWJ, Tai LM.

Heliyon. 2017 Jun 7;3(6):e00319. doi: 10.1016/j.heliyon.2017.e00319. eCollection 2017 Jun.


EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.

Tai LM, Balu D, Avila-Munoz E, Abdullah L, Thomas R, Collins N, Valencia-Olvera AC, LaDu MJ.

J Lipid Res. 2017 Sep;58(9):1733-1755. doi: 10.1194/jlr.R076315. Epub 2017 Apr 7. Review.


Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro.

Koster KP, Thomas R, Morris AWJ, Tai LM.

J Cereb Blood Flow Metab. 2016 Nov;36(11):1865-1871. Epub 2016 Sep 15.


Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice.

Thomas R, Zuchowska P, Morris AW, Marottoli FM, Sunny S, Deaton R, Gann PH, Tai LM.

Acta Neuropathol Commun. 2016 Oct 27;4(1):111.


Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE.

Koster KP, Smith C, Valencia-Olvera AC, Thatcher GR, Tai LM, LaDu MJ.

Curr Top Med Chem. 2017;17(6):708-720. Review.


Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.

Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR.

Mol Neurodegener. 2016 May 18;11(1):40. No abstract available.


A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.

Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR.

Mol Neurodegener. 2016 Apr 29;11:35. doi: 10.1186/s13024-016-0103-6. Erratum in: Mol Neurodegener. 2016;11(1):40.


The role of APOE in cerebrovascular dysfunction.

Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G.

Acta Neuropathol. 2016 May;131(5):709-23. doi: 10.1007/s00401-016-1547-z. Epub 2016 Feb 16. Review.


APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.

Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben Aissa M, Dai XM, Zhou M, Tai LM, Zhu YG, LaDu M, Chen XC.

Mol Neurodegener. 2015 Mar 5;10:7. doi: 10.1186/s13024-015-0002-2.


APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective.

Tai LM, Ghura S, Koster KP, Liakaite V, Maienschein-Cline M, Kanabar P, Collins N, Ben-Aissa M, Lei AZ, Bahroos N, Green SJ, Hendrickson B, Van Eldik LJ, LaDu MJ.

J Neurochem. 2015 May;133(4):465-88. doi: 10.1111/jnc.13072. Epub 2015 Mar 18. Review.


Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.

Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ.

J Biol Chem. 2014 Oct 31;289(44):30538-55. doi: 10.1074/jbc.M114.600833. Epub 2014 Sep 12.


Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW.

J Neuroinflammation. 2014 Jun 19;11:111. doi: 10.1186/1742-2094-11-111.


Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.

Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ.

Mol Neurodegener. 2014 Jan 4;9:2. doi: 10.1186/1750-1326-9-2. Review.


APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice.

Kunzler J, Youmans KL, Yu C, Ladu MJ, Tai LM.

Neurosci Lett. 2014 Feb 7;560:131-6. doi: 10.1016/j.neulet.2013.12.032. Epub 2013 Dec 22.


Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.

Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ.

J Biol Chem. 2013 Feb 22;288(8):5914-26. doi: 10.1074/jbc.M112.442103. Epub 2013 Jan 4.


APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ.

J Biol Chem. 2012 Dec 7;287(50):41774-86. doi: 10.1074/jbc.M112.407957. Epub 2012 Oct 11.


The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.

Tai LM, Jacobsen H, Ozmen L, Flohr A, Jakob-Roetne R, Caruso A, Grimm HP.

J Pharmacokinet Pharmacodyn. 2012 Jun;39(3):227-37. doi: 10.1007/s10928-012-9246-4. Epub 2012 Apr 6.


Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.

Youmans KL, Tai LM, Kanekiyo T, Stine WB Jr, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ.

Mol Neurodegener. 2012 Mar 16;7:8. doi: 10.1186/1750-1326-7-8.


APOE genotype alters glial activation and loss of synaptic markers in mice.

Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, LaDu MJ.

Glia. 2012 Apr;60(4):559-69. doi: 10.1002/glia.22289. Epub 2012 Jan 6.


Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.

LaDu MJ, Munson GW, Jungbauer L, Getz GS, Reardon CA, Tai LM, Yu C.

Biochim Biophys Acta. 2012 Feb;1821(2):295-302. doi: 10.1016/j.bbalip.2011.11.005. Epub 2011 Nov 23.


Introducing Human APOE into Aβ Transgenic Mouse Models.

Tai LM, Youmans KL, Jungbauer L, Yu C, Ladu MJ.

Int J Alzheimers Dis. 2011;2011:810981. doi: 10.4061/2011/810981. Epub 2011 Oct 19.


[The zonal characterization of elemental concentrations in brown rice of core collection for rice landrace in Yunnan Province by ICP-AES].

Zeng YW, Wang LX, Pu XY, Du J, Yang SM, Liu JF, Tai LM.

Guang Pu Xue Yu Guang Pu Fen Xi. 2009 Jun;29(6):1691-5. Chinese.


Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123.

Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Loughlin AJ, Romero IA.

Brain Res. 2009 Oct 6;1292:14-24. doi: 10.1016/j.brainres.2009.07.039. Epub 2009 Jul 23. Erratum in: Brain Res. 2010 Jan 8;1306:184. Male, A David K [corrected to Male, David K].


Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation.

Tai LM, Holloway KA, Male DK, Loughlin AJ, Romero IA.

J Cell Mol Med. 2010 May;14(5):1101-12. doi: 10.1111/j.1582-4934.2009.00717.x. Epub 2009 Apr 2.


P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta.

Tai LM, Loughlin AJ, Male DK, Romero IA.

J Cereb Blood Flow Metab. 2009 Jun;29(6):1079-83. doi: 10.1038/jcbfm.2009.42. Epub 2009 Apr 15.


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