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Items: 37


The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer.

Chern YJ, Wong JCT, Cheng GSW, Yu A, Yin Y, Schaeffer DF, Kennecke HF, Morin G, Tai IT.

Cell Death Dis. 2019 Jun 26;10(7):504. doi: 10.1038/s41419-019-1687-x.


Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2.

Weiswald LB, Hasan MR, Wong JCT, Pasiliao CC, Rahman M, Ren J, Yin Y, Gusscott S, Vacher S, Weng AP, Kennecke HF, Bièche I, Schaeffer DF, Yapp DT, Tai IT.

Mol Cancer Ther. 2017 Oct;16(10):2292-2303. doi: 10.1158/1535-7163.MCT-16-0666. Epub 2017 Jun 29.


Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment.

Hosseini-Beheshti E, Choi W, Weiswald LB, Kharmate G, Ghaffari M, Roshan-Moniri M, Hassona MD, Chan L, Chin MY, Tai IT, Rennie PS, Fazli L, Tomlinson Guns ES.

Oncotarget. 2016 Mar 22;7(12):14639-58. doi: 10.18632/oncotarget.7052.


Disposable sheath that facilitates endoscopic Raman spectroscopy.

Wang W, Short M, Tai IT, Zeng H.

J Biomed Opt. 2016 Feb;21(2):25001. doi: 10.1117/1.JBO.21.2.025001.


Development and in vivo testing of a high frequency endoscopic Raman spectroscopy system for potential applications in the detection of early colonic neoplasia.

Short MA, Wang W, Tai IT, Zeng H.

J Biophotonics. 2016 Jan;9(1-2):44-8. doi: 10.1002/jbio.201500205. Epub 2015 Nov 20.


Label-free surface-enhanced Raman spectroscopy for detection of colorectal cancer and precursor lesions using blood plasma.

Feng S, Wang W, Tai IT, Chen G, Chen R, Zeng H.

Biomed Opt Express. 2015 Aug 24;6(9):3494-502. doi: 10.1364/BOE.6.003494. eCollection 2015 Sep 1.


Correction: A Peptide of SPARC Interferes with the Interaction between Caspase8 and Bcl2 to Resensitize Chemoresistant Tumors and Enhance Their Regression In Vivo.

Rahman M, Chan AP, Tang MJ, Tai IT.

PLoS One. 2015 Apr 23;10(4):e0127226. doi: 10.1371/journal.pone.0127226. eCollection 2015. No abstract available.


Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer.

Neijzen R, Wong MQ, Gill N, Wang H, Karim T, Anantha M, Strutt D, Waterhouse D, Bally MB, Tai IT, Ng SS, Yapp DT.

J Control Release. 2015 Feb 10;199:72-83. doi: 10.1016/j.jconrel.2014.11.031. Epub 2014 Dec 8.


Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence.

Wong JC, Hasan MR, Rahman M, Yu AC, Chan SK, Schaeffer DF, Kennecke HF, Lim HJ, Owen D, Tai IT.

Int J Cancer. 2013 Oct 1;133(7):1567-77. doi: 10.1002/ijc.28180. Epub 2013 Apr 30.


Using high frequency Raman spectra for colonic neoplasia detection.

Short MA, Tai IT, Owen D, Zeng H.

Opt Express. 2013 Feb 25;21(4):5025-34. doi: 10.1364/OE.21.005025.


A handheld electromagnetically actuated fiber optic raster scanner for reflectance confocal imaging of biological tissues.

Mansoor H, Zeng H, Tai IT, Zhao J, Chiao M.

IEEE Trans Biomed Eng. 2013 May;60(5):1431-8. doi: 10.1109/TBME.2012.2236326. Epub 2012 Dec 31.


Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivo.

Rahman M, Selvarajan K, Hasan MR, Chan AP, Jin C, Kim J, Chan SK, Le ND, Kim YB, Tai IT.

Neoplasia. 2012 Jul;14(7):624-33.


Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.

Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, Hou YC, Griffith OL, Cheng GS, Novik K, Moore R, Luk M, Owen D, Brown CJ, Morin GB, Gill S, Tai IT, Marra MA.

Pharmacogenomics J. 2013 Apr;13(2):148-58. doi: 10.1038/tpj.2011.65. Epub 2012 Jan 17.


A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo.

Rahman M, Chan AP, Tang M, Tai IT.

PLoS One. 2011;6(11):e26390. doi: 10.1371/journal.pone.0026390. Epub 2011 Nov 1. Erratum in: PLoS One. 2015;10(4):e0127226.


Inhibition of VEGF induces cellular senescence in colorectal cancer cells.

Hasan MR, Ho SH, Owen DA, Tai IT.

Int J Cancer. 2011 Nov 1;129(9):2115-23. doi: 10.1002/ijc.26179. Epub 2011 Aug 3.


Absence of MMP2 expression correlates with poor clinical outcomes in rectal cancer, and is distinct from MMP1-related outcomes in colon cancer.

Wong JC, Chan SK, Schaeffer DF, Sagaert X, Lim HJ, Kennecke H, Owen DA, Suh KW, Kim YB, Tai IT.

Clin Cancer Res. 2011 Jun 15;17(12):4167-76. doi: 10.1158/1078-0432.CCR-10-1224. Epub 2011 Apr 29.


Alternative expression analysis by RNA sequencing.

Griffith M, Griffith OL, Mwenifumbo J, Goya R, Morrissy AS, Morin RD, Corbett R, Tang MJ, Hou YC, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, Li HI, McDonald H, Teague K, Zhao Y, Zeng T, Delaney A, Hirst M, Morin GB, Jones SJ, Tai IT, Marra MA.

Nat Methods. 2010 Oct;7(10):843-7. doi: 10.1038/nmeth.1503. Epub 2010 Sep 12.


Protective effects of methyl gallate on H2O2-induced apoptosis in PC12 cells.

Crispo JA, Piché M, Ansell DR, Eibl JK, Tai IT, Kumar A, Ross GM, Tai TC.

Biochem Biophys Res Commun. 2010 Mar 19;393(4):773-8. doi: 10.1016/j.bbrc.2010.02.079. Epub 2010 Feb 18.


Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53.

Chan JM, Ho SH, Tai IT.

Carcinogenesis. 2010 May;31(5):812-9. doi: 10.1093/carcin/bgq034. Epub 2010 Feb 17.


The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.

Khan MA, Steiner TS, Sham HP, Bergstrom KS, Huang JT, Assi K, Salh B, Tai IT, Li X, Vallance BA.

J Immunol. 2010 Mar 1;184(5):2305-13. doi: 10.4049/jimmunol.0900021. Epub 2010 Feb 3.


A rare case of isolated duodenal metastases from hepatocellular carcinoma associated with p53 and ki-67 expression: a case report.

Chung C, Al Ali J, Owen DA, Weiss AA, Yoshida EM, Tai IT.

Cases J. 2009 Dec 17;2:9344. doi: 10.1186/1757-1626-2-9344.


Developing a clinician-scientist career.

Tai IT.

Clin Invest Med. 2008 Oct 1;31(5):E300-1. No abstract available.


SPARC in cancer biology: its role in cancer progression and potential for therapy.

Tai IT, Tang MJ.

Drug Resist Updat. 2008 Dec;11(6):231-46. doi: 10.1016/j.drup.2008.08.005. Epub 2008 Oct 11. Review.


SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.

Cheetham S, Tang MJ, Mesak F, Kennecke H, Owen D, Tai IT.

Br J Cancer. 2008 Jun 3;98(11):1810-9. doi: 10.1038/sj.bjc.6604377. Epub 2008 May 6.


Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers.

Chan SK, Griffith OL, Tai IT, Jones SJ.

Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):543-52. doi: 10.1158/1055-9965.EPI-07-2615.


ALEXA: a microarray design platform for alternative expression analysis.

Griffith M, Tang MJ, Griffith OL, Morin RD, Chan SY, Asano JK, Zeng T, Flibotte S, Ally A, Baross A, Hirst M, Jones SJ, Morin GB, Tai IT, Marra MA.

Nat Methods. 2008 Feb;5(2):118. doi: 10.1038/nmeth0208-118. No abstract available.


Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy.

Tai IT, Dai M, Owen DA, Chen LB.

J Clin Invest. 2005 Jun;115(6):1492-502. Epub 2005 May 12.


Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies.

Tai IT, Dai M, Chen LB.

Carcinogenesis. 2005 May;26(5):908-15. Epub 2005 Feb 24.


Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.

Davies FE, Dring AM, Li C, Rawstron AC, Shammas MA, O'Connor SM, Fenton JA, Hideshima T, Chauhan D, Tai IT, Robinson E, Auclair D, Rees K, Gonzalez D, Ashcroft AJ, Dasgupta R, Mitsiades C, Mitsiades N, Chen LB, Wong WH, Munshi NC, Morgan GJ, Anderson KC.

Blood. 2003 Dec 15;102(13):4504-11. Epub 2003 Aug 28.


Xenografts of rat islets into diabetic mice. An evaluation of new smaller capsules.

Lum ZP, Krestow M, Tai IT, Vacek I, Sun AM.

Transplantation. 1992 Jun;53(6):1180-3.


Free versus microencapsulated pancreatic islet xenografts producing amelioration of streptozotocin toxicity.

Krestow M, Lum ZP, Tai IT, Sun AM.

Biomater Artif Cells Immobilization Biotechnol. 1992;20(1):43-51.


Prolonged reversal of diabetic state in NOD mice by xenografts of microencapsulated rat islets.

Lum ZP, Tai IT, Krestow M, Norton J, Vacek I, Sun AM.

Diabetes. 1991 Nov;40(11):1511-6.


Xenotransplantation of microencapsulated fetal rat islets.

Krestow M, Lum ZP, Tai IT, Sun A.

Transplantation. 1991 Mar;51(3):651-5.


Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic islets.

Fan MY, Lum ZP, Fu XW, Levesque L, Tai IT, Sun AM.

Diabetes. 1990 Apr;39(4):519-22.


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