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Items: 32

1.

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C.

EMBO Mol Med. 2019 Jun;11(6). pii: e9711. doi: 10.15252/emmm.201809711.

2.

In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.

Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Müller UC, Sgobio C, Herms J.

Glia. 2019 May;67(5):985-998. doi: 10.1002/glia.23584. Epub 2019 Jan 22.

PMID:
30667091
3.

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C.

Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7.

4.

Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.

Claes C, Van Den Daele J, Boon R, Schouteden S, Colombo A, Monasor LS, Fiers M, Ordovás L, Nami F, Bohrmann B, Tahirovic S, De Strooper B, Verfaillie CM.

Alzheimers Dement. 2019 Mar;15(3):453-464. doi: 10.1016/j.jalz.2018.09.006. Epub 2018 Nov 12.

5.

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.

Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A.

Mol Neurodegener. 2018 Sep 4;13(1):48. doi: 10.1186/s13024-018-0281-5.

6.

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.

Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S.

PLoS One. 2018 Jul 6;13(7):e0200344. doi: 10.1371/journal.pone.0200344. eCollection 2018.

7.

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C.

EMBO Rep. 2017 Jul;18(7):1186-1198. doi: 10.15252/embr.201743922. Epub 2017 May 8.

8.

Young microglia restore amyloid plaque clearance of aged microglia.

Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, Haass C, Tahirovic S.

EMBO J. 2017 Mar 1;36(5):583-603. doi: 10.15252/embj.201694591. Epub 2016 Dec 21.

9.

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D.

EMBO J. 2016 Nov 2;35(21):2350-2370. Epub 2016 Sep 12.

10.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

11.

Inhibition of amyloid-β plaque formation by α-synuclein.

Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M.

Nat Med. 2015 Jul;21(7):802-7. doi: 10.1038/nm.3885. Epub 2015 Jun 22.

PMID:
26099047
12.

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.

Banzhaf-Strathmann J, Benito E, May S, Arzberger T, Tahirovic S, Kretzschmar H, Fischer A, Edbauer D.

EMBO J. 2014 Aug 1;33(15):1667-80. doi: 10.15252/embj.201387576. Epub 2014 Jul 7.

13.

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C.

Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093.

14.

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.

Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.

Acta Neuropathol. 2014;127(6):845-60. doi: 10.1007/s00401-014-1262-6. Epub 2014 Mar 12.

PMID:
24619111
15.

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.

Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D.

EMBO J. 2014 Mar 3;33(5):450-67. doi: 10.1002/embj.201385857. Epub 2013 Dec 19.

16.

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.

Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C.

EMBO J. 2013 Jul 17;32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21.

17.

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C.

J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013.

18.

ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.

Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F.

Neuron. 2012 Dec 20;76(6):1091-107. doi: 10.1016/j.neuron.2012.09.038.

19.

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C.

EMBO J. 2012 Nov 14;31(22):4258-75. doi: 10.1038/emboj.2012.261. Epub 2012 Sep 11.

20.

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.

Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D.

EMBO Rep. 2012 Aug;13(8):759-64. doi: 10.1038/embor.2012.90. Epub 2012 Jun 19.

21.

Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).

Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D, Haass C.

J Biol Chem. 2012 Jun 29;287(27):23079-94. doi: 10.1074/jbc.M111.328757. Epub 2012 May 4.

22.

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells.

Malnar M, Kosicek M, Lisica A, Posavec M, Krolo A, Njavro J, Omerbasic D, Tahirovic S, Hecimovic S.

Biochim Biophys Acta. 2012 Aug;1822(8):1270-83. doi: 10.1016/j.bbadis.2012.04.002. Epub 2012 Apr 19.

23.

Electrical activity suppresses axon growth through Ca(v)1.2 channels in adult primary sensory neurons.

Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID, Bradke F.

Curr Biol. 2010 Jul 13;20(13):1154-64. doi: 10.1016/j.cub.2010.05.055. Epub 2010 Jun 24.

24.

Rac1 regulates neuronal polarization through the WAVE complex.

Tahirovic S, Hellal F, Neukirchen D, Hindges R, Garvalov BK, Flynn KC, Stradal TE, Chrostek-Grashoff A, Brakebusch C, Bradke F.

J Neurosci. 2010 May 19;30(20):6930-43. doi: 10.1523/JNEUROSCI.5395-09.2010.

25.

Neuronal polarity.

Tahirovic S, Bradke F.

Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a001644. doi: 10.1101/cshperspect.a001644. Review.

26.

Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon.

Ylera B, Ertürk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F.

Curr Biol. 2009 Jun 9;19(11):930-6. doi: 10.1016/j.cub.2009.04.017. Epub 2009 Apr 30.

27.

Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects.

Wiradjaja F, Ooms LM, Tahirovic S, Kuhne E, Devenish RJ, Munn AL, Piper RC, Mayinger P, Mitchell CA.

J Biol Chem. 2007 Jun 1;282(22):16295-307. Epub 2007 Mar 28.

28.

Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes.

Jeynov B, Lay D, Schmidt F, Tahirovic S, Just WW.

FEBS Lett. 2006 Oct 30;580(25):5917-24. Epub 2006 Oct 5.

29.

Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p.

Faulhammer F, Konrad G, Brankatschk B, Tahirovic S, Knödler A, Mayinger P.

J Cell Biol. 2005 Jan 17;168(2):185-91.

30.

Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.

Tahirovic S, Schorr M, Mayinger P.

Traffic. 2005 Feb;6(2):116-30.

31.

Role for lipid signaling and the cell integrity MAP kinase cascade in yeast septum biogenesis.

Tahirovic S, Schorr M, Then A, Berger J, Schwarz H, Mayinger P.

Curr Genet. 2003 May;43(2):71-8. Epub 2003 Mar 7.

PMID:
12695846
32.

The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase.

Schorr M, Then A, Tahirovic S, Hug N, Mayinger P.

Curr Biol. 2001 Sep 18;11(18):1421-6.

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