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Items: 1 to 50 of 85

1.

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing.

Verboom K, Van Loocke W, Volders PJ, Decaesteker B, Avila Cobos F, Bornschein S, de Bock CE, Kalender Atak Z, Clappier E, Aerts S, Cools J, Soulier J, Taghon T, Van Vlierberghe P, Vandesompele J, Speleman F, Durinck K.

Haematologica. 2018 Jun 28. pii: haematol.2018.190587. doi: 10.3324/haematol.2018.190587. [Epub ahead of print] No abstract available.

2.

Generation of adult human T-cell progenitors for immunotherapeutic applications.

Simons L, Ma K, de Chappedelaine C, Moiranghtem RD, Elkaim E, Olivré J, Susini S, Appourchaux K, Reimann C, Sadek H, Pellé O, Cagnard N, Magrin E, Lagresle-Peyrou C, Taghon T, Rausell A, Cavazzana M, André-Schmutz I.

J Allergy Clin Immunol. 2018 Apr;141(4):1491-1494.e4. doi: 10.1016/j.jaci.2017.10.034. Epub 2017 Dec 5. No abstract available.

3.

Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing.

Wallaert A, Van Loocke W, Hernandez L, Taghon T, Speleman F, Van Vlierberghe P.

Sci Rep. 2017 Aug 11;7(1):7901. doi: 10.1038/s41598-017-08148-x.

4.

The checkpoint for agonist selection precedes conventional selection in human thymus.

Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B.

Sci Immunol. 2017 Feb 24;2(8). pii: eaah4232. doi: 10.1126/sciimmunol.aah4232.

5.

A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.

Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Plum J, Dunay IR, Diefenbach A, Leclercq G.

Cell Rep. 2017 May 16;19(7):1431-1443. doi: 10.1016/j.celrep.2017.04.068.

6.

Human T cell development notched up a level.

Dolens AC, Taghon T.

Nat Methods. 2017 Apr 27;14(5):477-478. doi: 10.1038/nmeth.4277. No abstract available.

PMID:
28448067
7.

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.

Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, Bonte S, Taghon T, Leclercq G, Kerre T, Debets R, Vermijlen D, Abken H, Vandekerckhove B.

Oncoimmunology. 2017 Jan 19;6(3):e1283460. doi: 10.1080/2162402X.2017.1283460. eCollection 2017.

8.

T-ALL and thymocytes: a message of noncoding RNAs.

Wallaert A, Durinck K, Taghon T, Van Vlierberghe P, Speleman F.

J Hematol Oncol. 2017 Mar 7;10(1):66. doi: 10.1186/s13045-017-0432-0. Review.

9.

The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection.

Filtjens J, Coltel N, Cencig S, Taveirne S, Van Ammel E, Van Acker A, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Carlier Y, Truyens C, Leclercq G.

Front Immunol. 2016 Nov 10;7:472. eCollection 2016.

10.

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.

Van Acker A, Louagie E, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Elewaut D, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

Cancer Immunol Immunother. 2016 Nov;65(11):1365-1375. Epub 2016 Sep 1.

PMID:
27585789
11.

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

Unnikrishnan A, Guan YF, Huang Y, Beck D, Thoms JA, Peirs S, Knezevic K, Ma S, de Walle IV, de Jong I, Ali Z, Zhong L, Raftery MJ, Taghon T, Larsson J, MacKenzie KL, Van Vlierberghe P, Wong JW, Pimanda JE.

Nucleic Acids Res. 2016 Dec 15;44(22):10644-10661. Epub 2016 Sep 6.

12.

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

Drennan MB, Govindarajan S, Verheugen E, Coquet JM, Staal J, McGuire C, Taghon T, Leclercq G, Beyaert R, van Loo G, Lambrecht BN, Elewaut D.

J Exp Med. 2016 Sep 19;213(10):1973-81. doi: 10.1084/jem.20151065. Epub 2016 Aug 22.

13.

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

Filtjens J, Keirsse J, Van Ammel E, Taveirne S, Van Acker A, Kerre T, Taghon T, Vandekerckhove B, Plum J, Van Ginderachter JA, Leclercq G.

Sci Rep. 2016 Jul 29;6:30564. doi: 10.1038/srep30564.

14.

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia.

Wallaert A, Durinck K, Van Loocke W, Van de Walle I, Matthijssens F, Volders PJ, Avila Cobos F, Rombaut D, Rondou P, Mestdagh P, Vandesompele J, Poppe B, Taghon T, Soulier J, Van Vlierberghe P, Speleman F.

Leukemia. 2016 Sep;30(9):1927-30. doi: 10.1038/leu.2016.82. Epub 2016 Apr 22. No abstract available.

PMID:
27168467
15.

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.

Van de Walle I, Dolens AC, Durinck K, De Mulder K, Van Loocke W, Damle S, Waegemans E, De Medts J, Velghe I, De Smedt M, Vandekerckhove B, Kerre T, Plum J, Leclercq G, Rothenberg EV, Van Vlierberghe P, Speleman F, Taghon T.

Nat Commun. 2016 Apr 6;7:11171. doi: 10.1038/ncomms11171.

16.

Etiology of postanesthetic and postsedation events on the inpatient ward: data from a rapid response team at a tertiary care children's hospital.

Barry N, M Miller K, Ryshen G, Uffman J, Taghon TA, Tobias JD.

Paediatr Anaesth. 2016 May;26(5):504-11. doi: 10.1111/pan.12874. Epub 2016 Mar 12.

PMID:
26972832
17.

Humanized Mice to Study Human T Cell Development.

Bonte S, Snauwaert S, Vanhee S, Dolens AC, Taghon T, Vandekerckhove B, Kerre T.

Methods Mol Biol. 2016;1323:253-72. doi: 10.1007/978-1-4939-2809-5_21.

PMID:
26294414
18.

Approaches to Study Human T Cell Development.

Dolens AC, Van de Walle I, Taghon T.

Methods Mol Biol. 2016;1323:239-51. doi: 10.1007/978-1-4939-2809-5_20.

PMID:
26294413
19.

Characterization and Isolation of Human T Cell Progenitors.

Van de Walle I, Davids K, Taghon T.

Methods Mol Biol. 2016;1323:221-37. doi: 10.1007/978-1-4939-2809-5_19.

PMID:
26294412
20.

Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination.

Bogaert D, Van Schil K, Taghon T, Bordon V, Bonroy C, Dullaers M, De Baere E, Haerynck F.

Pediatr Allergy Immunol. 2016 Feb;27(1):93-6. doi: 10.1111/pai.12455. Epub 2015 Oct 1. No abstract available.

PMID:
26248889
21.

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia.

Durinck K, Van Loocke W, Van der Meulen J, Van de Walle I, Ongenaert M, Rondou P, Wallaert A, de Bock CE, Van Roy N, Poppe B, Cools J, Soulier J, Taghon T, Speleman F, Van Vlierberghe P.

Leukemia. 2015 Dec;29(12):2317-27. doi: 10.1038/leu.2015.162. Epub 2015 Jun 25.

PMID:
26108691
22.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ.

Nat Commun. 2015 Jan 7;6:5794. doi: 10.1038/ncomms6794.

23.

A comparison of functional magnetic resonance imaging findings in children with and without a history of early exposure to general anesthesia.

Taghon TA, Masunga AN, Small RH, Kashou NH.

Paediatr Anaesth. 2015 Mar;25(3):239-46. doi: 10.1111/pan.12606. Epub 2015 Jan 3.

PMID:
25557318
24.

Epigenetics in T-cell acute lymphoblastic leukemia.

Peirs S, Van der Meulen J, Van de Walle I, Taghon T, Speleman F, Poppe B, Van Vlierberghe P.

Immunol Rev. 2015 Jan;263(1):50-67. doi: 10.1111/imr.12237. Review.

PMID:
25510271
25.

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia.

Sanghvi VR, Mavrakis KJ, Van der Meulen J, Boice M, Wolfe AL, Carty M, Mohan P, Rondou P, Socci ND, Benoit Y, Taghon T, Van Vlierberghe P, Leslie CS, Speleman F, Wendel HG.

Sci Signal. 2014 Nov 18;7(352):ra111. doi: 10.1126/scisignal.2005500.

26.

Notch3 activation is sufficient but not required for inducing human T-lineage specification.

Waegemans E, Van de Walle I, De Medts J, De Smedt M, Kerre T, Vandekerckhove B, Leclercq G, Wang T, Plum J, Taghon T.

J Immunol. 2014 Dec 15;193(12):5997-6004. doi: 10.4049/jimmunol.1400764. Epub 2014 Nov 7.

27.

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis.

Vanhee S, De Mulder K, Van Caeneghem Y, Verstichel G, Van Roy N, Menten B, Velghe I, Philippé J, De Bleser D, Lambrecht BN, Taghon T, Leclercq G, Kerre T, Vandekerckhove B.

Haematologica. 2015 Feb;100(2):157-66. doi: 10.3324/haematol.2014.112144. Epub 2014 Nov 7.

28.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Durinck K, Wallaert A, Van de Walle I, Van Loocke W, Volders PJ, Vanhauwaert S, Geerdens E, Benoit Y, Van Roy N, Poppe B, Soulier J, Cools J, Mestdagh P, Vandesompele J, Rondou P, Van Vlierberghe P, Taghon T, Speleman F.

Haematologica. 2014 Dec;99(12):1808-16. doi: 10.3324/haematol.2014.115683. Epub 2014 Oct 24.

29.

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

Van der Meulen J, Sanghvi V, Mavrakis K, Durinck K, Fang F, Matthijssens F, Rondou P, Rosen M, Pieters T, Vandenberghe P, Delabesse E, Lammens T, De Moerloose B, Menten B, Van Roy N, Verhasselt B, Poppe B, Benoit Y, Taghon T, Melnick AM, Speleman F, Wendel HG, Van Vlierberghe P.

Blood. 2015 Jan 1;125(1):13-21. doi: 10.1182/blood-2014-05-577270. Epub 2014 Oct 15.

30.

Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases.

Van Acker A, Filtjens J, Van Welden S, Taveirne S, Van Ammel E, Vanhees M, Devisscher L, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

PLoS One. 2014 Oct 13;9(10):e110015. doi: 10.1371/journal.pone.0110015. eCollection 2014. Erratum in: PLoS One. 2015;10(4):e0124464.

31.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia.

Peirs S, Matthijssens F, Goossens S, Van de Walle I, Ruggero K, de Bock CE, Degryse S, Canté-Barrett K, Briot D, Clappier E, Lammens T, De Moerloose B, Benoit Y, Poppe B, Meijerink JP, Cools J, Soulier J, Rabbitts TH, Taghon T, Speleman F, Van Vlierberghe P.

Blood. 2014 Dec 11;124(25):3738-47. doi: 10.1182/blood-2014-05-574566. Epub 2014 Oct 9.

32.

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia.

Mets E, Van der Meulen J, Van Peer G, Boice M, Mestdagh P, Van de Walle I, Lammens T, Goossens S, De Moerloose B, Benoit Y, Van Roy N, Clappier E, Poppe B, Vandesompele J, Wendel HG, Taghon T, Rondou P, Soulier J, Van Vlierberghe P, Speleman F.

Leukemia. 2015 Apr;29(4):798-806. doi: 10.1038/leu.2014.276. Epub 2014 Sep 18.

33.

A medication-based trigger tool to identify adverse events in pediatric anesthesiology.

Taghon T, Elsey N, Miler V, McClead R, Tobias J.

Jt Comm J Qual Patient Saf. 2014 Jul;40(7):326-34. No abstract available.

PMID:
25130016
34.

Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma.

Finalet Ferreiro J, Rouhigharabaei L, Urbankova H, van der Krogt JA, Michaux L, Shetty S, Krenacs L, Tousseyn T, De Paepe P, Uyttebroeck A, Verhoef G, Taghon T, Vandenberghe P, Cools J, Wlodarska I.

PLoS One. 2014 Jul 24;9(7):e102977. doi: 10.1371/journal.pone.0102977. eCollection 2014.

35.

Oxymetazoline (Afrin®): maybe there is more that we need to know.

Tobias JD, Cartabuke R, Taghon T.

Paediatr Anaesth. 2014 Aug;24(8):795-8. doi: 10.1111/pan.12399. No abstract available.

PMID:
25039870
36.

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia.

Mets E, Van Peer G, Van der Meulen J, Boice M, Taghon T, Goossens S, Mestdagh P, Benoit Y, De Moerloose B, Van Roy N, Poppe B, Vandesompele J, Wendel HG, Van Vlierberghe P, Speleman F, Rondou P.

Haematologica. 2014 Aug;99(8):1326-33. doi: 10.3324/haematol.2013.099515. Epub 2014 Jun 3.

37.

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development.

Filtjens J, Foquet L, Taveirne S, Van Ammel E, Vanhees M, Van Acker A, Kerre T, Taghon T, Vandekerckhove B, Plum J, Van den Steen PE, Leclercq G.

PLoS One. 2014 Jan 30;9(1):e87463. doi: 10.1371/journal.pone.0087463. eCollection 2014.

38.

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.

Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, Kirchhoff F, Verhasselt B.

Retrovirology. 2013 Nov 15;10:137. doi: 10.1186/1742-4690-10-137.

39.

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection.

Snauwaert S, Verstichel G, Bonte S, Goetgeluk G, Vanhee S, Van Caeneghem Y, De Mulder K, Heirman C, Stauss H, Heemskerk MH, Taghon T, Leclercq G, Plum J, Langerak AW, Thielemans K, Kerre T, Vandekerckhove B.

Leukemia. 2014 Apr;28(4):830-41. doi: 10.1038/leu.2013.285. Epub 2013 Oct 4.

PMID:
24091848
40.

Current practices regarding codeine administration among pediatricians and pediatric subspecialists.

Cartabuke RS, Tobias JD, Taghon T, Rice J.

Clin Pediatr (Phila). 2014 Jan;53(1):26-30. doi: 10.1177/0009922813498151. Epub 2013 Aug 5.

PMID:
23922249
41.

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

Van de Walle I, Waegemans E, De Medts J, De Smet G, De Smedt M, Snauwaert S, Vandekerckhove B, Kerre T, Leclercq G, Plum J, Gridley T, Wang T, Koch U, Radtke F, Taghon T.

J Exp Med. 2013 Apr 8;210(4):683-97. doi: 10.1084/jem.20121798. Epub 2013 Mar 25.

42.

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.

Filtjens J, Taveirne S, Van Acker A, Van Ammel E, Vanhees M, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

J Leukoc Biol. 2013 May;93(5):699-711. doi: 10.1189/jlb.0812378. Epub 2013 Mar 8.

PMID:
23475576
43.

Perioperative hypothermia in the pediatric population: a quality improvement project.

Kim P, Taghon T, Fetzer M, Tobias JD.

Am J Med Qual. 2013 Sep-Oct;28(5):400-6. doi: 10.1177/1062860612473350. Epub 2013 Jan 25.

PMID:
23354871
44.

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.

Van Den Broeck T, Van Ammel E, Delforche M, Taveirne S, Kerre T, Vandekerckhove B, Taghon T, Plum J, Leclercq G.

J Immunol. 2013 Mar 1;190(5):1982-90. doi: 10.4049/jimmunol.1200354. Epub 2013 Jan 21.

45.

Severe intraoperative hypertension after induction of anesthesia in a child with a neuroblastoma.

Kako H, Taghon T, Veneziano G, Aldrink JH, Ayoob R, Tobias JD.

J Anesth. 2013 Jun;27(3):464-7. doi: 10.1007/s00540-012-1544-x. Epub 2013 Jan 5.

PMID:
23292755
46.

Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors.

Vermeire J, Naessens E, Vanderstraeten H, Landi A, Iannucci V, Van Nuffel A, Taghon T, Pizzato M, Verhasselt B.

PLoS One. 2012;7(12):e50859. doi: 10.1371/journal.pone.0050859. Epub 2012 Dec 5.

47.

Notch signaling during human T cell development.

Taghon T, Waegemans E, Van de Walle I.

Curr Top Microbiol Immunol. 2012;360:75-97. doi: 10.1007/82_2012_230. Review.

PMID:
22692833
48.

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia.

Snauwaert S, Vanhee S, Goetgeluk G, Verstichel G, Van Caeneghem Y, Velghe I, Philippé J, Berneman ZN, Plum J, Taghon T, Leclercq G, Thielemans K, Kerre T, Vandekerckhove B.

Haematologica. 2012 Oct;97(10):1539-47. doi: 10.3324/haematol.2012.065581. Epub 2012 Apr 24.

49.

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

Van Coppernolle S, Vanhee S, Verstichel G, Snauwaert S, van der Spek A, Velghe I, Sinnesael M, Heemskerk MH, Taghon T, Leclercq G, Plum J, Langerak AW, Kerre T, Vandekerckhove B.

Leukemia. 2012 Jan;26(1):127-38. doi: 10.1038/leu.2011.324. Epub 2011 Nov 4.

PMID:
22051534
50.

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setty M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG.

Nat Genet. 2011 Jun 5;43(7):673-8. doi: 10.1038/ng.858. Erratum in: Nat Genet. 2011 Aug;43(8):815. Setti, Manu [corrected to Setty, Manu].

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