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Mechanisms Underlying Interactions Between Low-Frequency Oscillations and Beat-to-Beat Variability of Celullar Ventricular Repolarization in Response to Sympathetic Stimulation: Implications for Arrhythmogenesis.

Sampedro-Puente DA, Fernandez-Bes J, Porter B, van Duijvenboden S, Taggart P, Pueyo E.

Front Physiol. 2019 Aug 2;10:916. doi: 10.3389/fphys.2019.00916. eCollection 2019.


No Evidence of Toxoplasma Gondii Exposure in South Australian Koalas (Phascolarctos cinereus).

Taggart PL, Fancourt BA, Fabijan J, Peacock DE, Speight KN, Caraguel CGB, McAllister MM.

J Parasitol. 2019 Aug;105(4):638-641.


Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.

Finlay M, Bhar-Amato J, Ng KE, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL, Lambiase PD, Tinker A.

Am J Physiol Cell Physiol. 2019 Jul 10. doi: 10.1152/ajpcell.00028.2019. [Epub ahead of print]


Spatial Analysis of a Cat-Borne Disease Reveals That Soil pH and Clay Content Are Risk Factors for Sarcocystosis in Sheep.

Taggart PL, Stevenson MA, Firestone SM, McAllister MM, Caraguel CGB.

Front Vet Sci. 2019 Apr 24;6:127. doi: 10.3389/fvets.2019.00127. eCollection 2019.


Characterizing the clinical implementation of a novel activation-repolarization metric to identify targets for catheter ablation of ventricular tachycardias using computational models.

Campos FO, Orini M, Taggart P, Hanson B, Lambiase PD, Porter B, Rinaldi CA, Gill J, Bishop MJ.

Comput Biol Med. 2019 May;108:263-275. doi: 10.1016/j.compbiomed.2019.03.018. Epub 2019 Mar 23.


Simultaneous Comparison of Electrocardiographic Imaging and Epicardial Contact Mapping in Structural Heart Disease.

Graham AJ, Orini M, Zacur E, Dhillon G, Daw H, Srinivasan NT, Lane JD, Cambridge A, Garcia J, O'Reilly NJ, Whittaker-Axon S, Taggart P, Lowe M, Finlay M, Earley MJ, Chow A, Sporton S, Dhinoja M, Schilling RJ, Hunter RJ, Lambiase PD.

Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007120. doi: 10.1161/CIRCEP.118.007120.


Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans.

van Duijvenboden S, Hanson B, Child N, Lambiase PD, Rinaldi CA, Jaswinder G, Taggart P, Orini M.

Ann Biomed Eng. 2019 May;47(5):1291-1299. doi: 10.1007/s10439-019-02221-4. Epub 2019 Feb 12.


Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

Orini M, Yanni J, Taggart P, Hanson B, Hayward M, Smith A, Zhang H, Colman M, Jones G, Jie X, Dobrzynski H, Boyett MR, Lambiase PD.

Europace. 2019 Jun 1;21(6):981-989. doi: 10.1093/europace/euz007.


Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia.

Taggart PL, Traub R, Fui S, Weinstein P.

J Vector Borne Dis. 2018 Jul-Sep;55(3):239-241. doi: 10.4103/0972-9062.249483. No abstract available.


Differences in the upslope of the precordial body surface ECG T wave reflect right to left dispersion of repolarization in the intact human heart.

Srinivasan NT, Orini M, Providencia R, Simon R, Lowe M, Segal OR, Chow AW, Schilling RJ, Hunter RJ, Taggart P, Lambiase PD.

Heart Rhythm. 2019 Jun;16(6):943-951. doi: 10.1016/j.hrthm.2018.12.006. Epub 2018 Dec 12.


Left ventricular activation-recovery interval variability predicts spontaneous ventricular tachyarrhythmia in patients with heart failure.

Porter B, Bishop MJ, Claridge S, Child N, Van Duijvenboden S, Bostock J, Sieniewicz BJ, Gould J, Sidhu B, Hanson B, Chen Z, Rinaldi CA, Taggart P, Gill JS.

Heart Rhythm. 2019 May;16(5):702-709. doi: 10.1016/j.hrthm.2018.11.013. Epub 2018 Dec 5.


Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation.

Srinivasan NT, Orini M, Providencia R, Dhinoja MB, Lowe MD, Ahsan SY, Chow AW, Hunter RJ, Schilling RJ, Taggart P, Lambiase PD.

Europace. 2019 Apr 1;21(4):616-625. doi: 10.1093/europace/euy260.


Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).

Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A, Tinker A, Gourine AV.

Circ Arrhythm Electrophysiol. 2018 Oct;11(10):e006740. doi: 10.1161/CIRCEP.118.006740.


Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.

Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL, Ben Simon R, Tinker A, Lambiase PD.

Circ Arrhythm Electrophysiol. 2018 Sep;11(9):e006330. doi: 10.1161/CIRCEP.118.006330.


Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders.

Martin CA, Orini M, Srinivasan NT, Bhar-Amato J, Honarbakhsh S, Chow AW, Lowe MD, Ben-Simon R, Elliott PM, Taggart P, Lambiase PD.

Int J Cardiol. 2018 Nov 15;271:75-80. doi: 10.1016/j.ijcard.2018.05.063. Epub 2018 May 20.


Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial Fibrillation: Results From the STARLIGHT Study.

Child N, Clayton RH, Roney CR, Laughner JI, Shuros A, Neuzil P, Petru J, Jackson T, Porter B, Bostock J, Niederer SA, Razavi RS, Rinaldi CA, Taggart P, Wright MJ, Gill J.

Circ Arrhythm Electrophysiol. 2018 Jun;11(6):e005897. doi: 10.1161/CIRCEP.117.005897. Erratum in: Circ Arrhythm Electrophysiol. 2018 Aug;11(8):e000030.


Corrigendum to "Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans" [J. Mol. Cell. Cardiol. 97 (2016) 93-105].

Pueyo E, Orini M, Rodríguez JF, Taggart P.

J Mol Cell Cardiol. 2018 Aug;121:305. doi: 10.1016/j.yjmcc.2018.05.006. Epub 2018 May 21. No abstract available.


Beat-to-Beat Variability of Ventricular Action Potential Duration Oscillates at Low Frequency During Sympathetic Provocation in Humans.

Porter B, van Duijvenboden S, Bishop MJ, Orini M, Claridge S, Gould J, Sieniewicz BJ, Sidhu B, Razavi R, Rinaldi CA, Gill JS, Taggart P.

Front Physiol. 2018 Apr 4;9:147. doi: 10.3389/fphys.2018.00147. eCollection 2018.


In vivo human sock-mapping validation of a simple model that explains unipolar electrogram morphology in relation to conduction-repolarization dynamics.

Orini M, Taggart P, Lambiase PD.

J Cardiovasc Electrophysiol. 2018 Jul;29(7):990-997. doi: 10.1111/jce.13606. Epub 2018 May 3.


Spatio-temporal Organization During Ventricular Fibrillation in the Human Heart.

Robson J, Aram P, Nash MP, Bradley CP, Hayward M, Paterson DJ, Taggart P, Clayton RH, Kadirkamanathan V.

Ann Biomed Eng. 2018 Jun;46(6):864-876. doi: 10.1007/s10439-018-2007-9. Epub 2018 Mar 15.


The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.

van Bilsen M, Patel HC, Bauersachs J, Böhm M, Borggrefe M, Brutsaert D, Coats AJS, de Boer RA, de Keulenaer GW, Filippatos GS, Floras J, Grassi G, Jankowska EA, Kornet L, Lunde IG, Maack C, Mahfoud F, Pollesello P, Ponikowski P, Ruschitzka F, Sabbah HN, Schultz HD, Seferovic P, Slart RHJA, Taggart P, Tocchetti CG, Van Laake LW, Zannad F, Heymans S, Lyon AR.

Eur J Heart Fail. 2017 Nov;19(11):1361-1378. doi: 10.1002/ejhf.921. Epub 2017 Sep 26. Review.


Spatiotemporal characterization of the transition from sinus rhythm to ventricular fibrillation during an acute ischemic event in the intact human heart by whole-heart sock-mapping.

Orini M, Taggart P, Hayward M, Lambiase PD.

HeartRhythm Case Rep. 2017 Feb 20;3(5):259-263. doi: 10.1016/j.hrcr.2017.01.002. eCollection 2017 May. No abstract available.


Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration.

Porter B, Bishop MJ, Claridge S, Behar J, Sieniewicz BJ, Webb J, Gould J, O'Neill M, Rinaldi CA, Razavi R, Gill JS, Taggart P.

Front Physiol. 2017 May 29;8:328. doi: 10.3389/fphys.2017.00328. eCollection 2017.


Mechano-electrical feedback in the clinical setting: Current perspectives.

Orini M, Nanda A, Yates M, Di Salvo C, Roberts N, Lambiase PD, Taggart P.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):365-375. doi: 10.1016/j.pbiomolbio.2017.06.001. Epub 2017 Jun 3. Review.


A multivariate time-frequency approach for tracking QT variability changes unrelated to heart rate variability.

Orini M, Taggart P, Lambiase PD.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:924-927. doi: 10.1109/EMBC.2016.7590852.


Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.

Santos D, Orini M, Zhou X, Bueno-Orovio A, Hanson B, Taggart P, Hayward M, Rodriguez B, Lambiase P.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:157-160. doi: 10.1109/EMBC.2016.7590664.


Significance of neuro-cardiac control mechanisms governed by higher regions of the brain.

Taggart P, Critchley H, van Duijvendoden S, Lambiase PD.

Auton Neurosci. 2016 Aug;199:54-65. doi: 10.1016/j.autneu.2016.08.013. Epub 2016 Aug 24. Review.


Interactions between Activation and Repolarization Restitution Properties in the Intact Human Heart: In-Vivo Whole-Heart Data and Mathematical Description.

Orini M, Taggart P, Srinivasan N, Hayward M, Lambiase PD.

PLoS One. 2016 Sep 2;11(9):e0161765. doi: 10.1371/journal.pone.0161765. eCollection 2016.


Ventricular stimulus site influences dynamic dispersion of repolarization in the intact human heart.

Srinivasan NT, Orini M, Simon RB, Providência R, Khan FZ, Segal OR, Babu GG, Bradley R, Rowland E, Ahsan S, Chow AW, Lowe MD, Taggart P, Lambiase PD.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H545-54. doi: 10.1152/ajpheart.00159.2016. Epub 2016 Jul 1.


Coupling of ventricular action potential duration and local strain patterns during reverse remodeling in responders and nonresponders to cardiac resynchronization therapy.

Chen Z, Hanson B, Sohal M, Sammut E, Jackson T, Child N, Claridge S, Behar J, Niederer S, Gill J, Carr-White G, Razavi R, Rinaldi CA, Taggart P.

Heart Rhythm. 2016 Sep;13(9):1898-904. doi: 10.1016/j.hrthm.2016.06.014. Epub 2016 Jun 11.


Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans.

Pueyo E, Orini M, Rodríguez JF, Taggart P.

J Mol Cell Cardiol. 2016 Aug;97:93-105. doi: 10.1016/j.yjmcc.2016.05.003. Epub 2016 May 11. Erratum in: J Mol Cell Cardiol. 2018 Aug;121:305.


Biophysical Modeling Predicts Ventricular Tachycardia Inducibility and Circuit Morphology: A Combined Clinical Validation and Computer Modeling Approach.

Chen Z, Cabrera-Lozoya R, Relan J, Sohal M, Shetty A, Karim R, Delingette H, Gill J, Rhode K, Ayache N, Taggart P, Rinaldi CA, Sermesant M, Razavi R.

J Cardiovasc Electrophysiol. 2016 Jul;27(7):851-60. doi: 10.1111/jce.12991. Epub 2016 Jun 8.


Investigating a Novel Activation-Repolarisation Time Metric to Predict Localised Vulnerability to Reentry Using Computational Modelling.

Hill YR, Child N, Hanson B, Wallman M, Coronel R, Plank G, Rinaldi CA, Gill J, Smith NP, Taggart P, Bishop MJ.

PLoS One. 2016 Mar 2;11(3):e0149342. doi: 10.1371/journal.pone.0149342. eCollection 2016.


Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve.

Dutta S, Mincholé A, Zacur E, Quinn TA, Taggart P, Rodriguez B.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):236-48. doi: 10.1016/j.pbiomolbio.2016.01.008. Epub 2016 Feb 2.


On how 2∶1 conduction block can induce T-wave alternans in the unipolar intracavitary electrogram: Modelling in-vivo human recordings from an ischemic heart.

Orini M, Taggart P, Hayward M, Lambiase P.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:5676-9. doi: 10.1109/EMBC.2015.7319680.


Analytical description of the slope of the APD-restitution curve to assess the interacting contribution of conduction and repolarization dynamics.

Orini M, Taggart P, Hayward M, Lambiase PD.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:5672-5. doi: 10.1109/EMBC.2015.7319679.


Accuracy of measurements derived from intracardiac unipolar electrograms: A simulation study.

van Duijvenboden S, Orini M, Taggart P, Hanson B.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:76-9. doi: 10.1109/EMBC.2015.7318304.


Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RA, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin JP, Varro A, Wallman M, Zhou X.

Europace. 2016 Sep;18(9):1287-98. doi: 10.1093/europace/euv320. Epub 2015 Nov 29.


In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes.

Zhou X, Bueno-Orovio A, Orini M, Hanson B, Hayward M, Taggart P, Lambiase PD, Burrage K, Rodriguez B.

Circ Res. 2016 Jan 22;118(2):266-78. doi: 10.1161/CIRCRESAHA.115.307836. Epub 2015 Nov 24.


Effective emotion regulation strategies improve fMRI and ECG markers of psychopathology in panic disorder: implications for psychological treatment action.

Reinecke A, Filippini N, Berna C, Western DG, Hanson B, Cooper MJ, Taggart P, Harmer CJ.

Transl Psychiatry. 2015 Nov 3;5:e673. doi: 10.1038/tp.2015.160.


Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans.

van Duijvenboden S, Hanson B, Child N, Orini M, Rinaldi CA, Gill JS, Taggart P.

Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2108-17. doi: 10.1152/ajpheart.00560.2015. Epub 2015 Oct 16.


Effect of mental stress on dynamic electrophysiological properties of the endocardium and epicardium in humans.

Finlay MC, Lambiase PD, Ben-Simon R, Taggart P.

Heart Rhythm. 2016 Jan;13(1):175-82. doi: 10.1016/j.hrthm.2015.08.011. Epub 2015 Aug 10.


An activation-repolarization time metric to predict localized regions of high susceptibility to reentry.

Child N, Bishop MJ, Hanson B, Coronel R, Opthof T, Boukens BJ, Walton RD, Efimov IR, Bostock J, Hill Y, Rinaldi CA, Razavi R, Gill J, Taggart P.

Heart Rhythm. 2015 Jul;12(7):1644-53. doi: 10.1016/j.hrthm.2015.04.013. Epub 2015 Apr 9.


Measurement bias in activation-recovery intervals from unipolar electrograms.

Western D, Hanson B, Taggart P.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H331-8. doi: 10.1152/ajpheart.00478.2014. Epub 2014 Nov 14.


Oscillatory behavior of ventricular action potential duration in heart failure patients at respiratory rate and low frequency.

Hanson B, Child N, Van Duijvenboden S, Orini M, Chen Z, Coronel R, Rinaldi CA, Gill JS, Gill JS, Taggart P.

Front Physiol. 2014 Oct 28;5:414. doi: 10.3389/fphys.2014.00414. eCollection 2014.


Effect of global cardiac ischemia on human ventricular fibrillation: insights from a multi-scale mechanistic model of the human heart.

Kazbanov IV, Clayton RH, Nash MP, Bradley CP, Paterson DJ, Hayward MP, Taggart P, Panfilov AV.

PLoS Comput Biol. 2014 Nov 6;10(11):e1003891. doi: 10.1371/journal.pcbi.1003891. eCollection 2014 Nov.


Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects.

Taggart P, Orini M, Hanson B, Hayward M, Clayton R, Dobrzynski H, Yanni J, Boyett M, Lambiase PD.

Prog Biophys Mol Biol. 2014 Aug;115(2-3):252-60. doi: 10.1016/j.pbiomolbio.2014.06.004. Epub 2014 Jun 24. Review.


Effect of mental challenge induced by movie clips on action potential duration in normal human subjects independent of heart rate.

Child N, Hanson B, Bishop M, Rinaldi CA, Bostock J, Western D, Cooklin M, O'Neil M, Wright M, Razavi R, Gill J, Taggart P.

Circ Arrhythm Electrophysiol. 2014 Jun;7(3):518-23. doi: 10.1161/CIRCEP.113.000909. Epub 2014 May 15.


Slow adaptation of ventricular repolarization as a cause of arrhythmia?

Bueno-Orovio A, Hanson BM, Gill JS, Taggart P, Rodriguez B.

Methods Inf Med. 2014;53(4):320-3. doi: 10.3414/ME13-02-0039. Epub 2014 May 9.


Heart rate variability at limiting stationarity: evidence of neuro-cardiac control mechanisms operating at ultra-low frequencies.

Fisher AC, Groves D, Eleuteri A, Mesum P, Patterson D, Taggart P.

Physiol Meas. 2014 Feb;35(2):309-22.


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