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Items: 1 to 50 of 71

1.

Targeting Proteases in Cystic Fibrosis Lung Disease: Paradigms, Progress, and Potential.

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC.

Am J Respir Crit Care Med. 2019 Oct 18. doi: 10.1164/rccm.201906-1190PP. [Epub ahead of print]

PMID:
31626562
2.

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.

Hill M, Twigg M, Sheridan EA, Hardy JG, Elborn JS, Taggart CC, Scott CJ, Migaud ME.

Pharmaceutics. 2019 Aug 2;11(8). pii: E379. doi: 10.3390/pharmaceutics11080379.

3.

Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection.

Carlile SR, Shiels J, Kerrigan L, Delaney R, Megaw J, Gilmore BF, Weldon S, Dalton JP, Taggart CC.

Sci Rep. 2019 Apr 15;9(1):6071. doi: 10.1038/s41598-019-42537-8.

4.

Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD.

Linden D, Guo-Parke H, Coyle PV, Fairley D, McAuley DF, Taggart CC, Kidney J.

Eur Respir Rev. 2019 Mar 14;28(151). pii: 180063. doi: 10.1183/16000617.0063-2018. Print 2019 Mar 31. Review.

5.

Targeting of cathepsin S reduces cystic fibrosis-like lung disease.

Small DM, Brown RR, Doherty DF, Abladey A, Zhou-Suckow Z, Delaney RJ, Kerrigan L, Dougan CM, Borensztajn KS, Holsinger L, Booth R, Scott CJ, López-Campos G, Elborn JS, Mall MA, Weldon S, Taggart CC.

Eur Respir J. 2019 Mar 28;53(3). pii: 1801523. doi: 10.1183/13993003.01523-2018. Print 2019 Mar.

PMID:
30655278
6.

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field.

Ghita M, Dunne VL, McMahon SJ, Osman SO, Small DM, Weldon S, Taggart CC, McGarry CK, Hounsell AR, Graves EE, Prise KM, Hanna GG, Butterworth KT.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1231-1240. doi: 10.1016/j.ijrobp.2018.12.010. Epub 2018 Dec 12.

PMID:
30552964
7.

Nanodelivery strategies for the treatment of multidrug-resistant bacterial infections.

Jiang L, Lin J, Taggart CC, Bengoechea JA, Scott CJ.

J Interdiscip Nanomed. 2018 Sep 4;3(3):111-121. doi: 10.1002/jin2.48. eCollection 2018 Sep. Review.

8.

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.

Dey T, Kalita J, Weldon S, Taggart CC.

J Clin Med. 2018 Aug 28;7(9). pii: E244. doi: 10.3390/jcm7090244. Review.

9.

Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles.

Jiang L, Greene MK, Insua JL, Pessoa JS, Small DM, Smyth P, McCann AP, Cogo F, Bengoechea JA, Taggart CC, Scott CJ.

J Control Release. 2018 Jun 10;279:316-325. doi: 10.1016/j.jconrel.2018.04.040. Epub 2018 Apr 25.

PMID:
29704616
10.

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.

Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA.

Eur Respir J. 2018 Mar 29;51(3). pii: 1701910. doi: 10.1183/13993003.01910-2017. Print 2018 Mar.

11.

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

Chen Q, Pandi SPS, Kerrigan L, McElvaney NG, Greene CM, Elborn JS, Taggart CC, Weldon S.

J Cyst Fibros. 2018 Sep;17(5):616-623. doi: 10.1016/j.jcf.2018.01.010. Epub 2018 Mar 2.

PMID:
29486923
12.

Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.

13.

Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy.

Dunne V, Ghita M, Small DM, Coffey CBM, Weldon S, Taggart CC, Osman SO, McGarry CK, Prise KM, Hanna GG, Butterworth KT.

Radiother Oncol. 2017 Sep;124(3):475-481. doi: 10.1016/j.radonc.2017.06.025. Epub 2017 Jul 8.

PMID:
28697853
14.

Activity of innate antimicrobial peptides and ivacaftor against clinical cystic fibrosis respiratory pathogens.

Payne JE, Dubois AV, Ingram RJ, Weldon S, Taggart CC, Elborn JS, Tunney MM.

Int J Antimicrob Agents. 2017 Sep;50(3):427-435. doi: 10.1016/j.ijantimicag.2017.04.014. Epub 2017 Jun 27.

PMID:
28666755
15.

Biomarkers to monitor exacerbations in cystic fibrosis.

Gray RD, Downey D, Taggart CC.

Expert Rev Respir Med. 2017 Apr;11(4):255-257. doi: 10.1080/17476348.2017.1307739. No abstract available.

PMID:
28299964
16.

The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease.

Small DM, Doherty DF, Dougan CM, Weldon S, Taggart CC.

Biol Chem. 2017 Apr 1;398(4):425-440. doi: 10.1515/hsz-2016-0262. Review.

PMID:
27930359
17.

A secretory leukocyte protease inhibitor variant with improved activity against lung infection.

Camper N, Glasgow AM, Osbourn M, Quinn DJ, Small DM, McLean DT, Lundy FT, Elborn JS, McNally P, Ingram RJ, Weldon S, Taggart CC.

Mucosal Immunol. 2016 May;9(3):669-76. doi: 10.1038/mi.2015.90. Epub 2015 Sep 16.

PMID:
26376365
18.

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity.

McGarry N, Greene CM, McElvaney NG, Weldon S, Taggart CC.

J Immunol Res. 2015;2015:507315. doi: 10.1155/2015/507315. Epub 2015 Jul 12.

19.

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung.

Glasgow AM, Small DM, Scott A, McLean DT, Camper N, Hamid U, Hegarty S, Parekh D, O'Kane C, Lundy FT, McNally P, Elborn JS, McAuley DF, Weldon S, Taggart CC.

Thorax. 2015 May;70(5):426-32. doi: 10.1136/thoraxjnl-2014-206488. Epub 2015 Mar 13.

PMID:
25770093
20.

Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: formulation, characterisation and functionalisation with dornase alfa (DNase).

Deacon J, Abdelghany SM, Quinn DJ, Schmid D, Megaw J, Donnelly RF, Jones DS, Kissenpfennig A, Elborn JS, Gilmore BF, Taggart CC, Scott CJ.

J Control Release. 2015 Jan 28;198:55-61. doi: 10.1016/j.jconrel.2014.11.022. Epub 2014 Dec 4.

PMID:
25481442
21.

A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation.

Small DM, Zani ML, Quinn DJ, Dallet-Choisy S, Glasgow AM, O'Kane C, McAuley DF, McNally P, Weldon S, Moreau T, Taggart CC.

Mol Ther. 2015 Jan;23(1):24-31. doi: 10.1038/mt.2014.162. Epub 2014 Sep 5.

22.

Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors.

Foronjy RF, Taggart CC, Dabo AJ, Weldon S, Cummins N, Geraghty P.

Mucosal Immunol. 2015 Jan;8(1):161-75. doi: 10.1038/mi.2014.54. Epub 2014 Jul 9.

23.

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.

Weldon S, McNally P, McAuley DF, Oglesby IK, Wohlford-Lenane CL, Bartlett JA, Scott CJ, McElvaney NG, Greene CM, McCray PB Jr, Taggart CC.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):165-74. doi: 10.1164/rccm.201311-1986OC.

24.

Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice.

Foronjy RF, Dabo AJ, Taggart CC, Weldon S, Geraghty P.

PLoS One. 2014 Feb 28;9(2):e90567. doi: 10.1371/journal.pone.0090567. eCollection 2014.

25.

Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury.

Kerrin A, Weldon S, Chung AH, Craig T, Simpson AJ, O'Kane CM, McAuley DF, Taggart CC.

Thorax. 2013 Apr;68(4):315-21. doi: 10.1136/thoraxjnl-2012-202536. Epub 2012 Dec 14.

PMID:
23242946
26.

Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection.

Abdelghany SM, Quinn DJ, Ingram RJ, Gilmore BF, Donnelly RF, Taggart CC, Scott CJ.

Int J Nanomedicine. 2012;7:4053-63. doi: 10.2147/IJN.S34341. Epub 2012 Jul 26.

27.

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

Butler CA, McQuaid S, Taggart CC, Weldon S, Carter R, Skibinski G, Warke TJ, Choy DF, McGarvey LP, Bradding P, Arron JR, Heaney LG.

Thorax. 2012 May;67(5):392-8. doi: 10.1136/thoraxjnl-2011-200760. Epub 2011 Dec 8.

PMID:
22156779
28.

Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.

Scott A, Weldon S, Buchanan PJ, Schock B, Ernst RK, McAuley DF, Tunney MM, Irwin CR, Elborn JS, Taggart CC.

PLoS One. 2011;6(10):e26525. doi: 10.1371/journal.pone.0026525. Epub 2011 Oct 18.

29.

SLPI and elafin: multifunctional antiproteases of the WFDC family.

Scott A, Weldon S, Taggart CC.

Biochem Soc Trans. 2011 Oct;39(5):1437-40. doi: 10.1042/BST0391437. Review.

PMID:
21936829
30.

The prevalence of alpha-1 antitrypsin deficiency in Ireland.

Carroll TP, O'Connor CA, Floyd O, McPartlin J, Kelleher DP, O'Brien G, Dimitrov BD, Morris VB, Taggart CC, McElvaney NG.

Respir Res. 2011 Jul 13;12:91. doi: 10.1186/1465-9921-12-91.

31.

Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production.

Zaric SS, Coulter WA, Shelburne CE, Fulton CR, Zaric MS, Scott A, Lappin MJ, Fitzgerald DC, Irwin CR, Taggart CC.

J Biol Chem. 2011 Aug 26;286(34):29492-500. doi: 10.1074/jbc.M111.252791. Epub 2011 Jun 24.

32.

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations.

McNally P, Ervine E, Shields MD, Dimitrov BD, El Nazir B, Taggart CC, Greene CM, McElvaney NG, Greally P.

Thorax. 2011 Feb;66(2):140-3. doi: 10.1136/thx.2009.130914. Epub 2010 Dec 15.

PMID:
21160087
33.

Impaired immune tolerance to Porphyromonas gingivalis lipopolysaccharide promotes neutrophil migration and decreased apoptosis.

Zaric S, Shelburne C, Darveau R, Quinn DJ, Weldon S, Taggart CC, Coulter WA.

Infect Immun. 2010 Oct;78(10):4151-6. doi: 10.1128/IAI.00600-10. Epub 2010 Aug 2.

34.

Antiproteases as therapeutics to target inflammation in cystic fibrosis.

Quinn DJ, Weldon S, Taggart CC.

Open Respir Med J. 2010 Mar 30;4:20-31. doi: 10.2174/1874306401004020020.

35.

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.

Guyot N, Bergsson G, Butler MW, Greene CM, Weldon S, Kessler E, Levine RL, O'Neill SJ, Taggart CC, McElvaney NG.

Biol Chem. 2010 Jun;391(6):705-16. doi: 10.1515/BC.2010.066.

36.

Biologic protease inhibitors as novel therapeutic agents.

Scott CJ, Taggart CC.

Biochimie. 2010 Nov;92(11):1681-8. doi: 10.1016/j.biochi.2010.03.010. Epub 2010 Mar 24. Review.

PMID:
20346385
37.

Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.

Weldon S, McNally P, McElvaney NG, Elborn JS, McAuley DF, Wartelle J, Belaaouaj A, Levine RL, Taggart CC.

J Immunol. 2009 Dec 15;183(12):8148-56. doi: 10.4049/jimmunol.0901716.

38.

Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells.

Greene CM, Miller SD, Carroll TP, Oglesby IK, Ahmed F, O'Mahony M, Taggart CC, McElvaney NG, O'Neill SJ.

Eur Respir J. 2010 May;35(5):1155-63. doi: 10.1183/09031936.00191908. Epub 2009 Oct 19.

39.

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.

Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF.

Am J Respir Crit Care Med. 2009 Jun 15;179(12):1107-14. doi: 10.1164/rccm.200810-1584OC. Epub 2009 Mar 26.

40.

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation.

Gibbons AM, McElvaney NG, Taggart CC, Cryan SA.

J Microencapsul. 2009 Sep;26(6):513-22. doi: 10.1080/02652040802466535.

PMID:
18925490
41.

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.

Guyot N, Butler MW, McNally P, Weldon S, Greene CM, Levine RL, O'Neill SJ, Taggart CC, McElvaney NG.

J Biol Chem. 2008 Nov 21;283(47):32377-85. doi: 10.1074/jbc.M803707200. Epub 2008 Sep 17.

42.

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.

Bergin DA, Greene CM, Sterchi EE, Kenna C, Geraghty P, Belaaouaj A, Taggart CC, O'Neill SJ, McElvaney NG.

J Biol Chem. 2008 Nov 14;283(46):31736-44. doi: 10.1074/jbc.M803732200. Epub 2008 Sep 4. Erratum in: J Biol Chem. 2009 Apr 3;284(14):9624. Belaaouaj, Abderazzaq [corrected to Belaaouaj, Abderrazzaq].

43.

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

Geraghty P, Rogan MP, Greene CM, Brantly ML, O'Neill SJ, Taggart CC, McElvaney NG.

Thorax. 2008 Jul;63(7):621-6. doi: 10.1136/thx.2007.088559. Epub 2008 Feb 4.

PMID:
18250185
44.

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.

Greene CM, Miller SD, Carroll T, McLean C, O'Mahony M, Lawless MW, O'Neill SJ, Taggart CC, McElvaney NG.

J Inherit Metab Dis. 2008 Feb;31(1):21-34. doi: 10.1007/s10545-007-0748-y. Epub 2008 Jan 16. Review.

PMID:
18193338
45.

Innate host defense functions of secretory leucoprotease inhibitor.

Weldon S, Taggart CC.

Exp Lung Res. 2007 Dec;33(10):485-91. Review.

PMID:
18075823
46.

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.

Geraghty P, Greene CM, O'Mahony M, O'Neill SJ, Taggart CC, McElvaney NG.

J Biol Chem. 2007 Nov 16;282(46):33389-95. Epub 2007 Sep 18.

47.

The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms.

Caraher EM, Gumulapurapu K, Taggart CC, Murphy P, McClean S, Callaghan M.

J Antimicrob Chemother. 2007 Sep;60(3):546-54. Epub 2007 Jun 26.

PMID:
17595284
48.

Alpha-1-antitrypsin deficiency: current concepts.

Mulgrew AT, Taggart CC, McElvaney NG.

Lung. 2007 Jul-Aug;185(4):191-201. Epub 2007 Jun 12. Review.

PMID:
17562108
49.

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.

Miller SD, Greene CM, McLean C, Lawless MW, Taggart CC, O'Neill SJ, McElvaney NG.

Hepatology. 2007 Aug;46(2):496-503.

PMID:
17559149
50.

Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.

Geraghty P, Rogan MP, Greene CM, Boxio RM, Poiriert T, O'Mahony M, Belaaouaj A, O'Neill SJ, Taggart CC, McElvaney NG.

J Immunol. 2007 May 1;178(9):5871-8.

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