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Items: 1 to 50 of 122

1.

ShapeShifter: a novel approach for identifying and quantifying stable lariat intronic species in RNAseq data.

Taggart AJ, Fairbrother WG.

Quant Biol. 2018 Sep;6(3):267-274. doi: 10.1007/s40484-018-0141-x. Epub 2018 Jul 25.

2.

Evaluation of a Quality Improvement Intervention That Eliminated Routine Use of Opioids After Cesarean Delivery.

Holland E, Bateman BT, Cole N, Taggart A, Robinson LA, Sugrue R, Xu X, Robinson JN.

Obstet Gynecol. 2019 Jan;133(1):91-97. doi: 10.1097/AOG.0000000000003010.

PMID:
30531571
3.

Burkitt Lymphoma Presenting as Menorrhagia and a Vaginal Mass in an Adolescent.

Wilkie GL, Taggart AA, Prensner JR, Billett AL, Laufer MR.

J Pediatr Adolesc Gynecol. 2019 Feb;32(1):90-92. doi: 10.1016/j.jpag.2018.09.009. Epub 2018 Sep 29.

PMID:
30278229
4.

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.

Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL.

Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019.

5.

Widespread intra-dependencies in the removal of introns from human transcripts.

Kim SW, Taggart AJ, Heintzelman C, Cygan KJ, Hull CG, Wang J, Shrestha B, Fairbrother WG.

Nucleic Acids Res. 2017 Sep 19;45(16):9503-9513. doi: 10.1093/nar/gkx661.

6.

Sensitivity to BST-2 restriction correlates with Orthobunyavirus host range.

Varela M, Piras IM, Mullan C, Shi X, Tilston-Lunel NL, Pinto RM, Taggart A, Welch SR, Neil SJD, Kreher F, Elliott RM, Palmarini M.

Virology. 2017 Sep;509:121-130. doi: 10.1016/j.virol.2017.06.017. Epub 2017 Jun 17.

7.

The effects of structure on pre-mRNA processing and stability.

Soemedi R, Cygan KJ, Rhine CL, Glidden DT, Taggart AJ, Lin CL, Fredericks AM, Fairbrother WG.

Methods. 2017 Aug 1;125:36-44. doi: 10.1016/j.ymeth.2017.06.001. Epub 2017 Jun 6. Review.

8.

Large-scale analysis of branchpoint usage across species and cell lines.

Taggart AJ, Lin CL, Shrestha B, Heintzelman C, Kim S, Fairbrother WG.

Genome Res. 2017 Apr;27(4):639-649. doi: 10.1101/gr.202820.115. Epub 2017 Jan 24.

9.

Ultraviolet Imaging with Low Cost Smartphone Sensors: Development and Application of a Raspberry Pi-Based UV Camera.

Wilkes TC, McGonigle AJ, Pering TD, Taggart AJ, White BS, Bryant RG, Willmott JR.

Sensors (Basel). 2016 Oct 6;16(10). pii: E1649.

10.

RNA structure in splicing: An evolutionary perspective.

Lin CL, Taggart AJ, Fairbrother WG.

RNA Biol. 2016 Sep;13(9):766-71. doi: 10.1080/15476286.2016.1208893. Epub 2016 Jul 25. Review.

11.

Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice.

Varela M, Pinto RM, Caporale M, Piras IM, Taggart A, Seehusen F, Hahn K, Janowicz A, de Souza WM, Baumgärtner W, Shi X, Palmarini M.

J Virol. 2016 May 12;90(11):5440-5450. doi: 10.1128/JVI.00424-16. Print 2016 Jun 1.

12.

RNA structure replaces the need for U2AF2 in splicing.

Lin CL, Taggart AJ, Lim KH, Cygan KJ, Ferraris L, Creton R, Huang YT, Fairbrother WG.

Genome Res. 2016 Jan;26(1):12-23. doi: 10.1101/gr.181008.114. Epub 2015 Nov 13.

13.

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Imbriglio JE, Shen DM, Liang R, Marby K, You M, Youm HW, Feng Z, London C, Xiong Y, Tata J, Verras A, Garcia-Calvo M, Song X, Addona GH, McLaren DG, He T, Murphy B, Metzger DE, Salituro G, Deckman D, Chen Q, Jin X, Stout SJ, Wang SP, Wilsie L, Palyha O, Han S, Hubbard BK, Previs SF, Pinto S, Taggart A.

J Med Chem. 2015 Dec 10;58(23):9345-53. doi: 10.1021/acs.jmedchem.5b01345. Epub 2015 Nov 20.

PMID:
26561979
14.

Global Reprogramming of Host SUMOylation during Influenza Virus Infection.

Domingues P, Golebiowski F, Tatham MH, Lopes AM, Taggart A, Hay RT, Hale BG.

Cell Rep. 2015 Nov 17;13(7):1467-1480. doi: 10.1016/j.celrep.2015.10.001. Epub 2015 Nov 5.

15.

Identification of DGAT2 Inhibitors Using Mass Spectrometry.

Song XS, Zhang J, Chen X, Palyha O, Chung C, Sonatore LM, Wilsie L, Stout S, McLaren DG, Taggart A, Imbriglio JE, Pinto S, Garcia-Calvo M, Addona GH.

J Biomol Screen. 2016 Feb;21(2):117-26. doi: 10.1177/1087057115607463. Epub 2015 Sep 24.

PMID:
26403520
16.

Characterization of a second open reading frame in genome segment 10 of bluetongue virus.

Stewart M, Hardy A, Barry G, Pinto RM, Caporale M, Melzi E, Hughes J, Taggart A, Janowicz A, Varela M, Ratinier M, Palmarini M.

J Gen Virol. 2015 Nov;96(11):3280-93. doi: 10.1099/jgv.0.000267. Epub 2015 Aug 19.

17.

The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor.

McKeown SC, Zecri FJ, Fortier E, Taggart A, Sviridenko L, Adams CM, McAllister KH, Pin SS.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4871-5. doi: 10.1016/j.bmcl.2014.08.045. Epub 2014 Aug 28.

PMID:
25241924
18.

Comment on: A case of certolizumab-induced interstitial lung disease in a patient with rheumatoid arthritis.

Savage EM, Millar AM, Taggart AJ.

Rheumatology (Oxford). 2014 Jun;53(6):1154-5. doi: 10.1093/rheumatology/keu142. Epub 2014 Mar 27. No abstract available.

PMID:
24681838
19.

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke.

Murray LS, Lu Y, Taggart A, Van Regemorter N, Vilain C, Abramowicz M, Kadler KE, Van Agtmael T.

Hum Mol Genet. 2014 Jan 15;23(2):283-92. doi: 10.1093/hmg/ddt418. Epub 2013 Sep 2.

20.

Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.

Lauring B, Taggart AK, Tata JR, Dunbar R, Caro L, Cheng K, Chin J, Colletti SL, Cote J, Khalilieh S, Liu J, Luo WL, Maclean AA, Peterson LB, Polis AB, Sirah W, Wu TJ, Liu X, Jin L, Wu K, Boatman PD, Semple G, Behan DP, Connolly DT, Lai E, Wagner JA, Wright SD, Cuffie C, Mitchel YB, Rader DJ, Paolini JF, Waters MG, Plump A.

Sci Transl Med. 2012 Aug 22;4(148):148ra115. doi: 10.1126/scitranslmed.3003877.

21.

Steroid injection for inferior heel pain: a randomised controlled trial.

Ball EM, McKeeman HM, Patterson C, Burns J, Yau WH, Moore OA, Benson C, Foo J, Wright GD, Taggart AJ.

Ann Rheum Dis. 2013 Jun;72(6):996-1002. doi: 10.1136/annrheumdis-2012-201508. Epub 2012 Jun 27.

PMID:
22739993
22.

Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo.

Taggart AJ, DeSimone AM, Shih JS, Filloux ME, Fairbrother WG.

Nat Struct Mol Biol. 2012 Jun 17;19(7):719-21. doi: 10.1038/nsmb.2327.

23.

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.

Boatman PD, Lauring B, Schrader TO, Kasem M, Johnson BR, Skinner P, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Luo WL, Caro L, Cote J, Lai E, Wagner J, Taggart AK, Carballo-Jane E, Hammond M, Colletti SL, Tata JR, Connolly DT, Waters MG, Richman JG.

J Med Chem. 2012 Apr 26;55(8):3644-66. doi: 10.1021/jm2010964. Epub 2012 Apr 9.

PMID:
22435740
24.

Fatal fibrosing alveolitis with certolizumab.

Millar A, McKew J, Taggart A.

Rheumatology (Oxford). 2012 May;51(5):953-5. doi: 10.1093/rheumatology/ker452. Epub 2012 Feb 10. No abstract available.

PMID:
22328567
25.

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.

McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, Balkovec JM, Devita RJ, Marsh DJ, Castro-Perez JM, Strack A, Johns DG, Previs SF, Hubbard BK, Roddy TP.

J Lipid Res. 2011 Jun;52(6):1150-61. doi: 10.1194/jlr.M011049. Epub 2011 Mar 17.

26.

The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.

Imbriglio JE, DiRocco D, Bodner R, Raghavan S, Chen W, Marley D, Esser C, Holt TG, Wolff MS, Taggart AK, Waters MG, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2011 May 1;21(9):2721-4. doi: 10.1016/j.bmcl.2010.11.116. Epub 2010 Dec 4.

PMID:
21185185
27.

GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.

Imbriglio JE, Chang S, Liang R, Raghavan S, Schmidt D, Smenton A, Tria S, Schrader TO, Jung JK, Esser C, Holt TG, Wolff MS, Taggart AK, Cheng K, Carballo-Jane E, Waters MG, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4472-4. doi: 10.1016/j.bmcl.2010.06.041. Epub 2010 Jun 10.

PMID:
20615702
28.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Ding FX, Shen HC, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Wang J, Tong X, Holt TG, Chen Q, Waters MG, Hammond ML, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3372-5. doi: 10.1016/j.bmcl.2010.04.013. Epub 2010 Apr 11.

PMID:
20452209
29.

Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib.

Yvan-Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, Sparrow CP, Taggart AK, Tall AR.

Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1430-8. doi: 10.1161/ATVBAHA.110.207142. Epub 2010 May 6.

30.

Anthranilic acid replacements in a niacin receptor agonist.

Schmidt D, Smenton A, Raghavan S, Shen H, Ding FX, Carballo-Jane E, Luell S, Ciecko T, Holt TG, Wolff M, Taggart A, Wilsie L, Krsmanovic M, Ren N, Blom D, Cheng K, McCann PE, Waters MG, Tata J, Colletti S.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3426-30. doi: 10.1016/j.bmcl.2010.04.001. Epub 2010 Apr 8.

PMID:
20444602
31.

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).

Boatman PD, Schrader TO, Kasem M, Johnson BR, Skinner PJ, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Taggart AK, Carballo-Jane E, Richman JG.

Bioorg Med Chem Lett. 2010 May 1;20(9):2797-800. doi: 10.1016/j.bmcl.2010.03.062. Epub 2010 Mar 20.

PMID:
20363624
32.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.

J Med Chem. 2010 Mar 25;53(6):2666-70. doi: 10.1021/jm100022r.

PMID:
20184326
33.

Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.

Schmidt D, Smenton A, Raghavan S, Carballo-Jane E, Lubell S, Ciecko T, Holt TG, Wolff M, Taggart A, Wilsie L, Krsmanovic M, Ren N, Blom D, Cheng K, McCann PE, Gerard Waters M, Tata J, Colletti S.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4768-72. doi: 10.1016/j.bmcl.2009.06.054. Epub 2009 Jun 17.

PMID:
19592242
34.

The Belfast musculoskeletal ultrasound course.

Taggart AJ, Wright SA, Ball E, Kane D, Wright G.

Rheumatology (Oxford). 2009 Sep;48(9):1073-6. doi: 10.1093/rheumatology/kep075. Epub 2009 May 11.

PMID:
19433435
35.

Contemporary treatment principles for early rheumatoid arthritis: a consensus statement.

Kiely PD, Brown AK, Edwards CJ, O'Reilly DT, Ostör AJ, Quinn M, Taggart A, Taylor PC, Wakefield RJ, Conaghan PG.

Rheumatology (Oxford). 2009 Jul;48(7):765-72. doi: 10.1093/rheumatology/kep073. Epub 2009 Apr 28.

PMID:
19401359
36.

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.

Shen HC, Ding FX, Deng Q, Wilsie LC, Krsmanovic ML, Taggart AK, Carballo-Jane E, Ren N, Cai TQ, Wu TJ, Wu KK, Cheng K, Chen Q, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.

J Med Chem. 2009 Apr 23;52(8):2587-602. doi: 10.1021/jm900151e.

PMID:
19309152
37.

GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.

Imbriglio JE, Chang S, Liang R, Raghavan S, Schmidt D, Smenton A, Tria S, Schrader TO, Jung JK, Esser C, Taggart AK, Cheng K, Carballo-Jane E, Gerard Waters M, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2121-4. doi: 10.1016/j.bmcl.2009.03.014. Epub 2009 Mar 9.

PMID:
19307116
38.

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).

Ren N, Kaplan R, Hernandez M, Cheng K, Jin L, Taggart AK, Zhu AY, Gan X, Wright SD, Cai TQ.

J Lipid Res. 2009 May;50(5):908-14. doi: 10.1194/jlr.M800625-JLR200. Epub 2009 Jan 9.

39.

Role of GPR81 in lactate-mediated reduction of adipose lipolysis.

Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG.

Biochem Biophys Res Commun. 2008 Dec 19;377(3):987-91. doi: 10.1016/j.bbrc.2008.10.088. Epub 2008 Oct 24.

PMID:
18952058
40.

Can sonography be used to predict the response to intra-articular corticosteroid injection in primary osteoarthritis of the knee?

Pendleton A, Millar A, O'Kane D, Wright GD, Taggart AJ.

Scand J Rheumatol. 2008 Sep-Oct;37(5):395-7. doi: 10.1080/03009740802050738. No abstract available.

PMID:
18821277
41.

Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.

Deng Q, Frie JL, Marley DM, Beresis RT, Ren N, Cai TQ, Taggart AK, Cheng K, Carballo-Jane E, Wang J, Tong X, Waters MG, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4963-7. doi: 10.1016/j.bmcl.2008.08.030. Epub 2008 Aug 14.

PMID:
18760600
42.

Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A.

Shen HC, Taggart AK, Wilsie LC, Waters MG, Hammond ML, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4948-51. doi: 10.1016/j.bmcl.2008.08.039. Epub 2008 Aug 14.

PMID:
18752940
43.

3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.

Semple G, Skinner PJ, Gharbaoui T, Shin YJ, Jung JK, Cherrier MC, Webb PJ, Tamura SY, Boatman PD, Sage CR, Schrader TO, Chen R, Colletti SL, Tata JR, Waters MG, Cheng K, Taggart AK, Cai TQ, Carballo-Jane E, Behan DP, Connolly DT, Richman JG.

J Med Chem. 2008 Aug 28;51(16):5101-8. doi: 10.1021/jm800258p. Epub 2008 Jul 30.

PMID:
18665582
44.

Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.

Raghavan S, Tria GS, Shen HC, Ding FX, Taggart AK, Ren N, Wilsie LC, Krsmanovic ML, Holt TG, Wolff MS, Waters MG, Hammond ML, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3163-7. doi: 10.1016/j.bmcl.2008.04.071. Epub 2008 May 1.

PMID:
18477506
45.

Multicentric reticulohistiocytosis: a lesson in screening for malignancy.

Millar A, O'Kane D, Taggart A.

Rheumatology (Oxford). 2008 Jul;47(7):1102-3. doi: 10.1093/rheumatology/ken131. Epub 2008 Apr 29. No abstract available.

PMID:
18445627
46.

Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.

Shen HC, Szymonifka MJ, Kharbanda D, Deng Q, Carballo-Jane E, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Taggart AK, Wang J, Tong X, Waters MG, Hammond ML, Tata JR, Colletti SL.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6723-8. Epub 2007 Oct 18.

PMID:
18029181
47.

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

Shen HC, Ding FX, Luell S, Forrest MJ, Carballo-Jane E, Wu KK, Wu TJ, Cheng K, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Deng Q, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.

J Med Chem. 2007 Dec 13;50(25):6303-6. Epub 2007 Nov 10.

PMID:
17994679
48.

Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.

Carballo-Jane E, Gerckens LS, Luell S, Parlapiano AS, Wolff M, Colletti SL, Tata JR, Taggart AK, Waters MG, Richman JG, McCann ME, Forrest MJ.

J Pharmacol Toxicol Methods. 2007 Nov-Dec;56(3):308-16. Epub 2007 Jun 23.

PMID:
17643322
49.

E-learning in ultrasonography: a web-based approach.

Filippucci E, Meenagh G, Ciapetti A, Iagnocco A, Taggart A, Grassi W.

Ann Rheum Dis. 2007 Jul;66(7):962-5. Epub 2007 Feb 28.

50.

High-resolution ultrasonography of the first metatarsal phalangeal joint in gout: a controlled study.

Wright SA, Filippucci E, McVeigh C, Grey A, McCarron M, Grassi W, Wright GD, Taggart AJ.

Ann Rheum Dis. 2007 Jul;66(7):859-64. Epub 2006 Dec 21.

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