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Items: 1 to 50 of 105

1.

Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation.

Rodríguez-Rodríguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov A Jr, Caravan P.

ACS Sens. 2019 Sep 27;4(9):2412-2419. doi: 10.1021/acssensors.9b01010. Epub 2019 Aug 22.

PMID:
31397156
2.

Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia.

Claiborne DT, Dudek TE, Maldini CR, Power KA, Ghebremichael M, Seung E, Mellors EF, Vrbanac VD, Krupp K, Bisesi A, Tager AM, Knipe DM, Boutwell CL, Allen TM.

J Virol. 2019 Sep 30;93(20). pii: e00814-19. doi: 10.1128/JVI.00814-19. Print 2019 Oct 15.

PMID:
31375576
3.

The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities.

Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK; Fibrosis Across Organs Symposium Working Group.

Am J Med Sci. 2019 May;357(5):405-410. doi: 10.1016/j.amjms.2019.02.014. No abstract available.

4.

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Shah NJ, Mao AS, Shih TY, Kerr MD, Sharda A, Raimondo TM, Weaver JC, Vrbanac VD, Deruaz M, Tager AM, Mooney DJ, Scadden DT.

Nat Biotechnol. 2019 Mar;37(3):293-302. doi: 10.1038/s41587-019-0017-2. Epub 2019 Feb 11.

5.

HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.

Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS.

Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021.

6.

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

Usmani SM, Murooka TT, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD, Mempel TR.

Cell Host Microbe. 2019 Jan 9;25(1):73-86.e5. doi: 10.1016/j.chom.2018.12.008.

PMID:
30629922
7.

Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis.

Montesi SB, Rao R, Liang LL, Goulart HE, Sharma A, Digumarthy SR, Shea BS, Seethamraju RT, Caravan P, Tager AM.

Eur Respir J. 2018 May 17;51(5). pii: 1800171. doi: 10.1183/13993003.00171-2018. Print 2018 May. No abstract available.

8.

A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection.

Princiotto AM, Vrbanac VD, Melillo B, Park J, Tager AM, Smith AB 3rd, Sodroski J, Madani N.

J Infect Dis. 2018 Jul 2;218(3):471-475. doi: 10.1093/infdis/jiy174.

9.

Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice.

Badamchi-Zadeh A, Tartaglia LJ, Abbink P, Bricault CA, Liu PT, Boyd M, Kirilova M, Mercado NB, Nanayakkara OS, Vrbanac VD, Tager AM, Larocca RA, Seaman MS, Barouch DH.

J Virol. 2018 Mar 14;92(7). pii: e01925-17. doi: 10.1128/JVI.01925-17. Print 2018 Apr 1.

10.

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM.

Sci Transl Med. 2017 Dec 13;9(420). pii: eaal3765. doi: 10.1126/scitranslmed.aal3765.

PMID:
29237758
11.

Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.

Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M.

Nat Med. 2017 Dec 7;23(12):1499. doi: 10.1038/nm1217-1499b.

PMID:
29216045
12.

The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.

Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):471-481. doi: 10.1165/rcmb.2017-0075OC.

13.

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.

Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M.

Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23. Erratum in: Nat Med. 2017 Dec 7;23 (12 ):1499.

14.

Endobronchial Optical Coherence Tomography for Low-Risk Microscopic Assessment and Diagnosis of Idiopathic Pulmonary Fibrosis In Vivo.

Hariri LP, Adams DC, Wain JC, Lanuti M, Muniappan A, Sharma A, Colby TV, Mino-Kenudson M, Mark EJ, Kradin RL, Goulart H, Tager AM, Suter MJ.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):949-952. doi: 10.1164/rccm.201707-1446LE. No abstract available.

15.

High sensitivity HPLC method for determination of the allysine concentration in tissue by use of a naphthol derivative.

Waghorn PA, Oliveira BL, Jones CM, Tager AM, Caravan P.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Oct 1;1064:7-13. doi: 10.1016/j.jchromb.2017.08.032. Epub 2017 Aug 26.

16.

Humanized mouse models of latent HIV infection.

Deruaz M, Tager AM.

Curr Opin Virol. 2017 Aug;25:97-104. doi: 10.1016/j.coviro.2017.07.027. Epub 2017 Aug 12. Review.

PMID:
28810166
17.

Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis.

Sakai N, Nakamura M, Lipson KE, Miyake T, Kamikawa Y, Sagara A, Shinozaki Y, Kitajima S, Toyama T, Hara A, Iwata Y, Shimizu M, Furuichi K, Kaneko S, Tager AM, Wada T.

Sci Rep. 2017 Jul 14;7(1):5392. doi: 10.1038/s41598-017-05624-2.

18.

Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine-Based Probe.

Waghorn PA, Jones CM, Rotile NJ, Koerner SK, Ferreira DS, Chen HH, Probst CK, Tager AM, Caravan P.

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9825-9828. doi: 10.1002/anie.201704773. Epub 2017 Jul 13.

19.

The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer.

Erstad DJ, Tager AM, Hoshida Y, Fuchs BC.

Mol Cell Oncol. 2017 Mar 31;4(3):e1311827. doi: 10.1080/23723556.2017.1311827. eCollection 2017.

20.

Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis.

Chen HH, Waghorn PA, Wei L, Tapias LF, Schühle DT, Rotile NJ, Jones CM, Looby RJ, Zhao G, Elliott JM, Probst CK, Mino-Kenudson M, Lauwers GY, Tager AM, Tanabe KK, Lanuti M, Fuchs BC, Caravan P.

JCI Insight. 2017 Jun 2;2(11). pii: 91506. doi: 10.1172/jci.insight.91506. eCollection 2017 Jun 2.

21.

Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.

Shea BS, Probst CK, Brazee PL, Rotile NJ, Blasi F, Weinreb PH, Black KE, Sosnovik DE, Van Cott EM, Violette SM, Caravan P, Tager AM.

JCI Insight. 2017 May 4;2(9). pii: 86608. doi: 10.1172/jci.insight.86608. eCollection 2017 May 4.

22.

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology.

Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.

23.

Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa.

Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD.

JCI Insight. 2017 Apr 6;2(7):e88533. doi: 10.1172/jci.insight.88533.

24.

Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.

Désogère P, Tapias LF, Hariri LP, Rotile NJ, Rietz TA, Probst CK, Blasi F, Day H, Mino-Kenudson M, Weinreb P, Violette SM, Fuchs BC, Tager AM, Lanuti M, Caravan P.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaaf4696. doi: 10.1126/scitranslmed.aaf4696.

25.

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease.

Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL.

J Nucl Med. 2017 Jun;58(6):1003-1008. doi: 10.2967/jnumed.116.186007. Epub 2017 Feb 16.

26.

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

Nakagawa S, Wei L, Song WM, Higashi T, Ghoshal S, Kim RS, Bian CB, Yamada S, Sun X, Venkatesh A, Goossens N, Bain G, Lauwers GY, Koh AP, El-Abtah M, Ahmad NB, Hoshida H, Erstad DJ, Gunasekaran G, Lee Y, Yu ML, Chuang WL, Dai CY, Kobayashi M, Kumada H, Beppu T, Baba H, Mahajan M, Nair VD, Lanuti M, Villanueva A, Sangiovanni A, Iavarone M, Colombo M, Llovet JM, Subramanian A, Tager AM, Friedman SL, Baumert TF, Schwarz ME, Chung RT, Tanabe KK, Zhang B, Fuchs BC, Hoshida Y; Precision Liver Cancer Prevention Consortium.

Cancer Cell. 2016 Dec 12;30(6):879-890. doi: 10.1016/j.ccell.2016.11.004.

27.

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.

Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ.

Biomaterials. 2017 Feb;117:44-53. doi: 10.1016/j.biomaterials.2016.11.048. Epub 2016 Nov 25.

28.

Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.

Sakai N, Chun J, Duffield JS, Lagares D, Wada T, Luster AD, Tager AM.

Kidney Int. 2017 Mar;91(3):628-641. doi: 10.1016/j.kint.2016.09.030. Epub 2016 Dec 4.

29.

An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis.

Castelino FV, Bain G, Pace VA, Black KE, George L, Probst CK, Goulet L, Lafyatis R, Tager AM.

Arthritis Rheumatol. 2016 Dec;68(12):2964-2974. doi: 10.1002/art.39797.

30.

Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo.

Deruaz M, Moldt B, Le KM, Power KA, Vrbanac VD, Tanno S, Ghebremichael MS, Allen TM, Tager AM, Burton DR, Luster AD.

J Infect Dis. 2016 Aug 15;214(4):612-6. doi: 10.1093/infdis/jiw203. Epub 2016 Jun 29.

31.

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice.

Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J.

Cell Rep. 2016 May 24;15(8):1715-27. doi: 10.1016/j.celrep.2016.04.048. Epub 2016 May 12.

32.

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization.

Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kühnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD Jr, Ochs M, Tager AM.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):105-16. doi: 10.1165/rcmb.2015-0152OC.

33.

Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.

Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM.

FASEB J. 2016 Jun;30(6):2435-50. doi: 10.1096/fj.201500197R. Epub 2016 Mar 22.

34.

Fibrogenic Lung Injury Induces Non-Cell-Autonomous Fibroblast Invasion.

Ahluwalia N, Grasberger PE, Mugo BM, Feghali-Bostwick C, Pardo A, Selman M, Lagares D, Tager AM.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):831-42. doi: 10.1165/rcmb.2015-0040OC.

35.

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.

Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH.

Nat Commun. 2015 Jun 25;6:7562. doi: 10.1038/ncomms8562.

36.

VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells.

Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH.

Science. 2015 Jun 19;348(6241):aaa8205. doi: 10.1126/science.aaa8205.

37.

Prevention vaginally of HIV-1 transmission in humanized BLT mice and mode of antiviral action of polyanionic carbosilane dendrimer G2-S16.

Sepúlveda-Crespo D, Serramía MJ, Tager AM, Vrbanac V, Gómez R, De La Mata FJ, Jiménez JL, Muñoz-Fernández MÁ.

Nanomedicine. 2015 Aug;11(6):1299-308. doi: 10.1016/j.nano.2015.04.013. Epub 2015 May 8.

PMID:
25959924
38.

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA.

Cell Stem Cell. 2014 Nov 6;15(5):643-52. doi: 10.1016/j.stem.2014.10.004. Epub 2014 Nov 6.

39.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12.

40.

The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.

Knipe RS, Tager AM, Liao JK.

Pharmacol Rev. 2015;67(1):103-17. doi: 10.1124/pr.114.009381. Review.

41.

New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.

Ahluwalia N, Shea BS, Tager AM.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):867-78. doi: 10.1164/rccm.201403-0509PP. Review.

42.

Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct?

Herzog EL, Mathur A, Tager AM, Feghali-Bostwick C, Schneider F, Varga J.

Arthritis Rheumatol. 2014 Aug;66(8):1967-78. doi: 10.1002/art.38702. Review. No abstract available.

43.

Fibrosis--a lethal component of systemic sclerosis.

Ho YY, Lagares D, Tager AM, Kapoor M.

Nat Rev Rheumatol. 2014 Jul;10(7):390-402. doi: 10.1038/nrrheum.2014.53. Epub 2014 Apr 22. Review.

PMID:
24752182
44.

Electron tomography of HIV-1 infection in gut-associated lymphoid tissue.

Ladinsky MS, Kieffer C, Olson G, Deruaz M, Vrbanac V, Tager AM, Kwon DS, Bjorkman PJ.

PLoS Pathog. 2014 Jan 30;10(1):e1003899. doi: 10.1371/journal.ppat.1003899. eCollection 2014 Jan.

45.

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis.

Montesi SB, Mathai SK, Brenner LN, Gorshkova IA, Berdyshev EV, Tager AM, Shea BS.

BMC Pulm Med. 2014 Jan 27;14:5. doi: 10.1186/1471-2466-14-5.

46.

PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads.

Seung E, Dudek TE, Allen TM, Freeman GJ, Luster AD, Tager AM.

PLoS One. 2013 Oct 21;8(10):e77780. doi: 10.1371/journal.pone.0077780. eCollection 2013.

47.

Humoral immunity in humanized mice: a work in progress.

Seung E, Tager AM.

J Infect Dis. 2013 Nov;208 Suppl 2:S155-9. doi: 10.1093/infdis/jit448. Review.

48.

Recent advances in humanized mice: accelerating the development of an HIV vaccine.

Tager AM, Pensiero M, Allen TM.

J Infect Dis. 2013 Nov;208 Suppl 2:S121-4. doi: 10.1093/infdis/jit451.

49.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE Jr, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22. doi: 10.1164/rccm.201306-1141WS.

50.

Airway-specific inducible transgene expression using aerosolized doxycycline.

Tata PR, Pardo-Saganta A, Prabhu M, Vinarsky V, Law BM, Fontaine BA, Tager AM, Rajagopal J.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1048-56. doi: 10.1165/rcmb.2012-0412OC.

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