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Distinct Immune Responses Elicited From Cervicovaginal Epithelial Cells by Lactic Acid and Short Chain Fatty Acids Associated With Optimal and Non-optimal Vaginal Microbiota.

Delgado-Diaz DJ, Tyssen D, Hayward JA, Gugasyan R, Hearps AC, Tachedjian G.

Front Cell Infect Microbiol. 2020 Jan 10;9:446. doi: 10.3389/fcimb.2019.00446. eCollection 2019.


Risk of Subsequent HIV Infection Following Sexually Transmissible Infections Among Men Who Have Sex With Men.

Harney BL, Agius PA, El-Hayek C, Fairley CK, Chow EPF, Roth N, Tee BK, Leslie D, Tachedjian G, Hellard M, Stoové M.

Open Forum Infect Dis. 2019 Aug 23;6(10):ofz376. doi: 10.1093/ofid/ofz376. eCollection 2019 Oct.


Effects of an over-the-counter lactic-acid containing intra-vaginal douching product on the vaginal microbiota.

van der Veer C, Bruisten SM, van Houdt R, Matser AA, Tachedjian G, van de Wijgert JHHM, de Vries HJC, van der Helm JJ.

BMC Microbiol. 2019 Jul 25;19(1):168. doi: 10.1186/s12866-019-1545-0.


Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes.

Selva KJ, Juno JA, Worley MJ, Chung AW, Tachedjian G, Kent SJ, Parsons MS.

AIDS Res Hum Retroviruses. 2019 Jun;35(6):553-556. doi: 10.1089/AID.2018.0219.


Oxazole-Benzenesulfonamide Derivatives Inhibit HIV-1 Reverse Transcriptase Interaction with Cellular eEF1A and Reduce Viral Replication.

Rawle DJ, Li D, Wu Z, Wang L, Choong M, Lor M, Reid RC, Fairlie DP, Harris J, Tachedjian G, Poulsen SA, Harrich D.

J Virol. 2019 May 29;93(12). pii: e00239-19. doi: 10.1128/JVI.00239-19. Print 2019 Jun 15.


A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats.

Kaminskas LM, Williams CC, Leong NJ, Chan LJ, Butcher NJ, Feeney OM, Porter CJH, Tyssen D, Tachedjian G, Ascher DB.

Eur J Pharm Biopharm. 2019 Apr;137:218-226. doi: 10.1016/j.ejpb.2019.03.008. Epub 2019 Mar 6.


Combined oral contraceptive pill-exposure alone does not reduce the risk of bacterial vaginosis recurrence in a pilot randomised controlled trial.

Vodstrcil LA, Plummer ME, Fairley CK, Tachedjian G, Law MG, Hocking JS, Worthington MK, Grant MM, Okoko N, Bradshaw CS.

Sci Rep. 2019 Mar 5;9(1):3555. doi: 10.1038/s41598-019-39879-8.


The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.

McKinnon LR, Achilles SL, Bradshaw CS, Burgener A, Crucitti T, Fredricks DN, Jaspan HB, Kaul R, Kaushic C, Klatt N, Kwon DS, Marrazzo JM, Masson L, McClelland RS, Ravel J, van de Wijgert JHHM, Vodstrcil LA, Tachedjian G.

AIDS Res Hum Retroviruses. 2019 Mar;35(3):219-228. doi: 10.1089/AID.2018.0304.


Host and Viral Proteins Modulating Ebola and Marburg Virus Egress.

Gordon TB, Hayward JA, Marsh GA, Baker ML, Tachedjian G.

Viruses. 2019 Jan 3;11(1). pii: E25. doi: 10.3390/v11010025. Review.


Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import.

Wagstaff KM, Headey S, Telwatte S, Tyssen D, Hearps AC, Thomas DR, Tachedjian G, Jans DA.

Cell Microbiol. 2019 Jan;21(1):e12953. doi: 10.1111/cmi.12953. Epub 2018 Sep 27.


Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid.

Tyssen D, Wang YY, Hayward JA, Agius PA, DeLong K, Aldunate M, Ravel J, Moench TR, Cone RA, Tachedjian G.

mSphere. 2018 Jul 5;3(4). pii: e00055-18. doi: 10.1128/mSphere.00055-18.


Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity.

Hayward JA, Tachedjian M, Cui J, Cheng AZ, Johnson A, Baker ML, Harris RS, Wang LF, Tachedjian G.

Mol Biol Evol. 2018 Jul 1;35(7):1626-1637. doi: 10.1093/molbev/msy048.


The implausible "in vivo" role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota.

Tachedjian G, O'Hanlon DE, Ravel J.

Microbiome. 2018 Feb 6;6(1):29. doi: 10.1186/s40168-018-0418-3.


The role of lactic acid production by probiotic Lactobacillus species in vaginal health.

Tachedjian G, Aldunate M, Bradshaw CS, Cone RA.

Res Microbiol. 2017 Nov - Dec;168(9-10):782-792. doi: 10.1016/j.resmic.2017.04.001. Epub 2017 Apr 20. Review.


Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition.

Hearps AC, Tyssen D, Srbinovski D, Bayigga L, Diaz DJD, Aldunate M, Cone RA, Gugasyan R, Anderson DJ, Tachedjian G.

Mucosal Immunol. 2017 Nov;10(6):1480-1490. doi: 10.1038/mi.2017.27. Epub 2017 Apr 12.


Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4+ T Cells following Latency Reversal.

Zerbato JM, Tachedjian G, Sluis-Cremer N.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01736-16. doi: 10.1128/AAC.01736-16. Print 2017 Mar.


Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.

Telwatte S, Brumme CJ, Hearps AC, Latham CF, Hayward JA, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G.

AIDS. 2016 Nov 28;30(18):2787-2793.


Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats.

Zhou P, Tachedjian M, Wynne JW, Boyd V, Cui J, Smith I, Cowled C, Ng JH, Mok L, Michalski WP, Mendenhall IH, Tachedjian G, Wang LF, Baker ML.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2696-701. doi: 10.1073/pnas.1518240113. Epub 2016 Feb 22.


High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.

Lloyd SB, Lichtfuss M, Amarasena TH, Alcantara S, De Rose R, Tachedjian G, Alinejad-Rokny H, Venturi V, Davenport MP, Winnall WR, Kent SJ.

Virology. 2016 May;492:1-10. doi: 10.1016/j.virol.2016.02.008. Epub 2016 Feb 19.


Critical Review: Mechanisms of HIV Transmission in Depo-Provera Users: The Likely Role of Hypoestrogenism.

Hickey M, Marino JL, Tachedjian G.

J Acquir Immune Defic Syndr. 2016 Jan 1;71(1):1-7. doi: 10.1097/QAI.0000000000000805. Review.


Bats and Rodents Shape Mammalian Retroviral Phylogeny.

Cui J, Tachedjian G, Wang LF.

Sci Rep. 2015 Nov 9;5:16561. doi: 10.1038/srep16561.


Why Do We Need New Drug Classes for HIV Treatment and Prevention?

Waheed AA, Tachedjian G.

Curr Top Med Chem. 2016;16(12):1343-9. Review.


Current and Emerging Drug Targets for Human Immunodeficiency Virus.

Waheed AA, Tachedjian G.

Curr Top Med Chem. 2016;16(10):1072-3. No abstract available.


Fragment Based Strategies for Discovery of Novel HIV-1 Reverse Transcriptase and Integrase Inhibitors.

Latham CF, La J, Tinetti RN, Chalmers DK, Tachedjian G.

Curr Top Med Chem. 2016;16(10):1135-53. Review.


Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.

Aldunate M, Srbinovski D, Hearps AC, Latham CF, Ramsland PA, Gugasyan R, Cone RA, Tachedjian G.

Front Physiol. 2015 Jun 2;6:164. doi: 10.3389/fphys.2015.00164. eCollection 2015. Review.


Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.

La J, Latham CF, Tinetti RN, Johnson A, Tyssen D, Huber KD, Sluis-Cremer N, Simpson JS, Headey SJ, Chalmers DK, Tachedjian G.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6979-84. doi: 10.1073/pnas.1423900112. Epub 2015 May 18.


Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.

Telwatte S, Hearps AC, Johnson A, Latham CF, Moore K, Agius P, Tachedjian M, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G.

Nucleic Acids Res. 2015 Mar 31;43(6):3256-71. doi: 10.1093/nar/gkv128. Epub 2015 Mar 12.


HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon.

Cornall A, Mak J, Greenway A, Tachedjian G.

Viruses. 2013 Sep 18;5(9):2235-52. doi: 10.3390/v5092235.


Sensitive assessment of the virologic outcomes of stopping and restarting non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy.

Geretti AM, Fox Z, Johnson JA, Booth C, Lipscomb J, Stuyver LJ, Tachedjian G, Baxter J, Touloumi G, Lehmann C, Owen A, Phillips A; INSIGHT Strategies for Management of Antiretroviral Therapy (SMART) Study Group.

PLoS One. 2013 Jul 18;8(7):e69266. doi: 10.1371/journal.pone.0069266. Print 2013.


The seventh (and last?) International Microbicides Conference: from discovery to delivery.

McGregor S, Tachedjian G, Haire BG, Kaldor JM.

Sex Health. 2013 Jul;10(3):240-5. doi: 10.1071/SH12211.


Vaginal concentrations of lactic acid potently inactivate HIV.

Aldunate M, Tyssen D, Johnson A, Zakir T, Sonza S, Moench T, Cone R, Tachedjian G.

J Antimicrob Chemother. 2013 Sep;68(9):2015-25. doi: 10.1093/jac/dkt156. Epub 2013 May 8.


The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes.

Gray LR, Tachedjian G, Ellett AM, Roche MJ, Cheng WJ, Guillemin GJ, Brew BJ, Turville SG, Wesselingh SL, Gorry PR, Churchill MJ.

PLoS One. 2013 Apr 16;8(4):e62196. doi: 10.1371/journal.pone.0062196. Print 2013.


Identification of diverse full-length endogenous betaretroviruses in megabats and microbats.

Hayward JA, Tachedjian M, Cui J, Field H, Holmes EC, Wang LF, Tachedjian G.

Retrovirology. 2013 Mar 27;10:35. doi: 10.1186/1742-4690-10-35.


No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Rezaei SD, Hearps AC, Mills J, Pedersen J, Tachedjian G.

Virol J. 2013 Jan 10;10:20. doi: 10.1186/1743-422X-10-20.


Host-pathogen interactions of retroviruses.

Waheed AA, Brass AL, Gummuluru S, Tachedjian G.

Mol Biol Int. 2012;2012:648512. doi: 10.1155/2012/648512. Epub 2012 Oct 24. No abstract available.


Biology of mucosally transmitted sexual infection-translating the basic science into novel HIV intervention: a workshop summary.

Purcell D, Cunningham A, Turville S, Tachedjian G, Landay A.

AIDS Res Hum Retroviruses. 2012 Nov;28(11):1389-96. doi: 10.1089/AID.2012.0276. Epub 2012 Oct 10.


Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions.

Henriques ST, Huang YH, Castanho MA, Bagatolli LA, Sonza S, Tachedjian G, Daly NL, Craik DJ.

J Biol Chem. 2012 Sep 28;287(40):33629-43. Epub 2012 Aug 1.


N348I in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine.

Yap SH, Herman BD, Radzio J, Sluis-Cremer N, Tachedjian G.

J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):153-7.


Identification of diverse groups of endogenous gammaretroviruses in mega- and microbats.

Cui J, Tachedjian G, Tachedjian M, Holmes EC, Zhang S, Wang LF.

J Gen Virol. 2012 Sep;93(Pt 9):2037-2045. doi: 10.1099/vir.0.043760-0. Epub 2012 Jun 13.


Identification of residues involved in NS2 homodimerization and elucidation of their impact on the HCV life cycle.

Gorzin AA, Ramsland PA, Tachedjian G, Gowans EJ.

J Viral Hepat. 2012 Mar;19(3):189-98. doi: 10.1111/j.1365-2893.2011.01504.x. Epub 2011 Aug 30.


Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses.

Cui J, Tachedjian M, Wang L, Tachedjian G, Wang LF, Zhang S.

J Virol. 2012 Apr;86(8):4288-93. doi: 10.1128/JVI.06624-11. Epub 2012 Feb 8.


SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans.

Price CF, Tyssen D, Sonza S, Davie A, Evans S, Lewis GR, Xia S, Spelman T, Hodsman P, Moench TR, Humberstone A, Paull JR, Tachedjian G.

PLoS One. 2011;6(9):e24095. doi: 10.1371/journal.pone.0024095. Epub 2011 Sep 15.


Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities.

Henriques ST, Huang YH, Rosengren KJ, Franquelim HG, Carvalho FA, Johnson A, Sonza S, Tachedjian G, Castanho MA, Daly NL, Craik DJ.

J Biol Chem. 2011 Jul 8;286(27):24231-41. doi: 10.1074/jbc.M111.253393. Epub 2011 May 16.


Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1.

Telwatte S, Moore K, Johnson A, Tyssen D, Sterjovski J, Aldunate M, Gorry PR, Ramsland PA, Lewis GR, Paull JR, Sonza S, Tachedjian G.

Antiviral Res. 2011 Jun;90(3):195-9. doi: 10.1016/j.antiviral.2011.03.186. Epub 2011 Apr 1.


Structure activity relationship of dendrimer microbicides with dual action antiviral activity.

Tyssen D, Henderson SA, Johnson A, Sterjovski J, Moore K, La J, Zanin M, Sonza S, Karellas P, Giannis MP, Krippner G, Wesselingh S, McCarthy T, Gorry PR, Ramsland PA, Cone R, Paull JR, Lewis GR, Tachedjian G.

PLoS One. 2010 Aug 23;5(8):e12309. doi: 10.1371/journal.pone.0012309.


Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model.

Cherry CL, Mobarok M, Wesselingh SL, Fain R, Weinstock S, Tachedjian G, Srivastava S, Tyssen DP, Glass JD, Hooker DJ.

Curr HIV Res. 2010 Apr;8(3):232-9.


N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations.

Sluis-Cremer N, Moore K, Radzio J, Sonza S, Tachedjian G.

AIDS. 2010 Jan 16;24(2):317-9. doi: 10.1097/QAD.0b013e3283315697.


Effect of reverse transcriptase inhibitors and mutations on the low-cost Cavidi reverse transcriptase viral load assay.

van Rooijen LB, Greengrass V, Morris LM, Plate MM, Gouillou M, Tachedjian G, Sluis-Cremer N, Hearps AC, Crowe SM.

J Acquir Immune Defic Syndr. 2009 Dec 1;52(4):527-9. doi: 10.1097/QAI.0b013e3181b9e726. No abstract available.


Maturation of the HIV reverse transcription complex: putting the jigsaw together.

Warrilow D, Tachedjian G, Harrich D.

Rev Med Virol. 2009 Nov;19(6):324-37. doi: 10.1002/rmv.627. Review.


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