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Items: 8


A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.

Wang Z, Tacchelly-Benites O, Noble GP, Johnson MK, Gagné JP, Poirier GG, Ahmed Y.

Genetics. 2019 Mar;211(3):913-923. doi: 10.1534/genetics.118.301393. Epub 2018 Dec 28.


Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.

Tacchelly-Benites O, Wang Z, Yang E, Benchabane H, Tian A, Randall MP, Ahmed Y.

PLoS Genet. 2018 Feb 6;14(2):e1007178. doi: 10.1371/journal.pgen.1007178. eCollection 2018 Feb.


Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R.

Elife. 2016 Dec 20;5. pii: e21459. doi: 10.7554/eLife.21459.


Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.

Wang Z, Tacchelly-Benites O, Yang E, Ahmed Y.

PLoS Genet. 2016 Dec 13;12(12):e1006494. doi: 10.1371/journal.pgen.1006494. eCollection 2016 Dec.


The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.

Wang Z, Tian A, Benchabane H, Tacchelly-Benites O, Yang E, Nojima H, Ahmed Y.

Development. 2016 May 15;143(10):1710-20. doi: 10.1242/dev.127647.


Wnt pathway activation by ADP-ribosylation.

Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y.

Nat Commun. 2016 May 3;7:11430. doi: 10.1038/ncomms11430.


Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.

Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y.

Genetics. 2016 May;203(1):269-81. doi: 10.1534/genetics.115.183244. Epub 2016 Mar 14.


Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes.

Tacchelly-Benites O, Wang Z, Yang E, Lee E, Ahmed Y.

Bioessays. 2013 Dec;35(12):1063-70. doi: 10.1002/bies.201300101. Epub 2013 Sep 19. Review.

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