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Items: 13


Caspase-1 interdomain linker cleavage is required for pyroptosis.

Ball DP, Taabazuing CY, Griswold AR, Orth EL, Rao SD, Kotliar IB, Vostal LE, Johnson DC, Bachovchin DA.

Life Sci Alliance. 2020 Feb 12;3(3). pii: e202000664. doi: 10.26508/lsa.202000664. Print 2020 Mar.


DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.

Griswold AR, Ball DP, Bhattacharjee A, Chui AJ, Rao SD, Taabazuing CY, Bachovchin DA.

ACS Chem Biol. 2019 Nov 15;14(11):2424-2429. doi: 10.1021/acschembio.9b00462. Epub 2019 Sep 20.


N-terminal degradation activates the NLRP1B inflammasome.

Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA.

Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14.


DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.

Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA.

Nat Med. 2018 Aug;24(8):1151-1156. doi: 10.1038/s41591-018-0082-y. Epub 2018 Jul 2.


Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.

Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA.

Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27.


Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.

Taabazuing CY, Okondo MC, Bachovchin DA.

Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4. doi: 10.1016/j.chembiol.2017.03.009. Epub 2017 Apr 6.


The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.

Hangasky JA, Taabazuing CY, Martin CB, Eron SJ, Knapp MJ.

J Inorg Biochem. 2017 Jan;166:26-33. doi: 10.1016/j.jinorgbio.2016.10.007. Epub 2016 Oct 17.


Substrate Promotes Productive Gas Binding in the α-Ketoglutarate-Dependent Oxygenase FIH.

Taabazuing CY, Fermann J, Garman S, Knapp MJ.

Biochemistry. 2016 Jan 19;55(2):277-86. doi: 10.1021/acs.biochem.5b01003. Epub 2016 Jan 5.


Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2.

Pektas S, Taabazuing CY, Knapp MJ.

Biochemistry. 2015 May 12;54(18):2851-7. doi: 10.1021/bi501540c. Epub 2015 Apr 28.


Oxygen sensing strategies in mammals and bacteria.

Taabazuing CY, Hangasky JA, Knapp MJ.

J Inorg Biochem. 2014 Apr;133:63-72. doi: 10.1016/j.jinorgbio.2013.12.010. Epub 2014 Jan 3. Review.


Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.

Hangasky JA, Taabazuing CY, Valliere MA, Knapp MJ.

Metallomics. 2013 Apr;5(4):287-301. doi: 10.1039/c3mt20153h. Review.


Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH).

Flagg SC, Martin CB, Taabazuing CY, Holmes BE, Knapp MJ.

J Inorg Biochem. 2012 Aug;113:25-30. doi: 10.1016/j.jinorgbio.2012.03.002. Epub 2012 Mar 17.


The second coordination sphere of FIH controls hydroxylation.

Saban E, Chen YH, Hangasky JA, Taabazuing CY, Holmes BE, Knapp MJ.

Biochemistry. 2011 May 31;50(21):4733-40. doi: 10.1021/bi102042t. Epub 2011 May 3.

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