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Items: 1 to 50 of 111

1.

Is there a risk of cancer development after Campylobacter infection?

Brauner A, Brandt L, Frisan T, Thelestam M, Ekbom A.

Scand J Gastroenterol. 2010 Aug;45(7-8):893-7. doi: 10.3109/00365521003734133.

PMID:
20334473
2.

Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.

Guerra L, Albihn A, Tronnersjö S, Yan Q, Guidi R, Stenerlöw B, Sterzenbach T, Josenhans C, Fox JG, Schauer DB, Thelestam M, Larsson LG, Henriksson M, Frisan T.

PLoS One. 2010 Jan 27;5(1):e8924. doi: 10.1371/journal.pone.0008924.

3.

A novel mode of translocation for cytolethal distending toxin.

Guerra L, Nemec KN, Massey S, Tatulian SA, Thelestam M, Frisan T, Teter K.

Biochim Biophys Acta. 2009 Mar;1793(3):489-95. doi: 10.1016/j.bbamcr.2008.11.017. Epub 2008 Dec 11.

4.

A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage.

Guerra L, Carr HS, Richter-Dahlfors A, Masucci MG, Thelestam M, Frost JA, Frisan T.

PLoS One. 2008 May 28;3(5):e2254. doi: 10.1371/journal.pone.0002254.

5.

Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage.

Saravia-Otten P, Gutierrez JM, Arvidson S, Thelestam M, Flock JI.

J Infect Dis. 2007 Sep 1;196(5):748-54. Epub 2007 Jul 18.

PMID:
17674318
6.

Effects of Clostridium perfringens phospholipase C in mammalian cells.

Flores-Díaz M, Thelestam M, Clark GC, Titball RW, Alape-Girón A.

Anaerobe. 2004 Apr;10(2):115-23.

PMID:
16701508
7.

Inhibition of hippocampal synaptic transmission by impairment of Ral function.

Owe-Larsson B, Chaves-Olarte E, Chauhan A, Kjaerulff O, Brask J, Thelestam M, Brodin L, Löw P.

Neuroreport. 2005 Nov 7;16(16):1805-8.

PMID:
16237331
8.

Cellular internalization of cytolethal distending toxin: a new end to a known pathway.

Guerra L, Teter K, Lilley BN, Stenerlöw B, Holmes RK, Ploegh HL, Sandvig K, Thelestam M, Frisan T.

Cell Microbiol. 2005 Jul;7(7):921-34.

PMID:
15953025
9.

A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.

Flores-Díaz M, Alape-Girón A, Clark G, Catimel B, Hirabayashi Y, Nice E, Gutiérrez JM, Titball R, Thelestam M.

J Biol Chem. 2005 Jul 22;280(29):26680-9. Epub 2005 May 26.

10.

Revised nomenclature of Clostridium difficile toxins and associated genes.

Rupnik M, Dupuy B, Fairweather NF, Gerding DN, Johnson S, Just I, Lyerly DM, Popoff MR, Rood JI, Sonenshein AL, Thelestam M, Wren BW, Wilkins TD, von Eichel-Streiber C.

J Med Microbiol. 2005 Feb;54(Pt 2):113-7.

PMID:
15673503
11.

Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases.

Saravia-Otten P, Frisan T, Thelestam M, Gutiérrez JM.

Toxicon. 2004 Dec 1;44(7):749-64.

PMID:
15500851
12.

Cytolethal distending toxins.

Thelestam M, Frisan T.

Rev Physiol Biochem Pharmacol. 2004;152:111-33. Epub 2004 Aug 27. Review.

PMID:
15338430
13.

A. actinomycetemcomitans cytolethal distending toxin.

Thelestam M, Frisan T.

J Immunol. 2004 May 15;172(10):5813; author reply 5813-4. No abstract available.

14.

Glucose starvation results in UDP-glucose deficiency and inactivation of glycogen synthase.

Higuita JC, Thelestam M, Katz A.

Arch Biochem Biophys. 2004 May 15;425(2):242-8.

PMID:
15111133
15.

A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements.

Flores-Diaz M, Higuita JC, Florin I, Okada T, Pollesello P, Bergman T, Thelestam M, Mori K, Alape-Giron A.

J Biol Chem. 2004 May 21;279(21):21724-31. Epub 2004 Mar 12.

16.

The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA.

Frisan T, Cortes-Bratti X, Chaves-Olarte E, Stenerlöw B, Thelestam M.

Cell Microbiol. 2003 Oct;5(10):695-707.

PMID:
12969375
17.

R-Ras glucosylation and transient RhoA activation determine the cytopathic effect produced by toxin B variants from toxin A-negative strains of Clostridium difficile.

Chaves-Olarte E, Freer E, Parra A, Guzmán-Verri C, Moreno E, Thelestam M.

J Biol Chem. 2003 Mar 7;278(10):7956-63. Epub 2002 Dec 19.

18.
19.

The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells.

Li L, Sharipo A, Chaves-Olarte E, Masucci MG, Levitsky V, Thelestam M, Frisan T.

Cell Microbiol. 2002 Feb;4(2):87-99.

PMID:
11896765
20.

Cytolethal distending toxins and activation of DNA damage-dependent checkpoint responses.

Frisan T, Cortes-Bratti X, Thelestam M.

Int J Med Microbiol. 2002 Feb;291(6-7):495-9. Review.

PMID:
11890549
21.

The cytolethal distending toxins induce DNA damage and cell cycle arrest.

Cortes-Bratti X, Frisan T, Thelestam M.

Toxicon. 2001 Nov;39(11):1729-36. Review.

PMID:
11595635
22.

GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42.

Guzmán-Verri C, Chaves-Olarte E, von Eichel-Streiber C, López-Goñi I, Thelestam M, Arvidson S, Gorvel JP, Moreno E.

J Biol Chem. 2001 Nov 30;276(48):44435-43. Epub 2001 Sep 28.

23.

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms.

Rojas E, Saravia P, Angulo Y, Arce V, Lomonte B, Chávez JJ, Velásquez R, Thelestam M, Gutiérrez JM.

Comp Biochem Physiol C Toxicol Pharmacol. 2001 Jun;129(2):151-62.

PMID:
11423387
24.

The impact of Haemophilus ducreyi cytolethal distending toxin on cells involved in immune response.

Svensson LA, Tarkowski A, Thelestam M, Lagergård T.

Microb Pathog. 2001 Mar;30(3):157-66.

PMID:
11273741
25.

Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.

Walker N, Holley J, Naylor CE, Flores-Díaz M, Alape-Girón A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, Basak AK, Miller J, Titball RW.

Arch Biochem Biophys. 2000 Dec 1;384(1):24-30.

PMID:
11147832
26.

Bacterial protein toxins--general conclusions.

Thelestam M.

Int J Med Microbiol. 2000 Oct;290(4-5):503-6. No abstract available.

PMID:
11111934
27.

Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi.

Cortes-Bratti X, Chaves-Olarte E, Lagergård T, Thelestam M.

Infect Immun. 2000 Dec;68(12):6903-11.

28.

The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.

Cortes-Bratti X, Karlsson C, Lagergård T, Thelestam M, Frisan T.

J Biol Chem. 2001 Feb 16;276(7):5296-302. Epub 2000 Nov 13.

29.

Cytotoxic effects of the Clostridium difficile toxins.

Thelestam M, Chaves-Olarte E.

Curr Top Microbiol Immunol. 2000;250:85-96. Review. No abstract available.

PMID:
10981358
30.

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.

Alape-Girón A, Flores-Díaz M, Guillouard I, Naylor CE, Titball RW, Rucavado A, Lomonte B, Basak AK, Gutiérrez JM, Cole ST, Thelestam M.

Eur J Biochem. 2000 Aug;267(16):5191-7.

31.

Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1.

Palsson EM, Popoff M, Thelestam M, O'Neill LA.

J Biol Chem. 2000 Mar 17;275(11):7818-25.

32.

A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins.

Chaves-Olarte E, Löw P, Freer E, Norlin T, Weidmann M, von Eichel-Streiber C, Thelestam M.

J Biol Chem. 1999 Apr 16;274(16):11046-52.

33.

Elapid venom toxins: multiple recruitments of ancient scaffolds.

Alape-Girón A, Persson B, Cederlund E, Flores-Díaz M, Gutiérrez JM, Thelestam M, Bergman T, Jörnvall H.

Eur J Biochem. 1999 Jan;259(1-2):225-34.

34.

The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase.

Cortes-Bratti X, Chaves-Olarte E, Lagergård T, Thelestam M.

J Clin Invest. 1999 Jan;103(1):107-15.

35.

Effects of Bacterial Toxins on Small GTP-binding Proteins.

Chaves-Olarte E, Cortes-Bratti X, Thelestam M.

Toxicol In Vitro. 1998 Oct;12(5):527-31. No abstract available.

PMID:
20654435
36.

UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C.

Flores-Díaz M, Alape-Girón A, Titball RW, Moos M, Guillouard I, Cole S, Howells AM, von Eichel-Streiber C, Florin I, Thelestam M.

J Biol Chem. 1998 Sep 18;273(38):24433-8.

37.

Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species).

Amuy E, Alape-Girón A, Lomonte B, Thelestam M, Gutiérrez JM.

Toxicon. 1997 Nov;35(11):1605-16.

PMID:
9428107
38.
39.

Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene.

Flores-Díaz M, Alape-Girón A, Persson B, Pollesello P, Moos M, von Eichel-Streiber C, Thelestam M, Florin I.

J Biol Chem. 1997 Sep 19;272(38):23784-91.

40.
41.

Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins.

von Eichel-Streiber C, Boquet P, Sauerborn M, Thelestam M.

Trends Microbiol. 1996 Oct;4(10):375-82. Review.

PMID:
8899962
42.

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

Popoff MR, Chaves-Olarte E, Lemichez E, von Eichel-Streiber C, Thelestam M, Chardin P, Cussac D, Antonny B, Chavrier P, Flatau G, Giry M, de Gunzburg J, Boquet P.

J Biol Chem. 1996 Apr 26;271(17):10217-24.

43.

UDP-glucose deficiency in a mutant cell line protects against glucosyltransferase toxins from Clostridium difficile and Clostridium sordellii.

Chaves-Olarte E, Florin I, Boquet P, Popoff M, von Eichel-Streiber C, Thelestam M.

J Biol Chem. 1996 Mar 22;271(12):6925-32.

44.

Characterization of multiple nicotinic acetylcholine receptor-binding proteins and phospholipases A2 from the venom of the coral snake Micrurus nigrocinctus.

Alape-Girón A, Stiles B, Schmidt J, Girón-Cortes M, Thelestam M, Jörnvall H, Bergman T.

FEBS Lett. 1996 Feb 12;380(1-2):29-32.

45.

Electrophoretic and immunochemical studies of Micrurus snake venoms.

Alape-Girón A, Lomonte B, Gustafsson B, Da Silva NJ, Thelestam M.

Toxicon. 1994 Jun;32(6):713-23.

PMID:
7940577
46.

Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies.

Alape-Girón A, Gustafsson B, Lomonte B, Thelestam M, Gutiérrez JM.

Toxicon. 1994 Jun;32(6):695-712.

PMID:
7940576
47.

Assay of cytopathogenic toxins in cultured cells.

Thelestam M, Florin I.

Methods Enzymol. 1994;235:679-90. No abstract available.

PMID:
8057936
48.
49.

Dithiothreitol generates an activated 250,000 mol. wt form of Clostridium difficile toxin B.

Shoshan MC, Bergman T, Thelestam M, Florin I.

Toxicon. 1993 Jul;31(7):845-52.

PMID:
8212030
50.

Activation of cellular phospholipase A2 by Clostridium difficile toxin B.

Shoshan MC, Florin I, Thelestam M.

J Cell Biochem. 1993 May;52(1):116-24.

PMID:
8320270

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