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Items: 1 to 50 of 123

1.

De novo dNTP production is essential for normal postnatal murine heart development.

Tran P, Wanrooij PH, Lorenzon P, Sharma S, Thelander L, Nilsson AK, Olofsson AK, Medini P, von Hofsten J, Stål P, Chabes A.

J Biol Chem. 2019 Jul 12. pii: jbc.RA119.009492. doi: 10.1074/jbc.RA119.009492. [Epub ahead of print]

PMID:
31300555
Free Article
2.

Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding.

Ranjbarian F, Vodnala M, Vodnala SM, Rofougaran R, Thelander L, Hofer A.

J Biol Chem. 2012 May 18;287(21):17628-36. doi: 10.1074/jbc.M112.340059. Epub 2012 Mar 21.

3.

Metal binding and activity of ribonucleotide reductase protein R2 mutants: conditions for formation of the mixed manganese-iron cofactor.

Popović-Bijelić A, Voevodskaya N, Domkin V, Thelander L, Gräslund A.

Biochemistry. 2009 Jul 14;48(27):6532-9. doi: 10.1021/bi900693s.

PMID:
19492792
4.

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

Pontarin G, Fijolek A, Pizzo P, Ferraro P, Rampazzo C, Pozzan T, Thelander L, Reichard PA, Bianchi V.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17801-6. doi: 10.1073/pnas.0808198105. Epub 2008 Nov 7.

5.

[Nucleic acid research--family history with two Nobel Prizes].

Lagerkvist U, Reichard P, Thelander L, Elias P.

Lakartidningen. 2008 Jan 23-29;105(4):235-6. Swedish. No abstract available.

PMID:
18306831
6.

Ribonucleotide reductase and mitochondrial DNA synthesis.

Thelander L.

Nat Genet. 2007 Jun;39(6):703-4. No abstract available.

PMID:
17534360
7.

p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

Pontarin G, Ferraro P, Håkansson P, Thelander L, Reichard P, Bianchi V.

J Biol Chem. 2007 Jun 8;282(23):16820-8. Epub 2007 Apr 7.

8.
9.

The involvement of Arg265 of mouse ribonucleotide reductase R2 protein in proton transfer and catalysis.

Narváez AJ, Voevodskaya N, Thelander L, Gräslund A.

J Biol Chem. 2006 Sep 8;281(36):26022-8. Epub 2006 Jul 9.

10.

Chlamydial ribonucleotide reductase: tyrosyl radical function in catalysis replaced by the FeIII-FeIV cluster.

Voevodskaya N, Narvaez AJ, Domkin V, Torrents E, Thelander L, Gräslund A.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9850-4. Epub 2006 Jun 15.

11.

Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells.

Håkansson P, Hofer A, Thelander L.

J Biol Chem. 2006 Mar 24;281(12):7834-41. Epub 2006 Jan 24.

12.

The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit.

Håkansson P, Dahl L, Chilkova O, Domkin V, Thelander L.

J Biol Chem. 2006 Jan 20;281(3):1778-83. Epub 2005 Nov 28.

13.

The ribonucleotide reductase R1 homolog of murine cytomegalovirus is not a functional enzyme subunit but is required for pathogenesis.

Lembo D, Donalisio M, Hofer A, Cornaglia M, Brune W, Koszinowski U, Thelander L, Landolfo S.

J Virol. 2004 Apr;78(8):4278-88.

14.
15.

DNA building blocks at the foundation of better survival.

Chabes A, Thelander L.

Cell Cycle. 2003 May-Jun;2(3):171-3. Review. No abstract available.

PMID:
12734415
16.
17.

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis.

Chabes AL, Pfleger CM, Kirschner MW, Thelander L.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3925-9. Epub 2003 Mar 24.

18.

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.

Chabes A, Georgieva B, Domkin V, Zhao X, Rothstein R, Thelander L.

Cell. 2003 Feb 7;112(3):391-401.

19.

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Saitoh S, Chabes A, McDonald WH, Thelander L, Yates JR, Russell P.

Cell. 2002 May 31;109(5):563-73.

20.
21.
22.

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.

Guittet O, Håkansson P, Voevodskaya N, Fridd S, Gräslund A, Arakawa H, Nakamura Y, Thelander L.

J Biol Chem. 2001 Nov 2;276(44):40647-51. Epub 2001 Aug 21.

23.

A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH and recombinant TBP, TFIIB, TFIIE and TFIIF.

Kotova I, Chabes AL, Segerman B, Flodell S, Thelander L, Björklund S.

Eur J Biochem. 2001 Aug;268(16):4527-36.

24.
25.

Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.

Hofer A, Steverding D, Chabes A, Brun R, Thelander L.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6412-6. Epub 2001 May 15.

26.

Expression of an altered ribonucleotide reductase activity associated with the replication of murine cytomegalovirus in quiescent fibroblasts.

Lembo D, Gribaudo G, Hofer A, Riera L, Cornaglia M, Mondo A, Angeretti A, Gariglio M, Thelander L, Landolfo S.

J Virol. 2000 Dec;74(24):11557-65.

27.

Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality.

Zhao X, Georgieva B, Chabes A, Domkin V, Ippel JH, Schleucher J, Wijmenga S, Thelander L, Rothstein R.

Mol Cell Biol. 2000 Dec;20(23):9076-83.

28.

Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase.

Reichard P, Eliasson R, Ingemarson R, Thelander L.

J Biol Chem. 2000 Oct 20;275(42):33021-6.

30.

Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.

Chabes A, Domkin V, Larsson G, Liu A, Graslund A, Wijmenga S, Thelander L.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2474-9.

31.

Yeast Sml1, a protein inhibitor of ribonucleotide reductase.

Chabes A, Domkin V, Thelander L.

J Biol Chem. 1999 Dec 17;274(51):36679-83.

32.

5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase.

Manfredini S, Baraldi PG, Durini E, Vertuani S, Balzarini J, De Clercq E, Karlsson A, Buzzoni V, Thelander L.

J Med Chem. 1999 Aug 26;42(17):3243-50.

PMID:
10464011
33.
34.

Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides.

Manfredini S, Baraldi PG, Durini E, Balzarini J, De Clercq E, Karlsson A, Buzzoni V, Thelander L.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1007-8.

PMID:
10432732
35.

The iron-oxygen reconstitution reaction in protein R2-Tyr-177 mutants of mouse ribonucleotide reductase. Epr and electron nuclear double resonance studies on a new transient tryptophan radical.

Pötsch S, Lendzian F, Ingemarson R, Hörnberg A, Thelander L, Lubitz W, Lassmann G, Gräslund A.

J Biol Chem. 1999 Jun 18;274(25):17696-704.

36.

Metabolic fate of oxidized guanine ribonucleotides in mammalian cells.

Hayakawa H, Hofer A, Thelander L, Kitajima S, Cai Y, Oshiro S, Yakushiji H, Nakabeppu Y, Kuwano M, Sekiguchi M.

Biochemistry. 1999 Mar 23;38(12):3610-4.

PMID:
10090747
37.

Allosteric regulation of Trypanosoma brucei ribonucleotide reductase studied in vitro and in vivo.

Hofer A, Ekanem JT, Thelander L.

J Biol Chem. 1998 Dec 18;273(51):34098-104.

38.
39.
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41.

Rnr4p, a novel ribonucleotide reductase small-subunit protein.

Wang PJ, Chabes A, Casagrande R, Tian XC, Thelander L, Huffaker TC.

Mol Cell Biol. 1997 Oct;17(10):6114-21.

42.
43.

Cloning and characterization of the R1 and R2 subunits of ribonucleotide reductase from Trypanosoma brucei.

Hofer A, Schmidt PP, Gräslund A, Thelander L.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6959-64.

44.

Apolipoprotein CII from chicken (Gallus domesticus). The amino-terminal domain is different from corresponding domains in mammals.

Andersson Y, Nilsson S, Lindberg A, Thelander L, Olivecrona G.

J Biol Chem. 1996 Dec 20;271(51):33060-6.

45.

The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.

Kauppi B, Nielsen BB, Ramaswamy S, Larsen IK, Thelander M, Thelander L, Eklund H.

J Mol Biol. 1996 Oct 11;262(5):706-20.

PMID:
8876648
46.

Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light.

Filatov D, Björklund S, Johansson E, Thelander L.

J Biol Chem. 1996 Sep 27;271(39):23698-704.

47.

High field EPR studies of mouse ribonucleotide reductase indicate hydrogen bonding of the tyrosyl radical.

Schmidt PP, Andersson KK, Barra AL, Thelander L, Gräslund A.

J Biol Chem. 1996 Sep 27;271(39):23615-8.

48.
49.

Formation of a free radical of the sulfenylimine type in the mouse ribonucleotide reductase reaction with 2'-azido-2'-deoxycytidine 5'-diphosphate.

Behravan G, Sen S, Rova U, Thelander L, Eckstein F, Gräslund A.

Biochim Biophys Acta. 1995 Dec 27;1264(3):323-9.

PMID:
8547320

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