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Items: 1 to 50 of 115

1.

Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.

O'Flaherty L, Shnyder SD, Cooper PA, Cross SJ, Wakefield JG, Pardo OE, Seckl MJ, Tavaré JM.

PLoS One. 2019 Apr 10;14(4):e0214610. doi: 10.1371/journal.pone.0214610. eCollection 2019.

2.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM.

Biochem J. 2018 Sep 25;475(18):2969-2983. doi: 10.1042/BCJ20180475.

3.

Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event.

Boal F, Hodgson LR, Reed SE, Yarwood SE, Just VJ, Stephens DJ, McCaffrey MW, Tavaré JM.

Cell Signal. 2016 Jan;28(1):74-82. doi: 10.1016/j.cellsig.2015.10.014. Epub 2015 Oct 26.

4.

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.

Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, Avizonis D, Pause A, Elder DJ, Artyomov MN, Jones RG.

Mol Cell. 2015 Oct 15;60(2):195-207. doi: 10.1016/j.molcel.2015.08.013.

5.

Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal.

Chen MZ, Hudson CA, Vincent EE, de Berker DA, May MT, Hers I, Dayan CM, Andrews RC, Tavaré JM.

PLoS One. 2015 Apr 13;10(4):e0120084. doi: 10.1371/journal.pone.0120084. eCollection 2015.

6.

Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.

Vincent EE, Elder DJ, O'Flaherty L, Pardo OE, Dzien P, Phillips L, Morgan C, Pawade J, May MT, Sohail M, Hetzel MR, Seckl MJ, Tavaré JM.

PLoS One. 2014 Dec 8;9(12):e114725. doi: 10.1371/journal.pone.0114725. eCollection 2014.

7.

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.

Stergiakouli E, Gaillard R, Tavaré JM, Balthasar N, Loos RJ, Taal HR, Evans DM, Rivadeneira F, St Pourcain B, Uitterlinden AG, Kemp JP, Hofman A, Ring SM, Cole TJ, Jaddoe VW, Davey Smith G, Timpson NJ.

Obesity (Silver Spring). 2014 Oct;22(10):2252-9. doi: 10.1002/oby.20840. Epub 2014 Jul 21.

8.

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

Liu Y, Lai YC, Hill EV, Tyteca D, Carpentier S, Ingvaldsen A, Vertommen D, Lantier L, Foretz M, Dequiedt F, Courtoy PJ, Erneux C, Viollet B, Shepherd PR, Tavaré JM, Jensen J, Rider MH.

Biochem J. 2013 Oct 15;455(2):195-206. doi: 10.1042/BJ20130644.

PMID:
23905686
9.

Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor.

Vincent EE, Elder DJ, Curwen J, Kilgour E, Hers I, Tavaré JM.

PLoS One. 2013 Jun 24;8(6):e66963. doi: 10.1371/journal.pone.0066963. Print 2013.

10.

Structural and population-based evaluations of TBC1D1 p.Arg125Trp.

Richardson TG, Thomas EC, Sessions RB, Lawlor DA, Tavaré JM, Day IN.

PLoS One. 2013 May 7;8(5):e63897. doi: 10.1371/journal.pone.0063897. Print 2013.

11.

A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.

Steinberg F, Gallon M, Winfield M, Thomas EC, Bell AJ, Heesom KJ, Tavaré JM, Cullen PJ.

Nat Cell Biol. 2013 May;15(5):461-71. doi: 10.1038/ncb2721. Epub 2013 Apr 7. Erratum in: Nat Cell Biol. 2014 Aug;16(8):821.

12.

A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes.

Reed SE, Hodgson LR, Song S, May MT, Kelly EE, McCaffrey MW, Mastick CC, Verkade P, Tavaré JM.

J Cell Sci. 2013 May 1;126(Pt 9):1931-41. doi: 10.1242/jcs.104307. Epub 2013 Feb 26.

13.

Identification of a novel signaling pathway and its relevance for GluA1 recycling.

Seebohm G, Neumann S, Theiss C, Novkovic T, Hill EV, Tavaré JM, Lang F, Hollmann M, Manahan-Vaughan D, Strutz-Seebohm N.

PLoS One. 2012;7(3):e33889. doi: 10.1371/journal.pone.0033889. Epub 2012 Mar 21.

14.

Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome.

Seebohm G, Strutz-Seebohm N, Ursu ON, Preisig-Müller R, Zuzarte M, Hill EV, Kienitz MC, Bendahhou S, Fauler M, Tapken D, Decher N, Collins A, Jurkat-Rott K, Steinmeyer K, Lehmann-Horn F, Daut J, Tavaré JM, Pott L, Bloch W, Lang F.

FASEB J. 2012 Feb;26(2):513-22. doi: 10.1096/fj.11-189126. Epub 2011 Oct 14.

PMID:
22002906
15.

Akt signalling in health and disease.

Hers I, Vincent EE, Tavaré JM.

Cell Signal. 2011 Oct;23(10):1515-27. doi: 10.1016/j.cellsig.2011.05.004. Epub 2011 May 17. Review.

PMID:
21620960
16.

Overexpression of the TXNDC5 protein in non-small cell lung carcinoma.

Vincent EE, Elder DJ, Phillips L, Heesom KJ, Pawade J, Luckett M, Sohail M, May MT, Hetzel MR, Tavaré JM.

Anticancer Res. 2011 May;31(5):1577-82.

PMID:
21617212
17.

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.

Vincent EE, Elder DJ, Thomas EC, Phillips L, Morgan C, Pawade J, Sohail M, May MT, Hetzel MR, Tavaré JM.

Br J Cancer. 2011 May 24;104(11):1755-61. doi: 10.1038/bjc.2011.132. Epub 2011 Apr 19.

18.

Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA.

J Biol Chem. 2011 Apr 15;286(15):13647-56. doi: 10.1074/jbc.M110.204248. Epub 2011 Feb 18.

19.

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM.

Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015.

20.

Regulation of PIKfyve phosphorylation by insulin and osmotic stress.

Hill EV, Hudson CA, Vertommen D, Rider MH, Tavaré JM.

Biochem Biophys Res Commun. 2010 Jul 9;397(4):650-5. doi: 10.1016/j.bbrc.2010.05.134. Epub 2010 Jun 1.

PMID:
20513353
21.

Regulation of the glutamate transporter EAAT4 by PIKfyve.

Alesutan IS, Ureche ON, Laufer J, Klaus F, Zürn A, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.

Cell Physiol Biochem. 2010;25(2-3):187-94. doi: 10.1159/000276569. Epub 2010 Jan 12.

22.

Regulation of the glutamate transporter EAAT2 by PIKfyve.

Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.

Cell Physiol Biochem. 2009;24(5-6):361-8. doi: 10.1159/000257428. Epub 2009 Nov 4.

23.

PIKfyve upregulates CFTR activity.

Gehring EM, Lam RS, Siraskar G, Koutsouki E, Seebohm G, Ureche ON, Ureche L, Baltaev R, Tavare JM, Lang F.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):952-7. doi: 10.1016/j.bbrc.2009.10.084. Epub 2009 Oct 21.

PMID:
19852935
24.

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

Lennon R, Pons D, Sabin MA, Wei C, Shield JP, Coward RJ, Tavaré JM, Mathieson PW, Saleem MA, Welsh GI.

Nephrol Dial Transplant. 2009 Nov;24(11):3288-96. doi: 10.1093/ndt/gfp302. Epub 2009 Jun 25.

PMID:
19556298
25.

Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1.

Lennon R, Welsh GI, Singh A, Satchell SC, Coward RJ, Tavaré JM, Mathieson PW, Saleem MA.

Diabetologia. 2009 Sep;52(9):1944-52. doi: 10.1007/s00125-009-1423-7. Epub 2009 Jun 17.

PMID:
19533082
26.

Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve.

Klaus F, Gehring EM, Zürn A, Laufer J, Lindner R, Strutz-Seebohm N, Tavaré JM, Rothstein JD, Boehmer C, Palmada M, Gruner I, Lang UE, Seebohm G, Lang F.

Neurochem Int. 2009 May-Jun;54(5-6):372-7.

PMID:
19418632
27.

The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets.

Leney SE, Tavaré JM.

J Endocrinol. 2009 Oct;203(1):1-18. doi: 10.1677/JOE-09-0037. Epub 2009 Apr 23. Review.

PMID:
19389739
28.

Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.

Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F.

Circ Res. 2008 Dec 5;103(12):1451-7. doi: 10.1161/CIRCRESAHA.108.177360. Epub 2008 Nov 13.

PMID:
19008479
29.

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles.

Heyward CA, Pettitt TR, Leney SE, Welsh GI, Tavaré JM, Wakelam MJ.

BMC Cell Biol. 2008 May 20;9:25. doi: 10.1186/1471-2121-9-25.

30.

Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes.

Welsh GI, Leney SE, Lloyd-Lewis B, Wherlock M, Lindsay AJ, McCaffrey MW, Tavaré JM.

J Cell Sci. 2007 Dec 1;120(Pt 23):4197-208. Epub 2007 Nov 14.

31.

Regulation of the Na(+), glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1.

Shojaiefard M, Strutz-Seebohm N, Tavaré JM, Seebohm G, Lang F.

Biochem Biophys Res Commun. 2007 Aug 10;359(4):843-7. Epub 2007 May 25.

PMID:
17570343
32.

Nephrin is critical for the action of insulin on human glomerular podocytes.

Coward RJ, Welsh GI, Koziell A, Hussain S, Lennon R, Ni L, Tavaré JM, Mathieson PW, Saleem MA.

Diabetes. 2007 Apr;56(4):1127-35.

33.

Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.

Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F.

Circ Res. 2007 Mar 16;100(5):686-92. Epub 2007 Feb 9.

PMID:
17293474
34.

Imaging of insulin signaling in skeletal muscle of living mice shows major role of T-tubules.

Lauritzen HP, Ploug T, Prats C, Tavaré JM, Galbo H.

Diabetes. 2006 May;55(5):1300-6.

35.

Regulation of small GTP-binding proteins by insulin.

Welsh GI, Hers I, Wherlock M, Tavaré JM.

Biochem Soc Trans. 2006 Apr;34(Pt 2):209-12. Review.

PMID:
16545078
36.

Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.

Hers I, Wherlock M, Homma Y, Yagisawa H, Tavaré JM.

J Biol Chem. 2006 Feb 24;281(8):4762-70. Epub 2005 Dec 6.

37.

The human glomerular podocyte is a novel target for insulin action.

Coward RJ, Welsh GI, Yang J, Tasman C, Lennon R, Koziell A, Satchell S, Holman GD, Kerjaschki D, Tavaré JM, Mathieson PW, Saleem MA.

Diabetes. 2005 Nov;54(11):3095-102.

38.

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.

Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S.

FEBS Lett. 2005 Sep 12;579(22):5089-94.

39.

Role of protein kinase B in insulin-regulated glucose uptake.

Welsh GI, Hers I, Berwick DC, Dell G, Wherlock M, Birkin R, Leney S, Tavaré JM.

Biochem Soc Trans. 2005 Apr;33(Pt 2):346-9. Review.

PMID:
15787603
40.
41.

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavaré JM.

J Cell Sci. 2004 Dec 1;117(Pt 25):5985-93. Epub 2004 Nov 16.

42.

Identifying protein kinase substrates: hunting for the organ-grinder's monkeys.

Berwick DC, Tavaré JM.

Trends Biochem Sci. 2004 May;29(5):227-32. Review. No abstract available.

PMID:
15130558
43.

Proteome analysis of adipogenesis.

Welsh GI, Griffiths MR, Webster KJ, Page MJ, Tavaré JM.

Proteomics. 2004 Apr;4(4):1042-51.

PMID:
15048985
44.

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment.

Wakefield JG, Stephens DJ, Tavaré JM.

J Cell Sci. 2003 Feb 15;116(Pt 4):637-46.

45.

Multiple signalling pathways mediate insulin-stimulated gene expression in 3T3-L1 adipocytes.

Culbert AA, Tavaré JM.

Biochim Biophys Acta. 2002 Oct 11;1578(1-3):43-50.

PMID:
12393186
46.
48.

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.

Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM.

J Biol Chem. 2002 Sep 13;277(37):33895-900. Epub 2002 Jul 9.

49.

Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles.

Ducluzeau PH, Fletcher LM, Welsh GI, Tavaré JM.

J Cell Sci. 2002 Jul 15;115(Pt 14):2857-66.

50.

Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes.

Ducluzeau PH, Fletcher LM, Vidal H, Laville M, Tavaré JM.

Diabetes Metab. 2002 Apr;28(2):85-92. Review.

PMID:
11976560

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