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Items: 9

1.

PBPK and its Virtual Populations: the Impact of Physiology on Pediatric Pharmacokinetic Predictions of Tramadol.

T'jollyn H, Vermeulen A, Van Bocxlaer J.

AAPS J. 2018 Nov 29;21(1):8. doi: 10.1208/s12248-018-0277-7.

PMID:
30498862
2.

A Physiologically Based Pharmacokinetic Perspective on the Clinical Utility of Albumin-Based Dose Adjustments in Critically Ill Patients.

T'jollyn H, Vermeulen A, Van Bocxlaer J, Colin P.

Clin Pharmacokinet. 2018 Jan;57(1):59-69. doi: 10.1007/s40262-017-0549-x.

PMID:
28497260
3.

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

T'jollyn H, Snoeys J, Van Bocxlaer J, De Bock L, Annaert P, Van Peer A, Allegaert K, Mannens G, Vermeulen A, Boussery K.

Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543. doi: 10.1007/s13318-016-0355-0.

PMID:
27317395
4.

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

T'jollyn H, Snoeys J, Vermeulen A, Michelet R, Cuyckens F, Mannens G, Van Peer A, Annaert P, Allegaert K, Van Bocxlaer J, Boussery K.

AAPS J. 2015 Nov;17(6):1376-87. doi: 10.1208/s12248-015-9803-z. Epub 2015 Jul 25.

5.

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

T'jollyn H, Snoeys J, Colin P, Van Bocxlaer J, Annaert P, Cuyckens F, Vermeulen A, Van Peer A, Allegaert K, Mannens G, Boussery K.

Pharm Res. 2015 Jan;32(1):260-74. doi: 10.1007/s11095-014-1460-x. Epub 2014 Jul 22.

PMID:
25048637
6.

Moxifloxacin dosing in post-bariatric surgery patients.

Colin P, Eleveld DJ, Struys MM, T'Jollyn H, Bortel LM, Ruige J, De Waele J, Van Bocxlaer J, Boussery K.

Br J Clin Pharmacol. 2014 Jul;78(1):84-93. doi: 10.1111/bcp.12302.

7.

Development and validation of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry.

Colin P, De Bock L, T'jollyn H, Boussery K, Van Bocxlaer J.

Talanta. 2013 Jan 15;103:285-93. doi: 10.1016/j.talanta.2012.10.046. Epub 2012 Oct 27.

PMID:
23200389
8.

Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity.

De Bock L, Boussery K, Colin P, De Smet J, T'jollyn H, Van Bocxlaer J.

Talanta. 2012 Jan 30;89:209-16. doi: 10.1016/j.talanta.2011.11.083. Epub 2011 Dec 9.

PMID:
22284482
9.

Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use.

T'jollyn H, Boussery K, Mortishire-Smith RJ, Coe K, De Boeck B, Van Bocxlaer JF, Mannens G.

Drug Metab Dispos. 2011 Nov;39(11):2066-75. doi: 10.1124/dmd.111.039982. Epub 2011 Aug 10.

PMID:
21832003

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