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Items: 1 to 50 of 168

1.

Pankreatische Pannikulitis mit Polyarthritis (PPP-Syndrom).

Braun A, Franke I, Tüting T, Gaffal E.

J Dtsch Dermatol Ges. 2019 May;17(5):546-548. doi: 10.1111/ddg.13839_g. No abstract available.

PMID:
31115981
2.

Pancreatic panniculitis with polyarthritis (PPP syndrome).

Braun A, Franke I, Tüting T, Gaffal E.

J Dtsch Dermatol Ges. 2019 May;17(5):546-547. doi: 10.1111/ddg.13839. Epub 2019 Apr 17. No abstract available.

PMID:
30994265
3.

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E.

Sci Signal. 2019 Mar 19;12(573). pii: eaau5948. doi: 10.1126/scisignal.aau5948.

PMID:
30890659
4.

Live or Let Die: T Cell Survival in Cancer Immunotherapy.

Ruotsalainen J, Tüting T.

Immunity. 2019 Feb 19;50(2):280-282. doi: 10.1016/j.immuni.2019.01.016.

PMID:
30784574
5.

Author Correction: Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin.

Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T.

Nature. 2019 Feb;566(7745):E10. doi: 10.1038/s41586-019-0958-0.

PMID:
30742076
6.

Age as key factor for pattern, timing, and extent of distant metastasis in patients with cutaneous melanoma: A study of the German Central Malignant Melanoma Registry.

Gassenmaier M, Keim U, Leiter U, Eigentler TK, Röcken M, Gesierich A, Moritz RKC, Heinzerling L, Tüting T, Wollina U, Garbe C.

J Am Acad Dermatol. 2019 May;80(5):1299-1307.e7. doi: 10.1016/j.jaad.2019.01.044. Epub 2019 Jan 29.

PMID:
30703453
7.

[Personalized medicine].

Eyerich K, Tüting T.

Hautarzt. 2019 Jan;70(1):4. doi: 10.1007/s00105-018-4331-2. German. No abstract available.

PMID:
30635691
8.

Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin.

Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T.

Nature. 2019 Jan;565(7739):366-371. doi: 10.1038/s41586-018-0812-9. Epub 2018 Dec 31. Erratum in: Nature. 2019 Feb;566(7745):E10.

PMID:
30598548
9.

Detection of a multilineage mosaic NRAS mutation c.181C>A (p.Gln61Lys) in an individual with a complex congenital nevus syndrome.

Ulrich M, Tinschert S, Siebert E, Franke I, Tüting T, Ulrich J, Schanze D, Wieland I, Zenker M.

Pigment Cell Melanoma Res. 2019 May;32(3):470-473. doi: 10.1111/pcmr.12761. Epub 2018 Dec 21. No abstract available.

PMID:
30548225
10.

Restoration of Endogenous Retrovirus Infectivity Impacts Mouse Cancer Models.

Ottina E, Levy P, Eksmond U, Merkenschlager J, Young GR, Roels J, Stoye JP, Tüting T, Calado DP, Kassiotis G.

Cancer Immunol Res. 2018 Nov;6(11):1292-1300. doi: 10.1158/2326-6066.CIR-18-0038. Epub 2018 Aug 24.

11.

RNA-seq analysis identifies different transcriptomic types and developmental trajectories of primary melanomas.

Kunz M, Löffler-Wirth H, Dannemann M, Willscher E, Doose G, Kelso J, Kottek T, Nickel B, Hopp L, Landsberg J, Hoffmann S, Tüting T, Zigrino P, Mauch C, Utikal J, Ziemer M, Schulze HJ, Hölzel M, Roesch A, Kneitz S, Meierjohann S, Bosserhoff A, Binder H, Schartl M.

Oncogene. 2018 Nov;37(47):6136-6151. doi: 10.1038/s41388-018-0385-y. Epub 2018 Jul 11.

PMID:
29995873
12.

Widespread spontaneous hyperproliferation, melanosis and melanoma in Hgf-Cdk4R24C mice.

van der Weyden L, Arends MJ, Brenn T, Tuting T, Adams DJ.

Melanoma Res. 2018 Feb;28(1):76-78. doi: 10.1097/CMR.0000000000000414. No abstract available.

13.

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M.

Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.

14.

Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients.

Teramoto Y, Keim U, Gesierich A, Schuler G, Fiedler E, Tüting T, Ulrich C, Wollina U, Hassel JC, Gutzmer R, Goerdt S, Zouboulis C, Leiter U, Eigentler TK, Garbe C.

Br J Dermatol. 2018 Feb;178(2):443-451. doi: 10.1111/bjd.15803. Epub 2017 Dec 20.

PMID:
28707317
15.

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.

Layer JP, Kronmüller MT, Quast T, van den Boorn-Konijnenberg D, Effern M, Hinze D, Althoff K, Schramm A, Westermann F, Peifer M, Hartmann G, Tüting T, Kolanus W, Fischer M, Schulte J, Hölzel M.

Oncoimmunology. 2017 Apr 28;6(6):e1320626. doi: 10.1080/2162402X.2017.1320626. eCollection 2017.

16.

MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy.

Reinhardt J, Landsberg J, Schmid-Burgk JL, Ramis BB, Bald T, Glodde N, Lopez-Ramos D, Young A, Ngiow SF, Nettersheim D, Schorle H, Quast T, Kolanus W, Schadendorf D, Long GV, Madore J, Scolyer RA, Ribas A, Smyth MJ, Tumeh PC, Tüting T, Hölzel M.

Cancer Res. 2017 Sep 1;77(17):4697-4709. doi: 10.1158/0008-5472.CAN-17-0395. Epub 2017 Jun 26.

17.

Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis.

Giebeler N, Schönefuß A, Landsberg J, Tüting T, Mauch C, Zigrino P.

Oncogene. 2017 Aug 31;36(35):5058-5067. doi: 10.1038/onc.2017.162. Epub 2017 May 29.

PMID:
28553955
18.

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.

Engel C, Brügmann G, Lambing S, Mühlenbeck LH, Marx S, Hagen C, Horváth D, Goldeck M, Ludwig J, Herzner AM, Drijfhout JW, Wenzel D, Coch C, Tüting T, Schlee M, Hornung V, Hartmann G, Van den Boorn JG.

Cancer Immunol Res. 2017 Jun;5(6):455-467. doi: 10.1158/2326-6066.CIR-16-0129-T. Epub 2017 May 3.

19.

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.

Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S.

J Exp Med. 2017 Feb;214(2):339-358. doi: 10.1084/jem.20160596. Epub 2017 Jan 17.

20.

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tüting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Hölzel M, Goding CR.

Genes Dev. 2017 Jan 1;31(1):18-33. doi: 10.1101/gad.290940.116. Epub 2017 Jan 17.

21.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.

22.

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.

Reuten R, Patel TR, McDougall M, Rama N, Nikodemus D, Gibert B, Delcros JG, Prein C, Meier M, Metzger S, Zhou Z, Kaltenberg J, McKee KK, Bald T, Tüting T, Zigrino P, Djonov V, Bloch W, Clausen-Schaumann H, Poschl E, Yurchenco PD, Ehrbar M, Mehlen P, Stetefeld J, Koch M.

Nat Commun. 2016 Nov 30;7:13515. doi: 10.1038/ncomms13515.

23.

Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells.

Sektioglu IM, Carretero R, Bulbuc N, Bald T, Tüting T, Rudensky AY, Hämmerling GJ.

Cancer Res. 2017 Jan 15;77(2):291-302. doi: 10.1158/0008-5472.CAN-16-0993. Epub 2016 Nov 22.

24.

RIG-I activation induces the release of extracellular vesicles with antitumor activity.

Daßler-Plenker J, Reiners KS, van den Boorn JG, Hansen HP, Putschli B, Barnert S, Schuberth-Wagner C, Schubert R, Tüting T, Hallek M, Schlee M, Hartmann G, Pogge von Strandmann E, Coch C.

Oncoimmunology. 2016 Aug 19;5(10):e1219827. eCollection 2016.

25.

Die tumorimmunologische Revolution in der Behandlung des fortgeschrittenen Melanoms.

Tüting T.

J Dtsch Dermatol Ges. 2016 Jul;14(7):655-6. doi: 10.1111/ddg.13094. No abstract available.

PMID:
27373238
26.

Inflammasome-Dependent Induction of Adaptive NK Cell Memory.

van den Boorn JG, Jakobs C, Hagen C, Renn M, Luiten RM, Melief CJ, Tüting T, Garbi N, Hartmann G, Hornung V.

Immunity. 2016 Jun 21;44(6):1406-21. doi: 10.1016/j.immuni.2016.05.008. Epub 2016 Jun 7.

27.

Inflammation-Induced Plasticity in Melanoma Therapy and Metastasis.

Hölzel M, Tüting T.

Trends Immunol. 2016 Jun;37(6):364-374. doi: 10.1016/j.it.2016.03.009. Epub 2016 Apr 15. Review.

PMID:
27151281
28.

CANCER. How neutrophils promote metastasis.

Tüting T, de Visser KE.

Science. 2016 Apr 8;352(6282):145-6. doi: 10.1126/science.aaf7300. No abstract available.

PMID:
27124439
29.

A stochastic model for immunotherapy of cancer.

Baar M, Coquille L, Mayer H, Hölzel M, Rogava M, Tüting T, Bovier A.

Sci Rep. 2016 Apr 11;6:24169. doi: 10.1038/srep24169.

30.

Phorbol ester-induced neutrophilic inflammatory responses selectively promote metastatic spread of melanoma in a TLR4-dependent manner.

Bald T, Landsberg J, Jansen P, Gaffal E, Tüting T.

Oncoimmunology. 2015 Sep 1;5(2):e1078964. eCollection 2016 Feb.

31.

The Role of Neutrophilic Inflammation, Angiotropism, and Pericytic Mimicry in Melanoma Progression and Metastasis.

Landsberg J, Tüting T, Barnhill RL, Lugassy C.

J Invest Dermatol. 2016 Feb;136(2):372-377. doi: 10.1016/j.jid.2015.11.013. Review.

32.

Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells.

Knappe N, Novak D, Weina K, Bernhardt M, Reith M, Larribere L, Hölzel M, Tüting T, Gebhardt C, Umansky V, Utikal J.

Stem Cells. 2016 Apr;34(4):832-46. doi: 10.1002/stem.2284. Epub 2016 Jan 19.

33.

Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells.

Lu KH, Tounsi A, Shridhar N, Küblbeck G, Klevenz A, Prokosch S, Bald T, Tüting T, Arnold B.

Front Immunol. 2015 Dec 24;6:645. doi: 10.3389/fimmu.2015.00645. eCollection 2015.

34.

Overexpression of hepatocyte growth factor and an oncogenic CDK4 variant in mice alters corneal stroma morphology but does not lead to spontaneous ocular melanoma.

Kilian MM, Herwig MC, Holz FG, Tüting T, Loeffler KU.

Melanoma Res. 2016 Feb;26(1):89-91. doi: 10.1097/CMR.0000000000000206. No abstract available.

PMID:
26731561
35.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

36.

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.

Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, Kohlmeyer J, Renn M, Phung B, Aymans P, Schmidt T, Hornung V, Davidson I, Goding CR, Jönsson G, Landsberg J, Tüting T, Hölzel M.

Nat Commun. 2015 Nov 4;6:8755. doi: 10.1038/ncomms9755.

37.

A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells.

Hölzel M, Landsberg J, Glodde N, Bald T, Rogava M, Riesenberg S, Becker A, Jönsson G, Tüting T.

Cancer Res. 2016 Jan 15;76(2):251-63. doi: 10.1158/0008-5472.CAN-15-1090. Epub 2015 Oct 28.

38.

Differential role of cannabinoids in the pathogenesis of skin cancer.

Glodde N, Jakobs M, Bald T, Tüting T, Gaffal E.

Life Sci. 2015 Oct 1;138:35-40. doi: 10.1016/j.lfs.2015.04.003. Epub 2015 Apr 25.

PMID:
25921771
39.

Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity.

Meister M, Tounsi A, Gaffal E, Bald T, Papatriantafyllou M, Ludwig J, Pougialis G, Bestvater F, Klotz L, Moldenhauer G, Tüting T, Hämmerling GJ, Arnold B, Oelert T.

J Invest Dermatol. 2015 Aug;135(8):1996-2004. doi: 10.1038/jid.2015.130. Epub 2015 Apr 2.

40.

Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus.

Kunz M, König IR, Schillert A, Kruppa J, Ziegler A, Grallert H, Müller-Nurasyid M, Lieb W, Franke A, Ranki A, Panelius J, Koskenmies S, Hasan T, Kere J, Rönn AC, Simon JC, Schmidt E, Wenzel J, Tüting T, Landsberg J, Zeller T, Blankenberg S, Gläser R, Patsinakidis N, Kuhn A, Ibrahim SM.

Exp Dermatol. 2015 Jul;24(7):510-5. doi: 10.1111/exd.12708. Epub 2015 May 4.

PMID:
25827949
41.

"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.

Day CP, Carter J, Weaver Ohler Z, Bonomi C, El Meskini R, Martin P, Graff-Cherry C, Feigenbaum L, Tüting T, Van Dyke T, Hollingshead M, Merlino G.

PLoS One. 2014 Nov 4;9(11):e109956. doi: 10.1371/journal.pone.0109956. eCollection 2014.

42.

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L.

Nat Med. 2014 Nov;20(11):1301-9. doi: 10.1038/nm.3708. Epub 2014 Oct 26.

PMID:
25344738
43.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

44.

Cannabinoid 1 receptors in keratinocytes attenuate fluorescein isothiocyanate-induced mouse atopic-like dermatitis.

Gaffal E, Glodde N, Jakobs M, Bald T, Tüting T.

Exp Dermatol. 2014 Jun;23(6):401-6. doi: 10.1111/exd.12414.

PMID:
24750433
45.

Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation.

Bald T, Landsberg J, Lopez-Ramos D, Renn M, Glodde N, Jansen P, Gaffal E, Steitz J, Tolba R, Kalinke U, Limmer A, Jönsson G, Hölzel M, Tüting T.

Cancer Discov. 2014 Jun;4(6):674-87. doi: 10.1158/2159-8290.CD-13-0458. Epub 2014 Mar 3.

46.

β-arrestin 2 inhibits proinflammatory chemokine production and attenuates contact allergic inflammation in the skin.

Gaffal E, Jakobs M, Glodde N, Schröder R, Kostenis E, Tüting T.

J Invest Dermatol. 2014 Aug;134(8):2131-2137. doi: 10.1038/jid.2014.117. Epub 2014 Feb 27.

47.

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T.

Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26.

PMID:
24572365
48.

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, Tüting T, Hartmann G, Barchet W.

Immunity. 2013 Sep 19;39(3):482-95. doi: 10.1016/j.immuni.2013.08.004. Epub 2013 Aug 29.

49.

Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors.

Gaffal E, Cron M, Glodde N, Tüting T.

Allergy. 2013 Aug;68(8):994-1000. doi: 10.1111/all.12183. Epub 2013 Jul 29.

PMID:
23889474
50.

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