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Items: 1 to 50 of 299

1.

Multicentre standardisation of chest MRI as radiation-free outcome measure of lung disease in young children with cystic fibrosis.

Wielpütz MO, von Stackelberg O, Stahl M, Jobst BJ, Eichinger M, Puderbach MU, Nährlich L, Barth S, Schneider C, Kopp MV, Ricklefs I, Buchholz M, Tümmler B, Dopfer C, Vogel-Claussen J, Kauczor HU, Mall MA.

J Cyst Fibros. 2018 Jul;17(4):518-527. doi: 10.1016/j.jcf.2018.05.003. Epub 2018 May 25.

PMID:
29805050
2.

[CF Lung Disease - a German S3 Guideline: Module 2: Diagnostics and Treatment in Chronic Infection with Pseudomonas aeruginosa].

Schwarz C, Schulte-Hubbert B, Bend J, Abele-Horn M, Baumann I, Bremer W, Brunsmann F, Dieninghoff D, Eickmeier O, Ellemunter H, Fischer R, Grosse-Onnebrink J, Hammermann J, Hebestreit H, Hogardt M, Hügel C, Hug M, Illing S, Jung A, Kahl B, Koitschev A, Mahlberg R, Mainz JG, Mattner F, Mehl A, Möller A, Muche-Borowski C, Nüßlein T, Puderbach M, Renner S, Rietschel E, Ringshausen FC, Schmidt S, Sedlacek L, Sitter H, Smaczny C, Tümmler B, Vonberg R, Wielpütz MO, Wilkens H, Wollschläger B, Zerlik J, Düesberg U, van Koningsbruggen-Rietschel S.

Pneumologie. 2018 May;72(5):347-392. doi: 10.1055/s-0044-100191. Epub 2018 May 14. German.

PMID:
29758578
3.

Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs.

Klockgether J, Cramer N, Fischer S, Wiehlmann L, Tümmler B.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):246-256. doi: 10.1165/rcmb.2017-0356OC.

PMID:
29470920
4.

The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C.

Open Biol. 2018 Jan;8(1). pii: 170250. doi: 10.1098/rsob.170250.

5.

Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis.

Graeber SY, Dopfer C, Naehrlich L, Gyulumyan L, Scheuermann H, Hirtz S, Wege S, Mairbäurl H, Dorda M, Hyde R, Bagheri-Hanson A, Rueckes-Nilges C, Fischer S, Mall MA, Tümmler B.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1433-1442. doi: 10.1164/rccm.201710-1983OC.

PMID:
29327948
6.

Airway microbial metagenomics.

Pienkowska K, Wiehlmann L, Tümmler B.

Microbes Infect. 2017 Dec 26. pii: S1286-4579(17)30224-1. doi: 10.1016/j.micinf.2017.12.002. [Epub ahead of print]

PMID:
29287982
7.

An informative intragenic microsatellite marker suggests the IL-1 receptor as a genetic modifier in cystic fibrosis.

Stanke F, Hector A, Hedtfeld S, Hartl D, Griese M, Tümmler B, Mall MA.

Eur Respir J. 2017 Dec 28;50(6). pii: 1700426. doi: 10.1183/13993003.00426-2017. Print 2017 Dec. No abstract available.

PMID:
29284683
8.

Functional lung MRI for regional monitoring of patients with cystic fibrosis.

Kaireit TF, Sorrentino SA, Renne J, Schoenfeld C, Voskrebenzev A, Gutberlet M, Schulz A, Jakob PM, Hansen G, Wacker F, Welte T, Tümmler B, Vogel-Claussen J.

PLoS One. 2017 Dec 7;12(12):e0187483. doi: 10.1371/journal.pone.0187483. eCollection 2017.

9.

Recent advances in understanding Pseudomonas aeruginosa as a pathogen.

Klockgether J, Tümmler B.

F1000Res. 2017 Jul 28;6:1261. doi: 10.12688/f1000research.10506.1. eCollection 2017. Review.

10.

Adherence of Pseudomonas aeruginosa to cystic fibrosis buccal epithelial cells.

Lingner M, Herrmann S, Tümmler B.

ERJ Open Res. 2017 Jan 17;3(1). pii: 00095-2016. doi: 10.1183/23120541.00095-2016. eCollection 2017 Jan.

11.

Impact of sample processing on human airways microbial metagenomes.

Wiehlmann L, Pienkowska K, Hedtfeld S, Dorda M, Tümmler B.

J Biotechnol. 2017 May 20;250:51-55. doi: 10.1016/j.jbiotec.2017.01.001. Epub 2017 Jan 23.

PMID:
28119120
12.

Variability of sweat chloride - A never ending story.

Tümmler B.

J Cyst Fibros. 2017 Jan;16(1):7-8. doi: 10.1016/j.jcf.2016.11.010. Epub 2016 Dec 7. No abstract available.

PMID:
27964834
13.

Key role of an ADP - ribose - dependent transcriptional regulator of NAD metabolism for fitness and virulence of Pseudomonas aeruginosa.

Okon E, Dethlefsen S, Pelnikevich A, Barneveld AV, Munder A, Tümmler B.

Int J Med Microbiol. 2017 Jan;307(1):83-94. doi: 10.1016/j.ijmm.2016.09.007. Epub 2016 Nov 5.

PMID:
27865623
14.

Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus.

Junge S, Görlich D, den Reijer M, Wiedemann B, Tümmler B, Ellemunter H, Dübbers A, Küster P, Ballmann M, Koerner-Rettberg C, Große-Onnebrink J, Heuer E, Sextro W, Mainz JG, Hammermann J, Riethmüller J, Graepler-Mainka U, Staab D, Wollschläger B, Szczepanski R, Schuster A, Tegtmeyer FK, Sutharsan S, Wald A, Nofer JR, van Wamel W, Becker K, Peters G, Kahl BC.

PLoS One. 2016 Nov 18;11(11):e0166220. doi: 10.1371/journal.pone.0166220. eCollection 2016.

15.

Multilocus amplicon sequencing of Pseudomonas aeruginosa cystic fibrosis airways isolates collected prior to and after early antipseudomonal chemotherapy.

Fischer S, Greipel L, Klockgether J, Dorda M, Wiehlmann L, Cramer N, Tümmler B.

J Cyst Fibros. 2017 May;16(3):346-352. doi: 10.1016/j.jcf.2016.10.013. Epub 2016 Nov 8.

PMID:
27836448
16.

Three-base periodicity of sites of sequence variation in Pseudomonas aeruginosa and Staphylococcus aureus core genomes.

Morán Losada P, Fischer S, Chouvarine P, Tümmler B.

FEBS Lett. 2016 Oct;590(20):3538-3543. doi: 10.1002/1873-3468.12431. Epub 2016 Oct 4.

17.

Filtration and Normalization of Sequencing Read Data in Whole-Metagenome Shotgun Samples.

Chouvarine P, Wiehlmann L, Moran Losada P, DeLuca DS, Tümmler B.

PLoS One. 2016 Oct 19;11(10):e0165015. doi: 10.1371/journal.pone.0165015. eCollection 2016.

18.

Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP.

Awah CU, Tamm S, Hedtfeld S, Steinemann D, Tümmler B, Tsiavaliaris G, Stanke F.

Biochim Biophys Acta. 2016 Nov;1859(11):1411-1428. doi: 10.1016/j.bbagrm.2016.09.002. Epub 2016 Sep 9.

PMID:
27616356
19.

The cystic fibrosis lower airways microbial metagenome.

Moran Losada P, Chouvarine P, Dorda M, Hedtfeld S, Mielke S, Schulz A, Wiehlmann L, Tümmler B.

ERJ Open Res. 2016 May 9;2(2). pii: 00096-2015. eCollection 2016 Apr.

20.

SNP synteny analysis of Staphylococcus aureus and Pseudomonas aeruginosa population genomics.

Losada PM, Tümmler B.

FEMS Microbiol Lett. 2016 Oct 3. pii: fnw229. [Epub ahead of print]

PMID:
27702754
21.

Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients.

Greipel L, Fischer S, Klockgether J, Dorda M, Mielke S, Wiehlmann L, Cramer N, Tümmler B.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6726-6734. doi: 10.1128/AAC.00724-16. Print 2016 Nov.

22.

Classification of CFTR mutation classes.

Stanke F, Tümmler B.

Lancet Respir Med. 2016 Aug;4(8):e36. doi: 10.1016/S2213-2600(16)30147-3. Epub 2016 Jul 1. No abstract available.

PMID:
27377412
23.

[Treatment of Cystic Fibrosis with CFTR Modulators].

Tümmler B.

Pneumologie. 2016 May;70(5):301-13. doi: 10.1055/s-0042-100607. Epub 2016 Feb 19. Review. German.

PMID:
26894479
24.

Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G.

Environ Microbiol. 2016 Oct;18(10):3390-3402. doi: 10.1111/1462-2920.13208. Epub 2016 Feb 4.

PMID:
26743546
25.

Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection.

Bianconi I, Jeukens J, Freschi L, Alcalá-Franco B, Facchini M, Boyle B, Molinaro A, Kukavica-Ibrulj I, Tümmler B, Levesque RC, Bragonzi A.

BMC Genomics. 2015 Dec 29;16:1105. doi: 10.1186/s12864-015-2276-8.

26.

Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14.

Fischer S, Klockgether J, Morán Losada P, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Dorda M, Goesmann A, Hilker R, Mielke S, Schönfelder T, Suerbaum S, Türk O, Woltemate S, Wiehlmann L, Tümmler B.

Environ Microbiol Rep. 2016 Apr;8(2):227-34. doi: 10.1111/1758-2229.12372. Epub 2016 Jan 28.

27.

Intestinal Current Measurements Detect Activation of Mutant CFTR in Patients with Cystic Fibrosis with the G551D Mutation Treated with Ivacaftor.

Graeber SY, Hug MJ, Sommerburg O, Hirtz S, Hentschel J, Heinzmann A, Dopfer C, Schulz A, Mainz JG, Tümmler B, Mall MA.

Am J Respir Crit Care Med. 2015 Nov 15;192(10):1252-5. doi: 10.1164/rccm.201507-1271LE. No abstract available.

PMID:
26568242
28.

Non-allergic asthma as a CFTR-related disorder.

Schulz A, Tümmler B.

J Cyst Fibros. 2016 Sep;15(5):641-4. doi: 10.1016/j.jcf.2015.10.011. Epub 2015 Oct 31.

29.

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.

Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, Larose S, Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, Camara M, Cantin A, Charette SJ, Dewar K, Déziel É, Grimwood K, Hancock RE, Harrison JJ, Heeb S, Jelsbak L, Jia B, Kenna DT, Kidd TJ, Klockgether J, Lam JS, Lamont IL, Lewenza S, Loman N, Malouin F, Manos J, McArthur AG, McKeown J, Milot J, Naghra H, Nguyen D, Pereira SK, Perron GG, Pirnay JP, Rainey PB, Rousseau S, Santos PM, Stephenson A, Taylor V, Turton JF, Waglechner N, Williams P, Thrane SW, Wright GD, Brinkman FS, Tucker NP, Tümmler B, Winstanley C, Levesque RC.

Front Microbiol. 2015 Sep 29;6:1036. doi: 10.3389/fmicb.2015.01036. eCollection 2015.

30.

Nasal potential difference of carriers of the W493R ENaC variant with non-cystic fibrosis bronchiectasis.

Rademacher J, Schulz A, Hedtfeld S, Stanke F, Ringshausen F, Welte T, Tümmler B.

Eur Respir J. 2016 Jan;47(1):322-4. doi: 10.1183/13993003.01128-2015. Epub 2015 Oct 9. No abstract available.

31.

Habitat-associated skew of clone abundance in the Pseudomonas aeruginosa population.

Wiehlmann L, Cramer N, Tümmler B.

Environ Microbiol Rep. 2015 Dec;7(6):955-60. doi: 10.1111/1758-2229.12340.

PMID:
26419222
32.

Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection.

Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS.

Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200. Epub 2015 Jul 27.

33.

Origins of cystic fibrosis lung disease.

Munder A, Tümmler B.

N Engl J Med. 2015 Apr 16;372(16):1574. doi: 10.1056/NEJMc1502191. No abstract available.

PMID:
25875272
34.

cCMP and cUMP occur in vivo.

Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V, Seifert R.

Biochem Biophys Res Commun. 2015 May 15;460(4):909-14. doi: 10.1016/j.bbrc.2015.03.115. Epub 2015 Mar 31.

35.

Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.

Chillappagari S, Venkatesan S, Garapati V, Mahavadi P, Munder A, Seubert A, Sarode G, Guenther A, Schmeck BT, Tümmler B, Henke MO.

Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L791-9. doi: 10.1152/ajplung.00167.2014. Epub 2014 Sep 19.

36.

Current concepts: host-pathogen interactions in cystic fibrosis airways disease.

Tang AC, Turvey SE, Alves MP, Regamey N, Tümmler B, Hartl D.

Eur Respir Rev. 2014 Sep;23(133):320-32. doi: 10.1183/09059180.00006113. Review.

37.

Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment.

Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Fischer S, Peng H, Schönfelder T, Türk O, Wiehlmann L, Wölbeling F, Gulbins E, Goesmann A, Tümmler B.

Environ Microbiol. 2015 Jan;17(1):29-46. doi: 10.1111/1462-2920.12606. Epub 2014 Sep 29.

PMID:
25156090
38.

AhR sensing of bacterial pigments regulates antibacterial defence.

Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH.

Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13.

PMID:
25119038
39.

Gerd Döring (1948-2013).

Tümmler B, Haas D.

FEMS Microbiol Lett. 2014 Jul;356(2):250-1. doi: 10.1111/1574-6968.12508. Epub 2014 Jun 30. No abstract available.

40.

The stony road to phe508del CFTR pharmacotherapy: smoothing the first rock.

Tümmler B.

Lancet Respir Med. 2014 Jul;2(7):508-9. doi: 10.1016/S2213-2600(14)70136-5. Epub 2014 Jun 24. No abstract available.

PMID:
24973279
41.

In vivo imaging of bioluminescent Pseudomonas aeruginosa in an acute murine airway infection model.

Munder A, Wölbeling F, Klockgether J, Wiehlmann L, Tümmler B.

Pathog Dis. 2014 Oct;72(1):74-7. doi: 10.1111/2049-632X.12184. Epub 2014 Jun 30.

PMID:
24833236
42.

Assessing Pseudomonas virulence using mammalian models: acute infection model.

Munder A, Tümmler B.

Methods Mol Biol. 2014;1149:773-91. doi: 10.1007/978-1-4939-0473-0_59.

PMID:
24818949
43.

Genotyping methods.

Tümmler B.

Methods Mol Biol. 2014;1149:33-47. doi: 10.1007/978-1-4939-0473-0_5.

PMID:
24818895
44.

The extensive set of accessory Pseudomonas aeruginosa genomic components.

Pohl S, Klockgether J, Eckweiler D, Khaledi A, Schniederjans M, Chouvarine P, Tümmler B, Häussler S.

FEMS Microbiol Lett. 2014 Jul;356(2):235-41. doi: 10.1111/1574-6968.12445. Epub 2014 May 12.

45.

Genome Sequence of Burkholderia cenocepacia H111, a Cystic Fibrosis Airway Isolate.

Carlier A, Agnoli K, Pessi G, Suppiger A, Jenul C, Schmid N, Tümmler B, Pinto-Carbo M, Eberl L.

Genome Announc. 2014 Apr 10;2(2). pii: e00298-14. doi: 10.1128/genomeA.00298-14.

46.

Advances in understanding Pseudomonas.

Tümmler B, Wiehlmann L, Klockgether J, Cramer N.

F1000Prime Rep. 2014 Feb 3;6:9. doi: 10.12703/P6-9. eCollection 2014. Review.

47.

Mutation-specific therapy in cystic fibrosis: the earlier, the better.

Tümmler B.

Lancet Respir Med. 2013 Oct;1(8):591-592. doi: 10.1016/S2213-2600(13)70186-3. Epub 2013 Sep 10. No abstract available.

PMID:
24461654
48.

Developing an international Pseudomonas aeruginosa reference panel.

De Soyza A, Hall AJ, Mahenthiralingam E, Drevinek P, Kaca W, Drulis-Kawa Z, Stoitsova SR, Toth V, Coenye T, Zlosnik JE, Burns JL, Sá-Correia I, De Vos D, Pirnay JP, Kidd TJ, Reid D, Manos J, Klockgether J, Wiehlmann L, Tümmler B, McClean S, Winstanley C; EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens”.

Microbiologyopen. 2013 Dec;2(6):1010-23. doi: 10.1002/mbo3.141. Epub 2013 Nov 11.

49.

The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells.

Stanke F, van Barneveld A, Hedtfeld S, Wölfl S, Becker T, Tümmler B.

Eur J Hum Genet. 2014 May;22(5):660-6. doi: 10.1038/ejhg.2013.209. Epub 2013 Oct 9.

50.

Nasal potential difference measurements in diagnosis of cystic fibrosis: an international survey.

Naehrlich L, Ballmann M, Davies J, Derichs N, Gonska T, Hjelte L, van Konigsbruggen-Rietschel S, Leal T, Melotti P, Middleton P, Tümmler B, Vermeulen F, Wilschanski M; ECFS Diagnostic Network Working Group.

J Cyst Fibros. 2014 Jan;13(1):24-8. doi: 10.1016/j.jcf.2013.08.006. Epub 2013 Sep 7.

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