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The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease. Desler C et al. Curr Med Chem. (2018)

Tuberculosis Outbreak in an Educational Institution in Norway. Norheim G et al. J Clin Microbiol. (2017)

A non-canonical mismatch repair pathway in prokaryotes. Castañeda-García A et al. Nat Commun. (2017)

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Items: 1 to 50 of 106


Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide.

Shi W, Cui P, Niu H, Zhang S, Tønjum T, Zhu B, Zhang Y.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e02681-18. doi: 10.1128/AAC.02681-18. Print 2019 Jun.


Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex.

Birhanu AG, Yimer SA, Kalayou S, Riaz T, Zegeye ED, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T.

Sci Rep. 2019 Feb 27;9(1):2927. doi: 10.1038/s41598-019-39654-9.


A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis.

Alfsnes K, Frye SA, Eriksson J, Eldholm V, Brynildsrud OB, Bohlin J, Harrison OB, Hood DW, Maiden MCJ, Tønjum T, Ambur OH.

Microb Genom. 2018 Nov;4(11). doi: 10.1099/mgen.0.000222. Epub 2018 Sep 25.


Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood.

Jensen HLB, Lillenes MS, Rabano A, Günther CC, Riaz T, Kalayou ST, Ulstein ID, Bøhmer T, Tønjum T.

Neurosci Lett. 2018 Apr 13;672:53-58. doi: 10.1016/j.neulet.2018.02.043. Epub 2018 Feb 21.


The helicase DinG responds to stress due to DNA double strand breaks.

Frye SA, Beyene GT, Namouchi A, Gómez-Muñoz M, Homberset H, Kalayou S, Riaz T, Tønjum T, Balasingham SV.

PLoS One. 2017 Nov 9;12(11):e0187900. doi: 10.1371/journal.pone.0187900. eCollection 2017.


Nε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains: Proteins Involved in Bioenergetics, Virulence, and Antimicrobial Resistance Are Acetylated.

Birhanu AG, Yimer SA, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T.

J Proteome Res. 2017 Nov 3;16(11):4045-4059. doi: 10.1021/acs.jproteome.7b00429. Epub 2017 Oct 4.


DprA from Neisseria meningitidis: properties and role in natural competence for transformation.

Hovland E, Beyene GT, Frye SA, Homberset H, Balasingham SV, Gómez-Muñoz M, Derrick JP, Tønjum T, Ambur OH.

Microbiology. 2017 Jul;163(7):1016-1029. doi: 10.1099/mic.0.000489. Epub 2017 Jul 21.


The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease.

Desler C, Lillenes MS, Tønjum T, Rasmussen LJ.

Curr Med Chem. 2018;25(40):5578-5587. doi: 10.2174/0929867324666170616110111. Review.


Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence.

Yimer SA, Birhanu AG, Kalayou S, Riaz T, Zegeye ED, Beyene GT, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T.

Front Microbiol. 2017 May 9;8:795. doi: 10.3389/fmicb.2017.00795. eCollection 2017.


Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis.

Beyene GT, Kalayou S, Riaz T, Tonjum T.

BMC Microbiol. 2017 Apr 21;17(1):96. doi: 10.1186/s12866-017-1004-8.


Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance.

Lillenes MS, Støen M, Günther CC, Selnes P, Stenset VT, Espeseth T, Reinvang I, Fladby T, Tønjum T.

Neurosci Lett. 2017 Apr 3;645:46-52. doi: 10.1016/j.neulet.2017.02.062. Epub 2017 Feb 24.


Tuberculosis Outbreak in an Educational Institution in Norway.

Norheim G, Seterelv S, Arnesen TM, Mengshoel AT, Tønjum T, Rønning JO, Eldholm V.

J Clin Microbiol. 2017 May;55(5):1327-1333. doi: 10.1128/JCM.01152-16. Epub 2017 Feb 15.


A non-canonical mismatch repair pathway in prokaryotes.

Castañeda-García A, Prieto AI, Rodríguez-Beltrán J, Alonso N, Cantillon D, Costas C, Pérez-Lago L, Zegeye ED, Herranz M, Plociński P, Tonjum T, García de Viedma D, Paget M, Waddell SJ, Rojas AM, Doherty AJ, Blázquez J.

Nat Commun. 2017 Jan 27;8:14246. doi: 10.1038/ncomms14246.


Characterization of the Neisseria meningitidis Helicase RecG.

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T.

PLoS One. 2016 Oct 13;11(10):e0164588. doi: 10.1371/journal.pone.0164588. eCollection 2016.


The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress.

Namouchi A, Gómez-Muñoz M, Frye SA, Moen LV, Rognes T, Tønjum T, Balasingham SV.

BMC Genomics. 2016 Oct 10;17(1):791.


Deciphering the recent phylogenetic expansion of the originally deeply rooted Mycobacterium tuberculosis lineage 7.

Yimer SA, Namouchi A, Zegeye ED, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T.

BMC Evol Biol. 2016 Jun 30;16(1):146. doi: 10.1186/s12862-016-0715-z.


Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease.

Lillenes MS, Rabano A, Støen M, Riaz T, Misaghian D, Møllersen L, Esbensen Y, Günther CC, Selnes P, Stenset VT, Fladby T, Tønjum T.

Mol Brain. 2016 May 28;9(1):61. doi: 10.1186/s13041-016-0237-z.


The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation.

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T.

PLoS One. 2015 Aug 6;10(8):e0134954. doi: 10.1371/journal.pone.0134954. eCollection 2015.


Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro.

Dahlberg D, Mariussen E, Goverud IL, Tønjum T, Mæhlen J, Antal EA, Hassel B.

Neurotoxicology. 2015 May;48:61-7. doi: 10.1016/j.neuro.2015.03.001. Epub 2015 Mar 7.


Mycobacterium tuberculosis lineage 7 strains are associated with prolonged patient delay in seeking treatment for pulmonary tuberculosis in Amhara Region, Ethiopia.

Yimer SA, Norheim G, Namouchi A, Zegeye ED, Kinander W, Tønjum T, Bekele S, Mannsåker T, Bjune G, Aseffa A, Holm-Hansen C.

J Clin Microbiol. 2015 Apr;53(4):1301-9. doi: 10.1128/JCM.03566-14. Epub 2015 Feb 11.


Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease.

Ricanek P, Lunde LK, Frye SA, Støen M, Nygård S, Morth JP, Rydning A, Vatn MH, Amiry-Moghaddam M, Tønjum T.

Clin Exp Gastroenterol. 2015 Jan 9;8:49-67. doi: 10.2147/CEG.S70119. eCollection 2015.


Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc.

Hassel B, Dahlberg D, Mariussen E, Goverud IL, Antal EA, Tønjum T, Maehlen J.

J Neurosci Res. 2014 Dec;92(12):1792-800. doi: 10.1002/jnr.23444. Epub 2014 Jul 4.


Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations.

Alfsnes K, Raynaud X, Tønjum T, Ambur OH.

PLoS One. 2014 Jul 7;9(7):e101637. doi: 10.1371/journal.pone.0101637. eCollection 2014.


[A knot on the aquarium owner's hand].

Mantaka P, Tønjum T, Gjersvik P.

Tidsskr Nor Laegeforen. 2014 Apr 8;134(7):715. doi: 10.4045/tidsskr.13.1425. eCollection 2014 Apr 8. Norwegian. No abstract available.


Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity.

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Kristiansen PE, Tønjum T.

Microbiology. 2014 Jan;160(Pt 1):217-227. doi: 10.1099/mic.0.072140-0. Epub 2013 Oct 29.


The synergies of microorganisms enlightened - convergent approaches to delineating coinfections.

Klenk HD, Ron E, Sansonetti P, Tønjum T.

Pathog Dis. 2013 Nov;69(2):71. doi: 10.1111/2049-632X.12101. No abstract available.


The glia doctrine: addressing the role of glial cells in healthy brain ageing.

Nagelhus EA, Amiry-Moghaddam M, Bergersen LH, Bjaalie JG, Eriksson J, Gundersen V, Leergaard TB, Morth JP, Storm-Mathisen J, Torp R, Walhovd KB, Tønjum T.

Mech Ageing Dev. 2013 Oct;134(10):449-59. doi: 10.1016/j.mad.2013.10.001. Epub 2013 Oct 17. Review.


Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model.

Lillenes MS, Støen M, Gómez-Muñoz M, Torp R, Günther CC, Nilsson LN, Tønjum T.

Mech Ageing Dev. 2013 Oct;134(10):467-77. doi: 10.1016/j.mad.2013.09.002. Epub 2013 Oct 11.


DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population.

Rasmussen LJ, Shiloh Y, Bergersen LH, Sander M, Bohr VA, Tønjum T.

Mech Ageing Dev. 2013 Oct;134(10):427-33. doi: 10.1016/j.mad.2013.05.001. Epub 2013 May 10. Review. No abstract available.


Dialects of the DNA uptake sequence in Neisseriaceae.

Frye SA, Nilsen M, Tønjum T, Ambur OH.

PLoS Genet. 2013 Apr;9(4):e1003458. doi: 10.1371/journal.pgen.1003458. Epub 2013 Apr 18.


DNA metabolism in mycobacterial pathogenesis.

Warner DF, Tønjum T, Mizrahi V.

Curr Top Microbiol Immunol. 2013;374:27-51. doi: 10.1007/82_2013_328. Review.


Gut bacterial profile in patients newly diagnosed with treatment-naïve Crohn's disease.

Ricanek P, Lothe SM, Frye SA, Rydning A, Vatn MH, Tønjum T.

Clin Exp Gastroenterol. 2012;5:173-86. doi: 10.2147/CEG.S33858. Epub 2012 Sep 24.


Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.

Berry JL, Phelan MM, Collins RF, Adomavicius T, Tønjum T, Frye SA, Bird L, Owens R, Ford RC, Lian LY, Derrick JP.

PLoS Pathog. 2012 Sep;8(9):e1002923. doi: 10.1371/journal.ppat.1002923. Epub 2012 Sep 13.


The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak.

Karch H, Denamur E, Dobrindt U, Finlay BB, Hengge R, Johannes L, Ron EZ, Tønjum T, Sansonetti PJ, Vicente M.

EMBO Mol Med. 2012 Sep;4(9):841-8. doi: 10.1002/emmm.201201662. Epub 2012 Aug 24. Review.


Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis.

Ambur OH, Frye SA, Nilsen M, Hovland E, Tønjum T.

PLoS One. 2012;7(7):e39742. doi: 10.1371/journal.pone.0039742. Epub 2012 Jul 2.


Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions.

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Tønjum T.

Microbiology. 2012 Aug;158(Pt 8):1982-93. doi: 10.1099/mic.0.058693-0. Epub 2012 May 24.


Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.

Balasingham SV, Zegeye ED, Homberset H, Rossi ML, Laerdahl JK, Bohr VA, Tønjum T.

PLoS One. 2012;7(5):e36960. doi: 10.1371/journal.pone.0036960. Epub 2012 May 16.


DNA base excision repair gene polymorphisms modulate human cognitive performance and decline during normal life span.

Lillenes MS, Espeseth T, Støen M, Lundervold AJ, Frye SA, Rootwelt H, Reinvang I, Tønjum T.

Mech Ageing Dev. 2011 Aug;132(8-9):449-58. doi: 10.1016/j.mad.2011.08.002. Epub 2011 Aug 22.


Kiss and run - phosphoglycerol modifications of N. Meningitidis pili mediate detachment.

Tønjum T, Koomey M.

Front Microbiol. 2011 Apr 27;2:82. doi: 10.3389/fmicb.2011.00082. eCollection 2011. No abstract available.


The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage.

Yang M, Aamodt RM, Dalhus B, Balasingham S, Helle I, Andersen P, Tønjum T, Alseth I, Rognes T, Bjørås M.

DNA Repair (Amst). 2011 Jun 10;10(6):595-602. doi: 10.1016/j.dnarep.2011.03.007. Epub 2011 May 12.


Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation.

Benam AV, Lång E, Alfsnes K, Fleckenstein B, Rowe AD, Hovland E, Ambur OH, Frye SA, Tønjum T.

Microbiology. 2011 May;157(Pt 5):1329-42. doi: 10.1099/mic.0.046896-0. Epub 2011 Feb 17.


Paucity of mycobacteria in mucosal bowel biopsies from adults and children with early inflammatory bowel disease.

Ricanek P, Lothe SM, Szpinda I, Jorde AT, Brackmann S, Perminow G, Jørgensen KK, Rydning A, Vatn MH, Tønjum T; IBSEN II study group.

J Crohns Colitis. 2010 Nov;4(5):561-6. doi: 10.1016/j.crohns.2010.05.003. Epub 2010 Jun 18.


Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans.

Aspholm M, Aas FE, Harrison OB, Quinn D, Vik A, Viburiene R, Tønjum T, Moir J, Maiden MC, Koomey M.

PLoS Pathog. 2010 Aug 19;6(8):e1001055. doi: 10.1371/journal.ppat.1001055.


Molecular diagnostics in tuberculosis: basis and implications for therapy.

Balasingham SV, Davidsen T, Szpinda I, Frye SA, Tønjum T.

Mol Diagn Ther. 2009;13(3):137-51. doi: 10.2165/01250444-200913030-00001. Review.


Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats.

Olsen I, Balasingham SV, Davidsen T, Debebe E, Rødland EA, van Soolingen D, Kremer K, Alseth I, Tønjum T.

FEMS Immunol Med Microbiol. 2009 Jul;56(2):151-61. doi: 10.1111/j.1574-695X.2009.00562.x. Epub 2009 Jun 3.


Genome dynamics in major bacterial pathogens.

Ambur OH, Davidsen T, Frye SA, Balasingham SV, Lagesen K, Rognes T, Tønjum T.

FEMS Microbiol Rev. 2009 May;33(3):453-70. Review.


Microbial DNA metabolism, genome dynamics and human disease.

Bayliss CD, Casadesus J, Rocha E, Tønjum T.

FEMS Microbiol Rev. 2009 May;33(3):451-2. No abstract available.


DNA repair in Mycobacterium tuberculosis revisited.

Dos Vultos T, Mestre O, Tonjum T, Gicquel B.

FEMS Microbiol Rev. 2009 May;33(3):471-87. doi: 10.1111/j.1574-6976.2009.00170.x. Review.


Identification of neisserial DNA binding components.

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T.

Microbiology. 2009 Mar;155(Pt 3):852-62. doi: 10.1099/mic.0.022640-0.

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