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Genome-wide DNA methylation profiling identifies two novel genes in cervical neoplasia.

El-Zein M, Cheishvili D, Gotlieb W, Gilbert L, Hemmings R, Behr MA, Szyf M, Franco EL; MARKER study group.

Int J Cancer. 2020 Jan 25. doi: 10.1002/ijc.32880. [Epub ahead of print]


The epigenetics of perinatal stress

Szyf M.

Dialogues Clin Neurosci. 2019 Dec;21(4):369-378. doi: 10.31887/DCNS.2019.21.4/mszyf.


Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children.

Hoye JR, Cheishvili D, Yarger HA, Roth TL, Szyf M, Dozier M.

Dev Psychopathol. 2019 Dec 19:1-9. doi: 10.1017/S0954579419001421. [Epub ahead of print]


Prenatal Glucocorticoid Exposure Results in Changes in Gene Transcription and DNA Methylation in the Female Juvenile Guinea Pig Hippocampus Across Three Generations.

Constantinof A, Boureau L, Moisiadis VG, Kostaki A, Szyf M, Matthews SG.

Sci Rep. 2019 Dec 3;9(1):18211. doi: 10.1038/s41598-019-54456-9.


Differential genome-wide DNA methylation patterns in childhood obesity.

Cao-Lei L, Elgbeili G, Szyf M, Laplante DP, King S.

BMC Res Notes. 2019 Mar 25;12(1):174. doi: 10.1186/s13104-019-4189-0.


A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E.

J Psychiatry Neurosci. 2019 May 1;44(3):205-213.


Antenatal Glucocorticoid Exposure Results in Sex-Specific and Transgenerational Changes in Prefrontal Cortex Gene Transcription that Relate to Behavioural Outcomes.

Constantinof A, Moisiadis VG, Kostaki A, Szyf M, Matthews SG.

Sci Rep. 2019 Jan 24;9(1):764. doi: 10.1038/s41598-018-37088-3.


Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood.

Schmidt M, Lax E, Zhou R, Cheishvili D, Ruder AM, Ludiro A, Lapert F, Macedo da Cruz A, Sandrini P, Calzoni T, Vaisheva F, Brandwein C, Luoni A, Massart R, Lanfumey L, Riva MA, Deuschle M, Gass P, Szyf M.

Transl Psychiatry. 2019 Jan 17;9(1):23. doi: 10.1038/s41398-018-0348-7.


DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation.

Cecil CAM, Walton E, Pingault JB, Provençal N, Pappa I, Vitaro F, Côté S, Szyf M, Tremblay RE, Tiemeier H, Viding E, McCrory EJ.

Am J Med Genet B Neuropsychiatr Genet. 2018 Dec;177(8):746-764. doi: 10.1002/ajmg.b.32689. Epub 2018 Nov 9.


P-Glycoprotein (P-gp)/ABCB1 plays a functional role in extravillous trophoblast (EVT) invasion and is decreased in the pre-eclamptic placenta.

Dunk CE, Pappas JJ, Lye P, Kibschull M, Javam M, Bloise E, Lye SJ, Szyf M, Matthews SG.

J Cell Mol Med. 2018 Nov;22(11):5378-5393. doi: 10.1111/jcmm.13810. Epub 2018 Sep 5.


A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention.

Lax E, Warhaftig G, Ohana D, Maayan R, Delayahu Y, Roska P, Ponizovsky AM, Weizman A, Yadid G, Szyf M.

Front Mol Neurosci. 2018 Sep 10;11:322. doi: 10.3389/fnmol.2018.00322. eCollection 2018.


Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L.

Transl Psychiatry. 2018 Aug 8;8(1):147. doi: 10.1038/s41398-018-0195-6.


Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.

Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L.

Psychoneuroendocrinology. 2018 Nov;97:196-205. doi: 10.1016/j.psyneuen.2018.07.019. Epub 2018 Jul 27.


The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics.

Lax E, Szyf M.

Prog Mol Biol Transl Sci. 2018;157:93-104. doi: 10.1016/bs.pmbts.2018.01.003. Epub 2018 Apr 11. Review.


Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women.

Cheishvili D, Parashar S, Mahmood N, Arakelian A, Kremer R, Goltzman D, Szyf M, Rabbani SA.

J Bone Miner Res. 2018 Nov;33(11):1980-1989. doi: 10.1002/jbmr.3527. Epub 2018 Jul 20.


DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse.

Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V.

Psychiatry Res. 2018 Jul;265:341-348. doi: 10.1016/j.psychres.2018.04.064. Epub 2018 May 8.


DNA methylation signatures of breast cancer in peripheral T-cells.

Parashar S, Cheishvili D, Mahmood N, Arakelian A, Tanvir I, Khan HA, Kremer R, Mihalcioiu C, Szyf M, Rabbani SA.

BMC Cancer. 2018 May 18;18(1):574. doi: 10.1186/s12885-018-4482-7.


Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial.

McMorrow AM, Connaughton RM, Magalhães TR, McGillicuddy FC, Hughes MF, Cheishvili D, Morine MJ, Ennis S, Healy ML, Roche EF, Tremblay RE, Szyf M, Lithander FE, Roche HM.

Mol Nutr Food Res. 2018 May;62(10):e1701008. doi: 10.1002/mnfr.201701008.


The DNA methylation landscape of enhancers in the guinea pig hippocampus.

Boureau L, Constantinof A, Moisiadis VG, Matthews SG, Szyf M.

Epigenomics. 2018 Apr 1;10(4):349-365. doi: 10.2217/epi-2017-0064. Epub 2018 Apr 4.


Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications.

Mahmood N, Cheishvili D, Arakelian A, Tanvir I, Khan HA, Pépin AS, Szyf M, Rabbani SA.

Oncotarget. 2017 Dec 26;9(4):5169-5183. doi: 10.18632/oncotarget.23704. eCollection 2018 Jan 12.


DNA methylation mediates the effect of maternal cognitive appraisal of a disaster in pregnancy on the child's C-peptide secretion in adolescence: Project Ice Storm.

Cao-Lei L, Dancause KN, Elgbeili G, Laplante DP, Szyf M, King S.

PLoS One. 2018 Feb 5;13(2):e0192199. doi: 10.1371/journal.pone.0192199. eCollection 2018.


The signature of liver cancer in immune cells DNA methylation.

Zhang Y, Petropoulos S, Liu J, Cheishvili D, Zhou R, Dymov S, Li K, Li N, Szyf M.

Clin Epigenetics. 2018 Jan 18;10:8. doi: 10.1186/s13148-017-0436-1. eCollection 2018.


S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice.

Ornoy A, Weinstein-Fudim L, Tfilin M, Ergaz Z, Yanai J, Szyf M, Turgeman G.

Neurotoxicol Teratol. 2019 Jan - Feb;71:64-74. doi: 10.1016/ Epub 2018 Jan 16.


S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells.

Wang Y, Sun Z, Szyf M.

Oncotarget. 2017 Dec 5;8(67):111866-111881. doi: 10.18632/oncotarget.22942. eCollection 2017 Dec 19.


Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T.

Neuropsychopharmacology. 2018 Apr;43(5):1138-1145. doi: 10.1038/npp.2017.290. Epub 2017 Nov 28.


Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone.

Enuka Y, Feldman ME, Chowdhury A, Srivastava S, Lindzen M, Sas-Chen A, Massart R, Cheishvili D, Suderman MJ, Zaltsman Y, Mazza CA, Shukla K, Körner C, Furth N, Lauriola M, Oren M, Wiemann S, Szyf M, Yarden Y.

Nucleic Acids Res. 2017 Dec 15;45(22):12681-12699. doi: 10.1093/nar/gkx865.


Prenatal Glucocorticoid Exposure Modifies Endocrine Function and Behaviour for 3 Generations Following Maternal and Paternal Transmission.

Moisiadis VG, Constantinof A, Kostaki A, Szyf M, Matthews SG.

Sci Rep. 2017 Sep 18;7(1):11814. doi: 10.1038/s41598-017-11635-w.


Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.

Gouin JP, Zhou QQ, Booij L, Boivin M, Côté SM, Hébert M, Ouellet-Morin I, Szyf M, Tremblay RE, Turecki G, Vitaro F.

Sci Rep. 2017 Aug 7;7(1):7446. doi: 10.1038/s41598-017-07950-x.


Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L.

Eur Neuropsychopharmacol. 2017 Oct;27(10):1032-1041. doi: 10.1016/j.euroneuro.2017.07.005. Epub 2017 Jul 31.


Epigenetic Alterations and Prenatal Maternal Depression.

Nemoda Z, Szyf M.

Birth Defects Res. 2017 Jul 17;109(12):888-897. doi: 10.1002/bdr2.1081. Review.


Prenatal stress and epigenetics.

Cao-Lei L, de Rooij SR, King S, Matthews SG, Metz GAS, Roseboom TJ, Szyf M.

Neurosci Biobehav Rev. 2017 May 18. pii: S0149-7634(16)30726-6. doi: 10.1016/j.neubiorev.2017.05.016. [Epub ahead of print] Review.


DNA methylation and transcription onset in the brain.

Massart R, Suderman M, Mongrain V, Szyf M.

Epigenomics. 2017 Jun;9(6):797-809. doi: 10.2217/epi-2016-0184. Epub 2017 May 18.


DNA methylation controls unmethylated transcription start sites in the genome in trans.

Cheishvili D, Christiansen S, Stochinsky R, Pepin AS, Sapozhnikov DM, Zhou R, Schmeltzer L, Dymov S, Szyf M.

Epigenomics. 2017 May;9(5):611-633. doi: 10.2217/epi-2016-0141. Epub 2017 May 4.


Anxiety-Related Behaviours Associated with microRNA-206-3p and BDNF Expression in Pregnant Female Mice Following Psychological Social Stress.

Miao Z, Mao F, Liang J, Szyf M, Wang Y, Sun ZS.

Mol Neurobiol. 2018 Feb;55(2):1097-1111. doi: 10.1007/s12035-016-0378-1. Epub 2017 Jan 14.


Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.

Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L.

Hum Brain Mapp. 2017 Apr;38(4):2037-2050. doi: 10.1002/hbm.23503. Epub 2016 Dec 29.


Therapeutic benefits of the methyl donor S-adenosylmethionine on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice.

Grégoire S, Millecamps M, Naso L, Do Carmo S, Cuello AC, Szyf M, Stone LS.

Pain. 2017 May;158(5):802-810. doi: 10.1097/j.pain.0000000000000811.


Prospects for Medications to Reverse Causative Epigenetic Processes in Neuropsychiatry Disorders.

Szyf M.

Neuropsychopharmacology. 2017 Jan;42(1):367-368. doi: 10.1038/npp.2016.219. No abstract available.


Ankyrin-3 as a molecular marker of early-life stress and vulnerability to psychiatric disorders.

Luoni A, Massart R, Nieratschker V, Nemoda Z, Blasi G, Gilles M, Witt SH, Suderman MJ, Suomi SJ, Porcelli A, Rizzo G, Fazio L, Torretta S, Rampino A, Berry A, Gass P, Cirulli F, Rietschel M, Bertolino A, Deuschle M, Szyf M, Riva MA.

Transl Psychiatry. 2016 Nov 8;6(11):e943. doi: 10.1038/tp.2016.211.


The elusive role of 5'-hydroxymethylcytosine.

Szyf M.

Epigenomics. 2016 Nov;8(11):1539-1551. Epub 2016 Oct 13. Review.


Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation.

Massart R, Nemoda Z, Suderman MJ, Sutti S, Ruggiero AM, Dettmer AM, Suomi SJ, Szyf M.

Dev Psychopathol. 2016 Nov;28(4pt2):1259-1272. Epub 2016 Sep 30.


Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders.

Richetto J, Massart R, Weber-Stadlbauer U, Szyf M, Riva MA, Meyer U.

Biol Psychiatry. 2017 Feb 1;81(3):265-276. doi: 10.1016/j.biopsych.2016.08.010. Epub 2016 Aug 12.


The Signature of Maternal Social Rank in Placenta Deoxyribonucleic Acid Methylation Profiles in Rhesus Monkeys.

Massart R, Suderman MJ, Nemoda Z, Sutti S, Ruggiero AM, Dettmer AM, Suomi SJ, Szyf M.

Child Dev. 2017 May;88(3):900-918. doi: 10.1111/cdev.12640. Epub 2016 Oct 14.


Pregnant women's cognitive appraisal of a natural disaster affects their children's BMI and central adiposity via DNA methylation: Project Ice Storm.

Cao-Lei L, Dancause KN, Elgbeili G, Laplante DP, Szyf M, King S.

Early Hum Dev. 2016 Dec;103:189-192. doi: 10.1016/j.earlhumdev.2016.09.013. Epub 2016 Oct 5.


Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer's Model.

Do Carmo S, Hanzel CE, Jacobs ML, Machnes Z, Iulita MF, Yang J, Yu L, Ducatenzeiler A, Danik M, Breuillaud LS, Bennett DA, Szyf M, Cuello AC.

Sci Rep. 2016 Sep 29;6:34051. doi: 10.1038/srep34051.


PARP-1 is required for retrieval of cocaine-associated memory by binding to the promoter of a novel gene encoding a putative transposase inhibitor.

Lax E, Friedman A, Massart R, Barnea R, Abraham L, Cheishvili D, Zada M, Ahdoot H, Bareli T, Warhaftig G, Visochek L, Suderman M, Cohen-Armon M, Szyf M, Yadid G.

Mol Psychiatry. 2017 Apr;22(4):570-579. doi: 10.1038/mp.2016.119. Epub 2016 Sep 6.


DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½  years: Project Ice Storm.

Cao-Lei L, Veru F, Elgbeili G, Szyf M, Laplante DP, King S.

Clin Epigenetics. 2016 May 12;8:54. doi: 10.1186/s13148-016-0219-0. eCollection 2016.


Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium.

Sutton EF, Gilmore LA, Dunger DB, Heijmans BT, Hivert MF, Ling C, Martinez JA, Ozanne SE, Simmons RA, Szyf M, Waterland RA, Redman LM, Ravussin E.

Obesity (Silver Spring). 2016 May;24(5):1018-26. doi: 10.1002/oby.21487. Epub 2016 Apr 1. Review.


The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion.

Szyf M, Tang YY, Hill KG, Musci R.

Transl Behav Med. 2016 Mar;6(1):55-62. doi: 10.1007/s13142-016-0387-7. Review.

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