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Items: 1 to 50 of 104


Discovery of early life stress interacting and sex-specific quantitative trait loci impacting cocaine responsiveness.

Bagley JR, Szumlinski KK, Kippin TE.

Br J Pharmacol. 2019 Mar 15. doi: 10.1111/bph.14661. [Epub ahead of print]


Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.

Campbell RR, Domingo RD, Williams AR, Wroten MG, McGregor HA, Waltermire RS, Greentree DI, Goulding SP, Thompson AB, Lee KM, Quadir SG, Jimenez Chavez CL, Coelho MA, Gould AT, von Jonquieres G, Klugmann M, Worley PF, Kippin TE, Szumlinski KK.

J Neurosci. 2019 Apr 3;39(14):2745-2761. doi: 10.1523/JNEUROSCI.1909-18.2018. Epub 2019 Feb 8.


DID it or DIDn't it? Exploration of a failure to replicate binge-like alcohol-drinking in C57BL/6J mice.

Szumlinski KK, Coelho MA, Lee KM, Tran T, Sern KR, Bernal A, Kippin TE.

Pharmacol Biochem Behav. 2019 Mar;178:3-18. doi: 10.1016/j.pbb.2018.12.002. Epub 2018 Dec 7.


mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice.

Lee KM, Coelho MA, Class MA, Sern KR, Bocz MD, Szumlinski KK.

Front Pharmacol. 2018 Nov 13;9:1306. doi: 10.3389/fphar.2018.01306. eCollection 2018.


PI3K activation within ventromedial prefrontal cortex regulates the expression of drug-seeking in two rodent species.

Szumlinski KK, Ary AW, Shin CB, Wroten MG, Courson J, Miller BW, Ruppert-Majer M, Hiller JW, Shahin JR, Ben-Shahar O, Kippin TE.

Addict Biol. 2018 Nov 18. doi: 10.1111/adb.12696. [Epub ahead of print]


Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley rats.

Ploense KL, Li X, Baker-Andresen D, Carr AE, Woodward N, Bagley J, Szumlinski KK, Bredy TW, Kippin TE.

Neuropharmacology. 2018 Dec;143:299-305. doi: 10.1016/j.neuropharm.2018.09.029. Epub 2018 Sep 27.


Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation.

Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD.

Neurosci Lett. 2018 Sep 25;684:109-114. doi: 10.1016/j.neulet.2018.07.015. Epub 2018 Jul 9.


Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice.

Santos-Rocha JB, Rae M, Teixeira AMA, Teixeira SA, Munhoz CD, Muscará MN, Marcourakis T, Szumlinski KK, Camarini R.

Alcohol. 2018 May;68:71-79. doi: 10.1016/j.alcohol.2017.10.004. Epub 2017 Oct 31.


mGlu5-dependent modulation of anxiety during early withdrawal from binge-drinking in adult and adolescent male mice.

Lee KM, Coelho MA, Class MA, Szumlinski KK.

Drug Alcohol Depend. 2018 Mar 1;184:1-11. doi: 10.1016/j.drugalcdep.2017.10.031. Epub 2018 Jan 5.


Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice.

Fultz EK, Szumlinski KK.

Drug Alcohol Depend. 2018 Feb 1;183:150-154. doi: 10.1016/j.drugalcdep.2017.10.034. Epub 2017 Dec 11.


Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression.

Ploense KL, Vieira P, Bubalo L, Olivarria G, Carr AE, Szumlinski KK, Kippin TE.

Psychopharmacology (Berl). 2018 May;235(5):1347-1359. doi: 10.1007/s00213-017-4798-z. Epub 2017 Dec 12.


Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction.

Datko MC, Hu JH, Williams M, Reyes CM, Lominac KD, von Jonquieres G, Klugmann M, Worley PF, Szumlinski KK.

Front Behav Neurosci. 2017 Nov 1;11:208. doi: 10.3389/fnbeh.2017.00208. eCollection 2017.


Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine.

Szumlinski KK, Shin CB.

Genes Brain Behav. 2018 Mar;17(3):e12440. doi: 10.1111/gbb.12440. Epub 2017 Dec 20. Review.


Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking.

Lee KM, Coelho MA, Sern KR, Szumlinski KK.

Neuropharmacology. 2018 Jan;128:448-459. doi: 10.1016/j.neuropharm.2017.11.001. Epub 2017 Nov 3.


Endogenous glutamate within the prelimbic and infralimbic cortices regulates the incubation of cocaine-seeking in rats.

Shin CB, Templeton TJ, Chiu AS, Kim J, Gable ES, Vieira PA, Kippin TE, Szumlinski KK.

Neuropharmacology. 2018 Jan;128:293-300. doi: 10.1016/j.neuropharm.2017.10.024. Epub 2017 Oct 20.


Anxiolytic effects of buspirone and MTEP in the Porsolt Forced Swim Test.

Lee KM, Coelho MA, Sern KR, Class MA, Bocz MD, Szumlinski KK.

Chronic Stress (Thousand Oaks). 2017 Jan-Dec;1. doi: 10.1177/2470547017712985. Epub 2017 Jun 27.


Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake.

Quadir SG, Guzelian E, Palmer MA, Martin DL, Kim J, Szumlinski KK.

Physiol Behav. 2019 May 1;203:100-112. doi: 10.1016/j.physbeh.2017.08.002. Epub 2017 Aug 10.


Negative Affect and Excessive Alcohol Intake Incubate during Protracted Withdrawal from Binge-Drinking in Adolescent, But Not Adult, Mice.

Lee KM, Coehlo MA, Solton NR, Szumlinski KK.

Front Psychol. 2017 Jul 6;8:1128. doi: 10.3389/fpsyg.2017.01128. eCollection 2017.


A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain.

Goulding SP, Szumlinski KK, Contet C, MacCoss MJ, Wu CC.

J Proteomics. 2017 Aug 23;166:127-137. doi: 10.1016/j.jprot.2017.07.008. Epub 2017 Jul 17.


Methamphetamine-alcohol interactions in murine models of sequential and simultaneous oral drug-taking.

Fultz EK, Martin DL, Hudson CN, Kippin TE, Szumlinski KK.

Drug Alcohol Depend. 2017 Aug 1;177:178-186. doi: 10.1016/j.drugalcdep.2017.03.026. Epub 2017 May 24.


Variability in prescription opioid intake and reinforcement amongst 129 substrains.

Jimenez SM, Healy AF, Coelho MA, Brown CN, Kippin TE, Szumlinski KK.

Genes Brain Behav. 2017 Sep;16(7):709-724. doi: 10.1111/gbb.12393. Epub 2017 Jun 20.


Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens.

Lee KM, Coelho MA, McGregor HA, Solton NR, Cohen M, Szumlinski KK.

Front Cell Neurosci. 2016 Nov 18;10:265. eCollection 2016.


Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly.

Szumlinski KK, Lominac KD, Campbell RR, Cohen M, Fultz EK, Brown CN, Miller BW, Quadir SG, Martin D, Thompson AB, von Jonquieres G, Klugmann M, Phillips TJ, Kippin TE.

Biol Psychiatry. 2017 Jun 1;81(11):959-970. doi: 10.1016/j.biopsych.2016.10.005. Epub 2016 Oct 13.


Cocaine Self-Administration Elevates GluN2B within dmPFC Mediating Heightened Cue-Elicited Operant Responding.

Szumlinski KK, Wroten MG, Miller BW, Sacramento AD, Cohen M, Ben-Shahar O, Kippin TE.

J Drug Abuse. 2016;2(2). pii: 22. Epub 2016 Apr 22.


Astrocytes: The Stars of Extinction-Related Learning or Cocaine-Induced Brain Plasticity?

Szumlinski KK.

Biol Psychiatry. 2016 Aug 1;80(3):176-8. doi: 10.1016/j.biopsych.2016.06.004. No abstract available.


Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.

Guo W, Molinaro G, Collins KA, Hays SA, Paylor R, Worley PF, Szumlinski KK, Huber KM.

J Neurosci. 2016 Feb 17;36(7):2131-47. doi: 10.1523/JNEUROSCI.2921-15.2016.


Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.

Bell RL, Hauser SR, McClintick J, Rahman S, Edenberg HJ, Szumlinski KK, McBride WJ.

Prog Mol Biol Transl Sci. 2016;137:41-85. doi: 10.1016/bs.pmbts.2015.10.018. Epub 2015 Nov 24. Review.


Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.

Miller BW, Wroten MG, Sacramento AD, Silva HE, Shin CB, Vieira PA, Ben-Shahar O, Kippin TE, Szumlinski KK.

Addict Biol. 2017 May;22(3):629-639. doi: 10.1111/adb.12354. Epub 2016 Jan 14.


Prefrontal glutamate correlates of methamphetamine sensitization and preference.

Lominac KD, Quadir SG, Barrett HM, McKenna CL, Schwartz LM, Ruiz PN, Wroten MG, Campbell RR, Miller BW, Holloway JJ, Travis KO, Rajasekar G, Maliniak D, Thompson AB, Urman LE, Kippin TE, Phillips TJ, Szumlinski KK.

Eur J Neurosci. 2016 Mar;43(5):689-702. doi: 10.1111/ejn.13159. Epub 2016 Feb 22.


Incubation of cocaine-craving relates to glutamate over-flow within ventromedial prefrontal cortex.

Shin CB, Serchia MM, Shahin JR, Ruppert-Majer MA, Kippin TE, Szumlinski KK.

Neuropharmacology. 2016 Mar;102:103-10. doi: 10.1016/j.neuropharm.2015.10.038. Epub 2015 Oct 30.


Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.

Smothers CT, Szumlinski KK, Worley PF, Woodward JJ.

Synapse. 2016 Jan;70(1):33-9. doi: 10.1002/syn.21869. Epub 2015 Oct 15.


Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats.

Haider A, Woodward NC, Lominac KD, Sacramento AD, Klugmann M, Bell RL, Szumlinski KK.

Alcohol. 2015 Sep;49(6):533-42. doi: 10.1016/j.alcohol.2015.03.009. Epub 2015 Jul 21.


Binge alcohol drinking elicits persistent negative affect in mice.

Lee KM, Coehlo M, McGregor HA, Waltermire RS, Szumlinski KK.

Behav Brain Res. 2015 Sep 15;291:385-398. doi: 10.1016/j.bbr.2015.05.055. Epub 2015 Jun 3.


Homer2 regulates alcohol and stress cross-sensitization.

Quadir SG, Santos JR, Campbell RR, Wroten MG, Singh N, Holloway JJ, Bal SK, Camarini R, Szumlinski KK.

Addict Biol. 2016 May;21(3):613-33. doi: 10.1111/adb.12252. Epub 2015 Apr 27.


Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption.

Cozzoli DK, Courson J, Rostock C, Campbell RR, Wroten MG, McGregor H, Caruana AL, Miller BW, Hu JH, Wu Zhang P, Xiao B, Worley PF, Crabbe JC, Finn DA, Szumlinski KK.

Biol Psychiatry. 2016 Mar 15;79(6):443-51. doi: 10.1016/j.biopsych.2015.01.019. Epub 2015 Mar 5.


Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation.

Lominac KD, McKenna CL, Schwartz LM, Ruiz PN, Wroten MG, Miller BW, Holloway JJ, Travis KO, Rajasekar G, Maliniak D, Thompson AB, Urman LE, Phillips TJ, Szumlinski KK.

Front Syst Neurosci. 2014 May 7;8:70. doi: 10.3389/fnsys.2014.00070. eCollection 2014.


mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.

Lum EN, Campbell RR, Rostock C, Szumlinski KK.

Neuropharmacology. 2014 Apr;79:679-87. doi: 10.1016/j.neuropharm.2014.01.024. Epub 2014 Jan 24.


Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving.

Loweth JA, Scheyer AF, Milovanovic M, LaCrosse AL, Flores-Barrera E, Werner CT, Li X, Ford KA, Le T, Olive MF, Szumlinski KK, Tseng KY, Wolf ME.

Nat Neurosci. 2014 Jan;17(1):73-80. doi: 10.1038/nn.3590. Epub 2013 Nov 24.


Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression: implications for relapse.

Gould AT, Sacramento AD, Wroten MG, Miller BW, von Jonquieres G, Klugmann M, Ben-Shahar O, Szumlinski KK.

Addict Biol. 2015 Jan;20(1):148-57. doi: 10.1111/adb.12088. Epub 2013 Sep 30.


Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala.

Cozzoli DK, Courson J, Wroten MG, Greentree DI, Lum EN, Campbell RR, Thompson AB, Maliniak D, Worley PF, Jonquieres G, Klugmann M, Finn DA, Szumlinski KK.

Neuropsychopharmacology. 2014 Jan;39(2):435-44. doi: 10.1038/npp.2013.214. Epub 2013 Aug 21.


A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.

Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF.

Cell. 2013 Aug 1;154(3):637-50. doi: 10.1016/j.cell.2013.07.001.


Maximizing peptide identification events in proteomic workflows using data-dependent acquisition (DDA).

Bateman NW, Goulding SP, Shulman NJ, Gadok AK, Szumlinski KK, MacCoss MJ, Wu CC.

Mol Cell Proteomics. 2014 Jan;13(1):329-38. doi: 10.1074/mcp.M112.026500. Epub 2013 Jul 2.


Homers at the Interface between Reward and Pain.

Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK.

Front Psychiatry. 2013 Jun 7;4:39. doi: 10.3389/fpsyt.2013.00039. eCollection 2013.


Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.

Obara I, Goulding SP, Hu JH, Klugmann M, Worley PF, Szumlinski KK.

Pain. 2013 Oct;154(10):1932-45. doi: 10.1016/j.pain.2013.03.035. Epub 2013 Apr 2.


Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.

Ary AW, Lominac KD, Wroten MG, Williams AR, Campbell RR, Ben-Shahar O, von Jonquieres G, Klugmann M, Szumlinski KK.

J Neurosci. 2013 May 8;33(19):8101-13. doi: 10.1523/JNEUROSCI.1727-12.2013.


Deficits in ventromedial prefrontal cortex group 1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administration.

Ben-Shahar O, Sacramento AD, Miller BW, Webb SM, Wroten MG, Silva HE, Caruana AL, Gordon EJ, Ploense KL, Ditzhazy J, Kippin TE, Szumlinski KK.

J Neurosci. 2013 Jan 9;33(2):495-506a. doi: 10.1523/JNEUROSCI.3710-12.2013.


New insights on neurobiological mechanisms underlying alcohol addiction.

Cui C, Noronha A, Morikawa H, Alvarez VA, Stuber GD, Szumlinski KK, Kash TL, Roberto M, Wilcox MV.

Neuropharmacology. 2013 Apr;67:223-32. doi: 10.1016/j.neuropharm.2012.09.022. Epub 2012 Nov 13. Review.


p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity.

Zhang L, Liu W, Szumlinski KK, Lew J.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20041-6. doi: 10.1073/pnas.1212914109. Epub 2012 Nov 14.


Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity.

Ary AW, Cozzoli DK, Finn DA, Crabbe JC, Dehoff MH, Worley PF, Szumlinski KK.

Alcohol. 2012 Jun;46(4):377-87. doi: 10.1016/j.alcohol.2011.10.003. Epub 2012 Mar 22.


Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.

Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK.

Alcohol Clin Exp Res. 2012 Sep;36(9):1623-33. doi: 10.1111/j.1530-0277.2012.01776.x. Epub 2012 Mar 20.

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