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Items: 47


Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.

Kim S, Alsaidan OA, Goodwin O, Li Q, Sulejmani E, Han Z, Bai A, Albers T, Beharry Z, Zheng YG, Norris JS, Szulc ZM, Bielawska A, Lebedyeva I, Pegan SD, Cai H.

Cancer Res. 2017 Dec 15;77(24):6950-6962. doi: 10.1158/0008-5472.CAN-17-0981. Epub 2017 Oct 16.


Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

Bai A, Mao C, Jenkins RW, Szulc ZM, Bielawska A, Hannun YA.

PLoS One. 2017 Jun 14;12(6):e0177805. doi: 10.1371/journal.pone.0177805. eCollection 2017.


HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy.

Thomas RJ, Oleinik N, Panneer Selvam S, Vaena SG, Dany M, Nganga RN, Depalma R, Baron KD, Kim J, Szulc ZM, Ogretmen B.

EMBO Mol Med. 2017 Aug;9(8):1030-1051. doi: 10.15252/emmm.201607088.


Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ.

Prostaglandins Other Lipid Mediat. 2017 May;130:47-56. doi: 10.1016/j.prostaglandins.2017.03.006. Epub 2017 Apr 2.


Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.

Podbielska M, Szulc ZM, Kurowska E, Hogan EL, Bielawski J, Bielawska A, Bhat NR.

J Lipid Res. 2016 Nov;57(11):2028-2039. Epub 2016 Sep 13.


Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.

Dany M, Gencer S, Nganga R, Thomas RJ, Oleinik N, Baron KD, Szulc ZM, Ruvolo P, Kornblau S, Andreeff M, Ogretmen B.

Blood. 2016 Oct 13;128(15):1944-1958. Epub 2016 Aug 18.


Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.

Korbelik M, Banáth J, Zhang W, Saw KM, Szulc ZM, Bielawska A, Separovic D.

Int J Cancer. 2016 Sep 15;139(6):1372-8. doi: 10.1002/ijc.30171. Epub 2016 May 18.


Ceramide channel: Structural basis for selective membrane targeting.

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M.

Chem Phys Lipids. 2016 Jan;194:110-116. doi: 10.1016/j.chemphyslip.2015.09.007. Epub 2015 Sep 25.


Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22.


2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells.

Kota V, Dhople VM, Fullbright G, Smythe NM, Szulc ZM, Bielawska A, Hama H.

J Proteome Res. 2013 Oct 4;12(10):4366-75. doi: 10.1021/pr4003432. Epub 2013 Sep 12.


Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.

Korbelik M, Zhang W, Saw KM, Szulc ZM, Bielawska A, Separovic D.

J Photochem Photobiol B. 2013 Sep 5;126:72-7. doi: 10.1016/j.jphotobiol.2013.06.013. Epub 2013 Jul 6.


Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B.

EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25.


LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X.

J Pharmacol Exp Ther. 2013 Jan;344(1):167-78. doi: 10.1124/jpet.112.199216. Epub 2012 Oct 18.


L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells.

Syed I, Szulc ZM, Ogretmen B, Kowluru A.

Cell Physiol Biochem. 2012;30(4):1051-8. doi: 10.1159/000341481. Epub 2012 Sep 24.


Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.

Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B.

Nat Chem Biol. 2012 Oct;8(10):831-8. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.


Identification of C(6) -ceramide-interacting proteins in D6P2T Schwannoma cells.

Kota V, Szulc ZM, Hama H.

Proteomics. 2012 Jul;12(13):2179-84. doi: 10.1002/pmic.201100527.


Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.

Perera MN, Lin SH, Peterson YK, Bielawska A, Szulc ZM, Bittman R, Colombini M.

Biochem J. 2012 Jul 1;445(1):81-91. doi: 10.1042/BJ20112103.


Ceramide channels: influence of molecular structure on channel formation in membranes.

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawski J, Bielawska A, Bittman R, Colombini M.

Biochim Biophys Acta. 2012 May;1818(5):1291-301. doi: 10.1016/j.bbamem.2012.02.010. Epub 2012 Feb 15.


Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase.

Thayyullathil F, Chathoth S, Hago A, Patel M, Szulc ZM, Hannun Y, Galadari S.

Biochim Biophys Acta. 2011 Apr;1811(4):242-52. doi: 10.1016/j.bbalip.2010.12.012. Epub 2011 Jan 9.


Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT.

J Lipid Res. 2011 Feb;52(2):278-88. doi: 10.1194/jlr.M012161. Epub 2010 Nov 16.


Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Bielawski J, Pierce JS, Snider J, Rembiesa B, Szulc ZM, Bielawska A.

Adv Exp Med Biol. 2010;688:46-59. Review.


Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells.

Szulc ZM, Bai A, Bielawski J, Mayroo N, Miller DE, Gracz H, Hannun YA, Bielawska A.

Bioorg Med Chem. 2010 Nov 1;18(21):7565-79. doi: 10.1016/j.bmc.2010.08.050. Epub 2010 Sep 28.


Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.

Mao Z, Sun W, Xu R, Novgorodov S, Szulc ZM, Bielawski J, Obeid LM, Mao C.

J Biol Chem. 2010 Sep 17;285(38):29078-90. doi: 10.1074/jbc.M110.105296. Epub 2010 Jul 13.


Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2).

Sun W, Jin J, Xu R, Hu W, Szulc ZM, Bielawski J, Obeid LM, Mao C.

J Biol Chem. 2010 Mar 19;285(12):8995-9007. doi: 10.1074/jbc.M109.069203. Epub 2010 Jan 20.


Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis.

Hu W, Xu R, Sun W, Szulc ZM, Bielawski J, Obeid LM, Mao C.

J Biol Chem. 2010 Mar 12;285(11):7964-76. doi: 10.1074/jbc.M109.063586. Epub 2010 Jan 12.


Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.

Bielawski J, Pierce JS, Snider J, Rembiesa B, Szulc ZM, Bielawska A.

Methods Mol Biol. 2009;579:443-67. doi: 10.1007/978-1-60761-322-0_22.


Synthesis and bioevaluation of omega-N-amino analogs of B13.

Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2009 Mar 1;17(5):1840-8. doi: 10.1016/j.bmc.2009.01.057. Epub 2009 Jan 31.


Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion.

Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C.

FASEB J. 2009 Feb;23(2):656-66. doi: 10.1096/fj.08-115634. Epub 2008 Oct 22.


Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.

Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA.

Br J Cancer. 2008 Jan 15;98(1):98-105. Epub 2007 Nov 20.


Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.

Bielawska A, Bielawski J, Szulc ZM, Mayroo N, Liu X, Bai A, Elojeimy S, Rembiesa B, Pierce J, Norris JS, Hannun YA.

Bioorg Med Chem. 2008 Jan 15;16(2):1032-45. Epub 2007 Aug 24. Erratum in: Bioorg Med Chem. 2008 Apr 1;16(7):4187.


Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.

Szulc ZM, Mayroo N, Bai A, Bielawski J, Liu X, Norris JS, Hannun YA, Bielawska A.

Bioorg Med Chem. 2008 Jan 15;16(2):1015-31. Epub 2007 Aug 24. Erratum in: Bioorg Med Chem. 2008 Apr 1;16(7):4186.


Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes.

Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C.

J Invest Dermatol. 2008 Feb;128(2):389-97. Epub 2007 Aug 23.


Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.

Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS.

Cancer Chemother Pharmacol. 2008 Feb;61(2):231-42. Epub 2007 Apr 12.


Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.

Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A.

J Biol Chem. 2007 Jun 8;282(23):16718-28. Epub 2007 Feb 5.


Tailoring structure-function and targeting properties of ceramides by site-specific cationization.

Szulc ZM, Bielawski J, Gracz H, Gustilo M, Mayroo N, Hannun YA, Obeid LM, Bielawska A.

Bioorg Med Chem. 2006 Nov 1;14(21):7083-104. Epub 2006 Aug 17.


Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM.

J Biol Chem. 2005 Apr 22;280(16):16096-105. Epub 2005 Feb 18.


Golgi fragmentation is associated with ceramide-induced cellular effects.

Hu W, Xu R, Zhang G, Jin J, Szulc ZM, Bielawski J, Hannun YA, Obeid LM, Mao C.

Mol Biol Cell. 2005 Mar;16(3):1555-67. Epub 2005 Jan 12.


Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells.

Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B.

Otolaryngol Head Neck Surg. 2005 Jan;132(1):55-62.


Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.

Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM.

J Biol Chem. 2003 Aug 15;278(33):31184-91. Epub 2003 Jun 3.


Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry.

Pettus BJ, Bielawska A, Kroesen BJ, Moeller PD, Szulc ZM, Hannun YA, Busman M.

Rapid Commun Mass Spectrom. 2003;17(11):1203-11.


Substrate specificity of rat brain ceramidase.

El Bawab S, Usta J, Roddy P, Szulc ZM, Bielawska A, Hannun YA.

J Lipid Res. 2002 Jan;43(1):141-8.


Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase.

Usta J, El Bawab S, Roddy P, Szulc ZM, Yusuf, Hannun A, Bielawska A.

Biochemistry. 2001 Aug 14;40(32):9657-68.


Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide.

Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM.

J Biol Chem. 2001 Jul 13;276(28):26577-88. Epub 2001 May 16.


Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.

El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA.

J Biol Chem. 2001 May 18;276(20):16758-66. Epub 2001 Feb 8.


Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.

Mao C, Xu R, Bielawska A, Szulc ZM, Obeid LM.

J Biol Chem. 2000 Oct 6;275(40):31369-78.

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