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Items: 1 to 50 of 215

1.

Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi.

Salerno-Goncalves R, Kayastha D, Fasano A, Levine MM, Sztein MB.

PLoS Negl Trop Dis. 2019 Aug 14;13(8):e0007650. doi: 10.1371/journal.pntd.0007650. eCollection 2019 Aug.

2.

Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development.

Mani S, Toapanta FR, McArthur MA, Qadri F, Svennerholm AM, Devriendt B, Phalipon A, Cohen D, Sztein MB.

Vaccine. 2019 Aug 7;37(34):4787-4793. doi: 10.1016/j.vaccine.2019.03.040. Epub 2019 Jun 20.

PMID:
31230883
3.

Characteristics of regulatory T-cell populations before and after Ty21a typhoid vaccination in children and adults.

Rudolph ME, McArthur MA, Magder LS, Barnes RS, Chen WH, Sztein MB.

Clin Immunol. 2019 Jun;203:14-22. doi: 10.1016/j.clim.2019.04.002. Epub 2019 Apr 4.

PMID:
30953793
4.

Diversity of Salmonella Typhi-responsive CD4 and CD8 T cells before and after Ty21a typhoid vaccination in children and adults.

Rudolph ME, McArthur MA, Magder LS, Barnes RS, Chen WH, Sztein MB.

Int Immunol. 2019 Apr 26;31(5):315-333. doi: 10.1093/intimm/dxz011.

PMID:
30951606
5.

Attenuated Oral Typhoid Vaccine Ty21a Elicits Lamina Propria and Intra-Epithelial Lymphocyte Tissue-Resident Effector Memory CD8 T Responses in the Human Terminal Ileum.

Booth JS, Patil SA, Goldberg E, Barnes RS, Greenwald BD, Sztein MB.

Front Immunol. 2019 Mar 14;10:424. doi: 10.3389/fimmu.2019.00424. eCollection 2019.

6.

Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen Presentation.

Rudolph ME, McArthur MA, Magder LS, Barnes RS, Chen WH, Sztein MB.

Front Immunol. 2019 Mar 4;10:257. doi: 10.3389/fimmu.2019.00257. eCollection 2019.

7.

Cell mediated immune responses elicited in volunteers following immunization with candidate live oral Salmonella enterica serovar Paratyphi A attenuated vaccine strain CVD 1902.

Wahid R, Kotloff KL, Levine MM, Sztein MB.

Clin Immunol. 2019 Apr;201:61-69. doi: 10.1016/j.clim.2019.03.003. Epub 2019 Mar 5.

PMID:
30849494
8.

Association between S. Typhi-specific memory CD4+ and CD8+ T responses in the terminal ileum mucosa and in peripheral blood elicited by the live oral typhoid vaccine Ty21a in humans.

Booth JS, Goldberg E, Patil SA, Greenwald BD, Sztein MB.

Hum Vaccin Immunother. 2019;15(6):1409-1420. doi: 10.1080/21645515.2018.1564570. Epub 2019 Apr 2.

9.

Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A.

Berry AA, Gottlieb ER, Kouriba B, Diarra I, Thera MA, Dutta S, Coulibaly D, Ouattara A, Niangaly A, Kone AK, Traore K, Tolo Y, Mishcherkin V, Soisson L, Diggs CL, Blackwelder WC, Laurens MB, Sztein MB, Doumbo OK, Plowe CV, Lyke KE.

Malar J. 2019 Jan 18;18(1):13. doi: 10.1186/s12936-019-2637-x.

10.

A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization.

Bernstein DI, Pasetti MF, Brady R, Buskirk AD, Wahid R, Dickey M, Cohen M, Baughman H, El-Khorazaty J, Maier N, Sztein MB, Baqar S, Bourgeois AL.

Vaccine. 2019 Jan 21;37(4):602-611. doi: 10.1016/j.vaccine.2018.12.011. Epub 2018 Dec 15.

PMID:
30563789
11.

Manipulation of Salmonella Typhi Gene Expression Impacts Innate Cell Responses in the Human Intestinal Mucosa.

Salerno-Gonçalves R, Galen JE, Levine MM, Fasano A, Sztein MB.

Front Immunol. 2018 Nov 1;9:2543. doi: 10.3389/fimmu.2018.02543. eCollection 2018.

12.

Effect of the live oral attenuated typhoid vaccine, Ty21a, on systemic and terminal ileum mucosal CD4+ T memory responses in humans.

Booth JS, Goldberg E, Patil SA, Barnes RS, Greenwald BD, Sztein MB.

Int Immunol. 2019 Feb 15;31(2):101-116. doi: 10.1093/intimm/dxy070.

13.

Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity.

Higginson EE, Ramachandran G, Panda A, Shipley ST, Kriel EH, DeTolla LJ, Lipsky M, Perkins DJ, Salerno-Goncalves R, Sztein MB, Pasetti MF, Levine MM, Tennant SM.

Infect Immun. 2018 Nov 20;86(12). pii: e00440-18. doi: 10.1128/IAI.00440-18. Print 2018 Dec.

14.

Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi.

Zhang Y, Brady A, Jones C, Song Y, Darton TC, Jones C, Blohmke CJ, Pollard AJ, Magder LS, Fasano A, Sztein MB, Fraser CM.

MBio. 2018 May 8;9(3). pii: e00686-18. doi: 10.1128/mBio.00686-18.

15.

Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue.

Nickerson KP, Senger S, Zhang Y, Lima R, Patel S, Ingano L, Flavahan WA, Kumar DKV, Fraser CM, Faherty CS, Sztein MB, Fiorentino M, Fasano A.

EBioMedicine. 2018 May;31:92-109. doi: 10.1016/j.ebiom.2018.04.005. Epub 2018 Apr 12.

16.

Correction: A clinically parameterized mathematical model of Shigella immunity to inform vaccine design.

Davis CL, Wahid R, Toapanta FR, Simon JK, Sztein MB.

PLoS One. 2018 Apr 19;13(4):e0196367. doi: 10.1371/journal.pone.0196367. eCollection 2018.

17.

Lipopolysaccharide-specific memory B cell responses to an attenuated live cholera vaccine are associated with protection against Vibrio cholerae infection.

Haney DJ, Lock MD, Gurwith M, Simon JK, Ishioka G, Cohen MB, Kirkpatrick BD, Lyon CE, Chen WH, Sztein MB, Levine MM, Harris JB.

Vaccine. 2018 May 11;36(20):2768-2773. doi: 10.1016/j.vaccine.2018.04.011. Epub 2018 Apr 11.

18.

Differences Between Pediatric and Adult T Cell Responses to In Vitro Staphylococcal Enterotoxin B Stimulation.

Rudolph ME, McArthur MA, Barnes RS, Magder LS, Chen WH, Sztein MB.

Front Immunol. 2018 Mar 20;9:498. doi: 10.3389/fimmu.2018.00498. eCollection 2018.

19.

T cell mediated immunity induced by the live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S in humans.

Toapanta FR, Bernal PJ, Kotloff KL, Levine MM, Sztein MB.

J Transl Med. 2018 Mar 13;16(1):61. doi: 10.1186/s12967-018-1439-1.

20.

Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium.

Lyke KE, Dabo A, Arama C, Diarra I, Plowe CV, Doumbo OK, Sztein MB.

Front Immunol. 2018 Feb 1;8:1995. doi: 10.3389/fimmu.2017.01995. eCollection 2017.

21.

A clinically parameterized mathematical model of Shigella immunity to inform vaccine design.

Davis CL, Wahid R, Toapanta FR, Simon JK, Sztein MB.

PLoS One. 2018 Jan 5;13(1):e0189571. doi: 10.1371/journal.pone.0189571. eCollection 2018. Erratum in: PLoS One. 2018 Apr 19;13(4):e0196367.

22.

Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria.

Sztein MB.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a029546. doi: 10.1101/cshperspect.a029546. Review.

PMID:
29254983
23.

Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization With the Ty21a Typhoid Vaccine in Humans.

Booth JS, Patil SA, Ghazi L, Barnes R, Fraser CM, Fasano A, Greenwald BD, Sztein MB.

Cell Mol Gastroenterol Hepatol. 2017 Aug 16;4(3):419-437. doi: 10.1016/j.jcmgh.2017.08.002. eCollection 2017 Nov.

24.

Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells.

Salerno-Gonçalves R, Tettelin H, Lou D, Steiner S, Rezwanul T, Guo Q, Picking WD, Nene V, Sztein MB.

PLoS Negl Trop Dis. 2017 Sep 5;11(9):e0005912. doi: 10.1371/journal.pntd.0005912. eCollection 2017 Sep.

25.

Identification of immune correlates of protection in Shigella infection by application of machine learning.

Arevalillo JM, Sztein MB, Kotloff KL, Levine MM, Simon JK.

J Biomed Inform. 2017 Oct;74:1-9. doi: 10.1016/j.jbi.2017.08.005. Epub 2017 Aug 9.

26.

Tularemia vaccine: Safety, reactogenicity, "Take" skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial.

Mulligan MJ, Stapleton JT, Keitel WA, Frey SE, Chen WH, Rouphael N, Edupuganti S, Beck A, Winokur PL, El Sahly HM, Patel SM, Atmar RL, Graham I, Anderson E, El-Kamary SS, Pasetti MF, Sztein MB, Hill H, Goll JB; DMID 08-0006 Tularemia Vaccine Study Group.

Vaccine. 2017 Aug 24;35(36):4730-4737. doi: 10.1016/j.vaccine.2017.07.024. Epub 2017 Jul 24.

27.

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells.

Salerno-Goncalves R, Luo D, Fresnay S, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ, Sztein MB.

Front Immunol. 2017 Apr 6;8:398. doi: 10.3389/fimmu.2017.00398. eCollection 2017.

28.

Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model.

Fresnay S, McArthur MA, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ, Sztein MB.

Front Immunol. 2017 Mar 2;8:208. doi: 10.3389/fimmu.2017.00208. eCollection 2017.

29.

Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans.

McArthur MA, Chen WH, Magder L, Levine MM, Sztein MB.

PLoS Negl Trop Dis. 2017 Jan 19;11(1):e0005291. doi: 10.1371/journal.pntd.0005291. eCollection 2017 Jan.

30.
31.

Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA, Moore M, Thompson BA, John T, Kingsley RA, Yu LM, Voysey M, Hindle Z, Lockhart S, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ.

PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004926. doi: 10.1371/journal.pntd.0004926. eCollection 2016 Aug.

32.

Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity.

Salerno-Goncalves R, Fasano A, Sztein MB.

J Vis Exp. 2016 Jul 25;(113). doi: 10.3791/54148.

33.

Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease.

Toapanta FR, Bernal PJ, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ, Sztein MB.

PLoS Negl Trop Dis. 2016 Jun 14;10(6):e0004766. doi: 10.1371/journal.pntd.0004766. eCollection 2016 Jun.

34.

Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS, Angus B, Zhou L, Hill J, Clare S, Kane L, Mukhopadhyay S, Schreiber F, Duque-Correa MA, Wright JC, Roumeliotis TI, Yu L, Choudhary JS, Mejias A, Ramilo O, Shanyinde M, Sztein MB, Kingsley RA, Lockhart S, Levine MM, Lynn DJ, Dougan G, Pollard AJ.

J Exp Med. 2016 May 30;213(6):1061-77. doi: 10.1084/jem.20151025. Epub 2016 May 23.

35.

Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate.

Graves SF, Kouriba B, Diarra I, Daou M, Niangaly A, Coulibaly D, Keita Y, Laurens MB, Berry AA, Vekemans J, Ripley Ballou W, Lanar DE, Dutta S, Gray Heppner D, Soisson L, Diggs CL, Thera MA, Doumbo OK, Plowe CV, Sztein MB, Lyke KE.

Vaccine. 2016 May 17;34(23):2546-55. doi: 10.1016/j.vaccine.2016.04.019. Epub 2016 Apr 15.

PMID:
27087149
36.

Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial cell responses.

Salerno-Goncalves R, Safavie F, Fasano A, Sztein MB.

Clin Exp Immunol. 2016 Sep;185(3):338-47. doi: 10.1111/cei.12801. Epub 2016 Jul 26.

37.

Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans.

Fresnay S, McArthur MA, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ, Sztein MB.

J Transl Med. 2016 Mar 1;14:62. doi: 10.1186/s12967-016-0819-7.

38.

Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial.

Tapia MD, Sow SO, Lyke KE, Haidara FC, Diallo F, Doumbia M, Traore A, Coulibaly F, Kodio M, Onwuchekwa U, Sztein MB, Wahid R, Campbell JD, Kieny MP, Moorthy V, Imoukhuede EB, Rampling T, Roman F, De Ryck I, Bellamy AR, Dally L, Mbaya OT, Ploquin A, Zhou Y, Stanley DA, Bailer R, Koup RA, Roederer M, Ledgerwood J, Hill AVS, Ballou WR, Sullivan N, Graham B, Levine MM.

Lancet Infect Dis. 2016 Jan;16(1):31-42. doi: 10.1016/S1473-3099(15)00362-X. Epub 2015 Nov 4.

39.

Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection.

Booth JS, Salerno-Goncalves R, Blanchard TG, Patil SA, Kader HA, Safta AM, Morningstar LM, Czinn SJ, Greenwald BD, Sztein MB.

Front Immunol. 2015 Sep 17;6:466. doi: 10.3389/fimmu.2015.00466. eCollection 2015.

40.

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

Toapanta FR, Bernal PJ, Fresnay S, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB.

PLoS Negl Trop Dis. 2015 Jun 11;9(6):e0003837. doi: 10.1371/journal.pntd.0003837. eCollection 2015 Jun.

41.

Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.

McArthur MA, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB.

PLoS Pathog. 2015 May 22;11(5):e1004914. doi: 10.1371/journal.ppat.1004914. eCollection 2015 May.

42.
43.

Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward.

Sztein MB, Salerno-Goncalves R, McArthur MA.

Front Immunol. 2014 Oct 27;5:516. doi: 10.3389/fimmu.2014.00516. eCollection 2014. Review.

44.

Gut-Homing Conventional Plasmablasts and CD27(-) Plasmablasts Elicited after a Short Time of Exposure to an Oral Live-Attenuated Shigella Vaccine Candidate in Humans.

Toapanta FR, Simon JK, Barry EM, Pasetti MF, Levine MM, Kotloff KL, Sztein MB.

Front Immunol. 2014 Aug 20;5:374. doi: 10.3389/fimmu.2014.00374. eCollection 2014.

45.

Characterization and functional properties of gastric tissue-resident memory T cells from children, adults, and the elderly.

Booth JS, Toapanta FR, Salerno-Goncalves R, Patil S, Kader HA, Safta AM, Czinn SJ, Greenwald BD, Sztein MB.

Front Immunol. 2014 Jun 19;5:294. doi: 10.3389/fimmu.2014.00294. eCollection 2014.

46.

An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.

Waddington CS, Darton TC, Jones C, Haworth K, Peters A, John T, Thompson BA, Kerridge SA, Kingsley RA, Zhou L, Holt KE, Yu LM, Lockhart S, Farrar JJ, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ.

Clin Infect Dis. 2014 May;58(9):1230-40. doi: 10.1093/cid/ciu078. Epub 2014 Feb 10.

47.

B cells modulate mucosal associated invariant T cell immune responses.

Salerno-Goncalves R, Rezwan T, Sztein MB.

Front Immunol. 2014 Jan 7;4:511. doi: 10.3389/fimmu.2013.00511. eCollection 2014 Jan 7.

48.

Live oral Salmonella enterica serovar Typhi vaccines Ty21a and CVD 909 induce opsonophagocytic functional antibodies in humans that cross-react with S. Paratyphi A and S. Paratyphi B.

Wahid R, Zafar SJ, McArthur MA, Pasetti MF, Levine MM, Sztein MB.

Clin Vaccine Immunol. 2014 Mar;21(3):427-34. doi: 10.1128/CVI.00786-13. Epub 2014 Jan 15.

49.

Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release.

Fiorentino M, Levine MM, Sztein MB, Fasano A.

PLoS One. 2014 Jan 9;9(1):e85211. doi: 10.1371/journal.pone.0085211. eCollection 2014.

50.

Dengue vaccines: recent developments, ongoing challenges and current candidates.

McArthur MA, Sztein MB, Edelman R.

Expert Rev Vaccines. 2013 Aug;12(8):933-53. doi: 10.1586/14760584.2013.815412. Review.

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