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Items: 1 to 50 of 53

1.

Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M.

Nat Cell Biol. 2019 Jun;21(6):792. doi: 10.1038/s41556-019-0316-3.

PMID:
30914825
2.

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M.

Nat Cell Biol. 2019 Feb;21(2):263-274. doi: 10.1038/s41556-018-0271-4. Epub 2019 Feb 1. Erratum in: Nat Cell Biol. 2019 Mar 26;:.

PMID:
30710150
3.

Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling.

Kelly AC, Smith KE, Purvis WG, Min CG, Weber CS, Cooksey AM, Hasilo C, Paraskevas S, Suszynski TM, Weegman BP, Anderson MJ, Camacho LE, Harland RC, Loudovaris T, Jandova J, Molano DS, Price ND, Georgiev IG, Scott WE 3rd, Manas DMD, Shaw JAM, OʼGorman D, Kin T, McCarthy FM, Szot GL, Posselt AM, Stock PG, Karatzas T, Shapiro AMJ, Lynch RM, Limesand SW, Papas KK.

Transplantation. 2019 Jan;103(1):160-167. doi: 10.1097/TP.0000000000002400.

PMID:
30095738
4.

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.

Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q.

Stem Cell Reports. 2017 Sep 12;9(3):807-819. doi: 10.1016/j.stemcr.2017.07.012. Epub 2017 Aug 10.

5.

Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.

Ricordi C, Goldstein JS, Balamurugan AN, Szot GL, Kin T, Liu C, Czarniecki CW, Barbaro B, Bridges ND, Cano J, Clarke WR, Eggerman TL, Hunsicker LG, Kaufman DB, Khan A, Lafontant DE, Linetsky E, Luo X, Markmann JF, Naji A, Korsgren O, Oberholzer J, Turgeon NA, Brandhorst D, Friberg AS, Lei J, Wang LJ, Wilhelm JJ, Willits J, Zhang X, Hering BJ, Posselt AM, Stock PG, Shapiro AMJ.

Diabetes. 2017 Sep;66(9):2531. doi: 10.2337/db17-er09a. Epub 2017 Jun 29. No abstract available.

6.

Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells.

Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK.

Nat Commun. 2017 Mar 8;8:14686. doi: 10.1038/ncomms14686.

7.

National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.

Ricordi C, Goldstein JS, Balamurugan AN, Szot GL, Kin T, Liu C, Czarniecki CW, Barbaro B, Bridges ND, Cano J, Clarke WR, Eggerman TL, Hunsicker LG, Kaufman DB, Khan A, Lafontant DE, Linetsky E, Luo X, Markmann JF, Naji A, Korsgren O, Oberholzer J, Turgeon NA, Brandhorst D, Chen X, Friberg AS, Lei J, Wang LJ, Wilhelm JJ, Willits J, Zhang X, Hering BJ, Posselt AM, Stock PG, Shapiro AM, Chen X.

Diabetes. 2016 Nov;65(11):3418-3428. Epub 2016 Jul 27. Erratum in: Diabetes. 2017 Sep;66(9):2531.

8.

A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.

Wang LJ, Kin T, O'Gorman D, Shapiro AMJ, Naziruddin B, Takita M, Levy MF, Posselt AM, Szot GL, Savari O, Barbaro B, McGarrigle J, Yeh CC, Oberholzer J, Lei J, Chen T, Lian M, Markmann JF, Alvarez A, Linetsky E, Ricordi C, Balamurugan AN, Loganathan G, Wilhelm JJ, Hering BJ, Bottino R, Trucco M, Liu C, Min Z, Li Y, Naji A, Fernandez LA, Ziemelis M, Danobeitia JS, Millis JM, Witkowski P.

Cell Transplant. 2016;25(8):1515-1523. doi: 10.3727/096368916X691141. Epub 2016 Feb 26.

9.

A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.

Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM.

Am J Transplant. 2016 Feb;16(2):518-26. doi: 10.1111/ajt.13536. Epub 2015 Nov 23.

10.

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.

Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M.

EMBO J. 2015 Jul 2;34(13):1759-72. doi: 10.15252/embj.201591058. Epub 2015 Apr 23.

11.

Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm.

Szot GL, Yadav M, Lang J, Kroon E, Kerr J, Kadoya K, Brandon EP, Baetge EE, Bour-Jordan H, Bluestone JA.

Cell Stem Cell. 2015 Feb 5;16(2):148-57. doi: 10.1016/j.stem.2014.12.001. Epub 2014 Dec 18.

12.

Autologous islet transplantation with remote islet isolation after pancreas resection for chronic pancreatitis.

Tai DS, Shen N, Szot GL, Posselt A, Feduska NJ, Habashy A, Clerkin B, Core E, Busuttil RW, Hines OJ, Reber HA, Lipshutz GS.

JAMA Surg. 2015 Feb;150(2):118-24. doi: 10.1001/jamasurg.2014.932.

PMID:
25494212
13.

Human islet viability and function is maintained during high-density shipment in silicone rubber membrane vessels.

Kitzmann JP, Pepper AR, Gala-Lopez B, Pawlick R, Kin T, O'Gorman D, Mueller KR, Gruessner AC, Avgoustiniatos ES, Karatzas T, Szot GL, Posselt AM, Stock PG, Wilson JR, Shapiro AM, Papas KK.

Transplant Proc. 2014 Jul-Aug;46(6):1989-91. doi: 10.1016/j.transproceed.2014.06.002.

14.

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.

Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann JF, Miyazaki S, Miyazaki J, Szot GL, Bottino R, Kim SK.

Elife. 2013 Nov 19;2:e00940. doi: 10.7554/eLife.00940.

15.

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

Putnam AL, Safinia N, Medvec A, Laszkowska M, Wray M, Mintz MA, Trotta E, Szot GL, Liu W, Lares A, Lee K, Laing A, Lechler RI, Riley JL, Bluestone JA, Lombardi G, Tang Q.

Am J Transplant. 2013 Nov;13(11):3010-20. doi: 10.1111/ajt.12433. Epub 2013 Sep 18.

16.

Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.

Villalta SA, Lang J, Kubeck S, Kabre B, Szot GL, Calderon B, Wasserfall C, Atkinson MA, Brekken RA, Pullen N, Arch RH, Bluestone JA.

Diabetes. 2013 Aug;62(8):2870-8. doi: 10.2337/db12-1619. Epub 2013 Jul 8.

17.

Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.

Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG.

Transplantation. 2010 Dec 27;90(12):1595-601. doi: 10.1097/TP.0b013e3181fe1377.

18.

Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.

Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG.

Am J Transplant. 2010 Aug;10(8):1870-80. doi: 10.1111/j.1600-6143.2010.03073.x.

19.

Clinical islet transplantation at the University of California, San Francisco.

Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG.

Clin Transpl. 2010:235-43.

PMID:
21698834
20.

Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.

Szot GL, Lee MR, Tavakol MM, Lang J, Dekovic F, Kerlan RK, Stock PG, Posselt AM.

Transplantation. 2009 Sep 27;88(6):753-6. doi: 10.1097/TP.0b013e3181b443ae. Review.

21.

Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.

Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q.

J Immunol. 2009 Mar 1;182(5):2590-600. doi: 10.4049/jimmunol.0803543.

22.

Expansion of human regulatory T-cells from patients with type 1 diabetes.

Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA.

Diabetes. 2009 Mar;58(3):652-62. doi: 10.2337/db08-1168. Epub 2008 Dec 15.

23.

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18895-900. doi: 10.1073/pnas.0810246105. Epub 2008 Nov 17.

24.

Transplantation of pancreatic islets into the kidney capsule of diabetic mice.

Szot GL, Koudria P, Bluestone JA.

J Vis Exp. 2007;(9):404. doi: 10.3791/404. Epub 2007 Oct 31.

25.

Murine pancreatic islet isolation.

Szot GL, Koudria P, Bluestone JA.

J Vis Exp. 2007;(7):255. doi: 10.3791/255. Epub 2007 Aug 22. No abstract available.

26.

Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV.

Nature. 2008 Oct 23;455(7216):1109-13. doi: 10.1038/nature07336. Epub 2008 Sep 21.

27.

Human albumin preserves islet mass and function better than whole serum during pretransplantation islet culture.

Lee RH, Carter J, Szot GL, Posselt A, Stock P.

Transplant Proc. 2008 Mar;40(2):384-6. doi: 10.1016/j.transproceed.2008.02.016.

PMID:
18374076
28.

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA.

J Exp Med. 2006 Jul 10;203(7):1701-11. Epub 2006 Jul 3.

29.

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA.

J Clin Invest. 2004 Oct;114(7):979-87.

30.

IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo.

Choi SE, Choi KM, Yoon IH, Shin JY, Kim JS, Park WY, Han DJ, Kim SC, Ahn C, Kim JY, Hwang ES, Cha CY, Szot GL, Yoon KH, Park CG.

Transpl Immunol. 2004 Jun-Jul;13(1):43-53.

PMID:
15203128
32.

CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.

Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA.

J Immunol. 2003 Feb 1;170(3):1510-6.

33.

Inability to induce tolerance through direct antigen presentation.

Rulifson IC, Szot GL, Palmer E, Bluestone JA.

Am J Transplant. 2002 Jul;2(6):510-9.

34.

Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.

Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newel KA, Thistlethwaite JR, Bluestone JA, Alegre ML.

Am J Transplant. 2001 May;1(1):38-46.

35.

Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection.

Meng L, Guo Z, Kim O, He G, Hart J, Szot GL, Wang J, Pearson TC, Larsen CP, Newell KA.

Transplant Proc. 2001 Feb-Mar;33(1-2):418-20. No abstract available.

PMID:
11266891
36.

Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.

Szot GL, Zhou P, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR Jr.

Transplantation. 2000 Mar 15;69(5):904-9. Erratum in: Transplantation 2000 Aug 27;70(4):707.

PMID:
10755548
37.

Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.

Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML.

J Immunol. 2000 Nov 15;165(10):5580-7.

39.

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.

Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA.

J Immunol. 1999 Sep 1;163(5):2358-62.

40.

Differential effect of an anti-CD8 monoclonal antibody on rejection of murine intestine and cardiac allografts.

He G, Kim OS, Thistlethwaite JR, Hart J, Siegel CT, Szot GL, Newell KA.

Transplant Proc. 1999 Feb-Mar;31(1-2):1239-41. No abstract available.

PMID:
10083553
41.

The role of CD8 and CD4 T cells in intestinal allograft rejection: a comparison of monoclonal antibody-treated and knockout mice.

He G, Hart J, Kim OS, Szot GL, Siegel CT, Thistlethwaite JR, Newell KA.

Transplantation. 1999 Jan 15;67(1):131-7.

PMID:
9921809
42.

Separate regulation of peripheral hematopoietic and thymic engraftment.

Sykes M, Szot GL, Swenson K, Pearson DA, Wekerle T.

Exp Hematol. 1998 Jun;26(6):457-65.

PMID:
9620278
44.

Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.

Levisetti MG, Padrid PA, Szot GL, Mittal N, Meehan SM, Wardrip CL, Gray GS, Bruce DS, Thistlethwaite JR Jr, Bluestone JA.

J Immunol. 1997 Dec 1;159(11):5187-91.

PMID:
9548454
45.
46.
47.

Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice.

Zhao Y, Fishman JA, Sergio JJ, Oliveros JL, Pearson DA, Szot GL, Wilkinson RA, Arn JS, Sachs DH, Sykes M.

J Immunol. 1997 Feb 15;158(4):1641-9.

PMID:
9029100
48.

Repopulation of mouse CD4 cells in BALB/c nude mice receiving fetal pig thymus/liver grafts.

Zhao Y, Sergio JJ, Pearson DA, Szot GL, Arn JS, Sachs DH, Sykes M.

Transplant Proc. 1997 Feb-Mar;29(1-2):1228-9. No abstract available.

PMID:
9123286
49.
50.

Interleukin-12 inhibits murine graft-versus-host disease.

Sykes M, Szot GL, Nguyen PL, Pearson DA.

Blood. 1995 Sep 15;86(6):2429-38.

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