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Items: 1 to 50 of 256

1.

Template-directed catalysis of a multi-step reaction pathway for nonenzymatic RNA primer extension.

Walton T, Pazienza L, Szostak JW.

Biochemistry. 2018 Dec 19. doi: 10.1021/acs.biochem.8b01156. [Epub ahead of print]

PMID:
30566332
2.

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA.

Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13318-13323. doi: 10.1073/pnas.1814367115. Epub 2018 Dec 3.

3.

Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II).

Jin L, Engelhart AE, Zhang W, Adamala K, Szostak JW.

J Am Chem Soc. 2018 Nov 7;140(44):15016-15021. doi: 10.1021/jacs.8b09617. Epub 2018 Oct 26.

PMID:
30335371
4.

Protocells and RNA Self-Replication.

Joyce GF, Szostak JW.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a034801. doi: 10.1101/cshperspect.a034801. Review.

PMID:
30181195
5.

Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.

Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI.

Mol Cell. 2018 Jul 19;71(2):244-255.e5. doi: 10.1016/j.molcel.2018.06.001. Epub 2018 Jul 5.

PMID:
29983320
6.

A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying.

Giurgiu C, Wright TH, O'Flaherty DK, Szostak JW.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9844-9848. doi: 10.1002/anie.201805785. Epub 2018 Jul 6.

PMID:
29939457
7.

Crystallographic observation of nonenzymatic RNA primer extension.

Zhang W, Walton T, Li L, Szostak JW.

Elife. 2018 May 31;7. pii: e36422. doi: 10.7554/eLife.36422.

8.

Copying of Mixed-Sequence RNA Templates inside Model Protocells.

O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW.

J Am Chem Soc. 2018 Apr 18;140(15):5171-5178. doi: 10.1021/jacs.8b00639. Epub 2018 Apr 9.

9.

Preparation, Purification, and Use of Fatty Acid-containing Liposomes.

Jin L, Engelhart AE, Adamala KP, Szostak JW.

J Vis Exp. 2018 Feb 9;(132). doi: 10.3791/57324.

10.

Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution.

Jin L, Kamat NP, Jena S, Szostak JW.

Small. 2018 Apr;14(15):e1704077. doi: 10.1002/smll.201704077. Epub 2018 Feb 26.

PMID:
29479815
11.

Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.

Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW.

J Am Chem Soc. 2018 Feb 28;140(8):2829-2840. doi: 10.1021/jacs.7b11750. Epub 2018 Feb 13.

PMID:
29411978
12.

Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth.

Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD.

Chem Commun (Camb). 2018 Jan 25;54(9):1121-1124. doi: 10.1039/c7cc07748c.

PMID:
29334083
13.

Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension.

Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW.

J Am Chem Soc. 2018 Jan 17;140(2):783-792. doi: 10.1021/jacs.7b11623. Epub 2018 Jan 2.

14.

Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.

Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW.

Nat Chem. 2017 Nov 23;9(12):1286. doi: 10.1038/nchem.2885.

PMID:
29168488
15.

UV-light-driven prebiotic synthesis of iron-sulfur clusters.

Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS.

Nat Chem. 2017 Dec;9(12):1229-1234. doi: 10.1038/nchem.2817. Epub 2017 Jul 10.

16.

A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension.

Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW.

J Am Chem Soc. 2017 Nov 22;139(46):16741-16747. doi: 10.1021/jacs.7b08784. Epub 2017 Nov 7.

PMID:
29112424
17.

A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5'-phosphoro-2-aminoimidazolide.

Walton T, Szostak JW.

Biochemistry. 2017 Oct 31;56(43):5739-5747. doi: 10.1021/acs.biochem.7b00792. Epub 2017 Oct 19.

PMID:
29022704
18.

Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.

Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P.

RNA Biol. 2017 Dec 2;14(12):1756-1765. doi: 10.1080/15476286.2017.1356566. Epub 2017 Oct 9.

19.

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.

Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7659-7664. doi: 10.1073/pnas.1704006114. Epub 2017 Jul 3.

20.

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation.

Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW.

J Am Chem Soc. 2017 Jul 5;139(26):8780-8783. doi: 10.1021/jacs.7b01562. Epub 2017 Jun 22.

PMID:
28640999
21.

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides.

Stairs S, Nikmal A, Bučar DK, Zheng SL, Szostak JW, Powner MW.

Nat Commun. 2017 May 19;8:15270. doi: 10.1038/ncomms15270.

22.

The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life.

Szostak JW.

Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11037-11043. doi: 10.1002/anie.201704048. Epub 2017 Jul 25. Review.

PMID:
28514493
23.

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides.

Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW.

J Am Chem Soc. 2017 Feb 8;139(5):1810-1813. doi: 10.1021/jacs.6b13148. Epub 2017 Jan 24.

24.

Unusual Base-Pairing Interactions in Monomer-Template Complexes.

Zhang W, Tam CP, Wang J, Szostak JW.

ACS Cent Sci. 2016 Dec 28;2(12):916-926. doi: 10.1021/acscentsci.6b00278. Epub 2016 Nov 2.

25.

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.

Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW.

J Am Chem Soc. 2017 Jan 18;139(2):571-574. doi: 10.1021/jacs.6b09760. Epub 2017 Jan 5.

PMID:
28055190
26.

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes.

Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW.

J Am Chem Soc. 2016 Dec 28;138(51):16669-16676. doi: 10.1021/jacs.6b08801. Epub 2016 Dec 13.

PMID:
27959544
27.

Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension.

Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW.

Chem Commun (Camb). 2016 Sep 29;52(80):11905-11907.

PMID:
27722518
28.

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.

Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW.

Nat Chem. 2016 Oct;8(10):915-21. doi: 10.1038/nchem.2551. Epub 2016 Jun 27. Retraction in: Nat Chem. 2017 Nov 23;9(12 ):1286.

29.

On the origin of life.

Szostak JW.

Medicina (B Aires). 2016;76(4):199-203.

30.

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension.

Walton T, Szostak JW.

J Am Chem Soc. 2016 Sep 14;138(36):11996-2002. doi: 10.1021/jacs.6b07977. Epub 2016 Sep 1.

PMID:
27552367
31.

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides.

Prywes N, Blain JC, Del Frate F, Szostak JW.

Elife. 2016 Jun 28;5. pii: e17756. doi: 10.7554/eLife.17756.

32.

Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying.

Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW.

Chem Commun (Camb). 2016 May 5;52(39):6529-32. doi: 10.1039/c6cc02692c.

PMID:
27109314
33.

A simple physical mechanism enables homeostasis in primitive cells.

Engelhart AE, Adamala KP, Szostak JW.

Nat Chem. 2016 May;8(5):448-53. doi: 10.1038/nchem.2475. Epub 2016 Mar 14.

34.

Collaboration between primitive cell membranes and soluble catalysts.

Adamala KP, Engelhart AE, Szostak JW.

Nat Commun. 2016 Mar 21;7:11041. doi: 10.1038/ncomms11041.

35.

Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis.

Li L, Lelyveld VS, Prywes N, Szostak JW.

J Am Chem Soc. 2016 Mar 30;138(12):3986-9. doi: 10.1021/jacs.6b00784. Epub 2016 Mar 17.

PMID:
26974265
36.

Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates.

Izgu EC, Oh SS, Szostak JW.

Chem Commun (Camb). 2016 Mar 4;52(18):3684-6. doi: 10.1039/c5cc10317g.

PMID:
26857159
37.

Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides.

Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW.

J Am Chem Soc. 2015 Dec 16;137(49):15378-81. doi: 10.1021/jacs.5b10596. Epub 2015 Dec 3.

38.

Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms.

Björkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW.

J Am Chem Soc. 2015 Nov 18;137(45):14430-8. doi: 10.1021/jacs.5b09438. Epub 2015 Nov 9.

39.

Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization.

Larsen AT, Fahrenbach AC, Sheng J, Pian J, Szostak JW.

Nucleic Acids Res. 2015 Sep 18;43(16):7675-87. doi: 10.1093/nar/gkv761. Epub 2015 Aug 3.

40.

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides.

Kamat NP, Tobé S, Hill IT, Szostak JW.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11735-9. doi: 10.1002/anie.201505742. Epub 2015 Jul 29.

41.

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations.

Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW.

Nat Protoc. 2015 Jun;10(6):927-38. doi: 10.1038/nprot.2015.054. Epub 2015 May 28.

42.

Uncovering the thermodynamics of monomer binding for RNA replication.

Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen AT, Blain JC, Szostak JW.

J Am Chem Soc. 2015 May 20;137(19):6373-82. doi: 10.1021/jacs.5b02707. Epub 2015 May 7.

43.

Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension.

Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW.

J Am Chem Soc. 2015 Feb 25;137(7):2769-75. doi: 10.1021/jacs.5b00445. Epub 2015 Feb 16.

44.

Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension.

Adamala K, Engelhart AE, Szostak JW.

J Am Chem Soc. 2015 Jan 14;137(1):483-9. doi: 10.1021/ja511564d. Epub 2014 Dec 31.

45.

Controlled growth of filamentous fatty acid vesicles under flow.

Hentrich C, Szostak JW.

Langmuir. 2014 Dec 16;30(49):14916-25. doi: 10.1021/la503933x. Epub 2014 Dec 1.

46.

Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions.

Budin I, Prwyes N, Zhang N, Szostak JW.

Biophys J. 2014 Oct 7;107(7):1582-90. doi: 10.1016/j.bpj.2014.07.067.

47.

Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs.

Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW.

J Am Chem Soc. 2014 Oct 1;136(39):13916-24. doi: 10.1021/ja508015a. Epub 2014 Sep 16.

48.

Progress toward synthetic cells.

Blain JC, Szostak JW.

Annu Rev Biochem. 2014;83:615-40. doi: 10.1146/annurev-biochem-080411-124036. Epub 2014 Mar 3. Review.

PMID:
24606140
49.

Rapid RNA exchange in aqueous two-phase system and coacervate droplets.

Jia TZ, Hentrich C, Szostak JW.

Orig Life Evol Biosph. 2014 Feb;44(1):1-12. doi: 10.1007/s11084-014-9355-8. Epub 2014 Feb 28.

50.

Structural insights into the effects of 2'-5' linkages on the RNA duplex.

Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3050-5. doi: 10.1073/pnas.1317799111. Epub 2014 Feb 10.

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