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Items: 4

1.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N.

J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

2.

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

Gerken PA, Wolstenhulme JR, Tumber A, Hatch SB, Zhang Y, Müller S, Chandler SA, Mair B, Li F, Nijman SMB, Konietzny R, Szommer T, Yapp C, Fedorov O, Benesch JLP, Vedadi M, Kessler BM, Kawamura A, Brennan PE, Smith MD.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15555-15559. doi: 10.1002/anie.201706788. Epub 2017 Nov 7.

3.

Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques.

Szommer T, Lukács A, Kovács J, Szabó MJ, Hoffmann MG, Schmitt MH, Gerencsér J.

Mol Divers. 2012 Feb;16(1):81-90. doi: 10.1007/s11030-012-9357-2. Epub 2012 Jan 26.

PMID:
22278610
4.

Enhanced hit-to-lead process using bioanalogous lead evolution and chemogenomics: application in designing selective matrix metalloprotease inhibitors.

Papp A, Szommer T, Barna L, Gyimesi G, Ferdinandy P, Spadoni C, Darvas F, Fujita T, Urge L, Dormán G.

Expert Opin Drug Discov. 2007 May;2(5):707-23. doi: 10.1517/17460441.2.5.707.

PMID:
23488960

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