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Items: 1 to 50 of 186


Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency.

Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A.

Nat Biotechnol. 2020 Jan;38(1):44-49. doi: 10.1038/s41587-019-0325-6. Epub 2019 Dec 9.


BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.

Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S.

Nature. 2019 Aug;572(7771):614-619. doi: 10.1038/s41586-019-1503-x. Epub 2019 Aug 21.


Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition.

Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ.

PLoS One. 2019 Apr 10;14(4):e0215218. doi: 10.1371/journal.pone.0215218. eCollection 2019.


Development of a flow-through USP 4 apparatus drug release assay for the evaluation of amphotericin B liposome.

Tang J, Srinivasan S, Yuan W, Ming R, Liu Y, Dai Z, Noble CO, Hayes ME, Zheng N, Jiang W, Szoka FC, Schwendeman A.

Eur J Pharm Biopharm. 2019 Jan;134:107-116. doi: 10.1016/j.ejpb.2018.11.010. Epub 2018 Nov 24.


Correction: Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation.

Dolor A, Kierstead P, Dai Z, Szoka FC.

Chem Commun (Camb). 2018 Nov 13;54(91):12891. doi: 10.1039/c8cc90487a.


Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation.

Dolor A, Kierstead P, Dai Z, Szoka FC.

Chem Commun (Camb). 2018 Oct 28;54(84):11949-11952. doi: 10.1039/c8cc05011b. Epub 2018 Oct 5. Erratum in: Chem Commun (Camb). 2018 Nov 13;54(91):12891.


Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery.

Dolor A, Szoka FC Jr.

Mol Pharm. 2018 Jun 4;15(6):2069-2083. doi: 10.1021/acs.molpharmaceut.8b00319. Epub 2018 May 16. Review.


Constrained Versus Free Cholesterol in DPPC Membranes: A Comparison of Chain Ordering Ability Using Deuterium NMR.

Shaghaghi M, Keyvanloo A, Huang Z, Szoka FC, Thewalt JL.

Langmuir. 2017 Dec 19;33(50):14405-14413. doi: 10.1021/acs.langmuir.7b03299. Epub 2017 Dec 5.


Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.

Lee S, Kivimäe S, Szoka FC.

Mol Ther Methods Clin Dev. 2017 Sep 7;7:60-73. doi: 10.1016/j.omtm.2017.08.007. eCollection 2017 Dec 15.


Biodistribution and In Vivo Antileishmanial Activity of 1,2-Distigmasterylhemisuccinoyl-sn-Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B.

Iman M, Huang Z, Alavizadeh SH, Szoka FC Jr, Jaafari MR.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e02525-16. doi: 10.1128/AAC.02525-16. Print 2017 Sep.


Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids.

Kieler-Ferguson HM, Chan D, Sockolosky J, Finney L, Maxey E, Vogt S, Szoka FC Jr.

Eur J Pharm Sci. 2017 May 30;103:85-93. doi: 10.1016/j.ejps.2017.03.003. Epub 2017 Mar 3.


Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes.

Yuan W, Kuai R, Dai Z, Yuan Y, Zheng N, Jiang W, Noble C, Hayes M, Szoka FC, Schwendeman A.

AAPS J. 2017 Jan;19(1):150-160. doi: 10.1208/s12248-016-9958-2. Epub 2016 Aug 2.


Macrophage-based cell therapies: The long and winding road.

Lee S, Kivimäe S, Dolor A, Szoka FC.

J Control Release. 2016 Oct 28;240:527-540. doi: 10.1016/j.jconrel.2016.07.018. Epub 2016 Jul 12. Review.


The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes.

Kierstead PH, Okochi H, Venditto VJ, Chuong TC, Kivimae S, Fréchet JMJ, Szoka FC.

J Control Release. 2015 Sep 10;213:1-9. doi: 10.1016/j.jconrel.2015.06.023. Epub 2015 Jun 18.


The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.

Sockolosky JT, Szoka FC.

Adv Drug Deliv Rev. 2015 Aug 30;91:109-24. doi: 10.1016/j.addr.2015.02.005. Epub 2015 Feb 19. Review.


Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice.

Sockolosky JT, Kivimäe S, Szoka FC.

PLoS One. 2014 Jul 24;9(7):e102566. doi: 10.1371/journal.pone.0102566. eCollection 2014.


Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids.

Venditto VJ, Dolor A, Kohli A, Salentinig S, Boyd BJ, Szoka FC Jr.

Chem Commun (Camb). 2014 Aug 21;50(65):9109-11. doi: 10.1039/c4cc02866j.


Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits.

Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC Jr.

Clin Vaccine Immunol. 2014 Aug;21(8):1086-93. doi: 10.1128/CVI.00320-14. Epub 2014 May 28.


Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan.

Kohli AG, Kivimäe S, Tiffany MR, Szoka FC.

J Control Release. 2014 Oct 10;191:105-14. doi: 10.1016/j.jconrel.2014.05.019. Epub 2014 May 20.


Designer lipids for drug delivery: from heads to tails.

Kohli AG, Kierstead PH, Venditto VJ, Walsh CL, Szoka FC.

J Control Release. 2014 Sep 28;190:274-87. doi: 10.1016/j.jconrel.2014.04.047. Epub 2014 May 6. Review.


Chemoenzymatic synthesis of oligohyaluronan-lipid conjugates.

Ruhela D, Kivimäe S, Szoka FC.

Bioconjug Chem. 2014 Apr 16;25(4):718-23. doi: 10.1021/bc4005975. Epub 2014 Mar 28.


A robust and quantitative method for tracking liposome contents after intravenous administration.

Kohli AG, Kieler-Ferguson HM, Chan D, Szoka FC.

J Control Release. 2014 Feb 28;176:86-93. doi: 10.1016/j.jconrel.2013.12.014. Epub 2013 Dec 22.


Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo.

Guo X, Gagne L, Chen H, Szoka FC.

J Liposome Res. 2014 Jun;24(2):90-8. doi: 10.3109/08982104.2013.848886. Epub 2013 Nov 5.


Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease.

Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI.

PLoS One. 2013;8(2):e56026. doi: 10.1371/journal.pone.0056026. Epub 2013 Feb 11.


Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs.

Kieler-Ferguson HM, Fréchet JM, Szoka FC Jr.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Mar-Apr;5(2):130-8. doi: 10.1002/wnan.1209. Epub 2013 Jan 17. Review.


Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery.

Walsh CL, Nguyen J, Tiffany MR, Szoka FC.

Bioconjug Chem. 2013 Jan 16;24(1):36-43. doi: 10.1021/bc300346h. Epub 2012 Dec 18.


Periplasmic production via the pET expression system of soluble, bioactive human growth hormone.

Sockolosky JT, Szoka FC.

Protein Expr Purif. 2013 Feb;87(2):129-35. doi: 10.1016/j.pep.2012.11.002. Epub 2012 Nov 17.


Rational design of membrane proximal external region lipopeptides containing chemical modifications for HIV-1 vaccination.

Venditto VJ, Watson DS, Motion M, Montefiori D, Szoka FC Jr.

Clin Vaccine Immunol. 2013 Jan;20(1):39-45. doi: 10.1128/CVI.00615-12. Epub 2012 Oct 31.


Cancer nanomedicines: so many papers and so few drugs!

Venditto VJ, Szoka FC Jr.

Adv Drug Deliv Rev. 2013 Jan;65(1):80-8. doi: 10.1016/j.addr.2012.09.038. Epub 2012 Oct 1. Review.


Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions.

Sockolosky JT, Tiffany MR, Szoka FC.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16095-100. doi: 10.1073/pnas.1208857109. Epub 2012 Sep 18.


Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.

Motion JP, Nguyen J, Szoka FC.

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9047-51. doi: 10.1002/anie.201204198. Epub 2012 Aug 6.


Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties.

Walsh CL, Nguyen J, Szoka FC.

Chem Commun (Camb). 2012 Jun 7;48(45):5575-7. doi: 10.1039/c2cc31710a. Epub 2012 Apr 26.


Nucleic acid delivery: the missing pieces of the puzzle?

Nguyen J, Szoka FC.

Acc Chem Res. 2012 Jul 17;45(7):1153-62. doi: 10.1021/ar3000162. Epub 2012 Mar 19. Review.


Inverse-phosphocholine lipids: a remix of a common phospholipid.

Perttu EK, Kohli AG, Szoka FC Jr.

J Am Chem Soc. 2012 Mar 14;134(10):4485-8. doi: 10.1021/ja210989h. Epub 2012 Feb 27.


Synthesis and characterization of betaine-like diacyl lipids: zwitterionic lipids with the cationic amine at the bilayer interface.

Kohli AG, Walsh CL, Szoka FC.

Chem Phys Lipids. 2012 Feb;165(2):252-9. doi: 10.1016/j.chemphyslip.2012.01.005. Epub 2012 Jan 24.


Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties.

Perttu EK, Szoka FC Jr.

Chem Commun (Camb). 2011 Dec 21;47(47):12613-5. doi: 10.1039/c1cc15804j. Epub 2011 Nov 2.


Asymmetric 1-alkyl-2-acyl phosphatidylcholine: a helper lipid for enhanced non-viral gene delivery.

Huang Z, Li W, Szoka FC Jr.

Int J Pharm. 2012 May 1;427(1):64-70. doi: 10.1016/j.ijpharm.2011.06.022. Epub 2011 Jun 21.


Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera.

Foglia F, Barlow DJ, Szoka FC, Huang Z, Rogers SE, Lawrence MJ.

Langmuir. 2011 Jul 5;27(13):8275-81. doi: 10.1021/la200739y. Epub 2011 Jun 2.


Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.

Riviere K, Kieler-Ferguson HM, Jerger K, Szoka FC Jr.

J Control Release. 2011 Aug 10;153(3):288-96. doi: 10.1016/j.jconrel.2011.05.005. Epub 2011 May 7.


Synthesis and properties of star-comb polymers and their doxorubicin conjugates.

Chen B, van der Poll DG, Jerger K, Floyd WC, Fréchet JM, Szoka FC.

Bioconjug Chem. 2011 Apr 20;22(4):617-24. doi: 10.1021/bc100400u. Epub 2011 Mar 4.


Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion.

Guy RH, Szoka FC Jr.

Phys Chem Chem Phys. 2011 Mar 28;13(12):5346-52. doi: 10.1039/c0cp02305a. Epub 2011 Feb 1.


Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice.

Watson DS, Platt VM, Cao L, Venditto VJ, Szoka FC Jr.

Clin Vaccine Immunol. 2011 Feb;18(2):289-97. doi: 10.1128/CVI.00425-10. Epub 2010 Dec 15.


Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice.

Floyd WC 3rd, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA.

ChemMedChem. 2011 Jan 3;6(1):49-53. doi: 10.1002/cmdc.201000377. No abstract available.


Convection and retro-convection enhanced delivery: some theoretical considerations related to drug targeting.

Motion JP, Huynh GH, Szoka FC Jr, Siegel RA.

Pharm Res. 2011 Mar;28(3):472-9. doi: 10.1007/s11095-010-0296-2. Epub 2010 Oct 21.


Influence of multivalent nitrilotriacetic acid lipid-ligand affinity on the circulation half-life in mice of a liposome-attached His6-protein.

Platt V, Huang Z, Cao L, Tiffany M, Riviere K, Szoka FC Jr.

Bioconjug Chem. 2010 May 19;21(5):892-902. doi: 10.1021/bc900448f.


Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration.

Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka FC Jr.

J Drug Target. 2011 Jan;19(1):14-24. doi: 10.3109/10611861003733953. Epub 2010 Mar 30.


Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer.

van der Poll DG, Kieler-Ferguson HM, Floyd WC, Guillaudeu SJ, Jerger K, Szoka FC, Fréchet JM.

Bioconjug Chem. 2010 Apr 21;21(4):764-73. doi: 10.1021/bc900553n.


Utilizing the O-antigen lipopolysaccharide biosynthesis pathway in Escherichia coli to interrogate the substrate specificities of exogenous glycosyltransferase genes in a combinatorial approach.

Johansen EB, Szoka FC, Zaleski A, Apicella MA, Gibson BW.

Glycobiology. 2010 Jun;20(6):763-74. doi: 10.1093/glycob/cwq033. Epub 2010 Mar 5.

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