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Items: 1 to 50 of 224

1.

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1094-L1106. doi: 10.1152/ajplung.00173.2018. Epub 2019 Mar 20.

PMID:
30892074
2.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

3.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC.

PMID:
30554520
4.

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.

PMID:
30530483
5.

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis.

Sala MA, Balderas-Martínez YI, Buendía-Roldan I, Abdala-Valencia H, Nam K, Jain M, Bhorade S, Bharat A, Reyfman PA, Ridge KM, Pardo A, Sznajder JI, Budinger GRS, Misharin AV, Selman M.

Respir Res. 2018 Nov 26;19(1):233. doi: 10.1186/s12931-018-0932-7.

6.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
7.

Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells.

Casalino-Matsuda SM, Wang N, Ruhoff PT, Matsuda H, Nlend MC, Nair A, Szleifer I, Beitel GJ, Sznajder JI, Sporn PHS.

Sci Rep. 2018 Sep 10;8(1):13508. doi: 10.1038/s41598-018-32008-x.

8.

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.

Shigemura M, Lecuona E, Angulo M, Homma T, Rodríguez DA, Gonzalez-Gonzalez FJ, Welch LC, Amarelle L, Kim SJ, Kaminski N, Budinger GRS, Solway J, Sznajder JI.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaat1662. doi: 10.1126/scitranslmed.aat1662.

PMID:
30185650
9.

Ubiquitin-proteasome signaling in lung injury.

Magnani ND, Dada LA, Sznajder JI.

Transl Res. 2018 Aug;198:29-39. doi: 10.1016/j.trsl.2018.04.003. Epub 2018 Apr 23. Review.

PMID:
29752900
10.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

11.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.

12.

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.

13.

Stretching to Understand How Proteostasis and the Unfolded Protein Response Regulate Lung Injury.

Lecuona E, Sznajder JI.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):143-144. doi: 10.1165/rcmb.2017-0170ED. No abstract available.

14.

Gas Exchange Disturbances Regulate Alveolar Fluid Clearance during Acute Lung Injury.

Vadász I, Sznajder JI.

Front Immunol. 2017 Jul 4;8:757. doi: 10.3389/fimmu.2017.00757. eCollection 2017. Review.

15.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

16.

Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.

Zhou Q, Dai J, Chen T, Dada LA, Zhang X, Zhang W, DeCamp MM, Winn RA, Sznajder JI, Zhou G.

Cell Signal. 2017 Oct;38:49-59. doi: 10.1016/j.cellsig.2017.06.016. Epub 2017 Jun 24.

17.

FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury.

Brazee PL, Soni PN, Tokhtaeva E, Magnani N, Yemelyanov A, Perlman HR, Ridge KM, Sznajder JI, Vagin O, Dada LA.

Front Immunol. 2017 Jun 1;8:623. doi: 10.3389/fimmu.2017.00623. eCollection 2017.

18.

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

Budinger GRS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1492-1500. doi: 10.1093/gerona/glx090. Review.

19.

Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections.

Peteranderl C, Sznajder JI, Herold S, Lecuona E.

Front Immunol. 2017 Apr 18;8:446. doi: 10.3389/fimmu.2017.00446. eCollection 2017. Review.

20.

Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.

Nin N, Muriel A, Peñuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Ríos F, Violi DA, Thille AW, González M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Soto L, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bülow HH, Zeggwagh AA, Anzueto A, Sznajder JI, Esteban A; VENTILA Group.

Intensive Care Med. 2017 Feb;43(2):200-208. doi: 10.1007/s00134-016-4611-1. Epub 2017 Jan 20.

21.

Metabolism and Skeletal Muscle Homeostasis in Lung Disease.

Ceco E, Weinberg SE, Chandel NS, Sznajder JI.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):28-34. doi: 10.1165/rcmb.2016-0355TR. Review.

22.

Effects of hypercapnia on the lung.

Shigemura M, Lecuona E, Sznajder JI.

J Physiol. 2017 Apr 15;595(8):2431-2437. doi: 10.1113/JP273781. Epub 2017 Feb 14. Review.

23.

Anti-Influenza Treatment: Drugs Currently Used and Under Development.

Amarelle L, Lecuona E, Sznajder JI.

Arch Bronconeumol. 2017 Jan;53(1):19-26. doi: 10.1016/j.arbres.2016.07.004. Epub 2016 Aug 9. Review. English, Spanish.

24.

The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits.

Tokhtaeva E, Sun H, Deiss-Yehiely N, Wen Y, Soni PN, Gabrielli NM, Marcus EA, Ridge KM, Sachs G, Vazquez-Levin M, Sznajder JI, Vagin O, Dada LA.

J Cell Sci. 2016 Jun 15;129(12):2394-406. doi: 10.1242/jcs.186148. Epub 2016 May 3.

25.

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.

Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT.

J Biol Chem. 2016 May 27;291(22):11800-8. doi: 10.1074/jbc.M116.713941. Epub 2016 Apr 4.

26.

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S.

J Clin Invest. 2016 Apr 1;126(4):1566-80. doi: 10.1172/JCI83931. Epub 2016 Mar 21.

27.

Corrigendum to "Calcium release-activated calcium (CRAC) channels mediate the β2 -adrenergic regulation of Na,K-ATPase" [FEBS Lett. 588 (24) (2014) 4686-4693].

Keller MJ, Lecuona E, Prakriya M, Cheng Y, Soberanes S, Scott Budinger GR, Sznajder JI.

FEBS Lett. 2015 Jan 30;589(3):414. doi: 10.1016/j.febslet.2014.12.017. No abstract available.

28.

Role of Linear Ubiquitination in Health and Disease.

Brazee P, Dada LA, Sznajder JI.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):761-8. doi: 10.1165/rcmb.2016-0014TR. Review.

29.

Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression.

Helenius IT, Nair A, Bittar HE, Sznajder JI, Sporn PH, Beitel GJ.

J Biomol Screen. 2016 Apr;21(4):363-71. doi: 10.1177/1087057115624091. Epub 2015 Dec 23.

30.

Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.

Helenius IT, Haake RJ, Kwon YJ, Hu JA, Krupinski T, Casalino-Matsuda SM, Sporn PHS, Sznajder JI, Beitel GJ.

J Immunol. 2016 Jan 15;196(2):655-667. doi: 10.4049/jimmunol.1501708. Epub 2015 Dec 7.

31.

Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.

Zhou Q, Chen T, Zhang W, Bozkanat M, Li Y, Xiao L, van Breemen RB, Christman JW, Sznajder JI, Zhou G.

Am J Respir Cell Mol Biol. 2016 May;54(5):728-39. doi: 10.1165/rcmb.2015-0111OC.

32.

Pleural Hypercarbia After Lung Surgery Is Associated With Persistent Alveolopleural Fistulae.

Bharat A, Graf N, Mullen A, Kanter J, Andrei AC, Sporn PH, DeCamp MM, Sznajder JI.

Chest. 2016 Jan;149(1):220-7. doi: 10.1378/chest.15-1591. Epub 2016 Jan 6.

33.

High CO2 Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation.

Dada LA, Trejo Bittar HE, Welch LC, Vagin O, Deiss-Yehiely N, Kelly AM, Baker MR, Capri J, Cohn W, Whitelegge JP, Vadász I, Gruenbaum Y, Sznajder JI.

Mol Cell Biol. 2015 Dec;35(23):3962-73. doi: 10.1128/MCB.00813-15. Epub 2015 Sep 14.

34.

Lung Edema Clearance: Relevance to Patients with Lung Injury.

Azzam ZS, Sznajder JI.

Rambam Maimonides Med J. 2015 Jul 30;6(3). doi: 10.5041/RMMJ.10210.

35.

Decreased CXCL12 is associated with impaired alveolar epithelial cell migration and poor lung healing after lung resection.

Kanter JA, Sun H, Chiu S, DeCamp MM, Sporn PH, Sznajder JI, Bharat A.

Surgery. 2015 Oct;158(4):1073-80; discussion 1080-2. doi: 10.1016/j.surg.2015.04.051. Epub 2015 Jul 23.

36.

Pleural Gas Analysis for Detection of Alveolopleural Fistulae.

Bharat A, Graf N, Cassidy E, Smith S, Gillespie C, Meyerson S, Sporn PH, Sznajder JI, DeCamp MM.

Ann Thorac Surg. 2015 Jun;99(6):2179-82. doi: 10.1016/j.athoracsur.2014.12.074.

37.

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.

Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng CY, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, Stegh AH.

Genes Dev. 2015 Apr 1;29(7):732-45. doi: 10.1101/gad.257394.114.

38.

Muscle dysfunction in patients with lung diseases: a growing epidemic.

Barreiro E, Sznajder JI, Nader GA, Budinger GR.

Am J Respir Crit Care Med. 2015 Mar 15;191(6):616-9. doi: 10.1164/rccm.201412-2189OE. No abstract available.

39.

High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1).

Jaitovich A, Angulo M, Lecuona E, Dada LA, Welch LC, Cheng Y, Gusarova G, Ceco E, Liu C, Shigemura M, Barreiro E, Patterson C, Nader GA, Sznajder JI.

J Biol Chem. 2015 Apr 3;290(14):9183-94. doi: 10.1074/jbc.M114.625715. Epub 2015 Feb 17.

40.

Blue journal conference. Aging and susceptibility to lung disease.

Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):261-9. doi: 10.1164/rccm.201410-1876PP. Review.

41.

Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014.

Agustí A, Antó JM, Auffray C, Barbé F, Barreiro E, Dorca J, Escarrabill J, Faner R, Furlong LI, Garcia-Aymerich J, Gea J, Lindmark B, Monsó E, Plaza V, Puhan MA, Roca J, Ruiz-Manzano J, Sampietro-Colom L, Sanz F, Serrano L, Sharpe J, Sibila O, Silverman EK, Sterk PJ, Sznajder JI.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):391-401. doi: 10.1164/rccm.201410-1935PP.

42.

Time to pass the baton.

Sznajder JI.

Am J Respir Crit Care Med. 2014 Dec 15;190(12):1327-8. doi: 10.1164/rccm.201411-2085ED. No abstract available.

PMID:
25496095
43.

Calcium release-activated calcium (CRAC) channels mediate the β(2)-adrenergic regulation of Na,K-ATPase.

Keller MJ, Lecuona E, Prakriya M, Cheng Y, Soberanes S, Budinger GR, Sznajder JI.

FEBS Lett. 2014 Dec 20;588(24):4686-93. doi: 10.1016/j.febslet.2014.10.041. Epub 2014 Nov 11. Erratum in: FEBS Lett. 2015 Jan 30;589(3):414.

44.

Fitness to fly in patients with lung disease.

Nicholson TT, Sznajder JI.

Ann Am Thorac Soc. 2014 Dec;11(10):1614-22. doi: 10.1513/AnnalsATS.201406-234PS. Review.

PMID:
25393882
45.

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.

Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GR, Radigan KA.

J Virol Methods. 2014 Dec;209:116-20. doi: 10.1016/j.jviromet.2014.09.004. Epub 2014 Sep 17.

46.

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):688-98. doi: 10.1164/rccm.201403-0463OC.

47.

The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.

Sharabi K, Charar C, Friedman N, Mizrahi I, Zaslaver A, Sznajder JI, Gruenbaum Y.

PLoS Genet. 2014 Aug 7;10(8):e1004529. doi: 10.1371/journal.pgen.1004529. eCollection 2014 Aug.

48.

Carbon dioxide-sensing in organisms and its implications for human disease.

Cummins EP, Selfridge AC, Sporn PH, Sznajder JI, Taylor CT.

Cell Mol Life Sci. 2014 Mar;71(5):831-45. doi: 10.1007/s00018-013-1470-6. Epub 2013 Sep 18. Review.

49.

Malfolded protein structure and proteostasis in lung diseases.

Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W.

Am J Respir Crit Care Med. 2014 Jan 1;189(1):96-103. doi: 10.1164/rccm.201306-1164WS.

50.

Healthcare disparities in patients with acute respiratory distress syndrome. Toward equity.

Garcia JG, Sznajder JI.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):631-2. doi: 10.1164/rccm.201307-1394ED. No abstract available.

PMID:
24032377

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