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Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

Gharahdaghi N, Rudrappa S, Brook MS, Idris I, Crossland H, Hamrock C, Abdul Aziz MH, Kadi F, Tarum J, Greenhaff PL, Constantin-Teodosiu D, Cegielski J, Phillips BE, Wilkinson DJ, Szewczyk NJ, Smith K, Atherton PJ.

J Cachexia Sarcopenia Muscle. 2019 Sep 30. doi: 10.1002/jcsm.12472. [Epub ahead of print]


Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.

Sudevan S, Takiura M, Kubota Y, Higashitani N, Cooke M, Ellwood RA, Etheridge T, Szewczyk NJ, Higashitani A.

FASEB J. 2019 Aug;33(8):9540-9550. doi: 10.1096/fj.201802298R. Epub 2019 Jun 4.


The acute transcriptional response to resistance exercise: impact of age and contraction mode.

Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, Smith K, Gallagher IJ, Kadi F, Szewczyk NJ, Atherton PJ, Etheridge T.

Aging (Albany NY). 2019 Apr 15;11(7):2111-2126. doi: 10.18632/aging.101904.


Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.

Gaffney CJ, Pollard A, Barratt TF, Constantin-Teodosiu D, Greenhaff PL, Szewczyk NJ.

Aging (Albany NY). 2018 Nov 19;10(11):3382-3396. doi: 10.18632/aging.101654.


Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs.

Hewitt JE, Pollard AK, Lesanpezeshki L, Deane CS, Gaffney CJ, Etheridge T, Szewczyk NJ, Vanapalli SA.

Dis Model Mech. 2018 Dec 4;11(12). pii: dmm036137. doi: 10.1242/dmm.036137.


NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans.

Rahman M, Hewitt JE, Van-Bussel F, Edwards H, Blawzdziewicz J, Szewczyk NJ, Driscoll M, Vanapalli SA.

Lab Chip. 2018 Jul 24;18(15):2187-2201. doi: 10.1039/c8lc00103k.


Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism.

Wilkinson DJ, Hossain T, Limb MC, Phillips BE, Lund J, Williams JP, Brook MS, Cegielski J, Philp A, Ashcroft S, Rathmacher JA, Szewczyk NJ, Smith K, Atherton PJ.

Clin Nutr. 2018 Dec;37(6 Pt A):2068-2075. doi: 10.1016/j.clnu.2017.09.024. Epub 2017 Oct 6.


Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males.

Quinlan JI, Maganaris CN, Franchi MV, Smith K, Atherton PJ, Szewczyk NJ, Greenhaff PL, Phillips BE, Blackwell JI, Boereboom C, Williams JP, Lund J, Narici MV.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):539-545. doi: 10.1093/gerona/glx149.


A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JL, Phillips BE, Szewczyk NJ, Kainulainen H, Lensu S, Koch LG, Britton SL, Greenhaff PL, Smith K, Atherton PJ.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E681-E689. doi: 10.1152/ajpendo.00157.2017. Epub 2017 Aug 15.


Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscle.

Lehmann S, Bass JJ, Barratt TF, Ali MZ, Szewczyk NJ.

J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):660-672. doi: 10.1002/jcsm.12196. Epub 2017 May 15.


Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ.

J Physiol. 2016 Dec 15;594(24):7399-7417. doi: 10.1113/JP272857. Epub 2016 Nov 7.


Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle.

Gaffney CJ, Shephard F, Chu J, Baillie DL, Rose A, Constantin-Teodosiu D, Greenhaff PL, Szewczyk NJ.

J Cachexia Sarcopenia Muscle. 2016 May;7(2):181-92. doi: 10.1002/jcsm.12040. Epub 2015 Jun 4.


An overview of technical considerations for Western blotting applications to physiological research.

Bass JJ, Wilkinson DJ, Rankin D, Phillips BE, Szewczyk NJ, Smith K, Atherton PJ.

Scand J Med Sci Sports. 2017 Jan;27(1):4-25. doi: 10.1111/sms.12702. Epub 2016 Jun 5. Review.


Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development.

Mora-Lorca JA, Sáenz-Narciso B, Gaffney CJ, Naranjo-Galindo FJ, Pedrajas JR, Guerrero-Gómez D, Dobrzynska A, Askjaer P, Szewczyk NJ, Cabello J, Miranda-Vizuete A.

Free Radic Biol Med. 2016 Jul;96:446-61. doi: 10.1016/j.freeradbiomed.2016.04.017. Epub 2016 Apr 24.


Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling.

Harada S, Hashizume T, Nemoto K, Shao Z, Higashitani N, Etheridge T, Szewczyk NJ, Fukui K, Higashibata A, Higashitani A.

NPJ Microgravity. 2016 Apr 7;2:16006. doi: 10.1038/npjmgrav.2016.6. eCollection 2016.


Commentaries on Viewpoint: A call for research to assess and promote functional resilience in astronaut crews.

Etheridge T, Szewczyk NJ, Zuo L, Chuang CC, Liu Z, Ward AT, Dier NL, Rotarius TR, Lalande S, Zhang X, Zhang M, Li G, Dong L, Gao F.

J Appl Physiol (1985). 2016 Feb 15;120(4):473-4. doi: 10.1152/japplphysiol.01036.2015. No abstract available.


Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans.

Higashibata A, Hashizume T, Nemoto K, Higashitani N, Etheridge T, Mori C, Harada S, Sugimoto T, Szewczyk NJ, Baba SA, Mogami Y, Fukui K, Higashitani A.

NPJ Microgravity. 2016 Jan 21;2:15022. doi: 10.1038/npjmgrav.2015.22. eCollection 2016.


Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ.

FASEB J. 2015 Nov;29(11):4485-96. doi: 10.1096/fj.15-273755. Epub 2015 Jul 13.


The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.

Etheridge T, Rahman M, Gaffney CJ, Shaw D, Shephard F, Magudia J, Solomon DE, Milne T, Blawzdziewicz J, Constantin-Teodosiu D, Greenhaff PL, Vanapalli SA, Szewczyk NJ.

FASEB J. 2015 Apr;29(4):1235-46. doi: 10.1096/fj.14-259119. Epub 2014 Dec 9.


Methods to assess subcellular compartments of muscle in C. elegans.

Gaffney CJ, Bass JJ, Barratt TF, Szewczyk NJ.

J Vis Exp. 2014 Nov 13;(93):e52043. doi: 10.3791/52043.


The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.

Estevez AO, Morgan KL, Szewczyk NJ, Gems D, Estevez M.

Neurotoxicology. 2014 Mar;41:28-43. doi: 10.1016/j.neuro.2013.12.012. Epub 2014 Jan 6.


A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.

Wilkinson DJ, Franchi MV, Brook MS, Narici MV, Williams JP, Mitchell WK, Szewczyk NJ, Greenhaff PL, Atherton PJ, Smith K.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E571-9. doi: 10.1152/ajpendo.00650.2013. Epub 2013 Dec 31.


Spaceflight and ageing: reflecting on Caenorhabditis elegans in space.

Honda Y, Honda S, Narici M, Szewczyk NJ.

Gerontology. 2014;60(2):138-42. doi: 10.1159/000354772. Epub 2013 Nov 5.


Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a Commercial Caenorhabditis elegans Spaceflight Experiment.

Warren P, Golden A, Hanover J, Love D, Shephard F, Szewczyk NJ.

Adv Space Res. 2013 Jun 1;51(12):2241-2250.


Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway.

Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E183-93. doi: 10.1152/ajpendo.00541.2012. Epub 2013 May 21.


Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.

Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A.

Antioxid Redox Signal. 2014 Jan 10;20(2):217-35. doi: 10.1089/ars.2012.5051. Epub 2013 Jul 3.


Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism.

Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ.

J Physiol. 2013 Jun 1;591(11):2911-23. doi: 10.1113/jphysiol.2013.253203. Epub 2013 Apr 3.


Integrated control of protein degradation in C. elegans muscle.

Lehmann S, Shephard F, Jacobson LA, Szewczyk NJ.

Worm. 2012 Jul 1;1(3):141-50. doi: 10.4161/worm.20465. Review.


Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation.

Lehmann S, Shephard F, Jacobson LA, Szewczyk NJ.

Genes (Basel). 2012;3(4):686-701. doi: 10.3390/genes3040686. Epub 2012 Nov 2.


Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S.

Sci Rep. 2012;2:487. doi: 10.1038/srep00487. Epub 2012 Jul 5.


Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans.

Estevez AO, Mueller CL, Morgan KL, Szewczyk NJ, Teece L, Miranda-Vizuete A, Estevez M.

Neurotoxicology. 2012 Oct;33(5):1021-32. doi: 10.1016/j.neuro.2012.04.019. Epub 2012 Apr 25.


The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics.

Etheridge T, Nemoto K, Hashizume T, Mori C, Sugimoto T, Suzuki H, Fukui K, Yamazaki T, Higashibata A, Szewczyk NJ, Higashitani A.

Commun Integr Biol. 2011 Nov 1;4(6):668-9.


Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.

Etheridge T, Oczypok EA, Lehmann S, Fields BD, Shephard F, Jacobson LA, Szewczyk NJ.

PLoS Genet. 2012 Jan;8(1):e1002471. doi: 10.1371/journal.pgen.1002471. Epub 2012 Jan 12.


Remote automated multi-generational growth and observation of an animal in low Earth orbit.

Oczypok EA, Etheridge T, Freeman J, Stodieck L, Johnsen R, Baillie D, Szewczyk NJ.

J R Soc Interface. 2012 Mar 7;9(68):596-9. doi: 10.1098/rsif.2011.0716. Epub 2011 Nov 30.


Identification and functional clustering of genes regulating muscle protein degradation from amongst the known C. elegans muscle mutants.

Shephard F, Adenle AA, Jacobson LA, Szewczyk NJ.

PLoS One. 2011;6(9):e24686. doi: 10.1371/journal.pone.0024686. Epub 2011 Sep 27.


The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight.

Etheridge T, Nemoto K, Hashizume T, Mori C, Sugimoto T, Suzuki H, Fukui K, Yamazaki T, Higashibata A, Szewczyk NJ, Higashitani A.

PLoS One. 2011;6(6):e20459. doi: 10.1371/journal.pone.0020459. Epub 2011 Jun 1.


Don't 'agonise' over the mechanisms underlying beta-agonist-induced muscle hypertrophy!

Atherton PJ, Szewczyk NJ.

J Physiol. 2011 Jan 1;589(Pt 1):1-2. doi: 10.1113/jphysiol.2010.201459. No abstract available.


The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans.

Morgan KL, Estevez AO, Mueller CL, Cacho-Valadez B, Miranda-Vizuete A, Szewczyk NJ, Estevez M.

Toxicol Sci. 2010 Dec;118(2):530-43. doi: 10.1093/toxsci/kfq273. Epub 2010 Sep 10.


Review of the results from the International C. elegans first experiment (ICE-FIRST).

Adenle AA, Johnsen B, Szewczyk NJ.

Adv Space Res. 2009 Jul 15;44(2):210-216.


Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells.

Atherton PJ, Szewczyk NJ, Selby A, Rankin D, Hillier K, Smith K, Rennie MJ, Loughna PT.

J Physiol. 2009 Jul 15;587(Pt 14):3719-27. doi: 10.1113/jphysiol.2009.169854. Epub 2009 May 26.


Description of International Caenorhabditis elegans Experiment first flight (ICE-FIRST).

Szewczyk NJ, Tillman J, Conley CA, Granger L, Segalat L, Higashitani A, Honda S, Honda Y, Kagawa H, Adachi R, Higashibata A, Fujimoto N, Kuriyama K, Ishioka N, Fukui K, Baillie D, Rose A, Gasset G, Eche B, Chaput D, Viso M.

Adv Space Res. 2008 Sep 15;42(6):1072-1079.


Genomic response of the nematode Caenorhabditis elegans to spaceflight.

Selch F, Higashibata A, Imamizo-Sato M, Higashitani A, Ishioka N, Szewczyk NJ, Conley CA.

Adv Space Res. 2008;41(5):807-815.


Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station.

Leandro LJ, Szewczyk NJ, Benguría A, Herranz R, Laván D, Medina FJ, Gasset G, Loon JV, Conley CA, Marco R.

Adv Space Res. 2007 Apr;40(4):506-512.


unc-94 encodes a tropomodulin in Caenorhabditis elegans.

Stevenson TO, Mercer KB, Cox EA, Szewczyk NJ, Conley CA, Hardin JD, Benian GM.

J Mol Biol. 2007 Dec 7;374(4):936-50. Epub 2007 Oct 10.


Biochemical and Molecular Biological Analyses of space-flown nematodes in Japan, the First International Caenorhabditis elegans Experiment (ICE-First).

Higashibata A, Higashitani A, Adachi R, Kagawa H, Honda S, Honda Y, Higashitani N, Sasagawa Y, Miyazawa Y, Szewczyk NJ, Conley CA, Fujimoto N, Fukui K, Shimazu T, Kuriyama K, Ishioka N.

Microgravity Sci Technol. 2007 Sep;19(5-6):159-163.


Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans.

Szewczyk NJ, Peterson BK, Barmada SJ, Parkinson LP, Jacobson LA.

EMBO J. 2007 Feb 21;26(4):935-43. Epub 2007 Feb 8.


Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction.

Szewczyk NJ, Udranszky IA, Kozak E, Sunga J, Kim SK, Jacobson LA, Conley CA.

J Exp Biol. 2006 Oct;209(Pt 20):4129-39.


Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight.

Higashibata A, Szewczyk NJ, Conley CA, Imamizo-Sato M, Higashitani A, Ishioka N.

J Exp Biol. 2006 Aug;209(Pt 16):3209-18. Erratum in: J Exp Biol. 2006 Sep;209(Pt 18):3695.


Caenorhabditis elegans survives atmospheric breakup of STS-107, space shuttle Columbia.

Szewczyk NJ, Mancinelli RL, McLamb W, Reed D, Blumberg BS, Conley CA.

Astrobiology. 2005 Dec;5(6):690-705.


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