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Items: 1 to 50 of 56

1.

Public Disclosure of the Filing of New Drug and Therapeutic Biologics Applications With the US Food and Drug Administration.

Chahal HS, Szeto D, Chaudhry AH, Sigelman DW, Kim S, Lurie PG.

JAMA Intern Med. 2019 Jun 3. doi: 10.1001/jamainternmed.2019.1213. [Epub ahead of print] No abstract available.

PMID:
31157824
2.

Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice.

More VR, Lao J, McLaren DG, Cumiskey AM, Murphy BA, Chen Y, Previs S, Stout S, Patel R, Satapati S, Li W, Kowalik E, Szeto D, Nawrocki A, Pocai A, Wang L, Carrington P.

PLoS One. 2017 Oct 24;12(10):e0186586. doi: 10.1371/journal.pone.0186586. eCollection 2017.

3.

GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent.

Pachanski MJ, Kirkland ME, Kosinski DT, Mane J, Cheewatrakoolpong B, Xue J, Szeto D, Forrest G, Miller C, Bunzel M, Plummer CW, Chobanian HR, Miller MW, Souza S, Thomas-Fowlkes BS, Ogawa AM, Weinglass AB, Di Salvo J, Li X, Feng Y, Tatosian DA, Howard AD, Colletti SL, Trujillo ME.

PLoS One. 2017 Oct 20;12(10):e0186033. doi: 10.1371/journal.pone.0186033. eCollection 2017.

4.

Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model.

Hampton C, Rosa R, Szeto D, Forrest G, Campbell B, Kennan R, Wang S, Huang CH, Gichuru L, Ping X, Shen X, Small K, Madwed J, Lynch JJ.

SAGE Open Med. 2017 Mar 30;5:2050312117700057. doi: 10.1177/2050312117700057. eCollection 2017.

5.

Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats.

Zhou X, Forrest MJ, Sharif-Rodriguez W, Forrest G, Szeto D, Urosevic-Price O, Zhu Y, Stevenson AS, Zhou Y, Stribling S, Dajee M, Walsh SP, Pasternak A, Sullivan KA.

Hypertension. 2017 Feb;69(2):332-338. doi: 10.1161/HYPERTENSIONAHA.116.08358. Epub 2016 Dec 5.

PMID:
27920129
6.

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies.

Kluk MJ, Lindsley RC, Aster JC, Lindeman NI, Szeto D, Hall D, Kuo FC.

J Mol Diagn. 2016 Jul;18(4):507-15. doi: 10.1016/j.jmoldx.2016.02.003.

7.

Detection of activating MAP2K1 mutations in atypical hairy cell leukemia and hairy cell leukemia variant.

Mason EF, Brown RD, Szeto DP, Gibson CJ, Jia Y, Garcia EP, Jacobson CA, Dal Cin P, Kuo FC, Pinkus GS, Lindeman NI, Sholl LM, Aster JC, Morgan EA.

Leuk Lymphoma. 2017 Jan;58(1):233-236. Epub 2016 May 31. No abstract available.

PMID:
27241017
8.

Glucagon receptor antagonism induces increased cholesterol absorption.

Guan HP, Yang X, Lu K, Wang SP, Castro-Perez JM, Previs S, Wright M, Shah V, Herath K, Xie D, Szeto D, Forrest G, Xiao JC, Palyha O, Sun LP, Andryuk PJ, Engel SS, Xiong Y, Lin S, Kelley DE, Erion MD, Davis HR, Wang L.

J Lipid Res. 2015 Nov;56(11):2183-95. doi: 10.1194/jlr.M060897. Epub 2015 Sep 15.

9.

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Petrilli W, London C, Liang GB, Tata J, Hu Q, Yin L, van Koppen CJ, Hartmann RW, Struthers M, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Xiong Y.

ACS Med Chem Lett. 2015 Jul 17;6(8):861-5. doi: 10.1021/acsmedchemlett.5b00048. eCollection 2015 Aug 13.

10.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Park MK, London C, Xiong Y, Tata J, Bennett DJ, Cooke A, Cai J, Carswell E, Robinson J, MacLean J, Brown L, Belshaw S, Clarkson TR, Liu K, Liang GB, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Kuethe J, Rivera N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Ali A.

ACS Med Chem Lett. 2015 Apr 7;6(5):573-8. doi: 10.1021/acsmedchemlett.5b00054. eCollection 2015 May 14.

11.

Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.

Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG.

Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21.

PMID:
24769414
12.

Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance.

Nawrocki AR, Rodriguez CG, Toolan DM, Price O, Henry M, Forrest G, Szeto D, Keohane CA, Pan Y, Smith KM, Raheem IT, Cox CD, Hwa J, Renger JJ, Smith SM.

Diabetes. 2014 Jan;63(1):300-11. doi: 10.2337/db13-0247. Epub 2013 Oct 7.

13.

Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure.

Zhou X, Zhang Z, Shin MK, Horwitz SB, Levorse JM, Zhu L, Sharif-Rodriguez W, Streltsov DY, Dajee M, Hernandez M, Pan Y, Urosevic-Price O, Wang L, Forrest G, Szeto D, Zhu Y, Cui Y, Michael B, Balogh LA, Welling PA, Wade JB, Roy S, Sullivan KA.

Hypertension. 2013 Aug;62(2):288-94. doi: 10.1161/HYPERTENSIONAHA.111.01051. Epub 2013 Jun 10.

PMID:
23753405
14.

Pulmonary large cell carcinoma lacking squamous differentiation is clinicopathologically indistinguishable from solid-subtype adenocarcinoma.

Hwang DH, Szeto DP, Perry AS, Bruce JL, Sholl LM.

Arch Pathol Lab Med. 2014 May;138(5):626-35. doi: 10.5858/arpa.2013-0179-OA. Epub 2013 Jun 5.

PMID:
23738762
15.

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.

Liu J, Gorski JN, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh DJ, McLaren DG, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, Sakaki J, Szeto D, Tong X, Xiao J, Yoshimoto R, Yu H, Roddy TP, Balkovec J, Pinto S.

Obesity (Silver Spring). 2013 Jul;21(7):1406-15. doi: 10.1002/oby.20193. Epub 2013 May 13.

16.

Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.

Lin HV, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, Kan Y, Levorse JM, Kowalik EJ Jr, Szeto DM, Yao X, Xiao J, Chen S, Liu J, Garcia-Calvo M, Shin MK, Pinto S.

PLoS One. 2013;8(1):e54480. doi: 10.1371/journal.pone.0054480. Epub 2013 Jan 15.

17.

In vivo imaging and quantitative analysis of zebrafish embryos by digital holographic microscopy.

Gao J, Lyon JA, Szeto DP, Chen J.

Biomed Opt Express. 2012 Oct 1;3(10):2623-35. doi: 10.1364/BOE.3.002623. Epub 2012 Sep 20.

18.

Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.

Lin HV, Frassetto A, Kowalik EJ Jr, Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, Marsh DJ.

PLoS One. 2012;7(4):e35240. doi: 10.1371/journal.pone.0035240. Epub 2012 Apr 10.

19.

Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.

Zhou X, Crook MF, Sharif-Rodriguez W, Zhu Y, Ruben Z, Pan Y, Urosevic-Price O, Wang L, Flattery AM, Forrest G, Szeto D, Zhao H, Roy S, Forrest MJ.

Clin Exp Hypertens. 2011;33(8):538-47. doi: 10.3109/10641963.2011.566956. Epub 2011 Sep 27.

20.

Zebrafish eve1 regulates the lateral and ventral fates of mesodermal progenitor cells at the onset of gastrulation.

Seebald JL, Szeto DP.

Dev Biol. 2011 Jan 1;349(1):78-89. doi: 10.1016/j.ydbio.2010.10.005. Epub 2010 Oct 13.

21.

Biocompatibility and biodistribution of surface-enhanced Raman scattering nanoprobes in zebrafish embryos: in vivo and multiplex imaging.

Wang Y, Seebald JL, Szeto DP, Irudayaraj J.

ACS Nano. 2010 Jul 27;4(7):4039-53. doi: 10.1021/nn100351h.

PMID:
20552995
22.
23.

Edgetic perturbation models of human inherited disorders.

Zhong Q, Simonis N, Li QR, Charloteaux B, Heuze F, Klitgord N, Tam S, Yu H, Venkatesan K, Mou D, Swearingen V, Yildirim MA, Yan H, Dricot A, Szeto D, Lin C, Hao T, Fan C, Milstein S, Dupuy D, Brasseur R, Hill DE, Cusick ME, Vidal M.

Mol Syst Biol. 2009;5:321. doi: 10.1038/msb.2009.80. Epub 2009 Nov 3.

24.

Large-scale RACE approach for proactive experimental definition of C. elegans ORFeome.

Salehi-Ashtiani K, Lin C, Hao T, Shen Y, Szeto D, Yang X, Ghamsari L, Lee H, Fan C, Murray RR, Milstein S, Svrzikapa N, Cusick ME, Roth FP, Hill DE, Vidal M.

Genome Res. 2009 Dec;19(12):2334-42. doi: 10.1101/gr.098640.109. Epub 2009 Oct 2.

25.

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.

Simonis N, Rual JF, Carvunis AR, Tasan M, Lemmens I, Hirozane-Kishikawa T, Hao T, Sahalie JM, Venkatesan K, Gebreab F, Cevik S, Klitgord N, Fan C, Braun P, Li N, Ayivi-Guedehoussou N, Dann E, Bertin N, Szeto D, Dricot A, Yildirim MA, Lin C, de Smet AS, Kao HL, Simon C, Smolyar A, Ahn JS, Tewari M, Boxem M, Milstein S, Yu H, Dreze M, Vandenhaute J, Gunsalus KC, Cusick ME, Hill DE, Tavernier J, Roth FP, Vidal M.

Nat Methods. 2009 Jan;6(1):47-54.

26.

An empirical framework for binary interactome mapping.

Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, Cevik S, Simon C, de Smet AS, Dann E, Smolyar A, Vinayagam A, Yu H, Szeto D, Borick H, Dricot A, Klitgord N, Murray RR, Lin C, Lalowski M, Timm J, Rau K, Boone C, Braun P, Cusick ME, Roth FP, Hill DE, Tavernier J, Wanker EE, Barabási AL, Vidal M.

Nat Methods. 2009 Jan;6(1):83-90. doi: 10.1038/nmeth.1280. Epub 2008 Dec 7.

27.

Isoform discovery by targeted cloning, 'deep-well' pooling and parallel sequencing.

Salehi-Ashtiani K, Yang X, Derti A, Tian W, Hao T, Lin C, Makowski K, Shen L, Murray RR, Szeto D, Tusneem N, Smith DR, Cusick ME, Hill DE, Roth FP, Vidal M.

Nat Methods. 2008 Jul;5(7):597-600. doi: 10.1038/nmeth.1224. Epub 2008 Jun 15.

28.

Efficient targeted transcript discovery via array-based normalization of RACE libraries.

Djebali S, Kapranov P, Foissac S, Lagarde J, Reymond A, Ucla C, Wyss C, Drenkow J, Dumais E, Murray RR, Lin C, Szeto D, Denoeud F, Calvo M, Frankish A, Harrow J, Makrythanasis P, Vidal M, Salehi-Ashtiani K, Antonarakis SE, Gingeras TR, Guigó R.

Nat Methods. 2008 Jul;5(7):629-35. doi: 10.1038/nmeth.1216. Epub 2008 May 25.

30.

Chordin cleavage is sizzling.

Kimelman D, Szeto DP.

Nat Cell Biol. 2006 Apr;8(4):305-7. No abstract available.

PMID:
16607266
31.

Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP.

Cooper MS, Szeto DP, Sommers-Herivel G, Topczewski J, Solnica-Krezel L, Kang HC, Johnson I, Kimelman D.

Dev Dyn. 2005 Feb;232(2):359-68.

32.

Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation.

Szeto DP, Kimelman D.

Development. 2004 Aug;131(15):3751-60. Epub 2004 Jul 7. Erratum in: Development. 2004 Aug;131(6):4117.

33.

Application of factorial design to accelerate identification of CHO growth factor requirements.

Chun C, Heineken K, Szeto D, Ryll T, Chamow S, Chung JD.

Biotechnol Prog. 2003 Jan-Feb;19(1):52-7.

PMID:
12573006
34.

HrT is required for cardiovascular development in zebrafish.

Szeto DP, Griffin KJ, Kimelman D.

Development. 2002 Nov;129(21):5093-101.

35.

Hedgehog signaling is required for pituitary gland development.

Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG.

Development. 2001 Feb;128(3):377-86.

36.

The ruv proteins of Thermotoga maritima: branch migration and resolution of Holliday junctions.

Gonzalez S, Rosenfeld A, Szeto D, Wetmur JG.

Biochim Biophys Acta. 2000 Dec 1;1494(3):217-25.

PMID:
11121578
37.

Regulation of somatic growth by the p160 coactivator p/CIP.

Wang Z, Rose DW, Hermanson O, Liu F, Herman T, Wu W, Szeto D, Gleiberman A, Krones A, Pratt K, Rosenfeld R, Glass CK, Rosenfeld MG.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13549-54.

38.

Multistep signaling and transcriptional requirements for pituitary organogenesis in vivo.

Rosenfeld MG, Briata P, Dasen J, Gleiberman AS, Kioussi C, Lin C, O'Connell SM, Ryan A, Szeto DP, Treier M.

Recent Prog Horm Res. 2000;55:1-13; discussion 13-4. Review.

PMID:
11036930
39.

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.

Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisúa-Belmonte JC, Rosenfeld MG.

Nature. 1999 Sep 16;401(6750):279-82.

PMID:
10499586
40.

Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types.

Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG.

Cell. 1999 May 28;97(5):587-98.

41.

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.

Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisúa-Belmonte JC, Rosenfeld MG.

Genes Dev. 1999 Feb 15;13(4):484-94.

42.

Signal-specific co-activator domain requirements for Pit-1 activation.

Xu L, Lavinsky RM, Dasen JS, Flynn SE, McInerney EM, Mullen TM, Heinzel T, Szeto D, Korzus E, Kurokawa R, Aggarwal AK, Rose DW, Glass CK, Rosenfeld MG.

Nature. 1998 Sep 17;395(6699):301-6.

PMID:
9751061
43.

Multistep signaling requirements for pituitary organogenesis in vivo.

Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG.

Genes Dev. 1998 Jun 1;12(11):1691-704.

44.
45.

P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.

Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7706-10.

46.

Benzophenothiazine and benzoporphyrin derivative combination phototherapy effectively eradicates large murine sarcomas.

Cincotta L, Szeto D, Lampros E, Hasan T, Cincotta AH.

Photochem Photobiol. 1996 Feb;63(2):229-37.

PMID:
8657737
47.

Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain.

Holloway JM, Szeto DP, Scully KM, Glass CK, Rosenfeld MG.

Genes Dev. 1995 Aug 15;9(16):1992-2006.

48.
49.

Octamer and SPH motifs in the U1 enhancer cooperate to activate U1 RNA gene expression.

Roebuck KA, Szeto DP, Green KP, Fan QN, Stumph WE.

Mol Cell Biol. 1990 Jan;10(1):341-52.

50.

Function of a bacterial activator protein that binds to transcriptional enhancers.

Popham DL, Szeto D, Keener J, Kustu S.

Science. 1989 Feb 3;243(4891):629-35.

PMID:
2563595

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