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Items: 1 to 50 of 149

1.

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer.

Ho DW, Tsui YM, Sze KM, Chan LK, Cheung TT, Lee E, Sham PC, Tsui SK, Lee TK, Ng IO.

Cancer Lett. 2019 Sep 10;459:176-185. doi: 10.1016/j.canlet.2019.06.002. Epub 2019 Jun 10.

PMID:
31195060
2.

Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.

Lam WH, Sze KH, Ke Y, Tse MK, Zhang H, Woo PCY, Lau SKP, Lau CCY, Xu S, Lai PM, Zhou T, Antonyuk SV, Kao RYT, Yuen KY, Hao Q.

Infect Immun. 2019 Mar 25;87(4). pii: e00679-18. doi: 10.1128/IAI.00679-18. Print 2019 Apr.

PMID:
30670555
3.

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication.

Yan B, Chu H, Yang D, Sze KH, Lai PM, Yuan S, Shuai H, Wang Y, Kao RY, Chan JF, Yuen KY.

Viruses. 2019 Jan 16;11(1). pii: E73. doi: 10.3390/v11010073.

4.

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY.

Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x.

5.

APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.

Ma W, Ho DW, Sze KM, Tsui YM, Chan LK, Lee JM, Ng IO.

Mol Carcinog. 2019 May;58(5):643-653. doi: 10.1002/mc.22956. Epub 2019 Jan 6.

PMID:
30575099
6.

Identification and characterization of GLDC as host susceptibility gene to severe influenza.

Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY.

EMBO Mol Med. 2019 Jan;11(1). pii: e9528. doi: 10.15252/emmm.201809528.

7.

Suppression of Staphylococcus aureus virulence by a small-molecule compound.

Gao P, Ho PL, Yan B, Sze KH, Davies J, Kao RYT.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):8003-8008. doi: 10.1073/pnas.1720520115. Epub 2018 Jul 16.

8.

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.

Chu H, Chan CM, Zhang X, Wang Y, Yuan S, Zhou J, Au-Yeung RK, Sze KH, Yang D, Shuai H, Hou Y, Li C, Zhao X, Poon VK, Leung SP, Yeung ML, Yan J, Lu G, Jin DY, Gao GF, Chan JF, Yuen KY.

J Biol Chem. 2018 Jul 27;293(30):11709-11726. doi: 10.1074/jbc.RA118.001897. Epub 2018 Jun 10.

9.

Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer.

Tse AP, Sze KM, Shea QT, Chiu EY, Tsang FH, Chiu DK, Zhang MS, Lee D, Xu IM, Chan CY, Koh HY, Wong CM, Zheng YP, Ng IO, Wong CC.

Oncogenesis. 2018 May 25;7(5):44. doi: 10.1038/s41389-018-0052-8.

10.

Age-specific seroprevalence of dengue infection in Hong Kong.

Lee P, Yeung ACM, Chen Z, Chan MCW, Sze KH, Chan PKS.

J Med Virol. 2018 Sep;90(9):1427-1430. doi: 10.1002/jmv.25216. Epub 2018 May 25.

PMID:
29718538
11.

Rhinovirus respiratory tract infection in hospitalized adult patients is associated with TH2 response irrespective of asthma.

To KKW, Lu L, Fong CHY, Wu AKL, Mok KY, Yip CCY, Ke YH, Sze KH, Lau SKP, Hung IFN, Yuen KY.

J Infect. 2018 May;76(5):465-474. doi: 10.1016/j.jinf.2018.02.005. Epub 2018 Feb 15.

PMID:
29454786
12.

A novel fracture mechanics model explaining the axial penetration of bone-like porous, compressible solids by various orthopaedic implant tips.

Kulper SA, Sze KY, Fang CX, Ren X, Guo M, Schneider K, Leung F, Lu W, Ngan A.

J Mech Behav Biomed Mater. 2018 Apr;80:128-136. doi: 10.1016/j.jmbbm.2018.01.025. Epub 2018 Feb 3.

PMID:
29414468
13.

Nonparametric Online Learning Control for Soft Continuum Robot: An Enabling Technique for Effective Endoscopic Navigation.

Lee KH, Fu DKC, Leong MCW, Chow M, Fu HC, Althoefer K, Sze KY, Yeung CK, Kwok KW.

Soft Robot. 2017 Dec;4(4):324-337. doi: 10.1089/soro.2016.0065. Epub 2017 Aug 28.

14.

Mp1p homologues as virulence factors in Aspergillus fumigatus.

Woo PCY, Lau SKP, Lau CCY, Tung ETK, Au-Yeung RKH, Cai JP, Chong KTK, Sze KH, Kao RY, Hao Q, Yuen KY.

Med Mycol. 2018 Apr 1;56(3):350-360. doi: 10.1093/mmy/myx052.

PMID:
28992243
15.

A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis.

Tse H, Gu Q, Sze KH, Chu IK, Kao RY, Lee KC, Lam CW, Yang D, Tai SS, Ke Y, Chan E, Chan WM, Dai J, Leung SP, Leung SY, Yuen KY.

J Biol Chem. 2017 Nov 24;292(47):19503-19520. doi: 10.1074/jbc.M117.791558. Epub 2017 Sep 26.

16.

Development and initial validation of a novel smoothed-particle hydrodynamics-based simulation model of trabecular bone penetration by metallic implants.

Kulper SA, Fang CX, Ren X, Guo M, Sze KY, Leung FKL, Lu WW.

J Orthop Res. 2018 Apr;36(4):1114-1123. doi: 10.1002/jor.23734. Epub 2017 Nov 16.

17.

Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.

Zhang BZ, Cai J, Yu B, Xiong L, Lin Q, Yang XY, Xu C, Zheng S, Kao RY, Sze K, Yuen KY, Huang JD.

J Infect Dis. 2017 Jul 15;216(2):245-253. doi: 10.1093/infdis/jix290.

18.

Hepatitis B infection acquired after haematopioetic stem cell transplant through horizontal mode.

Chan MCW, Cheng FWT, Sze KH, Wong AH, Leung AWK, Chan PKS, Li CK.

J Med Virol. 2017 Oct;89(10):1882-1884. doi: 10.1002/jmv.24835. Epub 2017 May 23.

PMID:
28460154
19.

Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma.

Tsui YM, Sze KM, Tung EK, Ho DW, Lee TK, Ng IO.

Oncotarget. 2017 Jun 13;8(24):39430-39442. doi: 10.18632/oncotarget.17049.

20.

C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway.

Ching RHH, Sze KMF, Lau EYT, Chiu YT, Lee JMF, Ng IOL, Lee TKW.

Oncotarget. 2017 Apr 4;8(14):23507-23516. doi: 10.18632/oncotarget.15183.

21.

Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response.

Sze KH, Lam WH, Zhang H, Ke YH, Tse MK, Woo PCY, Lau SKP, Lau CCY, Cai JP, Tung ETK, Lo RKC, Xu S, Kao RYT, Hao Q, Yuen KY.

Cell Chem Biol. 2017 Feb 16;24(2):182-194. doi: 10.1016/j.chembiol.2016.12.014. Epub 2017 Jan 19.

22.

A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.

Zhang BZ, Cai J, Yu B, Hua Y, Lau CC, Kao RY, Sze KH, Yuen KY, Huang JD.

BMC Infect Dis. 2016 Oct 22;16(1):596.

23.

Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei.

Woo PC, Lau SK, Lau CC, Tung ET, Chong KT, Yang F, Zhang H, Lo RK, Cai JP, Au-Yeung RK, Ng WF, Tse H, Wong SS, Xu S, Lam WH, Tse MK, Sze KH, Kao RY, Reiner NE, Hao Q, Yuen KY.

PLoS Negl Trop Dis. 2016 Aug 25;10(8):e0004907. doi: 10.1371/journal.pntd.0004907. eCollection 2016 Aug.

24.

RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma.

Ma W, Sze KM, Chan LK, Lee JM, Wei LL, Wong CM, Lee TK, Wong CC, Ng IO.

Oncotarget. 2016 Jul 5;7(27):41445-41459. doi: 10.18632/oncotarget.9441.

25.

Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia.

To KK, Lee KC, Wong SS, Sze KH, Ke YH, Lui YM, Tang BS, Li IW, Lau SK, Hung IF, Law CY, Lam CW, Yuen KY.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):249-54. doi: 10.1016/j.diagmicrobio.2016.03.012. Epub 2016 Mar 14.

PMID:
27105773
26.

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization.

Chan CM, Chu H, Zhang AJ, Leung LH, Sze KH, Kao RY, Chik KK, To KK, Chan JF, Chen H, Jin DY, Liu L, Yuen KY.

Virology. 2016 Jul;494:78-88. doi: 10.1016/j.virol.2016.04.008. Epub 2016 Apr 14.

27.

Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis.

Lau SK, Lee KC, Lo GC, Ding VS, Chow WN, Ke TY, Curreem SO, To KK, Ho DT, Sridhar S, Wong SC, Chan JF, Hung IF, Sze KH, Lam CW, Yuen KY, Woo PC.

Int J Mol Sci. 2016 Feb 27;17(3):307. doi: 10.3390/ijms17030307.

28.

Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma.

Chiu YT, Wong JK, Choi SW, Sze KM, Ho DW, Chan LK, Lee JM, Man K, Cherny S, Yang WL, Wong CM, Sham PC, Ng IO.

J Hepatol. 2016 Jun;64(6):1256-64. doi: 10.1016/j.jhep.2016.02.005. Epub 2016 Feb 8.

29.

Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics.

Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RY.

J Virol. 2015 Dec 16;90(5):2690-701. doi: 10.1128/JVI.02326-15.

30.

Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis.

Wong CM, Wei L, Law CT, Ho DW, Tsang FH, Au SL, Sze KM, Lee JM, Wong CC, Ng IO.

Hepatology. 2016 Feb;63(2):474-87. doi: 10.1002/hep.28304. Epub 2015 Dec 14. Erratum in: Hepatology. 2016 Apr;63(4):1403.

PMID:
26481868
31.

Role of hepatitis B virus X protein in liver cancer.

Ng IO, Sze KM, Chu GK.

Hong Kong Med J. 2015 Jun;21 Suppl 4:27-30. No abstract available.

32.

Patient-specific instrument can achieve same accuracy with less resection time than navigation assistance in periacetabular pelvic tumor surgery: a cadaveric study.

Wong KC, Sze KY, Wong IO, Wong CM, Kumta SM.

Int J Comput Assist Radiol Surg. 2016 Feb;11(2):307-16. doi: 10.1007/s11548-015-1250-x. Epub 2015 Jul 7.

PMID:
26148694
34.
35.

Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia.

To KK, Lee KC, Wong SS, Lo KC, Lui YM, Jahan AS, Wu AL, Ke YH, Law CY, Sze KH, Lau SK, Woo PC, Lam CW, Yuen KY.

J Infect. 2015 May;70(5):433-44. doi: 10.1016/j.jinf.2015.02.011. Epub 2015 Feb 26.

PMID:
25727996
36.

An odyssey through salpingitis isthmica nodosa.

Bolaji II, Oktaba M, Mohee K, Sze KY.

Eur J Obstet Gynecol Reprod Biol. 2015 Jan;184:73-9. doi: 10.1016/j.ejogrb.2014.11.014. Epub 2014 Nov 20. Review.

PMID:
25463639
37.

Recombinant ESAT-6-like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model.

Zhang BZ, Hua YH, Yu B, Lau CC, Cai JP, Zheng SY, Yam WC, Kao RY, Sze KH, Zheng BJ, Yuen KY, Huang JD.

Infect Immun. 2015 Jan;83(1):339-45. doi: 10.1128/IAI.02498-14. Epub 2014 Nov 3.

38.

The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei.

Woo PC, Lam CW, Tam EW, Lee KC, Yung KK, Leung CK, Sze KH, Lau SK, Yuen KY.

Sci Rep. 2014 Oct 22;4:6728. doi: 10.1038/srep06728.

39.

Is there such a thing as protocol immunosuppression in liver transplantation?

McCaughan GW, Sze KC, Strasser SI.

Expert Rev Gastroenterol Hepatol. 2015 Jan;9(1):1-4. doi: 10.1586/17474124.2014.954550. Epub 2014 Aug 28. Review.

PMID:
25164689
40.

Quantitative metabolomics of urine for rapid etiological diagnosis of urinary tract infection: evaluation of a microbial-mammalian co-metabolite as a diagnostic biomarker.

Lam CW, Law CY, Sze KH, To KK.

Clin Chim Acta. 2015 Jan 1;438:24-8. doi: 10.1016/j.cca.2014.07.038. Epub 2014 Aug 6.

PMID:
25108210
41.

NMR-based metabolomic urinalysis: a rapid screening test for urinary tract infection.

Lam CW, Law CY, To KK, Cheung SK, Lee KC, Sze KH, Leung KF, Yuen KY.

Clin Chim Acta. 2014 Sep 25;436:217-23. doi: 10.1016/j.cca.2014.05.014. Epub 2014 Jun 6.

PMID:
24909875
42.

Bioengineering a multicomponent spinal motion segment construct--a 3D model for complex tissue engineering.

Chik TK, Chooi WH, Li YY, Ho FC, Cheng HW, Choy TH, Sze KY, Luk KK, Cheung KM, Chan BP.

Adv Healthc Mater. 2015 Jan 7;4(1):99-112. doi: 10.1002/adhm.201400192. Epub 2014 May 20.

PMID:
24846571
43.

Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions.

Higdon LE, Deets KA, Friesen TJ, Sze KY, Fink PJ.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5652-7. doi: 10.1073/pnas.1321803111. Epub 2014 Mar 31.

44.

Current options for the diagnosis of chronic pancreatitis.

Sze KC, Pirola RC, Apte MV, Wilson JS.

Expert Rev Mol Diagn. 2014 Mar;14(2):199-215. doi: 10.1586/14737159.2014.883277. Epub 2014 Feb 10. Review.

PMID:
24512138
45.

Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma.

Sze KM, Chu GK, Mak QH, Lee JM, Ng IO.

J Pathol. 2014 May;233(1):51-60. doi: 10.1002/path.4319. Epub 2014 Jan 27.

PMID:
24374861
46.

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.

Song YQ, Karasugi T, Cheung KM, Chiba K, Ho DW, Miyake A, Kao PY, Sze KL, Yee A, Takahashi A, Kawaguchi Y, Mikami Y, Matsumoto M, Togawa D, Kanayama M, Shi D, Dai J, Jiang Q, Wu C, Tian W, Wang N, Leong JC, Luk KD, Yip SP, Cherny SS, Wang J, Mundlos S, Kelempisioti A, Eskola PJ, Männikkö M, Mäkelä P, Karppinen J, Järvelin MR, O'Reilly PF, Kubo M, Kimura T, Kubo T, Toyama Y, Mizuta H, Cheah KS, Tsunoda T, Sham PC, Ikegawa S, Chan D.

J Clin Invest. 2013 Nov;123(11):4909-17.

47.

Myocardial fibrosis and QTc are reduced following treatment with spironolactone or amiloride in stroke survivors: a randomised placebo-controlled cross-over trial.

Wong KY, Wong SY, McSwiggan S, Ogston SA, Sze KY, MacWalter RS, Struthers AD.

Int J Cardiol. 2013 Oct 15;168(6):5229-33. doi: 10.1016/j.ijcard.2013.08.027. Epub 2013 Aug 15.

PMID:
23993727
48.

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control.

Wong MK, Sze KH, Chen T, Cho CK, Law HC, Chu IK, Wong AO.

Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E348-66. doi: 10.1152/ajpendo.00141.2013. Epub 2013 May 28.

49.

Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii.

Tse MK, Cheung SK, Ke YH, Lau CC, Sze KH, Yuen KY.

Biomol NMR Assign. 2014 Apr;8(1):173-6. doi: 10.1007/s12104-013-9477-3. Epub 2013 Apr 25.

PMID:
23616102
50.

A semi-discrete finite element method for a class of time-fractional diffusion equations.

Sun H, Chen W, Sze KY.

Philos Trans A Math Phys Eng Sci. 2013 Apr 1;371(1990):20120268. doi: 10.1098/rsta.2012.0268. Print 2013 May 13.

PMID:
23547234

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