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Items: 48


Effects of The Poly(ADP-ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis.

Ahmad A, Haas De Mello A, Szczesny B, Törö G, Marcatti M, Druzhyna N, Liaudet L, Tarantini S, Salomao R, Garcia Soriano F, Szabo C.

Shock. 2019 Jul 2. doi: 10.1097/SHK.0000000000001402. [Epub ahead of print]


The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis.

Ahmad A, Vieira JC, de Mello AH, de Lima TM, Ariga SK, Barbeiro DF, Barbeiro HV, Szczesny B, Törö G, Druzhyna N, Randi EB, Marcatti M, Toliver-Kinsky T, Kiss A, Liaudet L, Salomao R, Soriano FG, Szabo C.

Pharmacol Res. 2019 Jul;145:104263. doi: 10.1016/j.phrs.2019.104263. Epub 2019 May 6.


Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages.

Koo SJ, Szczesny B, Wan X, Putluri N, Garg NJ.

Front Immunol. 2018 Feb 16;9:202. doi: 10.3389/fimmu.2018.00202. eCollection 2018.


Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells.

Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C.

Sci Rep. 2018 Jan 17;8(1):914. doi: 10.1038/s41598-018-19216-1.


Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection.

Ibitokou SA, Dillon BE, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, Szabo C, Abu-Elheiga L, Porter C, Tuvdendorj D, Stephens R.

J Immunol. 2018 Jan 15;200(2):643-656. doi: 10.4049/jimmunol.1602110. Epub 2017 Dec 13.


Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation.

Oláh G, Módis K, Törö G, Hellmich MR, Szczesny B, Szabo C.

Biochem Pharmacol. 2018 Mar;149:186-204. doi: 10.1016/j.bcp.2017.10.011. Epub 2017 Oct 23.


Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.

Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K, Szabo C, Chao C, Hellmich MR.

Cancer Res. 2017 Nov 1;77(21):5741-5754. doi: 10.1158/0008-5472.CAN-16-3480. Epub 2017 Sep 18.


Olaparib protects cardiomyocytes against oxidative stress and improves graft contractility during the early phase after heart transplantation in rats.

Korkmaz-Icöz S, Szczesny B, Marcatti M, Li S, Ruppert M, Lasitschka F, Loganathan S, Szabó C, Szabó G.

Br J Pharmacol. 2018 Jan;175(2):246-261. doi: 10.1111/bph.13983. Epub 2017 Oct 2.


Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors.

Steiger AK, Marcatti M, Szabo C, Szczesny B, Pluth MD.

ACS Chem Biol. 2017 Aug 18;12(8):2117-2123. doi: 10.1021/acschembio.7b00279. Epub 2017 Jun 30.


Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.

Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C.

Sci Rep. 2016 Nov 3;6:36125. doi: 10.1038/srep36125.


Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.

Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C.

Pharmacol Res. 2016 Nov;113(Pt A):18-37. doi: 10.1016/j.phrs.2016.08.016. Epub 2016 Aug 10.


Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant.

López-García I, Gerő D, Szczesny B, Szoleczky P, Olah G, Módis K, Zhang K, Gao J, Wu P, Sowers LC, DeWitt D, Prough DS, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):284-300. doi: 10.1111/bph.13642. Epub 2016 Nov 15.


Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi.

Koo SJ, Chowdhury IH, Szczesny B, Wan X, Garg NJ.

Infect Immun. 2016 Nov 18;84(12):3527-3541. Print 2016 Dec.


Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance.

Rios EC, Soriano FG, Olah G, Gerö D, Szczesny B, Szabo C.

J Inflamm (Lond). 2016 Apr 1;13:10. doi: 10.1186/s12950-016-0119-2. eCollection 2016.


Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work.

Brunyanszki A, Szczesny B, Virág L, Szabo C.

Free Radic Biol Med. 2016 Nov;100:257-270. doi: 10.1016/j.freeradbiomed.2016.02.024. Epub 2016 Mar 8. Review.


Time-Dependent and Organ-Specific Changes in Mitochondrial Function, Mitochondrial DNA Integrity, Oxidative Stress and Mononuclear Cell Infiltration in a Mouse Model of Burn Injury.

Szczesny B, Brunyánszki A, Ahmad A, Oláh G, Porter C, Toliver-Kinsky T, Sidossis L, Herndon DN, Szabo C.

PLoS One. 2015 Dec 2;10(12):e0143730. doi: 10.1371/journal.pone.0143730. eCollection 2015.


Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics.

Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS.

Burns. 2016 Feb;42(1):112-122. doi: 10.1016/j.burns.2015.10.026. Epub 2015 Nov 23.


Upregulation and Mitochondrial Sequestration of Hemoglobin Occur in Circulating Leukocytes during Critical Illness, Conferring a Cytoprotective Phenotype.

Brunyanszki A, Erdelyi K, Szczesny B, Olah G, Salomao R, Herndon DN, Szabo C.

Mol Med. 2015 Nov;21(1):666-675. doi: 10.2119/molmed.2015.00187. Epub 2015 Aug 17.


Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.

Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT.

PLoS Genet. 2015 Aug 6;11(8):e1005267. doi: 10.1371/journal.pgen.1005267. eCollection 2015 Aug.


Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress.

Oláh G, Szczesny B, Brunyánszki A, López-García IA, Gerö D, Radák Z, Szabo C.

PLoS One. 2015 Jul 28;10(7):e0134227. doi: 10.1371/journal.pone.0134227. eCollection 2015.


Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue.

Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS.

Shock. 2015 Sep;44(3):258-64. doi: 10.1097/SHK.0000000000000410.


Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling.

Rios EC, Szczesny B, Soriano FG, Olah G, Szabo C.

Int J Mol Med. 2015 Jun;35(6):1741-6. doi: 10.3892/ijmm.2015.2176. Epub 2015 Apr 8.


Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.

Coletta C, Módis K, Szczesny B, Brunyánszki A, Oláh G, Rios EC, Yanagi K, Ahmad A, Papapetropoulos A, Szabo C.

Mol Med. 2015 Feb 18;21:1-14. doi: 10.2119/molmed.2015.00035.


Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function.

Szczesny B, Brunyanszki A, Olah G, Mitra S, Szabo C.

Nucleic Acids Res. 2014 Dec 1;42(21):13161-73. doi: 10.1093/nar/gku1089. Epub 2014 Nov 5.


Characterization of spiraling patterns in spatial rock-paper-scissors games.

Szczesny B, Mobilia M, Rucklidge AM.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Sep;90(3):032704. Epub 2014 Sep 8.


Cyclic dominance in evolutionary games: a review.

Szolnoki A, Mobilia M, Jiang LL, Szczesny B, Rucklidge AM, Perc M.

J R Soc Interface. 2014 Nov 6;11(100):20140735. doi: 10.1098/rsif.2014.0735. Review.


Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress.

Brunyanszki A, Olah G, Coletta C, Szczesny B, Szabo C.

Mol Pharmacol. 2014 Oct;86(4):450-62. doi: 10.1124/mol.114.094318. Epub 2014 Jul 28.


AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.

Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C.

Nitric Oxide. 2014 Sep 15;41:120-30. doi: 10.1016/j.niox.2014.04.008. Epub 2014 Apr 19.


Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.

Módis K, Coletta C, Asimakopoulou A, Szczesny B, Chao C, Papapetropoulos A, Hellmich MR, Szabo C.

Nitric Oxide. 2014 Sep 15;41:146-56. doi: 10.1016/j.niox.2014.03.001. Epub 2014 Mar 22.


Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage.

Szczesny B, Olah G, Walker DK, Volpi E, Rasmussen BB, Szabo C, Mitra S.

PLoS One. 2013 Sep 16;8(9):e75201. doi: 10.1371/journal.pone.0075201. eCollection 2013.


Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.

Szabo C, Coletta C, Chao C, Módis K, Szczesny B, Papapetropoulos A, Hellmich MR.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12474-9. doi: 10.1073/pnas.1306241110. Epub 2013 Jul 8.


Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.

Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Maiti B, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA.

J Biol Chem. 2013 Mar 22;288(12):8445-55. doi: 10.1074/jbc.M112.422774. Epub 2013 Jan 25.


Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation.

Bacsi A, Aguilera-Aguirre L, Szczesny B, Radak Z, Hazra TK, Sur S, Ba X, Boldogh I.

DNA Repair (Amst). 2013 Jan 1;12(1):18-26. doi: 10.1016/j.dnarep.2012.10.002. Epub 2012 Nov 3.


Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.

Hegde ML, Mantha AK, Hazra TK, Bhakat KK, Mitra S, Szczesny B.

Mech Ageing Dev. 2012 Apr;133(4):157-68. doi: 10.1016/j.mad.2012.01.005. Epub 2012 Jan 31. Review.


Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.

Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS, Hazra TK.

J Biol Chem. 2012 Jan 20;287(4):2819-29. doi: 10.1074/jbc.M111.272179. Epub 2011 Nov 30.


Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.

Tann AW, Boldogh I, Meiss G, Qian W, Van Houten B, Mitra S, Szczesny B.

J Biol Chem. 2011 Sep 16;286(37):31975-83. doi: 10.1074/jbc.M110.215715. Epub 2011 Jul 18.


Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria.

Zhang H, Xie C, Spencer HJ, Zuo C, Higuchi M, Ranganathan G, Kern PA, Chou MW, Huang Q, Szczesny B, Mitra S, Watson AJ, Margison GP, Fan CY.

Am J Pathol. 2011 Apr;178(4):1715-27. doi: 10.1016/j.ajpath.2010.12.038.


Production and characterization of recombinant protein preparations of Endonuclease G-homologs from yeast, C. elegans and humans.

Kieper J, Lauber C, Gimadutdinow O, Urbańska A, Cymerman I, Ghosh M, Szczesny B, Meiss G.

Protein Expr Purif. 2010 Sep;73(1):99-106. doi: 10.1016/j.pep.2010.04.001. Epub 2010 Apr 9.


Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury.

Szczesny B, Tann AW, Mitra S.

Mech Ageing Dev. 2010 May;131(5):330-7. doi: 10.1016/j.mad.2010.03.009. Epub 2010 Apr 2.


Long patch base excision repair in mammalian mitochondrial genomes.

Szczesny B, Tann AW, Longley MJ, Copeland WC, Mitra S.

J Biol Chem. 2008 Sep 26;283(39):26349-56. doi: 10.1074/jbc.M803491200. Epub 2008 Jul 17.


Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

Mitra S, Izumi T, Boldogh I, Bhakat KK, Chattopadhyay R, Szczesny B.

DNA Repair (Amst). 2007 Apr 1;6(4):461-9. Epub 2006 Dec 12.


Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.

Chattopadhyay R, Wiederhold L, Szczesny B, Boldogh I, Hazra TK, Izumi T, Mitra S.

Nucleic Acids Res. 2006 Apr 14;34(7):2067-76. Print 2006.


Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver.

Szczesny B, Mitra S.

Mech Ageing Dev. 2005 Oct;126(10):1071-8.


Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution.

Szczesny B, Bhakat KK, Mitra S, Boldogh I.

Mech Ageing Dev. 2004 Oct-Nov;125(10-11):755-65.


The pea mitochondrial atp6: RNA editing and similarity of presequences in the Vicieae tribe.

Gibala M, Szczesny B, Kieleczawa J, Janska H.

Curr Genet. 2004 Oct;46(4):235-9. Epub 2004 Aug 21.


Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases.

Szczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10670-5. Epub 2003 Sep 5.


A higher plant mitochondrial homologue of the yeast m-AAA protease. Molecular cloning, localization, and putative function.

Kolodziejczak M, Kolaczkowska A, Szczesny B, Urantowka A, Knorpp C, Kieleczawa J, Janska H.

J Biol Chem. 2002 Nov 15;277(46):43792-8. Epub 2002 Sep 11.

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