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Items: 17


Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.

Leong TL, Gayevskiy V, Steinfort DP, De Massy MR, Gonzalez-Rajal A, Marini KD, Stone E, Chin V, Havryk A, Plit M, Irving LB, Jennings BR, McCloy RA, Jayasekara WSN, Alamgeer M, Boolell V, Field A, Russell PA, Kumar B, Gough DJ, Szczepny A, Ganju V, Rossello FJ, Cain JE, Papenfuss AT, Asselin-Labat ML, Cowley MJ, Watkins DN.

Oncogene. 2019 Mar;38(10):1661-1675. doi: 10.1038/s41388-018-0536-1. Epub 2018 Oct 22.


Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.

Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara WSN, Alamgeer M, Boolell V, Han JZR, Waugh T, Lee HC, Oakes SR, Kumar B, Harrison CA, Hedger MP, Lorensuhewa N, Kita B, Barrow R, Robinson BW, de Kretser DM, Wu J, Ganju V, Sweet-Cordero EA, Burgess A, Martelotto LG, Rossello FJ, Cain JE, Watkins DN.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaat3504. doi: 10.1126/scitranslmed.aat3504.


The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.

Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN.

Oncogene. 2018 Apr;37(14):1939-1948. doi: 10.1038/s41388-017-0022-1. Epub 2018 Jan 25.


The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.

Szczepny A, Rogers S, Jayasekara WSN, Park K, McCloy RA, Cochrane CR, Ganju V, Cooper WA, Sage J, Peacock CD, Cain JE, Burgess A, Watkins DN.

Oncogene. 2017 Sep 28;36(39):5544-5550. doi: 10.1038/onc.2017.173. Epub 2017 Jun 5.


Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma.

Miller A, McLeod L, Alhayyani S, Szczepny A, Watkins DN, Chen W, Enriori P, Ferlin W, Ruwanpura S, Jenkins BJ.

Oncogene. 2017 May 25;36(21):3059-3066. doi: 10.1038/onc.2016.437. Epub 2016 Nov 28.


Hedgehog Signaling in the Maintenance of Cancer Stem Cells.

Cochrane CR, Szczepny A, Watkins DN, Cain JE.

Cancers (Basel). 2015 Aug 11;7(3):1554-85. doi: 10.3390/cancers7030851. Review.


Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens.

Leong TL, Marini KD, Rossello FJ, Jayasekara SN, Russell PA, Prodanovic Z, Kumar B, Ganju V, Alamgeer M, Irving LB, Steinfort DP, Peacock CD, Cain JE, Szczepny A, Watkins DN.

PLoS One. 2014 Sep 5;9(9):e106862. doi: 10.1371/journal.pone.0106862. eCollection 2014.


Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

Szczepny A, Wagstaff KM, Dias M, Gajewska K, Wang C, Davies RG, Kaur G, Ly-Huynh J, Loveland KL, Jans DA.

Biochem J. 2014 Aug 1;461(3):469-76. doi: 10.1042/BJ20130709.


Dynamic Hedgehog signalling pathway activity in germline stem cells.

Sahin Z, Szczepny A, McLaughlin EA, Meistrich ML, Zhou W, Ustunel I, Loveland KL.

Andrology. 2014 Mar;2(2):267-74. doi: 10.1111/j.2047-2927.2014.00187.x.


The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer.

Alamgeer M, Ganju V, Szczepny A, Russell PA, Prodanovic Z, Kumar B, Wainer Z, Brown T, Schneider-Kolsky M, Conron M, Wright G, Watkins DN.

Thorax. 2013 Dec;68(12):1095-104. doi: 10.1136/thoraxjnl-2012-203021. Epub 2013 Jul 22.


Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.

Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BR, Sadler AJ.

Immunity. 2012 May 25;36(5):795-806. doi: 10.1016/j.immuni.2012.02.020.


A crucial requirement for Hedgehog signaling in small cell lung cancer.

Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J.

Nat Med. 2011 Oct 9;17(11):1504-8. doi: 10.1038/nm.2473.


Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.

Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Harmon JW, Phillips WA, Watkins DN.

Gastroenterology. 2010 May;138(5):1810-22. doi: 10.1053/j.gastro.2010.01.048. Epub 2010 Feb 4.


Identification of Hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system.

Szczepny A, Hogarth CA, Young J, Loveland KL.

Biol Reprod. 2009 Feb;80(2):258-63. doi: 10.1095/biolreprod.108.067926. Epub 2008 Oct 8.


Expression of Wsb2 in the developing and adult mouse testis.

Sarraj MA, McClive PJ, Szczepny A, Daggag H, Loveland KL, Sinclair AH.

Reproduction. 2007 Apr;133(4):753-61.


Expression of hedgehog signalling components in adult mouse testis.

Szczepny A, Hime GR, Loveland KL.

Dev Dyn. 2006 Nov;235(11):3063-70.


Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis.

Loveland KL, Hogarth C, Szczepny A, Prabhu SM, Jans DA.

Biol Reprod. 2006 Jan;74(1):67-74. Epub 2005 Sep 28.


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