Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 68


Profibrotic epithelial phenotype: a central role for MRTF and TAZ.

Bialik JF, Ding M, Speight P, Dan Q, Miranda MZ, Di Ciano-Oliveira C, Kofler MM, Rotstein OD, Pedersen SF, Szászi K, Kapus A.

Sci Rep. 2019 Mar 13;9(1):4323. doi: 10.1038/s41598-019-40764-7.


Mediated nuclear import and export of TAZ and the underlying molecular requirements.

Kofler M, Speight P, Little D, Di Ciano-Oliveira C, Szászi K, Kapus A.

Nat Commun. 2018 Nov 23;9(1):4966. doi: 10.1038/s41467-018-07450-0.


Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock.

Leung CH, Caldarone CA, Guan R, Wen XY, Ailenberg M, Kapus A, Szaszi K, Rotstein OD.

Antioxid Redox Signal. 2019 May 10;30(14):1760-1773. doi: 10.1089/ars.2018.7541. Epub 2018 Dec 20.


Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis.

Rabani R, Volchuk A, Jerkic M, Ormesher L, Garces-Ramirez L, Canton J, Masterson C, Gagnon S, Tatham KC, Marshall J, Grinstein S, Laffey JG, Szaszi K, Curley GF.

Eur Respir J. 2018 Apr 26;51(4). pii: 1702021. doi: 10.1183/13993003.02021-2017. Print 2018 Apr.


Hemorrhagic Shock/Resuscitation Reduces the M2 Phenotype of Alveolar Macrophages: A Potential Mechanism Contributing to Increased LPS-Induced Lung Injury.

Safavian D, Leung CH, Kapus A, Ailenberg M, Szaszi K, Shani R, Di Ciano-Oliveira C, Ghazarian M, Rotstein O.

Shock. 2019 Feb;51(2):213-220. doi: 10.1097/SHK.0000000000001135.


Should basic science matter to clinicians?

Filewod NC, Batt J, Kapus A, Szaszi K, Fairn GD, Slutsky AS, Lee WL.

Lancet. 2018 Feb 3;391(10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. No abstract available.


Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac.

Amoozadeh Y, Anwer S, Dan Q, Venugopal S, Shi Y, Branchard E, Liedtke E, Ailenberg M, Rotstein OD, Kapus A, Szászi K.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C366-C378. doi: 10.1152/ajpcell.00234.2017. Epub 2017 Nov 29.


TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism.

Miranda MZ, Bialik JF, Speight P, Dan Q, Yeung T, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2017 Sep 8;292(36):14902-14920. doi: 10.1074/jbc.M117.780502. Epub 2017 Jul 24.


Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction.

Krauszman A, Mak TW, Szaszi K, Kuebler WM.

Cardiovasc Res. 2017 Jul 1;113(8):869-878. doi: 10.1093/cvr/cvx076.


Tumor Necrosis Factor-α Increases Claudin-1, 4, and 7 Expression in Tubular Cells: Role in Permeability Changes.

Amoozadeh Y, Dan Q, Anwer S, Huang HH, Barbieri V, Waheed F, Maishan M, Szászi K.

J Cell Physiol. 2017 Aug;232(8):2210-2220. doi: 10.1002/jcp.25736. Epub 2017 Mar 3.


Tsr Chemoreceptor Interacts With IL-8 Provoking E. coli Transmigration Across Human Lung Epithelial Cells.

Han B, Li M, Xu Y, Islam D, Khang J, Del Sorbo L, Lee W, Szaszi K, Zhong N, Slutsky AS, Li Y, Zhang H.

Sci Rep. 2016 Aug 10;6:31087. doi: 10.1038/srep31087.


Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src.

Tsang JL, Jia SH, Parodo J, Plant P, Lodyga M, Charbonney E, Szaszi K, Kapus A, Marshall JC.

PLoS One. 2016 Apr 21;11(4):e0153946. doi: 10.1371/journal.pone.0153946. eCollection 2016.


A basic scientist's reflections on research funding.

Szaszi K.

Can J Kidney Health Dis. 2015 Dec 1;2:50. doi: 10.1186/s40697-015-0087-0. eCollection 2015. No abstract available.


Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.

Rozycki M, Bialik JF, Speight P, Dan Q, Knudsen TE, Szeto SG, Yuen DA, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2016 Jan 1;291(1):227-43. doi: 10.1074/jbc.M115.674606. Epub 2015 Nov 10.


Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.

Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):370-83. doi: 10.1165/rcmb.2014-0225OC.


The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Zhang H, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL.

Sci Rep. 2015 Jun 5;5:11030. doi: 10.1038/srep11030.


Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions.

Amoozadeh Y, Dan Q, Xiao J, Waheed F, Szászi K.

Am J Physiol Cell Physiol. 2015 Jul 1;309(1):C38-50. doi: 10.1152/ajpcell.00388.2014. Epub 2015 May 6.


Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.

Tawadros PS, Powers KA, Ailenberg M, Birch SE, Marshall JC, Szaszi K, Kapus A, Rotstein OD.

Shock. 2015 Aug;44(2):157-65. doi: 10.1097/SHK.0000000000000392.


Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation.

Ailenberg M, Di Ciano-Oliveira C, Szaszi K, Dan Q, Rozycki M, Kapus A, Rotstein OD.

Br J Pharmacol. 2015 Aug;172(15):3748-63. doi: 10.1111/bph.13162. Epub 2015 May 15.


New insights into functions, regulation, and pathological roles of tight junctions in kidney tubular epithelium.

Szaszi K, Amoozadeh Y.

Int Rev Cell Mol Biol. 2014;308:205-71. doi: 10.1016/B978-0-12-800097-7.00006-3. Review.


Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.

Mouawad F, Aoudjit L, Jiang R, Szaszi K, Takano T.

J Biol Chem. 2014 Feb 14;289(7):4206-18. doi: 10.1074/jbc.M113.506816. Epub 2013 Dec 19.


Angiotensin-(1-7) protects from experimental acute lung injury.

Klein N, Gembardt F, Supé S, Kaestle SM, Nickles H, Erfinanda L, Lei X, Yin J, Wang L, Mertens M, Szaszi K, Walther T, Kuebler WM.

Crit Care Med. 2013 Nov;41(11):e334-43. doi: 10.1097/CCM.0b013e31828a6688.


Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.

Waheed F, Dan Q, Amoozadeh Y, Zhang Y, Tanimura S, Speight P, Kapus A, Szászi K.

Mol Biol Cell. 2013 Apr;24(7):1068-82. doi: 10.1091/mbc.E12-09-0661. Epub 2013 Feb 6.


Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton.

Ly DL, Waheed F, Lodyga M, Speight P, Masszi A, Nakano H, Hersom M, Pedersen SF, Szászi K, Kapus A.

Am J Physiol Cell Physiol. 2013 Jan 15;304(2):C115-27. doi: 10.1152/ajpcell.00290.2012. Epub 2012 Oct 10.


Affinity precipitation of active Rho-GEFs using a GST-tagged mutant Rho protein (GST-RhoA(G17A)) from epithelial cell lysates.

Waheed F, Speight P, Dan Q, Garcia-Mata R, Szaszi K.

J Vis Exp. 2012 Mar 31;(61). pii: 3932. doi: 10.3791/3932.


RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells.

Martin-Martin N, Dan Q, Amoozadeh Y, Waheed F, McMorrow T, Ryan MP, Szászi K.

Int J Biochem Cell Biol. 2012 Jan;44(1):178-88. doi: 10.1016/j.biocel.2011.10.014. Epub 2011 Nov 2.


Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase.

Malam Z, Parodo J, Waheed F, Szaszi K, Kapus A, Marshall JC.

J Immunol. 2011 Jun 1;186(11):6474-84. doi: 10.4049/jimmunol.1003706. Epub 2011 Apr 25.


The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.

Kakiashvili E, Dan Q, Vandermeer M, Zhang Y, Waheed F, Pham M, Szászi K.

J Biol Chem. 2011 Mar 18;286(11):9268-79. doi: 10.1074/jbc.M110.179903. Epub 2011 Jan 6.


Altered inhibitory κBα expression in LPS-stimulated alveolar macrophages following resuscitated hemorrhagic shock.

Papia G, Fan J, Kapus A, Szaszi K, Marshall JC, Tawadros P, Ailenberg M, Rotstein OD.

Shock. 2011 Feb;35(2):171-7. doi: 10.1097/SHK.0b013e3181f21d2d.


Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase.

Waheed F, Speight P, Kawai G, Dan Q, Kapus A, Szászi K.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1376-87. doi: 10.1152/ajpcell.00408.2009. Epub 2010 Mar 17.


Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3.

Masszi A, Speight P, Charbonney E, Lodyga M, Nakano H, Szászi K, Kapus A.

J Cell Biol. 2010 Feb 8;188(3):383-99. doi: 10.1083/jcb.200906155. Epub 2010 Feb 1.


Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/reperfusion injury: the role of High Mobility Group-Box 1.

Wang F, Birch SE, He R, Tawadros P, Szaszi K, Kapus A, Rotstein OD.

Ann Surg. 2010 Feb;251(2):292-9. doi: 10.1097/SLA.0b013e3181bfda8c.


GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.

Kakiashvili E, Speight P, Waheed F, Seth R, Lodyga M, Tanimura S, Kohno M, Rotstein OD, Kapus A, Szászi K.

J Biol Chem. 2009 Apr 24;284(17):11454-66. doi: 10.1074/jbc.M805933200. Epub 2009 Mar 3.


Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.

Thirone AC, Speight P, Zulys M, Rotstein OD, Szászi K, Pedersen SF, Kapus A.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C463-75. doi: 10.1152/ajpcell.00467.2008. Epub 2008 Dec 24.


Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.

Sebe A, Masszi A, Zulys M, Yeung T, Speight P, Rotstein OD, Nakano H, Mucsi I, Szászi K, Kapus A.

FEBS Lett. 2008 Jan 23;582(2):291-8. Epub 2007 Dec 27.


Stilbazulenyl nitrone decreases oxidative stress and reduces lung injury after hemorrhagic shock/resuscitation and LPS.

Tawadros PS, Powers KA, Yang I, Becker DA, Ginsberg MD, Szaszi K, Kapus A, Rotstein OD.

Antioxid Redox Signal. 2007 Nov;9(11):1971-7.


Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway.

Zhao XH, Laschinger C, Arora P, Szászi K, Kapus A, McCulloch CA.

J Cell Sci. 2007 May 15;120(Pt 10):1801-9. Epub 2007 Apr 24.


Coupling between apical and paracellular transport processes.

Kapus A, Szászi K.

Biochem Cell Biol. 2006 Dec;84(6):870-80. Review.


Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

Fan L, Sebe A, Péterfi Z, Masszi A, Thirone AC, Rotstein OD, Nakano H, McCulloch CA, Szászi K, Mucsi I, Kapus A.

Mol Biol Cell. 2007 Mar;18(3):1083-97. Epub 2007 Jan 10.


Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants.

Hyduk SJ, Chan JR, Duffy ST, Chen M, Peterson MD, Waddell TK, Digby GC, Szaszi K, Kapus A, Cybulsky MI.

Blood. 2007 Jan 1;109(1):176-84. Epub 2006 Sep 7.


Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages.

Powers KA, Szászi K, Khadaroo RG, Tawadros PS, Marshall JC, Kapus A, Rotstein OD.

J Exp Med. 2006 Aug 7;203(8):1951-61. Epub 2006 Jul 17.


Osmotic stress and the cytoskeleton: the R(h)ole of Rho GTPases.

Di Ciano-Oliveira C, Thirone AC, Szászi K, Kapus A.

Acta Physiol (Oxf). 2006 May-Jun;187(1-2):257-72. Review.


Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia: role in apical retention and targeting.

Alexander RT, Furuya W, Szászi K, Orlowski J, Grinstein S.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12253-8. Epub 2005 Aug 15.


Depolarization induces Rho-Rho kinase-mediated myosin light chain phosphorylation in kidney tubular cells.

Szászi K, Sirokmány G, Di Ciano-Oliveira C, Rotstein OD, Kapus A.

Am J Physiol Cell Physiol. 2005 Sep;289(3):C673-85. Epub 2005 Apr 27.


Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis.

Szászi K, Jones JJ, Nathens AB, Lo AY, Marsden PA, Kapus A, Rotstein OD.

Free Radic Biol Med. 2005 May 15;38(10):1333-43.


Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?

Di Ciano-Oliveira C, Lodyga M, Fan L, Szászi K, Hosoya H, Rotstein OD, Kapus A.

Am J Physiol Cell Physiol. 2005 Jul;289(1):C68-81. Epub 2005 Feb 23.


Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10.

Oreopoulos GD, Wu H, Szaszi K, Fan J, Marshall JC, Khadaroo RG, He R, Kapus A, Rotstein OD.

Hepatology. 2004 Jul;40(1):211-20.


Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B.

Hayashi H, Szászi K, Coady-Osberg N, Furuya W, Bretscher AP, Orlowski J, Grinstein S.

J Gen Physiol. 2004 May;123(5):491-504. Epub 2004 Apr 12.

Supplemental Content

Loading ...
Support Center