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J Crit Care. 2018 Jun;45:239-246. doi: 10.1016/j.jcrc.2018.02.012. Epub 2018 Mar 2.

Major publications in the critical care pharmacotherapy literature: January-December 2017.

Author information

1
Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, United States. Electronic address: drayton_hammond@rush.edu.
2
Touro University California College of Pharmacy, 1310 Club Drive, Vallejo, CA 94592, United States.
3
Roosevelt University College of Pharmacy, 430 S. Michigan Avenue, Chicago, IL 60605, United States. Electronic address: ccooper15@roosevelt.edu.
4
Loyola University Medical Center, 2160 S 1st Avenue, Maywood, IL 60153, United States. Electronic address: edonahey@lumc.edu.
5
Eskenazi Health, 720 Eskenazi Avenue, Indianapolis, IN 46202, United States. Electronic address: serena.harris@eskenazihealth.edu.
6
Roper St Francis Healthcare, 2095 Henry Tecklenburg Drive, Charleston, SC 29414, United States.
7
University of California, San Francisco Medical Center, 533 Parnassus Ave., Box 0622, San Francisco, CA 94143, United States. Electronic address: Amanda.Morris@ucsf.edu.
8
NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, 630 West 168th Street, NY, New York 10032, United States. Electronic address: mop9020@nyp.org.
9
John H. Stroger, Jr. Hospital of Cook County, 1901 West Harrison Street, LL175, Chicago, IL 60612, United States. Electronic address: aplewa@cookcountyhhs.org.
10
Cleveland Clinic Fairview Hospital, 18101 Lorain Road, Cleveland, OH 44111, United States. Electronic address: poorea@ccf.org.
11
Froedtert & the Medical College of Wisconsin - Community Memorial Hospital, W180 N8085 Town Hall Rd, Menomonee Falls, WI 53226, United States. Electronic address: ryan.szaniawski@froedtert.com.
12
United Healthcare Medicare and Retirement - Part D STARs, 2655 Warrenville Road, 3rd floor, Downers Grove, IL 60515, United States. Electronic address: deanna_horner@uhc.com.

Abstract

PURPOSE:

To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2017. The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 32 journals monthly for impactful articles and reviewed 115 during 2017. Two meta-analyses and eight original research trials were reviewed here from those included in the monthly CCPLU. Meta-analyses on early, goal-directed therapy for septic shock and statin therapy for acute respiratory distress syndrome were summarized. Original research trials that were included evaluate thrombolytic therapy in severe stroke, hyperoxia and hypertonic saline in septic shock, intraoperative ketamine for prevention of post-operative delirium, intravenous ketorolac dosing regimens for acute pain, angiotensin II for vasodilatory shock, dabigatran reversal with idarucizumab, bivalirudin versus heparin monotherapy for myocardial infarction, and balanced crystalloids versus saline fluid resuscitation.

CONCLUSION:

This clinical review provides perspectives on impactful critical care pharmacotherapy publications in 2017.

KEYWORDS:

Critical care; Drug therapy; Review; Septic shock

PMID:
29496373
DOI:
10.1016/j.jcrc.2018.02.012
[Indexed for MEDLINE]

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