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First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells.

Minev BR, Lander E, Feller JF, Berman M, Greenwood BM, Minev I, Santidrian AF, Nguyen D, Draganov D, Killinc MO, Vyalkova A, Kesari S, McClay E, Carabulea G, Marincola FM, Butterfield LH, Szalay AA.

J Transl Med. 2019 Aug 19;17(1):271. doi: 10.1186/s12967-019-2011-3.


Vaccinia virus injected human tumors: oncolytic virus efficiency predicted by antigen profiling analysis fitted boolean models.

Cecil A, Gentschev I, Adelfinger M, Dandekar T, Szalay AA.

Bioengineered. 2019 Dec;10(1):190-196. doi: 10.1080/21655979.2019.1622220.


Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers.

Draganov DD, Santidrian AF, Minev I, Nguyen D, Kilinc MO, Petrov I, Vyalkova A, Lander E, Berman M, Minev B, Szalay AA.

J Transl Med. 2019 Mar 27;17(1):100. doi: 10.1186/s12967-019-1829-z.


The ratio of ADSCs to HSC-progenitors in adipose tissue derived SVF may provide the key to predict the outcome of stem-cell therapy.

Kilinc MO, Santidrian A, Minev I, Toth R, Draganov D, Nguyen D, Lander E, Berman M, Minev B, Szalay AA.

Clin Transl Med. 2018 Feb 7;7(1):5. doi: 10.1186/s40169-018-0183-8.


Phase I Trial of Intravenous Oncolytic Vaccinia Virus (GL-ONC1) with Cisplatin and Radiotherapy in Patients with Locoregionally Advanced Head and Neck Carcinoma.

Mell LK, Brumund KT, Daniels GA, Advani SJ, Zakeri K, Wright ME, Onyeama SJ, Weisman RA, Sanghvi PR, Martin PJ, Szalay AA.

Clin Cancer Res. 2017 Oct 1;23(19):5696-5702. doi: 10.1158/1078-0432.CCR-16-3232. Epub 2017 Jul 5.


Humanized Mice with Subcutaneous Human Solid Tumors for Immune Response Analysis of Vaccinia Virus-Mediated Oncolysis.

Tsoneva D, Minev B, Frentzen A, Zhang Q, Wege AK, Szalay AA.

Mol Ther Oncolytics. 2017 Mar 21;5:41-61. doi: 10.1016/j.omto.2017.03.001. eCollection 2017 Jun 16.


Molecular network, pathway, and functional analysis of time-dependent gene changes associated with pancreatic cancer susceptibility to oncolytic vaccinia virotherapy.

Haddad D, Socci N, Chen CH, Chen NG, Zhang Q, Carpenter SG, Mittra A, Szalay AA, Fong Y.

Mol Ther Oncolytics. 2016 Mar 16;3:16008. doi: 10.1038/mto.2016.8. eCollection 2016.


Recombinant vaccinia virus GLV-1h68 is a promising oncolytic vector in the treatment of cholangiocarcinoma.

Pugalenthi A, Mojica K, Ady JW, Johnsen C, Love D, Chen NG, Aguilar RJ, Szalay AA, Fong Y.

Cancer Gene Ther. 2015 Dec;22(12):591-6. doi: 10.1038/cgt.2015.60. Epub 2015 Nov 20.


Drug-Encoded Biomarkers for Monitoring Biological Therapies.

Tsoneva D, Stritzker J, Bedenk K, Zhang Q, Frentzen A, Cappello J, Fischer U, Szalay AA.

PLoS One. 2015 Sep 8;10(9):e0137573. doi: 10.1371/journal.pone.0137573. eCollection 2015.


Preclinical Testing Oncolytic Vaccinia Virus Strain GLV-5b451 Expressing an Anti-VEGF Single-Chain Antibody for Canine Cancer Therapy.

Adelfinger M, Bessler S, Frentzen A, Cecil A, Langbein-Laugwitz J, Gentschev I, Szalay AA.

Viruses. 2015 Jul 20;7(7):4075-92. doi: 10.3390/v7072811.


Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent.

Kirscher L, Deán-Ben XL, Scadeng M, Zaremba A, Zhang Q, Kober C, Fehm TF, Razansky D, Ntziachristos V, Stritzker J, Szalay AA.

Theranostics. 2015 Jun 15;5(10):1045-57. doi: 10.7150/thno.12533. eCollection 2015.


Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps.

Kober C, Rohn S, Weibel S, Geissinger U, Chen NG, Szalay AA.

J Transl Med. 2015 Jul 7;13:216. doi: 10.1186/s12967-015-0586-x.


Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma.

Ady JW, Johnsen C, Mojica K, Heffner J, Love D, Pugalenthi A, Belin LJ, Chen NG, Yu YA, Szalay AA, Fong Y.

Surgery. 2015 Aug;158(2):331-8. doi: 10.1016/j.surg.2015.03.044. Epub 2015 Jun 3.


Gene therapy using therapeutic and diagnostic recombinant oncolytic vaccinia virus GLV-1h153 for management of colorectal peritoneal carcinomatosis.

Eveno C, Mojica K, Ady JW, Thorek DL, Longo V, Belin LJ, Gholami S, Johnsen C, Zanzonico P, Chen N, Yu T, Szalay AA, Fong Y.

Surgery. 2015 Feb;157(2):331-7. doi: 10.1016/j.surg.2014.09.008.


Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.

Kober C, Weibel S, Rohn S, Kirscher L, Szalay AA.

Mol Ther Oncolytics. 2015 Jun 24;2:15009. doi: 10.1038/mto.2015.9. eCollection 2015.


Expression of anti-VEGF antibody together with anti-EGFR or anti-FAP enhances tumor regression as a result of vaccinia virotherapy.

Huang T, Wang H, Chen NG, Frentzen A, Minev B, Szalay AA.

Mol Ther Oncolytics. 2015 Mar 18;2:15003. doi: 10.1038/mto.2015.3. eCollection 2015.


Antigen profiling analysis of vaccinia virus injected canine tumors: oncolytic virus efficiency predicted by boolean models.

Cecil A, Gentschev I, Adelfinger M, Nolte I, Dandekar T, Szalay AA.

Bioengineered. 2014 Sep-Oct;5(5):319-25. doi: 10.4161/bioe.32227.


Silk-elastin-like protein polymer matrix for intraoperative delivery of an oncolytic vaccinia virus.

Price DL, Li P, Chen CH, Wong D, Yu Z, Chen NG, Yu YA, Szalay AA, Cappello J, Fong Y, Wong RJ.

Head Neck. 2016 Feb;38(2):237-46. doi: 10.1002/hed.23877. Epub 2015 Jun 16.


Evaluation of a new recombinant oncolytic vaccinia virus strain GLV-5b451 for feline mammary carcinoma therapy.

Adelfinger M, Gentschev I, Grimm de Guibert J, Weibel S, Langbein-Laugwitz J, Härtl B, Murua Escobar H, Nolte I, Chen NG, Aguilar RJ, Yu YA, Zhang Q, Frentzen A, Szalay AA.

PLoS One. 2014 Aug 5;9(8):e104337. doi: 10.1371/journal.pone.0104337. eCollection 2014.


Inducible gene expression in tumors colonized by modified oncolytic vaccinia virus strains.

Stritzker J, Huppertz S, Zhang Q, Geissinger U, Härtl B, Gentschev I, Szalay AA.

J Virol. 2014 Oct;88(19):11556-67. doi: 10.1128/JVI.00681-14. Epub 2014 Jul 23.


Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma.

Pencavel TD, Wilkinson MJ, Mansfield DC, Khan AA, Seth R, Karapanagiotou EM, Roulstone V, Aguilar RJ, Chen NG, Szalay AA, Hayes AJ, Harrington KJ.

Int J Cancer. 2015 Feb 15;136(4):965-76. doi: 10.1002/ijc.29059. Epub 2014 Jul 22.


Oncolytic immunotherapy using recombinant vaccinia virus GLV-1h68 kills sorafenib-resistant hepatocellular carcinoma efficiently.

Ady JW, Heffner J, Mojica K, Johnsen C, Belin LJ, Love D, Chen CT, Pugalenthi A, Klein E, Chen NG, Yu YA, Szalay AA, Fong Y.

Surgery. 2014 Aug;156(2):263-9. doi: 10.1016/j.surg.2014.03.031. Epub 2014 Jun 21.


Characterization of metastasis formation and virotherapy in the human C33A cervical cancer model.

Donat U, Rother J, Schäfer S, Hess M, Härtl B, Kober C, Langbein-Laugwitz J, Stritzker J, Chen NG, Aguilar RJ, Weibel S, Szalay AA.

PLoS One. 2014 Jun 2;9(6):e98533. doi: 10.1371/journal.pone.0098533. eCollection 2014.


Oncolytic virotherapy of canine and feline cancer.

Gentschev I, Patil SS, Petrov I, Cappello J, Adelfinger M, Szalay AA.

Viruses. 2014 May 16;6(5):2122-37. doi: 10.3390/v6052122. Review.


Biotherapeutic approaches to target cancer stem cells.

Duggal R, Minev B, Geissinger U, Wang H, Chen NG, Koka PS, Szalay AA.

J Stem Cells. 2013;8(3-4):135-49. doi: jsc.2014.8.3/4.135. Review.


PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses.

Ruiz-Hernández E, Hess M, Melen GJ, Theek B, Talelli M, Shi Y, Ozbakir B, Teunissen EA, Ramírez M, Moeckel D, Kiessling F, Storm G, Scheeren HW, Hennink WE, Szalay AA, Stritzker J, Lammers T.

Polym Chem. 2014 Mar 7;(5):1674-1681. doi: 10.1039/C3PY01097J.


Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer.

Dai MH, Liu SL, Chen NG, Zhang TP, You L, Q Zhang F, Chou TC, Szalay AA, Fong Y, Zhao YP.

Cancer Lett. 2014 Mar 28;344(2):282-90. doi: 10.1016/j.canlet.2013.11.007. Epub 2013 Dec 7.


Vaccinia virus GLV-1h153 in combination with 131I shows increased efficiency in treating triple-negative breast cancer.

Gholami S, Chen CH, Lou E, Belin LJ, Fujisawa S, Longo VA, Chen NG, Gönen M, Zanzonico PB, Szalay AA, Fong Y.

FASEB J. 2014 Feb;28(2):676-82. doi: 10.1096/fj.13-237222. Epub 2013 Nov 1.


Optical detection and virotherapy of live metastatic tumor cells in body fluids with vaccinia strains.

Wang H, Chen NG, Minev BR, Zimmermann M, Aguilar RJ, Zhang Q, Sturm JB, Fend F, Yu YA, Cappello J, Lauer UM, Szalay AA.

PLoS One. 2013 Sep 3;8(9):e71105. doi: 10.1371/journal.pone.0071105. eCollection 2013.


An oncolytic vaccinia virus expressing the human sodium iodine symporter prolongs survival and facilitates SPECT/CT imaging in an orthotopic model of malignant pleural mesothelioma.

Belin LJ, Ady JW, Lewis C, Marano D, Gholami S, Mojica K, Eveno C, Longo V, Zanzonico PB, Chen NG, Szalay AA, Fong Y.

Surgery. 2013 Sep;154(3):486-95. doi: 10.1016/j.surg.2013.06.004. Epub 2013 Jul 23.


Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival.

Duggal R, Geissinger U, Zhang Q, Aguilar J, Chen NG, Binda E, Vescovi AL, Szalay AA.

J Transl Med. 2013 Jun 24;11:155. doi: 10.1186/1479-5876-11-155.


Vaccinia virus-mediated expression of human erythropoietin in tumors enhances virotherapy and alleviates cancer-related anemia in mice.

Nguyen DH, Chen NG, Zhang Q, Le HT, Aguilar RJ, Yu YA, Cappello J, Szalay AA.

Mol Ther. 2013 Nov;21(11):2054-62. doi: 10.1038/mt.2013.149. Epub 2013 Jun 14.


Combination of fractionated irradiation with anti-VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium.

Buckel L, Advani SJ, Frentzen A, Zhang Q, Yu YA, Chen NG, Ehrig K, Stritzker J, Mundt AJ, Szalay AA.

Int J Cancer. 2013 Dec 15;133(12):2989-99. doi: 10.1002/ijc.28296. Epub 2013 Aug 5.


Single-agent combinatorial cancer therapy.

Stritzker J, Szalay AA.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8325-6. doi: 10.1073/pnas.1305832110. Epub 2013 May 10. No abstract available.


Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer.

Weibel S, Hofmann E, Basse-Luesebrink TC, Donat U, Seubert C, Adelfinger M, Gnamlin P, Kober C, Frentzen A, Gentschev I, Jakob PM, Szalay AA.

J Transl Med. 2013 May 1;11:106. doi: 10.1186/1479-5876-11-106.


Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in (V600D/E)BRAF mutant melanoma depends on JNK and TNF-α signaling.

Kyula JN, Khan AA, Mansfield D, Karapanagiotou EM, McLaughlin M, Roulstone V, Zaidi S, Pencavel T, Touchefeu Y, Seth R, Chen NG, Yu YA, Zhang Q, Melcher AA, Vile RG, Pandha HS, Ajaz M, Szalay AA, Harrington KJ.

Oncogene. 2014 Mar 27;33(13):1700-12. doi: 10.1038/onc.2013.112. Epub 2013 Apr 29.


Growth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV-1h68.

Ehrig K, Kilinc MO, Chen NG, Stritzker J, Buckel L, Zhang Q, Szalay AA.

J Transl Med. 2013 Mar 26;11:79. doi: 10.1186/1479-5876-11-79.


Vaccinia virus GLV-1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer.

Gholami S, Chen CH, Belin LJ, Lou E, Fujisawa S, Antonacci C, Carew A, Chen NG, De Brot M, Zanzonico PB, Szalay AA, Fong Y.

Breast Cancer Res. 2013 Mar 18;15(2):R26. doi: 10.1186/bcr3404.


Imaging of intratumoral inflammation during oncolytic virotherapy of tumors by 19F-magnetic resonance imaging (MRI).

Weibel S, Basse-Luesebrink TC, Hess M, Hofmann E, Seubert C, Langbein-Laugwitz J, Gentschev I, Sturm VJ, Ye Y, Kampf T, Jakob PM, Szalay AA.

PLoS One. 2013;8(2):e56317. doi: 10.1371/journal.pone.0056317. Epub 2013 Feb 18.


Oncolytic vaccinia virus therapy of salivary gland carcinoma.

Chernichenko N, Linkov G, Li P, Bakst RL, Chen CH, He S, Yu YA, Chen NG, Szalay AA, Fong Y, Wong RJ.

JAMA Otolaryngol Head Neck Surg. 2013 Feb;139(2):173-82. doi: 10.1001/jamaoto.2013.1360.


Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer.

Stritzker J, Kirscher L, Scadeng M, Deliolanis NC, Morscher S, Symvoulidis P, Schaefer K, Zhang Q, Buckel L, Hess M, Donat U, Bradley WG, Ntziachristos V, Szalay AA.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3316-20. doi: 10.1073/pnas.1216916110. Epub 2013 Feb 11.


A vaccinia virus encoding the human sodium iodide symporter facilitates long-term image monitoring of virotherapy and targeted radiotherapy of pancreatic cancer.

Haddad D, Zanzonico PB, Carlin S, Chen CH, Chen NG, Zhang Q, Yu YA, Longo V, Mojica K, Aguilar RJ, Szalay AA, Fong Y.

J Nucl Med. 2012 Dec;53(12):1933-42. doi: 10.2967/jnumed.112.105056. Epub 2012 Nov 8.


Correlates between host and viral transcriptional program associated with different oncolytic vaccinia virus isolates.

Reinboth J, Ascierto ML, Chen NG, Zhang Q, Yu YA, Aguilar RJ, Carretero R, Worschech A, Zhao Y, Wang E, Marincola FM, Szalay AA.

Hum Gene Ther Methods. 2012 Oct;23(5):285-96. doi: 10.1089/hgtb.2012.057. Epub 2012 Nov 6.


Characterization and evaluation of a new oncolytic vaccinia virus strain LIVP6.1.1 for canine cancer therapy.

Gentschev I, Patil SS, Adelfinger M, Weibel S, Geissinger U, Frentzen A, Chen NG, Yu YA, Zhang Q, Ogilvie G, Szalay AA.

Bioengineered. 2013 Mar-Apr;4(2):84-9. doi: 10.4161/bioe.22462. Epub 2012 Oct 23.


Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.

Patil SS, Gentschev I, Adelfinger M, Donat U, Hess M, Weibel S, Nolte I, Frentzen A, Szalay AA.

PLoS One. 2012;7(10):e47472. doi: 10.1371/journal.pone.0047472. Epub 2012 Oct 16.


Preferential colonization of metastases by oncolytic vaccinia virus strain GLV-1h68 in a human PC-3 prostate cancer model in nude mice.

Donat U, Weibel S, Hess M, Stritzker J, Härtl B, Sturm JB, Chen NG, Gentschev I, Szalay AA.

PLoS One. 2012;7(9):e45942. doi: 10.1371/journal.pone.0045942. Epub 2012 Sep 25.


Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors.

Schäfer S, Weibel S, Donat U, Zhang Q, Aguilar RJ, Chen NG, Szalay AA.

BMC Cancer. 2012 Aug 23;12:366. doi: 10.1186/1471-2407-12-366.


Imaging characteristics, tissue distribution, and spread of a novel oncolytic vaccinia virus carrying the human sodium iodide symporter.

Haddad D, Chen CH, Carlin S, Silberhumer G, Chen NG, Zhang Q, Longo V, Carpenter SG, Mittra A, Carson J, Au J, Gonen M, Zanzonico PB, Szalay AA, Fong Y.

PLoS One. 2012;7(8):e41647. doi: 10.1371/journal.pone.0041647. Epub 2012 Aug 17.

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